Alnylam Pharmaceuticals (ALNY) Operating Income (2009 - 2026)
Alnylam Pharmaceuticals posted quarterly Operating Income of $268.6 million for Q1 2026, up 1386.07% year-on-year from $18.1 million in Q1 2025, and up 103.95% on a QoQ basis from $131.7 million in Q4 2025.
Alnylam Pharmaceuticals (ALNY) has 18 years of Operating Income data on file, last reported at $268.6 million in Q1 2026.
- For the quarter ending Q1 2026, Operating Income rose 1386.07% year-over-year to $268.6 million; the trailing twelve-month figure through Mar 2026 stood at $752.1 million (up 751.92% YoY), and the FY2025 full-year result was $501.6 million, up 383.56% from the prior year.
- Operating Income for Q1 2026 stood at $268.6 million, up from $131.7 million in the prior quarter.
- Across five years, Operating Income topped out at $368.0 million in Q3 2025 and bottomed at -$258.0 million in Q3 2022.
- The 5-year median for Operating Income is -$76.9 million (2024), against an average of -$27.9 million.
- The widest annual swing landed in 2024, when Operating Income tumbled 135.96%; it then soared 1386.07% in 2026.
- A 5-year view of Operating Income shows it stood at -$188.6 million in 2022, then surged by 38.28% to -$116.4 million in 2023, then grew by 9.66% to -$105.2 million in 2024, then jumped by 225.26% to $131.7 million in 2025, then soared by 103.95% to $268.6 million in 2026.
- The last three Operating Income figures came in at $268.6 million (Q1 2026), $131.7 million (Q4 2025), and $368.0 million (Q3 2025), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Op. Inc (Qtr) |
|---|---|---|---|---|---|
| 1 | Quantum Biopharma | 961,148.99 Bn | 961,148.98 Bn | - | -2.97 Mn |
| 2 | Alterity Therapeutics | 744,933.29 Bn | 744,933.26 Bn | - | - |
| 3 | Legend Biotech | 2,540.00 Bn | 2,539.71 Bn | 242.10 Mn | -19.70 Mn |
| 4 | Nanobiotix | 2,199.85 Bn | 2,199.78 Bn | - | - |
| 5 | Akari Therapeutics | 1,635.88 Bn | 1,635.88 Bn | - | -15.76 Mn |
| 6 | Vertex Pharmaceuticals | 111.32 Bn | 104.07 Bn | 2.59 Bn | 1.14 Bn |
| 7 | Evaxion A | 62.56 Bn | 62.54 Bn | - | -3.82 Mn |
| 8 | Regeneron Pharmaceuticals | 62.55 Bn | 53.79 Bn | 3.31 Bn | 642.90 Mn |
| 9 | Alnylam Pharmaceuticals | 39.57 Bn | 36.56 Bn | 959.66 Mn | 268.64 Mn |
| 10 | Revolution Medicines | 32.39 Bn | 32.39 Bn | - | -445.22 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | 268.64 Mn |
| Dec 31, 2025 | 131.72 Mn |
| Sep 30, 2025 | 367.98 Mn |
| Jun 30, 2025 | -16.20 Mn |
| Mar 31, 2025 | 18.08 Mn |
| Dec 31, 2024 | -105.16 Mn |
| Sep 30, 2024 | -76.91 Mn |
| Jun 30, 2024 | 48.61 Mn |
| Mar 31, 2024 | -43.44 Mn |
| Dec 31, 2023 | -116.40 Mn |
| Sep 30, 2023 | 213.87 Mn |
| Jun 30, 2023 | -229.83 Mn |
| Mar 31, 2023 | -149.81 Mn |
| Dec 31, 2022 | -188.61 Mn |
| Sep 30, 2022 | -258.04 Mn |
| Jun 30, 2022 | -191.69 Mn |
| Mar 31, 2022 | -146.73 Mn |
| Dec 31, 2021 | -194.56 Mn |
| Sep 30, 2021 | -181.68 Mn |
| Jun 30, 2021 | -146.16 Mn |
| Mar 31, 2021 | -186.25 Mn |
| Dec 31, 2020 | -194.22 Mn |
| Sep 30, 2020 | -225.20 Mn |
| Jun 30, 2020 | -198.86 Mn |
| Mar 31, 2020 | -210.16 Mn |
| Dec 31, 2019 | -298.07 Mn |
| Sep 30, 2019 | -216.30 Mn |
| Jun 30, 2019 | -236.27 Mn |
| Mar 31, 2019 | -188.79 Mn |
| Dec 31, 2018 | -220.36 Mn |
| Sep 30, 2018 | -254.56 Mn |
| Jun 30, 2018 | -192.35 Mn |
| Mar 31, 2018 | -147.41 Mn |
| Dec 31, 2017 | -147.30 Mn |
| Sep 30, 2017 | -125.80 Mn |
| Jun 30, 2017 | -120.47 Mn |
| Mar 31, 2017 | -106.51 Mn |
| Dec 31, 2016 | -115.43 Mn |
| Sep 30, 2016 | -106.68 Mn |
| Jun 30, 2016 | -92.45 Mn |
| Mar 31, 2016 | -110.03 Mn |
| Dec 31, 2015 | -92.51 Mn |
| Sep 30, 2015 | -78.33 Mn |
| Jun 30, 2015 | -72.94 Mn |
| Mar 31, 2015 | -52.22 Mn |
| Dec 31, 2014 | -45.71 Mn |
| Sep 30, 2014 | -45.20 Mn |
| Jun 30, 2014 | -45.01 Mn |
| Mar 31, 2014 | -269.06 Mn |
| Dec 31, 2013 | -29.59 Mn |
| Sep 30, 2013 | -32.23 Mn |
| Jun 30, 2013 | -21.31 Mn |
| Mar 31, 2013 | -9.80 Mn |
| Dec 31, 2012 | -88.35 Mn |
| Sep 30, 2012 | -18.15 Mn |
| Jun 30, 2012 | -12.07 Mn |
| Mar 31, 2012 | -10.89 Mn |
| Dec 31, 2011 | -13.59 Mn |
| Sep 30, 2011 | -12.44 Mn |
| Jun 30, 2011 | -13.12 Mn |
| Mar 31, 2011 | -15.68 Mn |
| Dec 31, 2010 | -12.41 Mn |
| Sep 30, 2010 | -8.73 Mn |
| Jun 30, 2010 | -11.63 Mn |
| Mar 31, 2010 | -11.31 Mn |
| Dec 31, 2009 | -8.07 Mn |
| Sep 30, 2009 | -9.65 Mn |
| Jun 30, 2009 | -22.41 Mn |