Alumis (ALMS) Operating Income (2023 - 2026)
Alumis (ALMS) posted quarterly Operating Income of -$96.4 million for Q4 2025, up 2.21% year-over-year from -$94.4 million in Q4 2024, and up 16.35% quarter-over-quarter from -$115.3 million in Q3 2025.
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Alumis (ALMS) Operating Income (2023 - 2026) Analysis & Trends
Alumis (ALMS) has reported Operating Income for 3 consecutive years, with -$96.4 million the latest figure, recorded in Q4 2025.
- In Q4 2025, Operating Income rose 2.21% year-over-year to -$96.4 million; the TTM figure through Dec 2025 stood at -$453.8 million (down 50.89% YoY), while the FY2025 annual figure was -$453.8 million, down 50.89% from the prior year.
- Operating Income climbed to -$96.4 million in Q4 2025 per ALMS's latest filing, from -$115.3 million in the prior quarter.
- Across five years, Operating Income topped out at -$37.6 million in Q2 2023 and bottomed at -$140.5 million in Q2 2025.
- Historically, Operating Income has averaged -$79.6 million across 3 years, with a median of -$96.4 million in 2025.
- On a YoY basis, Operating Income climbed as much as 2.21% in 2025 and fell as far as 150.34% in 2025.
- Alumis' Operating Income stood at -$40.1 million in 2023, then sank by 145.74% to -$98.6 million in 2024, then gained by 2.21% to -$96.4 million in 2025.
- Business Quant data shows ALMS's Operating Income at -$96.4 million in Q4 2025, -$115.3 million in Q3 2025, and -$140.5 million in Q2 2025.
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Op. Inc (Qtr) |
|---|---|---|---|---|---|
| 1 | Vertex Pharmaceuticals | 138.78 Bn | 130.92 Bn | 2.84 Bn | 1.25 Bn |
| 2 | Regeneron Pharmaceuticals | 85.50 Bn | 77.51 Bn | 3.93 Bn | 1.29 Bn |
| 3 | Argenx Se | 63.51 Bn | 58.32 Bn | 1.37 Bn | 493.00 Mn |
| 4 | Moderna | 58.06 Bn | 52.92 Bn | 52.00 Mn | -815.00 Mn |
| 5 | Revolution Medicines | 44.04 Bn | 44.04 Bn | - | -505.13 Mn |
| 6 | BeOne Medicines | 40.04 Bn | 34.94 Bn | 1.53 Bn | 325.05 Mn |
| 7 | Alnylam Pharmaceuticals | 35.45 Bn | 32.14 Bn | 992.69 Mn | 231.44 Mn |
| 8 | Royalty Pharma | 28.41 Bn | 27.57 Bn | - | 133.12 Mn |
| 9 | Insmed | 27.42 Bn | 26.26 Bn | 358.27 Mn | -1.55 Mn |
| 10 | Alumis | 1.43 Bn | 924.11 Mn | - | -148.86 Mn |
Historic Data
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Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -148.86 Mn |
| Dec 31, 2025 | -96.45 Mn |
| Sep 30, 2025 | -115.29 Mn |
| Jun 30, 2025 | -140.54 Mn |
| Mar 31, 2025 | -101.53 Mn |
| Dec 31, 2024 | -98.62 Mn |
| Sep 30, 2024 | -98.40 Mn |
| Jun 30, 2024 | -56.14 Mn |
| Mar 31, 2024 | -47.59 Mn |
| Dec 31, 2023 | -40.13 Mn |
| Sep 30, 2023 | -43.76 Mn |
| Jun 30, 2023 | -37.62 Mn |