Arcellx (ACLX) Operating Income (2021 - 2025)

Arcellx's (ACLX) quarterly Operating Income came in at -$63.7 million in Q4 2025, down 19.81% year-on-year from -$79.4 million in Q4 2024, and down 3.09% quarter-over-quarter from -$61.8 million in Q3 2025.

Arcellx (ACLX) Operating Income (2021 - 2025) Analysis & Trends

Arcellx's Operating Income history runs 5 years deep, the most recent figure standing at -$63.7 million for Q4 2025.

  • On a quarterly basis, Operating Income fell 19.81% year-over-year to -$63.7 million in Q4 2025; TTM through Dec 2025 was -$253.1 million, a 83.97% decrease from a year earlier, with the FY2025 full-year figure at -$253.1 million, down 83.97% from the prior year.
  • Operating Income slipped to -$63.7 million in Q4 2025 per ACLX's latest filing, from -$61.8 million in the prior quarter.
  • Across five years, Operating Income topped out at $15.0 million in Q4 2023 and bottomed at -$93.9 million in Q3 2022.
  • The 5-year median for Operating Income is -$32.5 million (2022), against an average of -$36.8 million.
  • Across the five-year window, Operating Income soared 137.49% in 2023 and sank 454.37% in 2024, its largest moves.
  • Year by year, Operating Income stood at -$20.7 million in 2021, then tumbled by 93.27% to -$40.0 million in 2022, then surged by 137.49% to $15.0 million in 2023, then sank by 454.37% to -$53.2 million in 2024, then fell by 19.81% to -$63.7 million in 2025.
  • Per Business Quant, the three latest ACLX Operating Income figures stand at -$63.7 million (Q4 2025), -$61.8 million (Q3 2025), and -$58.7 million (Q2 2025).

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Op. Inc (Qtr)
1 Oculis Holding AG 67,072.09 Bn 67,072.09 Bn - -27.75 Mn
2 Nanobiotix 1,894.61 Bn 1,894.55 Bn - -
3 Akari Therapeutics 1,014.18 Bn 1,014.18 Bn - -15.76 Mn
4 BeOne Medicines 471.64 Bn 466.85 Bn 1.35 Bn 249.90 Mn
5 Vertex Pharmaceuticals 121.72 Bn 114.47 Bn 2.59 Bn 1.14 Bn
6 Regeneron Pharmaceuticals 68.28 Bn 59.52 Bn 3.31 Bn 642.90 Mn
7 Belite Bio 61.40 Bn 61.40 Bn - -32.68 Mn
8 Argenx Se 56.94 Bn 56.94 Bn 1.18 Bn 394.00 Mn
9 Revolution Medicines 37.37 Bn 37.37 Bn - -445.22 Mn
10 Arcellx 6.48 Bn 6.48 Bn - -63.68 Mn

Historic Data

Download Data
DateValue
Dec 31, 2025 -63.68 Mn
Sep 30, 2025 -61.78 Mn
Jun 30, 2025 -58.73 Mn
Mar 31, 2025 -68.90 Mn
Dec 31, 2024 -53.15 Mn
Sep 30, 2024 -33.62 Mn
Jun 30, 2024 -34.99 Mn
Mar 31, 2024 -15.81 Mn
Dec 31, 2023 15.00 Mn
Sep 30, 2023 -44.86 Mn
Jun 30, 2023 -29.56 Mn
Mar 31, 2023 -30.46 Mn
Dec 31, 2022 -40.00 Mn
Sep 30, 2022 -93.88 Mn
Jun 30, 2022 -31.29 Mn
Mar 31, 2022 -26.09 Mn
Dec 31, 2021 -20.70 Mn
Sep 30, 2021 -17.11 Mn
Jun 30, 2021 -15.93 Mn
Mar 31, 2021 -11.28 Mn