SRPT vs CRSP vs SLBT Stock Comparison

Sarepta Therapeutics, CRISPR Therapeutics AG and SL Science Holding Prices as of Nov 5, 2026 Peers: Industry group
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CRSP CRISPR Therapeutics AG
$48.56 -10.1% 1M -14.8% 1Y
Market cap
$4.71B
P/E
–
Revenue (TTM)
$25.17M
Div. yield
–
Gene and Cell Therapy Healthcare
3 wins

Head to Head

9 decided of 12

Sarepta Therapeutics leads on 6 of the 12 questions below (Sarepta Therapeutics 6, CRISPR Therapeutics AG 3). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionSRPTCRSPSLBTLeader
Larger companyMarket capitalisation $1.88B $4.71B $1.96B CRSP
Cheaper on earningsLower P/E, profitable companies only -19.6x -10.3x — –
Cheaper on forward earningsLower price / next fiscal year consensus EPS 6.1x — — –
Faster revenue growthRevenue growth, trailing twelve months -18.9% -34.3% — SRPT
More profitableNet margin, trailing twelve months -4.8% -1,812.1% — SRPT
Better return on capitalReturn on invested capital -2.1% -23.3% — SRPT
Less leveragedLower net debt / EBITDA 1.3x 3.3x — SRPT
Higher dividend yieldTrailing dividend yield — — 0.00% –
Better 1-year returnPrice return, last 12 months -6.0% -14.8% -91.3% SRPT
Better 5-year returnAnnualised price return, 5 years -27.7%/yr -11.7%/yr — CRSP
Less volatileAnnualised volatility, 1 year 68.7% 57.1% 177.0% CRSP
Higher overall scoreMean of the five percentile scores vs peers 76/100 47/100 — SRPT

Percentile Scorecard

SRPTCRSPSLBT

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisSRPTCRSPSLBT
Valuation 98 #17 of 634 51 #310 of 634 11 #567 of 634
Growth 84 #101 of 608 27 #445 of 608 –
Profitability 81 #108 of 557 37 #354 of 557 –
Financial Health 33 #438 of 654 69 #202 of 654 57 #281 of 654
Shareholder Returns 87 #53 of 403 51 #198 of 403 –
Overall 76 47 –
  • SRPT ranked among 671 companies in Pharmaceuticals and Biotechnology
  • CRSP ranked among 671 companies in Pharmaceuticals and Biotechnology
  • SLBT ranked among 671 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodSRPTCRSPSLBTSPY
1 month +1.4%-10.1%-40.8% -5.9%
3 months +4.6%-6.0%-67.0% -4.6%
6 months -15.6%-7.4%-88.6% +0.2%
Year to date -18.4%-7.4%-91.5% +7.5%
1 year -6.0%-14.8%-91.3% +8.2%
3 years -78.1%-5.9%— +68.3%
3 years, per year -39.7%-2.0%— +19.0%
5 years -80.3%-46.2%— +56.5%
5 years, per year -27.7%-11.7%— +9.4%
10 years -55.2%+219.5%— +251.5%
10 years, per year -7.7%+12.3%— +13.4%

Risk

MeasureSRPTCRSPSLBTSPY
Volatility, 1Y 68.7%57.1%177.0% 13.6%
Downside volatility, 1Y 64.0%53.6%171.2% 14.2%
Beta vs S&P 500, 1Y 1.751.780.58 1.00
Return / volatility, 1Y -0.09-0.26-0.52 0.60
Max drawdown, 5Y -92.7%-66.8%-93.0% -25.4%
From 52-week high -26.4%-21.5%-93.0% -5.9%
52-week high $23.83$61.89$12.81 $779.14
52-week low $14.86$44.34$0.90 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleSRPTCRSPSLBT
P/E now vs peer median -19.6xmedian 17.8x -10.3xmedian 17.8x —median 17.8x
P/S now vs peer median 1.0xmedian 8.1x 187.1xmedian 8.1x —median 8.1x
EV/EBITDA now vs peer median -111.1xmedian 15.7x -5.9xmedian 15.7x —median 15.7x
P/FCF now vs peer median 10.7xmedian 21.0x -12.5xmedian 21.0x -1,045xmedian 21.0x
P/B now vs peer median 1.2xmedian 2.0x 2.9xmedian 2.0x 281.5xmedian 2.0x
PEG now vs peer median -0.38median 0.36 5.33median 0.36 —median 0.36

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsSRPTCRSPSLBT
Revenue $1.96B $25.17M –
Gross profit $1.11B – –
Operating income -$48.90M -$532.33M –
Net income -$114.62M -$456.14M –
Free cash flow $176.40M -$376.72M –
R&D $653.10M $291.14M –
EPS (diluted) $-0.89 $-4.72 –
Cash & equivalents $472.80M $192.03M $8.31M
Total debt $857.36M $586.93M –
Shares (diluted) 105.93M 96.74M –
Enterprise value -$1.38B -$4.34B $1.95B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricSRPTCRSPSLBT
P/E -19.6x -10.3x –
P/FCF 10.7x -12.5x -1,045x
P/Operating cash flow 10.1x -12.6x –
P/S 1.0x 187.1x –
P/B 1.2x 2.9x 281.5x
P/Tangible book 1.3x 2.9x 281.5x
EV/EBITDA -111.1x -5.9x –
EV/EBIT -38.0x -5.7x –
EV/Revenue 1.0x 120.2x –
EV/FCF 10.5x -8.0x –
EV/Operating cash flow 10.0x -8.1x –
PEG (3Y EPS CAGR) -0.38 5.33 –

Growth

14 metrics
MetricSRPTCRSPSLBT
Revenue growth (1Y) -18.9% -34.3% –
Revenue CAGR (3Y) 21.0% -47.1% –
Gross profit growth (1Y) -39.6% – –
Gross profit CAGR (3Y) 4.7% – –
Operating income growth (1Y) 61.3% 7.3% –
Operating income CAGR (3Y) 50.3% -7.9% –
Net income growth (1Y) 19.4% 6.6% –
Net income CAGR (3Y) 45.1% -8.9% –
EPS growth (1Y) 26.5% 11.8% –
EPS CAGR (3Y) 51.4% -1.9% –
Operating cash flow growth (1Y) 175.9% -23.8% –
Operating cash flow CAGR (3Y) 32.8% -10.5% –
Free cash flow growth (1Y) 146.3% -24.3% –
Free cash flow CAGR (3Y) 31.9% -8.8% –

Profitability

14 metrics
MetricSRPTCRSPSLBT
Gross margin 56.8% – –
EBITDA margin -0.9% -2,038% –
Operating margin -2.5% -2,115% –
Pretax margin -4.7% -1,802% –
Net margin -4.8% -1,812% –
FCF margin 9.0% -1,497% –
Operating cash flow margin 9.5% -1,488% –
Return on equity -7.5% -26.9% –
Return on assets -3.6% -17.5% –
Return on invested capital -2.1% -23.3% –
Return on capital employed -1.9% -21.6% –
Asset turnover 0.6x 0.0x –
Cash conversion (OCF / net income) -1.6x 0.8x –
Stock comp / revenue 7.0% 276.8% –

Financial Health

11 metrics
MetricSRPTCRSPSLBT
Debt / assets 27.1% 23.0% –
Debt / equity 0.6x 0.4x –
Net debt / EBITDA 1.3x 3.3x –
Debt / FCF 4.9x -1.6x –
Liabilities / assets 51.7% 35.5% 21.8%
Equity / assets 48.3% 64.5% 78.2%
Interest coverage – – –
Current ratio 3.5x 16.2x 4.4x
Quick ratio 2.0x 16.1x 4.3x
Cash ratio 1.3x 16.1x 4.3x
Altman Z-score -0.16 2.20 –

Shareholder Returns

7 metrics
MetricSRPTCRSPSLBT
Dividend yield – – –
Net buyback yield 0.0% -2.9% –
Shareholder yield 0.0% -2.9% 0.0%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusSRPTCRSPSLBT
Forward P/E 6.1xFY2026 – –
EPS, next fiscal year $2.88FY2026 $-4.27FY2026 –
EPS growth, the year after -88.5% – –
Revenue, next fiscal year $1.76BFY2026 $33.04MFY2026 –
Revenue growth, next FY -20.1%FY2026 +841.2%FY2026 –
Revenue growth, the year after -21.5% +271.8% –

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersSRPTCRSPSLBT
Held by institutions 100.0% 78.9% –
Institutions holding 326 520 –
Change in shares held, QoQ +4.5% -1.0% –
Institutions buying 148 238 –
Institutions selling 117 139 –
Buyers to sellers 1.26 1.71 –

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

SRPTCRSPSLBT
SRPT 1.00 0.37 0.01
CRSP 0.37 1.00 -0.03
SLBT 0.01 -0.03 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, SRPT, CRSP and SLBT?

CRISPR Therapeutics AG (CRSP) is the largest by market capitalisation: Sarepta Therapeutics (SRPT) $1.88B, CRISPR Therapeutics AG (CRSP) $4.71B, SL Science Holding (SLBT) $1.96B.

Which company is growing faster?

Sarepta Therapeutics (SRPT) grew revenue fastest over the trailing twelve months: Sarepta Therapeutics (SRPT) -18.9%, CRISPR Therapeutics AG (CRSP) -34.3%.

Which company is more profitable?

Sarepta Therapeutics (SRPT) has the highest net margin (Sarepta Therapeutics (SRPT) -4.8%, CRISPR Therapeutics AG (CRSP) -1,812.1%). On return on invested capital, Sarepta Therapeutics (SRPT) leads (Sarepta Therapeutics (SRPT) -2.1%, CRISPR Therapeutics AG (CRSP) -23.3%).

Which stock has performed better?

Over the past year Sarepta Therapeutics (SRPT) returned the most: Sarepta Therapeutics (SRPT) -6.0%, CRISPR Therapeutics AG (CRSP) -14.8%, SL Science Holding (SLBT) -91.3%. Over five years, CRISPR Therapeutics AG (CRSP) compounded fastest (Sarepta Therapeutics (SRPT) -27.7%/yr, CRISPR Therapeutics AG (CRSP) -11.7%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, CRISPR Therapeutics AG (CRSP) has been the steadiest (Sarepta Therapeutics (SRPT) 68.7%, CRISPR Therapeutics AG (CRSP) 57.1%, SL Science Holding (SLBT) 177.0%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, SRPT, CRSP and SLBT?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Sarepta Therapeutics (SRPT) leads on 6. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.