Annexon (ANNX) Return on Assets [ROA] (2020 - 2026)
Annexon (ANNX) recorded Return on Assets [ROA] of -82.74% in Q2 2026, down 11.90 percentage points from -70.84% a year earlier and down 6.86 percentage points from the prior quarter.
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Analysis
Annexon (ANNX) Return on Assets [ROA] (2020 - 2026) Analysis & Trends
For FY2025, Annexon reported Return on Assets [ROA] of -68.96%, down 21.39 percentage points from FY2024.
- Annual Return on Assets [ROA] has a five-year change of -37.71 percentage points (FY2020 to FY2025).
- Across earlier years, Return on Assets [ROA] came in at -47.57% in FY2024 (+1.75 pp), -49.32% in FY2023 (+1.57 pp), -50.90% in FY2022 (-10.24 pp) and -40.66% in FY2021 (-9.41 pp).
- Quarterly Return on Assets [ROA] has ranged from -88.56% in Q3 2025 to -33.54% in Q3 2024 over the past five years.
- On a year-over-year basis, Return on Assets [ROA] has declined for six consecutive quarters, with an average year-over-year change of -15.89 percentage points over the last eight quarters.
- Peak year-over-year performance for Return on Assets [ROA] in the last five years was a gain of 35.33 percentage points in Q3 2024, against a drop of 55.03 percentage points in Q3 2025 at the low end.
- Per Business Quant, the preceding three quarters came in at -75.88% (Q1 2026), -85.42% (Q4 2025) and -88.56% (Q3 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | ROA (Qtr) |
|---|---|---|---|---|---|
| 1 | Johnson & Johnson | 638.12 Bn | 556.64 Bn | 17.26 Bn | 10.47% |
| 2 | AbbVie | 462.60 Bn | 435.75 Bn | 12.70 Bn | 4.65% |
| 3 | Merck | 358.70 Bn | 313.13 Bn | 12.21 Bn | 2.45% |
| 4 | Novartis Ag | 272.16 Bn | 228.03 Bn | 11.24 Bn | 28.37% |
| 5 | Astrazeneca | 250.36 Bn | 223.92 Bn | 12.86 Bn | 9.10% |
| 6 | Amgen | 227.87 Bn | 183.27 Bn | 7.24 Bn | 9.29% |
| 7 | Gilead Sciences | 184.97 Bn | 159.08 Bn | 6.22 Bn | -6.13% |
| 8 | Pfizer | 162.61 Bn | 109.56 Bn | 10.94 Bn | 2.14% |
| 9 | Vertex Pharmaceuticals | 132.45 Bn | 104.46 Bn | 2.84 Bn | 16.34% |
| 10 | Annexon | 738.58 Mn | 738.58 Mn | - | -82.74% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -82.74% |
| Mar 31, 2026 | -75.88% |
| Dec 31, 2025 | -85.42% |
| Sep 30, 2025 | -88.56% |
| Jun 30, 2025 | -70.84% |
| Mar 31, 2025 | -56.01% |
| Dec 31, 2024 | -42.28% |
| Sep 30, 2024 | -33.54% |
| Jun 30, 2024 | -35.75% |
| Mar 31, 2024 | -43.56% |
| Dec 31, 2023 | -57.32% |
| Sep 30, 2023 | -68.86% |
| Jun 30, 2023 | -60.46% |
| Mar 31, 2023 | -54.67% |
| Dec 31, 2022 | -48.71% |
| Sep 30, 2022 | -54.88% |
| Jun 30, 2022 | -61.91% |
| Mar 31, 2022 | -52.00% |
| Dec 31, 2021 | -43.72% |
| Sep 30, 2021 | -36.23% |
API Access
Annexon Return on Assets [ROA] API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=return-on-assets-%5Broa%5D&ticker=ANNX&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "return-on-assets-[roa]", "ticker": "ANNX", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=return-on-assets-%5Broa%5D&ticker=ANNX&period=max&api_key=YOUR_API_KEY");
const data = await res.json();