SLDB vs KRYS vs BEAM Stock Comparison

Solid Biosciences, Krystal Biotech and Beam Therapeutics Prices as of Oct 27, 2026 Peers: Industry group
KRYS Krystal Biotech, Inc.
$320.58 -7.3% 1M +68.8% 1Y
Market cap
$9.45B
P/E
39.2x
Revenue (TTM)
$440.53M
Div. yield
–
Gene and Cell Therapy Healthcare
6 wins
BEAM Beam Therapeutics Inc.
$24.90 +2.6% 1M -6.8% 1Y
Market cap
$2.83B
P/E
–
Revenue (TTM)
$156.04M
Div. yield
–
Gene and Cell Therapy Healthcare
1 win

Head to Head

7 decided of 12

Krystal Biotech leads on 6 of the 12 questions below (Krystal Biotech 6, Beam Therapeutics 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionSLDBKRYSBEAMLeader
Larger companyMarket capitalisation $909.55M $9.45B $2.83B KRYS
Cheaper on earningsLower P/E, profitable companies only -4.4x 39.2x -33.1x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — 46.2x — –
Faster revenue growthRevenue growth, trailing twelve months — +22.6% +158.9% BEAM
More profitableNet margin, trailing twelve months — 54.8% -54.7% KRYS
Better return on capitalReturn on invested capital — — — –
Less leveragedLower net debt / EBITDA — — 3.0x –
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months +4.9% +68.8% -6.8% KRYS
Better 5-year returnAnnualised price return, 5 years -26.0%/yr +43.0%/yr -23.4%/yr KRYS
Less volatileAnnualised volatility, 1 year 78.4% 38.1% 69.2% KRYS
Higher overall scoreMean of the five percentile scores vs peers 42/100 85/100 69/100 KRYS

Percentile Scorecard

SLDBKRYSBEAM

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisSLDBKRYSBEAM
Valuation 34 #413 of 625 79 #131 of 625 54 #286 of 625
Growth 19 #488 of 602 93 #43 of 602 77 #137 of 602
Profitability 50 #276 of 551 96 #22 of 551 64 #198 of 551
Financial Health 88 #78 of 656 84 #105 of 656 81 #128 of 656
Shareholder Returns 18 #300 of 365 70 #109 of 365 67 #123 of 365
Overall 42 85 69
  • SLDB ranked among 672 companies in Pharmaceuticals and Biotechnology
  • KRYS ranked among 672 companies in Pharmaceuticals and Biotechnology
  • BEAM ranked among 672 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodSLDBKRYSBEAMSPY
1 month -15.1%-7.3%+2.6% -0.2%
3 months -22.3%-12.0%-5.3% +3.9%
6 months -16.9%+19.1%-18.5% +8.2%
Year to date +9.8%+30.0%-10.2% +12.9%
1 year +4.9%+68.8%-6.8% +12.3%
3 years +227.5%+180.8%+33.7% +87.4%
3 years, per year +48.5%+41.1%+10.2% +23.3%
5 years -77.8%+496.2%-73.6% +67.9%
5 years, per year -26.0%+43.0%-23.4% +10.9%

Risk

MeasureSLDBKRYSBEAMSPY
Volatility, 1Y 78.4%38.1%69.2% 12.7%
Downside volatility, 1Y 77.0%37.3%63.8% 12.7%
Beta vs S&P 500, 1Y 2.120.692.06 1.00
Return / volatility, 1Y 0.061.81-0.10 0.97
Max drawdown, 5Y -94.9%-44.5%-85.3% -25.4%
From 52-week high -44.5%-15.2%-34.3% -1.2%
52-week high $11.15$378.15$37.92 $779.14
52-week low $3.93$185.05$20.60 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleSLDBKRYSBEAM
P/E now vs peer median -4.3xmedian 17.2x 39.2xmedian 17.2x -30.4xmedian 17.2x
P/S now vs peer median —median 9.0x 21.5xmedian 9.0x 16.5xmedian 9.0x
EV/EBITDA now vs peer median -2.4xmedian 16.3x 42.4xmedian 16.3x -4.3xmedian 16.3x
P/FCF now vs peer median -4.7xmedian 18.7x 36.8xmedian 18.7x -6.9xmedian 18.7x
P/B now vs peer median 2.4xmedian 2.2x 7.0xmedian 2.2x 2.4xmedian 2.2x
PEG now vs peer median -0.13median 0.33 0.76median 0.33 -0.72median 0.33

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsSLDBKRYSBEAM
Revenue – $440.53M $156.04M
Gross profit – $416.91M –
Operating income -$212.15M $197.75M -$378.02M
Net income -$207.10M $241.47M -$86.52M
Free cash flow -$187.82M $257.78M -$372.77M
R&D $167.40M $59.23M $408.66M
EPS (diluted) $-1.44 $7.88 $-0.82
Cash & equivalents $159.39M $427.74M $219.83M
Total debt – – $100.26M
Shares (diluted) 143.69M 30.66M 104.33M
Enterprise value -$272.80M $6.23B -$1.85B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricSLDBKRYSBEAM
P/E -4.3x 39.2x -30.4x
P/FCF -4.7x 36.8x -6.9x
P/Operating cash flow -4.8x 34.8x -7.2x
P/S – 21.5x 16.5x
P/B 2.4x 7.0x 2.4x
P/Tangible book 2.4x 7.0x 2.4x
EV/EBITDA -2.4x 42.4x -4.3x
EV/EBIT -2.4x 43.7x -4.0x
EV/Revenue – 19.6x 9.7x
EV/FCF -2.7x 33.5x -4.1x
EV/Operating cash flow -2.7x 31.7x -4.2x
PEG (3Y EPS CAGR) -0.13 0.76 -0.72

Growth

14 metrics
MetricSLDBKRYSBEAM
Revenue growth (1Y) – 22.6% 158.9%
Revenue CAGR (3Y) – – 24.9%
Gross profit growth (1Y) – 24.3% –
Gross profit CAGR (3Y) – – –
Operating income growth (1Y) -35.3% 41.8% 15.2%
Operating income CAGR (3Y) -22.8% 48.8% 0.3%
Net income growth (1Y) -34.4% 64.6% 78.2%
Net income CAGR (3Y) -31.9% 54.9% 35.8%
EPS growth (1Y) 11.9% 59.7% 79.0%
EPS CAGR (3Y) 32.0% 51.8% 42.4%
Operating cash flow growth (1Y) -52.4% 39.4% -4.2%
Operating cash flow CAGR (3Y) -19.2% 67.0% -2.0%
Free cash flow growth (1Y) -52.3% 39.0% -4.8%
Free cash flow CAGR (3Y) -18.4% 58.6% 0.7%

Profitability

14 metrics
MetricSLDBKRYSBEAM
Gross margin – 94.6% –
EBITDA margin – 46.2% -228.0%
Operating margin – 44.9% -242.3%
Pretax margin – 51.4% -54.4%
Net margin – 54.8% -54.7%
FCF margin – 58.5% -238.9%
Operating cash flow margin – 61.8% -230.3%
Return on equity -55.4% 18.3% -7.6%
Return on assets -49.1% 16.7% -5.9%
Return on invested capital – – –
Return on capital employed -54.0% 15.0% -27.9%
Asset turnover – 0.3x 0.1x
Cash conversion (OCF / net income) 0.9x 1.1x 4.2x
Stock comp / revenue – 12.4% 52.2%

Financial Health

11 metrics
MetricSLDBKRYSBEAM
Debt / assets – – 7.2%
Debt / equity – – 0.1x
Net debt / EBITDA – – 3.0x
Debt / FCF – – -0.3x
Liabilities / assets 11.1% 9.4% 23.0%
Equity / assets 88.9% 90.6% 77.0%
Interest coverage – – –
Current ratio 13.8x 8.3x 14.6x
Quick ratio 13.2x 7.7x 14.3x
Cash ratio 13.2x 6.6x 14.3x
Altman Z-score – 41.82 3.08

Shareholder Returns

7 metrics
MetricSLDBKRYSBEAM
Dividend yield – – –
Net buyback yield -27.0% -0.4% -0.6%
Shareholder yield -27.0% -0.4% -0.6%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusSLDBKRYSBEAM
Forward P/E – 46.2xFY2026 –
EPS, next fiscal year $-1.63FY2026 $6.94FY2026 $-4.22FY2026
EPS growth, next FY – +1.5%FY2026 –
EPS growth, the year after – +25.5% –
Revenue, next fiscal year $0.00FY2026 $514.54MFY2026 $49.46MFY2026
Revenue growth, next FY – +32.2%FY2026 -64.6%FY2026
Revenue growth, the year after – +33.4% +23.6%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersSLDBKRYSBEAM
Held by institutions 79.7% 99.8% 100.0%
Institutions holding 157 421 277
Change in shares held, QoQ +18.9% +4.6% +1.0%
Institutions buying 101 271 154
Institutions selling 37 106 75
Buyers to sellers 2.73 2.56 2.05

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

SLDBKRYSBEAM
SLDB 1.00 0.32 0.54
KRYS 0.32 1.00 0.35
BEAM 0.54 0.35 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, SLDB, KRYS and BEAM?

Krystal Biotech (KRYS) is the largest by market capitalisation: Solid Biosciences (SLDB) $909.55M, Krystal Biotech (KRYS) $9.45B, Beam Therapeutics (BEAM) $2.83B.

Which company is growing faster?

Beam Therapeutics (BEAM) grew revenue fastest over the trailing twelve months: Krystal Biotech (KRYS) +22.6%, Beam Therapeutics (BEAM) +158.9%.

Which company is more profitable?

Krystal Biotech (KRYS) has the highest net margin (Krystal Biotech (KRYS) 54.8%, Beam Therapeutics (BEAM) -54.7%).

Which stock has performed better?

Over the past year Krystal Biotech (KRYS) returned the most: Solid Biosciences (SLDB) +4.9%, Krystal Biotech (KRYS) +68.8%, Beam Therapeutics (BEAM) -6.8%. Over five years, Krystal Biotech (KRYS) compounded fastest (Solid Biosciences (SLDB) -26.0%/yr, Krystal Biotech (KRYS) +43.0%/yr, Beam Therapeutics (BEAM) -23.4%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Krystal Biotech (KRYS) has been the steadiest (Solid Biosciences (SLDB) 78.4%, Krystal Biotech (KRYS) 38.1%, Beam Therapeutics (BEAM) 69.2%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, SLDB, KRYS and BEAM?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Krystal Biotech (KRYS) leads on 6. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.