SLDB vs IOVA vs CRSP Stock Comparison

Solid Biosciences, Iovance Biotherapeutics and CRISPR Therapeutics AG Prices as of Nov 4, 2026 Peers: Industry group
1 more company in this comparison (SRPT) Create a free account to keep reading and compare up to 10 companies.
CRSP CRISPR Therapeutics AG
$51.78 -9.7% 1M -8.2% 1Y
Market cap
$4.68B
P/E
–
Revenue (TTM)
$25.17M
Div. yield
–
Gene and Cell Therapy Healthcare
3 wins

Head to Head

7 decided of 12

Iovance Biotherapeutics leads on 4 of the 12 questions below (Iovance Biotherapeutics 4, CRISPR Therapeutics AG 3). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionSLDBIOVACRSPLeader
Larger companyMarket capitalisation $875.06M $3.63B $4.68B CRSP
Cheaper on earningsLower P/E, profitable companies only -4.2x -12.5x -10.3x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — — — –
Faster revenue growthRevenue growth, trailing twelve months — +34.5% -34.3% IOVA
More profitableNet margin, trailing twelve months — -89.1% -1,812.1% IOVA
Better return on capitalReturn on invested capital — — -23.3% –
Less leveragedLower net debt / EBITDA — — 3.3x –
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months +47.8% +378.0% -8.2% IOVA
Better 5-year returnAnnualised price return, 5 years -28.7%/yr -19.0%/yr -10.5%/yr CRSP
Less volatileAnnualised volatility, 1 year 76.6% 109.2% 56.8% CRSP
Higher overall scoreMean of the five percentile scores vs peers 44/100 62/100 48/100 IOVA

Percentile Scorecard

SLDBIOVACRSP

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisSLDBIOVACRSP
Valuation 41 #375 of 634 65 #220 of 634 52 #302 of 634
Growth 21 #482 of 607 81 #114 of 607 27 #443 of 607
Profitability 51 #275 of 557 63 #205 of 557 37 #351 of 557
Financial Health 88 #78 of 654 62 #251 of 654 70 #200 of 654
Shareholder Returns 21 #317 of 400 40 #239 of 400 52 #192 of 400
Overall 44 62 48
  • SLDB ranked among 671 companies in Pharmaceuticals and Biotechnology
  • IOVA ranked among 671 companies in Pharmaceuticals and Biotechnology
  • CRSP ranked among 671 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodSLDBIOVACRSPSPY
1 month -7.6%-38.5%-9.7% -1.0%
3 months -25.3%+100.5%-1.3% -0.4%
6 months -9.4%+112.7%-6.0% +4.5%
Year to date +15.6%+218.7%-1.3% +12.4%
1 year +47.8%+378.0%-8.2% +13.6%
3 years +129.6%+106.7%+1.5% +76.4%
3 years, per year +31.9%+27.4%+0.5% +20.8%
5 years -81.6%-65.2%-42.6% +63.7%
5 years, per year -28.7%-19.0%-10.5% +10.4%
10 years —+50.0%+240.7% +267.7%
10 years, per year —+4.1%+13.0% +13.9%

Risk

MeasureSLDBIOVACRSPSPY
Volatility, 1Y 76.6%109.2%56.8% 12.8%
Downside volatility, 1Y 72.8%94.2%53.1% 12.7%
Beta vs S&P 500, 1Y 2.021.451.83 1.00
Return / volatility, 1Y 0.623.46-0.14 1.06
Max drawdown, 5Y -94.7%-93.4%-66.8% -25.4%
From 52-week high -41.5%-41.5%-16.3% -1.6%
52-week high $11.15$14.86$61.89 $779.14
52-week low $3.93$1.81$44.34 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleSLDBIOVACRSP
P/E now vs peer median -4.5xmedian 18.0x -13.5xmedian 18.0x -11.0xmedian 18.0x
P/S now vs peer median —median 9.1x 12.1xmedian 9.1x 199.5xmedian 9.1x
EV/EBITDA now vs peer median -2.7xmedian 16.2x -13.8xmedian 16.2x -6.5xmedian 16.2x
P/FCF now vs peer median -5.0xmedian 21.7x -13.3xmedian 21.7x -13.3xmedian 21.7x
P/B now vs peer median 2.5xmedian 2.2x 5.4xmedian 2.2x 3.0xmedian 2.2x
PEG now vs peer median -0.14median 0.38 -0.45median 0.38 5.68median 0.38

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsSLDBIOVACRSP
Revenue – $324.97M $25.17M
Gross profit – $157.29M –
Operating income -$212.15M -$301.31M -$532.33M
Net income -$207.10M -$289.51M -$456.14M
Free cash flow -$187.82M -$296.40M -$376.72M
R&D $167.40M $267.72M $291.14M
EPS (diluted) $-1.44 $-0.64 $-4.72
Cash & equivalents $159.39M $110.80M $192.03M
Total debt – – $586.93M
Shares (diluted) 143.69M 450.19M 96.74M
Enterprise value -$307.29M $2.42B -$4.38B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricSLDBIOVACRSP
P/E -4.5x -13.5x -11.0x
P/FCF -5.0x -13.3x -13.3x
P/Operating cash flow -5.0x -14.9x -13.4x
P/S – 12.1x 199.5x
P/B 2.5x 5.4x 3.0x
P/Tangible book 2.5x 8.3x 3.0x
EV/EBITDA -2.7x -13.8x -6.5x
EV/EBIT -2.6x -12.1x -6.3x
EV/Revenue – 11.2x 132.6x
EV/FCF -3.0x -12.3x -8.9x
EV/Operating cash flow -3.0x -13.8x -8.9x
PEG (3Y EPS CAGR) -0.14 -0.45 5.68

Growth

14 metrics
MetricSLDBIOVACRSP
Revenue growth (1Y) – 34.5% -34.3%
Revenue CAGR (3Y) – 1,009% -47.1%
Gross profit growth (1Y) – 95.1% –
Gross profit CAGR (3Y) – – –
Operating income growth (1Y) -35.3% 26.6% 7.3%
Operating income CAGR (3Y) -22.8% 11.1% -7.9%
Net income growth (1Y) -34.4% 25.8% 6.6%
Net income CAGR (3Y) -31.9% 11.6% -8.9%
EPS growth (1Y) 11.9% 44.8% 11.8%
EPS CAGR (3Y) 32.0% 29.9% -1.9%
Operating cash flow growth (1Y) -52.4% 12.9% -23.8%
Operating cash flow CAGR (3Y) -19.2% 7.6% -10.5%
Free cash flow growth (1Y) -52.3% 8.4% -24.3%
Free cash flow CAGR (3Y) -18.4% 5.8% -8.8%

Profitability

14 metrics
MetricSLDBIOVACRSP
Gross margin – 48.4% –
EBITDA margin – -81.4% -2,038%
Operating margin – -92.7% -2,115%
Pretax margin – -90.4% -1,802%
Net margin – -89.1% -1,812%
FCF margin – -91.2% -1,497%
Operating cash flow margin – -81.3% -1,488%
Return on equity -55.4% -39.7% -26.9%
Return on assets -49.1% -31.4% -17.5%
Return on invested capital – – -23.3%
Return on capital employed -54.0% -37.0% -21.6%
Asset turnover – 0.4x 0.0x
Cash conversion (OCF / net income) 0.9x 0.9x 0.8x
Stock comp / revenue – 14.4% 276.8%

Financial Health

11 metrics
MetricSLDBIOVACRSP
Debt / assets – – 23.0%
Debt / equity – – 0.4x
Net debt / EBITDA – – 3.3x
Debt / FCF – – -1.6x
Liabilities / assets 11.1% 19.6% 35.5%
Equity / assets 88.9% 80.4% 64.5%
Interest coverage – – –
Current ratio 13.8x 4.3x 16.2x
Quick ratio 13.2x 3.7x 16.1x
Cash ratio 13.2x 2.8x 16.1x
Altman Z-score – 8.47 2.40

Shareholder Returns

7 metrics
MetricSLDBIOVACRSP
Dividend yield – – –
Net buyback yield -25.7% -7.5% -2.7%
Shareholder yield -25.7% -7.5% -2.7%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusSLDBIOVACRSP
EPS, next fiscal year $-1.63FY2026 $-0.47FY2026 $-4.10FY2026
Revenue, next fiscal year $0.00FY2026 $434.71MFY2026 $38.73MFY2026
Revenue growth, next FY – +65.0%FY2026 +1,003.4%FY2026
Revenue growth, the year after – +33.0% +266.1%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersSLDBIOVACRSP
Held by institutions 79.7% 63.3% 78.9%
Institutions holding 157 292 520
Change in shares held, QoQ +18.9% +6.5% -1.0%
Institutions buying 101 174 238
Institutions selling 37 66 139
Buyers to sellers 2.73 2.64 1.71

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

SLDBIOVACRSP
SLDB 1.00 0.27 0.49
IOVA 0.27 1.00 0.33
CRSP 0.49 0.33 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, SLDB, IOVA and CRSP?

CRISPR Therapeutics AG (CRSP) is the largest by market capitalisation: Solid Biosciences (SLDB) $875.06M, Iovance Biotherapeutics (IOVA) $3.63B, CRISPR Therapeutics AG (CRSP) $4.68B.

Which company is growing faster?

Iovance Biotherapeutics (IOVA) grew revenue fastest over the trailing twelve months: Iovance Biotherapeutics (IOVA) +34.5%, CRISPR Therapeutics AG (CRSP) -34.3%.

Which company is more profitable?

Iovance Biotherapeutics (IOVA) has the highest net margin (Iovance Biotherapeutics (IOVA) -89.1%, CRISPR Therapeutics AG (CRSP) -1,812.1%).

Which stock has performed better?

Over the past year Iovance Biotherapeutics (IOVA) returned the most: Solid Biosciences (SLDB) +47.8%, Iovance Biotherapeutics (IOVA) +378.0%, CRISPR Therapeutics AG (CRSP) -8.2%. Over five years, CRISPR Therapeutics AG (CRSP) compounded fastest (Solid Biosciences (SLDB) -28.7%/yr, Iovance Biotherapeutics (IOVA) -19.0%/yr, CRISPR Therapeutics AG (CRSP) -10.5%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, CRISPR Therapeutics AG (CRSP) has been the steadiest (Solid Biosciences (SLDB) 76.6%, Iovance Biotherapeutics (IOVA) 109.2%, CRISPR Therapeutics AG (CRSP) 56.8%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, SLDB, IOVA and CRSP?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Iovance Biotherapeutics (IOVA) leads on 4. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.