SLBT vs SRPT vs TSHA Stock Comparison

SL Science Holding, Sarepta Therapeutics and Taysha Gene Therapies Prices as of Oct 28, 2026 Peers: Industry group
SLBT SL Science Holding Ltd
$1.21 -37.3% 1M -88.3% 1Y
Market cap
$2.64B
P/E
–
Revenue (TTM)
—
Div. yield
–
Gene and Cell Therapy Healthcare
1 win

Head to Head

8 decided of 12

Sarepta Therapeutics leads on 4 of the 12 questions below (Sarepta Therapeutics 4, Taysha Gene Therapies 3, SL Science Holding 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionSLBTSRPTTSHALeader
Larger companyMarket capitalisation $2.64B $2.04B $1.38B SLBT
Cheaper on earningsLower P/E, profitable companies only — -17.4x -10.4x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — 6.7x — –
Faster revenue growthRevenue growth, trailing twelve months — -20.4% -32.3% SRPT
More profitableNet margin, trailing twelve months — -5.9% -2,728.0% SRPT
Better return on capitalReturn on invested capital — -6.1% — –
Less leveragedLower net debt / EBITDA — -0.6x 2.7x SRPT
Higher dividend yieldTrailing dividend yield 0.00% — — –
Better 1-year returnPrice return, last 12 months -88.3% -20.2% -15.2% TSHA
Better 5-year returnAnnualised price return, 5 years — -24.6%/yr -23.0%/yr TSHA
Less volatileAnnualised volatility, 1 year 175.5% 81.1% 71.5% TSHA
Higher overall scoreMean of the five percentile scores vs peers — 67/100 49/100 SRPT

Percentile Scorecard

SLBTSRPTTSHA

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisSLBTSRPTTSHA
Valuation 11 #556 of 625 96 #25 of 625 45 #344 of 625
Growth – 64 #217 of 602 17 #503 of 602
Profitability – 79 #114 of 549 28 #396 of 549
Financial Health 58 #276 of 654 33 #436 of 654 76 #158 of 654
Shareholder Returns – 61 #145 of 367 78 #80 of 367
Overall – 67 49
  • SLBT ranked among 672 companies in Pharmaceuticals and Biotechnology
  • SRPT ranked among 672 companies in Pharmaceuticals and Biotechnology
  • TSHA ranked among 672 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodSLBTSRPTTSHASPY
1 month -37.3%+2.8%-15.2% +0.9%
3 months -53.5%+24.4%-24.6% +5.9%
6 months -87.9%-6.5%-32.5% +8.5%
Year to date -88.5%-10.2%-23.1% +13.3%
1 year -88.3%-20.2%-15.2% +12.4%
3 years —-81.9%+91.4% +88.1%
3 years, per year —-43.5%+24.2% +23.5%
5 years —-75.6%-73.0% +68.2%
5 years, per year —-24.6%-23.0% +11.0%
10 years —-52.8%— +263.4%
10 years, per year —-7.2%— +13.8%

Risk

MeasureSLBTSRPTTSHASPY
Volatility, 1Y 175.5%81.1%71.5% 12.7%
Downside volatility, 1Y 170.6%85.9%69.8% 12.7%
Beta vs S&P 500, 1Y 0.232.081.83 1.00
Return / volatility, 1Y -0.50-0.25-0.21 0.98
Max drawdown, 5Y -91.0%-92.7%-96.5% -25.4%
From 52-week high -90.6%-21.0%-39.4% -0.9%
52-week high $12.81$24.45$6.98 $779.14
52-week low $1.15$14.86$3.51 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleSLBTSRPTTSHA
P/E now vs peer median —median 17.4x -17.4xmedian 17.4x -10.4xmedian 17.4x
P/S now vs peer median —median 9.1x 1.0xmedian 9.1x 250.9xmedian 9.1x
EV/EBITDA now vs peer median —median 17.1x -21.3xmedian 17.1x -6.4xmedian 17.1x
P/FCF now vs peer median -1,406xmedian 19.0x 24.9xmedian 19.0x -10.4xmedian 19.0x
P/B now vs peer median 378.4xmedian 2.2x 1.3xmedian 2.2x 3.6xmedian 2.2x
PEG now vs peer median —median 0.34 -0.33median 0.34 -0.26median 0.34

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsSLBTSRPTTSHA
Revenue – $1.97B $5.49M
Gross profit – $1.17B –
Operating income – -$143.25M -$153.16M
Net income – -$136.73M -$149.63M
Free cash flow – $81.85M -$132.57M
R&D – $789.44M $123.14M
EPS (diluted) – $-1.11 $-0.41
Cash & equivalents $8.31M $571.15M $455.41M
Total debt – $847.62M $49.26M
Shares (diluted) – 105.43M 369.04M
Enterprise value $2.62B -$1.19B $26.91M

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricSLBTSRPTTSHA
P/E – -17.4x -10.4x
P/FCF -1,406x 24.9x -10.4x
P/Operating cash flow – 18.4x -10.4x
P/S – 1.0x 250.9x
P/B 378.4x 1.3x 3.6x
P/Tangible book 378.4x 1.4x 3.6x
EV/EBITDA – -21.3x -6.4x
EV/EBIT – -14.7x -6.3x
EV/Revenue – 1.1x 176.8x
EV/FCF – 25.7x -7.3x
EV/Operating cash flow – 18.9x -7.3x
PEG (3Y EPS CAGR) – -0.33 -0.26

Growth

14 metrics
MetricSLBTSRPTTSHA
Revenue growth (1Y) – -20.4% -32.3%
Revenue CAGR (3Y) – 25.3% -9.1%
Gross profit growth (1Y) – -40.7% –
Gross profit CAGR (3Y) – 10.6% –
Operating income growth (1Y) – -15,270% -62.9%
Operating income CAGR (3Y) – 34.5% -8.7%
Net income growth (1Y) – -135.9% -61.4%
Net income CAGR (3Y) – 46.8% -6.5%
EPS growth (1Y) – -215.7% -30.3%
EPS CAGR (3Y) – 52.3% 40.5%
Operating cash flow growth (1Y) – 136.9% -61.0%
Operating cash flow CAGR (3Y) – 30.6% -35.6%
Free cash flow growth (1Y) – 118.1% -60.6%
Free cash flow CAGR (3Y) – 29.1% -29.4%

Profitability

14 metrics
MetricSLBTSRPTTSHA
Gross margin – 59.1% –
EBITDA margin – -5.0% -2,770%
Operating margin – -7.3% -2,792%
Pretax margin – -6.6% -2,593%
Net margin – -5.9% -2,728%
FCF margin – 4.1% -2,417%
Operating cash flow margin – 5.6% -2,410%
Return on equity – -9.0% -47.5%
Return on assets – -4.3% -36.9%
Return on invested capital – -6.1% –
Return on capital employed – -5.3% -42.6%
Asset turnover – 0.6x 0.0x
Cash conversion (OCF / net income) – -0.8x 0.9x
Stock comp / revenue – 6.3% 331.3%

Financial Health

11 metrics
MetricSLBTSRPTTSHA
Debt / assets – 26.6% 10.5%
Debt / equity – 0.6x 0.1x
Net debt / EBITDA – -0.6x 2.7x
Debt / FCF – 10.4x -0.4x
Liabilities / assets 21.8% 52.1% 17.7%
Equity / assets 78.2% 47.9% 82.3%
Interest coverage – – -3,647x
Current ratio 4.4x 4.4x 17.8x
Quick ratio 4.3x 2.4x 17.5x
Cash ratio 4.3x 1.6x 17.5x
Altman Z-score – -0.14 7.59

Shareholder Returns

7 metrics
MetricSLBTSRPTTSHA
Dividend yield – – –
Net buyback yield – -1.1% -0.2%
Shareholder yield 0.0% -1.1% -0.2%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusSLBTSRPTTSHA
Forward P/E – 6.7xFY2026 –
EPS, next fiscal year – $2.88FY2026 $-0.47FY2026
EPS growth, the year after – -88.5% –
Revenue, next fiscal year – $1.76BFY2026 $1.96MFY2026
Revenue growth, next FY – -20.1%FY2026 -80.0%FY2026
Revenue growth, the year after – -21.5% +1,298.6%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersSLBTSRPTTSHA
Held by institutions – 100.0% 81.2%
Institutions holding – 324 209
Change in shares held, QoQ – +4.5% +12.7%
Institutions buying – 148 140
Institutions selling – 115 42
Buyers to sellers – 1.29 3.33

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

SLBTSRPTTSHA
SLBT 1.00 0.00 -0.03
SRPT 0.00 1.00 0.36
TSHA -0.03 0.36 1.00

Add a Peer

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Frequently Asked Questions

Which is bigger, SLBT, SRPT and TSHA?

SL Science Holding (SLBT) is the largest by market capitalisation: SL Science Holding (SLBT) $2.64B, Sarepta Therapeutics (SRPT) $2.04B, Taysha Gene Therapies (TSHA) $1.38B.

Which company is growing faster?

Sarepta Therapeutics (SRPT) grew revenue fastest over the trailing twelve months: Sarepta Therapeutics (SRPT) -20.4%, Taysha Gene Therapies (TSHA) -32.3%.

Which company is more profitable?

Sarepta Therapeutics (SRPT) has the highest net margin (Sarepta Therapeutics (SRPT) -5.9%, Taysha Gene Therapies (TSHA) -2,728.0%).

Which stock has performed better?

Over the past year Taysha Gene Therapies (TSHA) returned the most: SL Science Holding (SLBT) -88.3%, Sarepta Therapeutics (SRPT) -20.2%, Taysha Gene Therapies (TSHA) -15.2%. Over five years, Taysha Gene Therapies (TSHA) compounded fastest (Sarepta Therapeutics (SRPT) -24.6%/yr, Taysha Gene Therapies (TSHA) -23.0%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Taysha Gene Therapies (TSHA) has been the steadiest (SL Science Holding (SLBT) 175.5%, Sarepta Therapeutics (SRPT) 81.1%, Taysha Gene Therapies (TSHA) 71.5%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, SLBT, SRPT and TSHA?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Sarepta Therapeutics (SRPT) leads on 4. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.