TECH vs TWST vs TXG Stock Comparison

Bio-Techne, Twist Bioscience and 10x Genomics Prices as of Oct 27, 2026 Peers: Industry group
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TECH BIO-TECHNE Corp
$72.60 0.0% 1M +13.0% 1Y
Market cap
$11.33B
P/E
62.3x
Revenue (TTM)
$1.22B
Div. yield
0.00%
Life Sciences Tools Healthcare
6 wins
TWST Twist Bioscience Corp
$159.85 -12.6% 1M +367.7% 1Y
Market cap
$10.90B
P/E
–
Revenue (TTM)
$431.80M
Div. yield
–
Life Sciences Tools Healthcare
2 wins
TXG 10x Genomics, Inc.
$78.02 -9.0% 1M +474.1% 1Y
Market cap
$10.89B
P/E
–
Revenue (TTM)
$616.91M
Div. yield
–
Life Sciences Tools Healthcare
1 win

Head to Head

9 decided of 12

Bio-Techne leads on 6 of the 12 questions below (Bio-Techne 6, Twist Bioscience 2, 10x Genomics 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionTECHTWSTTXGLeader
Larger companyMarket capitalisation $11.33B $10.90B $10.89B TECH
Cheaper on earningsLower P/E, profitable companies only 62.3x -79.7x -145.0x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS 33.6x — — –
Faster revenue growthRevenue growth, trailing twelve months -0.4% +19.2% -4.3% TWST
More profitableNet margin, trailing twelve months 15.0% -31.7% -12.2% TECH
Better return on capitalReturn on invested capital 8.3% -31.1% — TECH
Less leveragedLower net debt / EBITDA -0.2x 1.3x — TECH
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months +13.0% +367.7% +474.1% TXG
Better 5-year returnAnnualised price return, 5 years -10.8%/yr +5.6%/yr -13.9%/yr TWST
Less volatileAnnualised volatility, 1 year 43.5% 78.8% 73.9% TECH
Higher overall scoreMean of the five percentile scores vs peers 66/100 50/100 61/100 TECH

Percentile Scorecard

TECHTWSTTXG

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisTECHTWSTTXG
Valuation 58 #96 of 227 29 #162 of 227 43 #130 of 227
Growth 40 #131 of 219 55 #99 of 219 66 #76 of 219
Profitability 94 #14 of 206 41 #123 of 206 63 #77 of 206
Financial Health 86 #34 of 238 73 #64 of 238 68 #78 of 238
Shareholder Returns 51 #66 of 134 52 #65 of 134 68 #44 of 134
Overall 66 50 61
  • TECH ranked among 247 companies in Medical Devices and Diagnostics
  • TWST ranked among 247 companies in Medical Devices and Diagnostics
  • TXG ranked among 247 companies in Medical Devices and Diagnostics

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodTECHTWSTTXGSPY
1 month 0.0%-12.6%-9.0% -0.2%
3 months +0.7%+80.5%+65.8% +3.9%
6 months +35.7%+170.2%+265.1% +8.2%
Year to date +23.4%+403.9%+378.4% +12.9%
1 year +13.0%+367.7%+474.1% +12.3%
3 years +21.9%+957.9%+114.3% +87.4%
3 years, per year +6.8%+119.6%+28.9% +23.3%
5 years -43.6%+31.4%-52.6% +67.9%
5 years, per year -10.8%+5.6%-13.9% +10.9%
10 years +187.0%—— +261.1%
10 years, per year +11.1%—— +13.7%

Risk

MeasureTECHTWSTTXGSPY
Volatility, 1Y 43.5%78.8%73.9% 12.7%
Downside volatility, 1Y 43.4%69.5%66.1% 12.7%
Beta vs S&P 500, 1Y 0.772.692.22 1.00
Return / volatility, 1Y 0.304.676.41 0.97
Max drawdown, 5Y -67.0%-91.5%-96.1% -25.4%
From 52-week high -0.1%-22.0%-20.2% -1.2%
52-week high $72.69$205.00$97.74 $779.14
52-week low $43.30$25.45$12.44 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleTECHTWSTTXG
P/E now vs peer median 62.3xmedian 29.6x -72.9xmedian 29.6x -135.0xmedian 29.6x
P/S now vs peer median 9.3xmedian 2.9x 23.2xmedian 2.9x 16.5xmedian 2.9x
EV/EBITDA now vs peer median 32.3xmedian 17.4x -82.5xmedian 17.4x -227.8xmedian 17.4x
P/FCF now vs peer median 43.1xmedian 22.3x -102.1xmedian 22.3x 83.7xmedian 22.3x
P/B now vs peer median 5.4xmedian 2.3x 22.5xmedian 2.3x 12.3xmedian 2.3x
PEG now vs peer median -4.77median 1.04 -4.61median 1.04 -5.03median 1.04

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsTECHTWSTTXG
Revenue $1.22B $431.80M $616.91M
Gross profit $799.07M $224.39M $432.03M
Operating income $251.89M -$144.98M -$88.38M
Net income $181.86M -$136.80M -$75.13M
Free cash flow $263.22M -$98.12M $121.44M
R&D $94.77M $71.86M $226.80M
EPS (diluted) $1.16 $-2.19 $-0.58
Cash & equivalents $264.71M $117.44M –
Total debt $200.00M $15.00M –
Shares (diluted) 157.01M 62.40M 129.98M
Enterprise value $10.54B $10.13B $10.70B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricTECHTWSTTXG
P/E 62.3x -72.9x -135.0x
P/FCF 43.1x -102.1x 83.7x
P/Operating cash flow 38.8x -188.8x 80.0x
P/S 9.3x 23.2x 16.5x
P/B 5.4x 22.5x 12.3x
P/Tangible book 6.3x 23.1x 13.3x
EV/EBITDA 32.3x -82.5x -227.8x
EV/EBIT 44.7x -68.1x -114.4x
EV/Revenue 9.3x 22.9x 16.4x
EV/FCF 42.8x -100.6x 83.3x
EV/Operating cash flow 38.6x -185.9x 79.6x
PEG (3Y EPS CAGR) -4.77 -4.61 -5.03

Growth

14 metrics
MetricTECHTWSTTXG
Revenue growth (1Y) -0.4% 19.2% -4.3%
Revenue CAGR (3Y) 2.2% 22.4% 2.8%
Gross profit growth (1Y) 1.1% 25.8% -3.5%
Gross profit CAGR (3Y) 1.3% 35.1% 1.1%
Operating income growth (1Y) 146.3% -1.8% 12.1%
Operating income CAGR (3Y) -5.5% 13.5% 20.9%
Net income growth (1Y) 147.8% -60.6% 11.2%
Net income CAGR (3Y) -14.0% 13.2% 24.2%
EPS growth (1Y) 152.0% -57.5% 14.9%
EPS CAGR (3Y) -13.1% 15.8% 26.8%
Operating cash flow growth (1Y) 1.6% -3.8% 89.8%
Operating cash flow CAGR (3Y) 4.7% 24.4% 135.5%
Free cash flow growth (1Y) 2.6% -42.8% 113.5%
Free cash flow CAGR (3Y) 6.8% 15.9% 44.7%

Profitability

14 metrics
MetricTECHTWSTTXG
Gross margin 65.8% 52.0% 70.0%
EBITDA margin 28.7% -27.7% -7.2%
Operating margin 20.7% -33.6% -14.3%
Pretax margin 19.8% -31.5% -12.1%
Net margin 15.0% -31.7% -12.2%
FCF margin 21.7% -22.7% 19.7%
Operating cash flow margin 24.0% -12.3% 20.6%
Return on equity 8.7% -30.4% -9.2%
Return on assets 7.1% -20.3% -7.3%
Return on invested capital 8.3% -31.1% –
Return on capital employed 10.5% -26.2% -9.8%
Asset turnover 0.5x 0.6x 0.6x
Cash conversion (OCF / net income) 1.6x 0.4x -1.7x
Stock comp / revenue 0.5% 15.4% 16.0%

Financial Health

11 metrics
MetricTECHTWSTTXG
Debt / assets 7.7% 2.2% –
Debt / equity 0.1x 0.0x –
Net debt / EBITDA -0.2x 1.3x –
Debt / FCF 0.8x -0.2x –
Liabilities / assets 18.5% 33.7% 19.9%
Equity / assets 81.5% 66.3% 80.1%
Interest coverage 26.2x – –
Current ratio 4.5x 2.7x 5.7x
Quick ratio 2.9x 1.9x 0.8x
Cash ratio 1.6x 1.4x 0.4x
Altman Z-score 15.89 23.83 28.69

Shareholder Returns

7 metrics
MetricTECHTWSTTXG
Dividend yield 0.4% – –
Net buyback yield -0.3% -0.1% -0.1%
Shareholder yield 0.1% -0.1% -0.1%
Payout ratio (earnings) 27.4% – –
Payout ratio (FCF) 19.0% – –
Dividend growth (1Y) -0.9% – –
Dividend CAGR (3Y) -0.2% – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusTECHTWSTTXG
Forward P/E 33.6xFY2027 – –
EPS, next fiscal year $2.16FY2027 $-2.02FY2026 $-0.79FY2026
EPS growth, next FY +11.9%FY2027 – –
EPS growth, the year after +5.1% – –
Revenue, next fiscal year $1.19BFY2027 $469.33MFY2026 $580.42MFY2026
Revenue growth, next FY -2.1%FY2027 +24.6%FY2026 -9.7%FY2026
Revenue growth, the year after +13.5% +21.5% +24.6%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersTECHTWSTTXG
Held by institutions 100.0% 100.0% 100.0%
Institutions holding 597 335 389
Change in shares held, QoQ -0.6% -0.8% +2.4%
Institutions buying 293 188 197
Institutions selling 241 102 137
Buyers to sellers 1.22 1.84 1.44

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

TECHTWSTTXG
TECH 1.00 0.32 0.34
TWST 0.32 1.00 0.60
TXG 0.34 0.60 1.00

Add a Peer

Largest companies in the same industry

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Frequently Asked Questions

Which is bigger, TECH, TWST and TXG?

Bio-Techne (TECH) is the largest by market capitalisation: Bio-Techne (TECH) $11.33B, Twist Bioscience (TWST) $10.90B, 10x Genomics (TXG) $10.89B.

Which company is growing faster?

Twist Bioscience (TWST) grew revenue fastest over the trailing twelve months: Bio-Techne (TECH) -0.4%, Twist Bioscience (TWST) +19.2%, 10x Genomics (TXG) -4.3%.

Which company is more profitable?

Bio-Techne (TECH) has the highest net margin (Bio-Techne (TECH) 15.0%, Twist Bioscience (TWST) -31.7%, 10x Genomics (TXG) -12.2%). On return on invested capital, Bio-Techne (TECH) leads (Bio-Techne (TECH) 8.3%, Twist Bioscience (TWST) -31.1%).

Which stock has performed better?

Over the past year 10x Genomics (TXG) returned the most: Bio-Techne (TECH) +13.0%, Twist Bioscience (TWST) +367.7%, 10x Genomics (TXG) +474.1%. Over five years, Twist Bioscience (TWST) compounded fastest (Bio-Techne (TECH) -10.8%/yr, Twist Bioscience (TWST) +5.6%/yr, 10x Genomics (TXG) -13.9%/yr). Returns are price only, before dividends.

Which pays a higher dividend?

Only one of these companies pays a dividend: Bio-Techne (TECH) 0.00%, Twist Bioscience (TWST) 0.00%, 10x Genomics (TXG) 0.00%. Twist Bioscience (TWST) and 10x Genomics (TXG) pays no regular dividend.

Which stock is riskier?

By one-year price volatility, Bio-Techne (TECH) has been the steadiest (Bio-Techne (TECH) 43.5%, Twist Bioscience (TWST) 78.8%, 10x Genomics (TXG) 73.9%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, TECH, TWST and TXG?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Bio-Techne (TECH) leads on 6. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.