Amylyx Pharmaceuticals (AMLX) EBITDA (2021 - 2026)

Amylyx Pharmaceuticals (AMLX) recorded quarterly EBITDA of -$41.4 million in Q1 2026, down 148.03% quarter-over-quarter from $86.3 million in Q4 2025, and down 15.73% on a YoY basis from -$49.2 million in Q1 2025.

Amylyx Pharmaceuticals (AMLX) EBITDA (2021 - 2026) Analysis & Trends

Amylyx Pharmaceuticals' EBITDA history runs 6 years deep, the most recent figure standing at -$41.4 million for Q1 2026.

  • In Q1 2026, EBITDA fell 15.73% year-over-year to -$41.4 million; the TTM figure through Mar 2026 stood at -$34.0 million (down 248.82% YoY), while the FY2025 annual figure was -$30.4 million, up 52.11% from the prior year.
  • EBITDA was -$41.4 million for Q1 2026 at Amylyx Pharmaceuticals, down from $86.3 million in the prior quarter.
  • In the past five years, EBITDA ranged from a high of $210.6 million in Q4 2024 to a low of -$122.1 million in Q1 2024.
  • Historically, EBITDA has averaged -$17.4 million across 5 years, with a median of -$41.4 million in 2026.
  • Biggest YoY gain for EBITDA was 10790.8% in 2024; the steepest drop was 5848.86% in 2024.
  • A 5-year view of EBITDA shows it stood at -$44.6 million in 2022, then surged by 104.34% to $1.9 million in 2023, then jumped by 10790.8% to $210.6 million in 2024, then slumped by 59.03% to $86.3 million in 2025, then slumped by 148.03% to -$41.4 million in 2026.
  • The last three EBITDA figures came in at -$41.4 million (Q1 2026), $86.3 million (Q4 2025), and -$36.0 million (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) EBITDA (Qtr)
1 Teva Pharmaceutical Industries 38.34 Bn 34.60 Bn 1.97 Bn 652.00 Mn
2 Zoetis 33.27 Bn 31.33 Bn 1.62 Bn 833.00 Mn
3 United Therapeutics 23.75 Bn 21.60 Bn 648.10 Mn 325.80 Mn
4 Aurora Cannabis 17.11 Bn 17.03 Bn 33.43 Mn -681,231.97
5 Neurocrine Biosciences 16.37 Bn 15.05 Bn 800.70 Mn 185.20 Mn
6 Elanco Animal Health 11.78 Bn 11.35 Bn 785.00 Mn 307.00 Mn
7 Alkermes 7.05 Bn 6.54 Bn -116.06 Mn -67.29 Mn
8 Lantheus Holdings 6.49 Bn 5.99 Bn 230.92 Mn 81.33 Mn
9 Hims & Hers Health 6.19 Bn 5.44 Bn 396.79 Mn -98.81 Mn
10 Amylyx Pharmaceuticals 1.44 Bn 1.44 Bn - -41.45 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 -41.45 Mn
Dec 31, 2025 86.30 Mn
Sep 30, 2025 -36.03 Mn
Jun 30, 2025 -42.86 Mn
Mar 31, 2025 -35.82 Mn
Dec 31, 2024 210.63 Mn
Sep 30, 2024 -75.66 Mn
Jun 30, 2024 -76.29 Mn
Mar 31, 2024 -122.13 Mn
Dec 31, 2023 1.93 Mn
Sep 30, 2023 18.72 Mn
Jun 30, 2023 20.20 Mn
Mar 31, 2023 -2.05 Mn
Dec 31, 2022 -44.59 Mn
Sep 30, 2022 -54.68 Mn
Jun 30, 2022 -54.25 Mn
Mar 31, 2022 -47.81 Mn
Dec 31, 2021 -28.32 Mn
Sep 30, 2021 -22.92 Mn
Jun 30, 2021 -18.59 Mn