SLBT vs TSHA Stock Comparison

SL Science Holding and Taysha Gene Therapies Prices as of Oct 27, 2026 Peers: Industry group
SLBT SL Science Holding Ltd
$1.19 -24.2% 1M -88.5% 1Y
Market cap
$2.59B
P/E
–
Revenue (TTM)
—
Div. yield
–
Gene and Cell Therapy Healthcare
1 win

Head to Head

3 decided of 12

Taysha Gene Therapies leads on 2 of the 12 questions below (Taysha Gene Therapies 2, SL Science Holding 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionSLBTTSHALeader
Larger companyMarket capitalisation $2.59B $1.38B SLBT
Cheaper on earningsLower P/E, profitable companies only — -10.5x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — — –
Faster revenue growthRevenue growth, trailing twelve months — -32.3% –
More profitableNet margin, trailing twelve months — -2,728.0% –
Better return on capitalReturn on invested capital — — –
Less leveragedLower net debt / EBITDA — 2.7x –
Higher dividend yieldTrailing dividend yield 0.00% — –
Better 1-year returnPrice return, last 12 months -88.5% -12.9% TSHA
Better 5-year returnAnnualised price return, 5 years — -23.5%/yr –
Less volatileAnnualised volatility, 1 year 175.4% 71.6% TSHA
Higher overall scoreMean of the five percentile scores vs peers — 49/100 –

Percentile Scorecard

SLBTTSHA

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisSLBTTSHA
Valuation 11 #555 of 625 45 #346 of 625
Growth – 16 #506 of 602
Profitability – 28 #397 of 551
Financial Health 58 #279 of 656 76 #159 of 656
Shareholder Returns – 78 #80 of 365
Overall – 49
  • SLBT ranked among 672 companies in Pharmaceuticals and Biotechnology
  • TSHA ranked among 672 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodSLBTTSHASPY
1 month -24.2%-9.0% -0.2%
3 months -56.7%-22.2% +3.9%
6 months -84.9%-32.5% +8.2%
Year to date -88.7%-22.7% +12.9%
1 year -88.5%-12.9% +12.3%
3 years —+92.3% +87.4%
3 years, per year —+24.4% +23.3%
5 years —-73.8% +67.9%
5 years, per year —-23.5% +10.9%

Risk

MeasureSLBTTSHASPY
Volatility, 1Y 175.4%71.6% 12.7%
Downside volatility, 1Y 170.6%70.1% 12.7%
Beta vs S&P 500, 1Y 0.231.83 1.00
Return / volatility, 1Y -0.50-0.18 0.97
Max drawdown, 5Y -91.0%-96.5% -25.4%
From 52-week high -90.7%-39.1% -1.2%
52-week high $12.81$6.98 $779.14
52-week low $1.15$3.51 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleSLBTTSHA
P/E now vs peer median —median 17.2x -10.5xmedian 17.2x
P/S now vs peer median —median 9.0x 252.1xmedian 9.0x
EV/EBITDA now vs peer median —median 16.3x -6.4xmedian 16.3x
P/FCF now vs peer median -1,382xmedian 18.7x -10.4xmedian 18.7x
P/B now vs peer median 372.2xmedian 2.2x 3.6xmedian 2.2x
PEG now vs peer median —median 0.33 -0.26median 0.33

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsSLBTTSHA
Revenue – $5.49M
Operating income – -$153.16M
Net income – -$149.63M
Free cash flow – -$132.57M
R&D – $123.14M
EPS (diluted) – $-0.41
Cash & equivalents $8.31M $455.41M
Total debt – $49.26M
Shares (diluted) – 369.04M
Enterprise value $2.58B $33.42M

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricSLBTTSHA
P/E – -10.5x
P/FCF -1,382x -10.4x
P/Operating cash flow – -10.5x
P/S – 252.1x
P/B 372.2x 3.6x
P/Tangible book 372.2x 3.6x
EV/EBITDA – -6.4x
EV/EBIT – -6.4x
EV/Revenue – 178.0x
EV/FCF – -7.4x
EV/Operating cash flow – -7.4x
PEG (3Y EPS CAGR) – -0.26

Growth

14 metrics
MetricSLBTTSHA
Revenue growth (1Y) – -32.3%
Revenue CAGR (3Y) – -9.1%
Gross profit growth (1Y) – –
Gross profit CAGR (3Y) – –
Operating income growth (1Y) – -62.9%
Operating income CAGR (3Y) – -8.7%
Net income growth (1Y) – -61.4%
Net income CAGR (3Y) – -6.5%
EPS growth (1Y) – -30.3%
EPS CAGR (3Y) – 40.5%
Operating cash flow growth (1Y) – -61.0%
Operating cash flow CAGR (3Y) – -35.6%
Free cash flow growth (1Y) – -60.6%
Free cash flow CAGR (3Y) – -29.4%

Profitability

14 metrics
MetricSLBTTSHA
Gross margin – –
EBITDA margin – -2,770%
Operating margin – -2,792%
Pretax margin – -2,593%
Net margin – -2,728%
FCF margin – -2,417%
Operating cash flow margin – -2,410%
Return on equity – -47.5%
Return on assets – -36.9%
Return on invested capital – –
Return on capital employed – -42.6%
Asset turnover – 0.0x
Cash conversion (OCF / net income) – 0.9x
Stock comp / revenue – 331.3%

Financial Health

11 metrics
MetricSLBTTSHA
Debt / assets – 10.5%
Debt / equity – 0.1x
Net debt / EBITDA – 2.7x
Debt / FCF – -0.4x
Liabilities / assets 21.8% 17.7%
Equity / assets 78.2% 82.3%
Interest coverage – -3,647x
Current ratio 4.4x 17.8x
Quick ratio 4.3x 17.5x
Cash ratio 4.3x 17.5x
Altman Z-score – 7.64

Shareholder Returns

7 metrics
MetricSLBTTSHA
Dividend yield – –
Net buyback yield – -0.2%
Shareholder yield 0.0% -0.2%
Payout ratio (earnings) – –
Payout ratio (FCF) – –
Dividend growth (1Y) – –
Dividend CAGR (3Y) – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusSLBTTSHA
EPS, next fiscal year – $-0.47FY2026
Revenue, next fiscal year – $1.96MFY2026
Revenue growth, next FY – -80.0%FY2026
Revenue growth, the year after – +1,298.6%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersSLBTTSHA
Held by institutions – 81.2%
Institutions holding – 209
Change in shares held, QoQ – +12.7%
Institutions buying – 140
Institutions selling – 42
Buyers to sellers – 3.33

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

SLBTTSHA
SLBT 1.00 -0.03
TSHA -0.03 1.00

Add a Peer

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Frequently Asked Questions

Which is bigger, SLBT and TSHA?

SL Science Holding (SLBT) is the largest by market capitalisation: SL Science Holding (SLBT) $2.59B, Taysha Gene Therapies (TSHA) $1.38B.

Which stock has performed better?

Over the past year Taysha Gene Therapies (TSHA) returned the most: SL Science Holding (SLBT) -88.5%, Taysha Gene Therapies (TSHA) -12.9%. Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Taysha Gene Therapies (TSHA) has been the steadiest (SL Science Holding (SLBT) 175.4%, Taysha Gene Therapies (TSHA) 71.6%). Volatility measures how widely the price swings, not the risk of the business.

Do SLBT and TSHA move together?

Their daily returns over the past year have a correlation of -0.03, a negative relationship. Holding both diversifies more than two closely linked stocks would.

Which is the better stock, SLBT and TSHA?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Taysha Gene Therapies (TSHA) leads on 2. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.