SLBT vs SRPT vs IOVA Stock Comparison

SL Science Holding, Sarepta Therapeutics and Iovance Biotherapeutics Prices as of Nov 5, 2026 Peers: Industry group
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Head to Head

7 decided of 12

Iovance Biotherapeutics leads on 4 of the 12 questions below (Iovance Biotherapeutics 4, Sarepta Therapeutics 3). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionSLBTSRPTIOVALeader
Larger companyMarket capitalisation $1.96B $1.88B $3.58B IOVA
Cheaper on earningsLower P/E, profitable companies only — -19.6x -16.0x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — 6.1x — –
Faster revenue growthRevenue growth, trailing twelve months — -18.9% +51.3% IOVA
More profitableNet margin, trailing twelve months — -4.8% -58.2% SRPT
Better return on capitalReturn on invested capital — -2.1% — –
Less leveragedLower net debt / EBITDA — 1.3x — –
Higher dividend yieldTrailing dividend yield 0.00% — — –
Better 1-year returnPrice return, last 12 months -91.3% -6.0% +327.6% IOVA
Better 5-year returnAnnualised price return, 5 years — -27.7%/yr -20.9%/yr IOVA
Less volatileAnnualised volatility, 1 year 177.0% 68.7% 109.9% SRPT
Higher overall scoreMean of the five percentile scores vs peers — 76/100 67/100 SRPT

Percentile Scorecard

SLBTSRPTIOVA

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisSLBTSRPTIOVA
Valuation 11 #567 of 634 98 #17 of 634 70 #190 of 634
Growth – 84 #101 of 608 91 #58 of 608
Profitability – 81 #108 of 557 67 #182 of 557
Financial Health 57 #281 of 654 33 #438 of 654 68 #213 of 654
Shareholder Returns – 87 #53 of 403 39 #245 of 403
Overall – 76 67
  • SLBT ranked among 671 companies in Pharmaceuticals and Biotechnology
  • SRPT ranked among 671 companies in Pharmaceuticals and Biotechnology
  • IOVA ranked among 671 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodSLBTSRPTIOVASPY
1 month -40.8%+1.4%-40.3% -5.9%
3 months -67.0%+4.6%+24.6% -4.6%
6 months -88.6%-15.6%+118.0% +0.2%
Year to date -91.5%-18.4%+183.5% +7.5%
1 year -91.3%-6.0%+327.6% +8.2%
3 years —-78.1%+79.2% +68.3%
3 years, per year —-39.7%+21.5% +19.0%
5 years —-80.3%-69.0% +56.5%
5 years, per year —-27.7%-20.9% +9.4%
10 years —-55.2%+33.4% +251.5%
10 years, per year —-7.7%+2.9% +13.4%

Risk

MeasureSLBTSRPTIOVASPY
Volatility, 1Y 177.0%68.7%109.9% 13.6%
Downside volatility, 1Y 171.2%64.0%95.6% 14.2%
Beta vs S&P 500, 1Y 0.581.751.60 1.00
Return / volatility, 1Y -0.52-0.092.98 0.60
Max drawdown, 5Y -93.0%-92.7%-93.4% -25.4%
From 52-week high -93.0%-26.4%-47.9% -5.9%
52-week high $12.81$23.83$14.86 $779.14
52-week low $0.90$14.86$1.81 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleSLBTSRPTIOVA
P/E now vs peer median —median 17.8x -19.6xmedian 17.8x -16.0xmedian 17.8x
P/S now vs peer median —median 8.1x 1.0xmedian 8.1x 9.4xmedian 8.1x
EV/EBITDA now vs peer median —median 15.7x -111.1xmedian 15.7x -16.6xmedian 15.7x
P/FCF now vs peer median -1,045xmedian 21.0x 10.7xmedian 21.0x -16.6xmedian 21.0x
P/B now vs peer median 281.5xmedian 2.0x 1.2xmedian 2.0x 4.4xmedian 2.0x
PEG now vs peer median —median 0.36 -0.38median 0.36 -0.46median 0.36

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsSLBTSRPTIOVA
Revenue – $1.96B $378.98M
Gross profit – $1.11B $201.75M
Operating income – -$48.90M -$230.38M
Net income – -$114.62M -$220.56M
Free cash flow – $176.40M -$216.07M
R&D – $653.10M $241.88M
EPS (diluted) – $-0.89 $-0.48
Cash & equivalents $8.31M $472.80M $57.93M
Total debt – $857.36M –
Shares (diluted) – 105.93M 455.92M
Enterprise value $1.95B -$1.38B $2.30B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricSLBTSRPTIOVA
P/E – -19.6x -16.0x
P/FCF -1,045x 10.7x -16.6x
P/Operating cash flow – 10.1x -18.9x
P/S – 1.0x 9.4x
P/B 281.5x 1.2x 4.4x
P/Tangible book 281.5x 1.3x 6.5x
EV/EBITDA – -111.1x -16.6x
EV/EBIT – -38.0x -13.9x
EV/Revenue – 1.0x 8.5x
EV/FCF – 10.5x -14.8x
EV/Operating cash flow – 10.0x -16.9x
PEG (3Y EPS CAGR) – -0.38 -0.46

Growth

14 metrics
MetricSLBTSRPTIOVA
Revenue growth (1Y) – -18.9% 51.3%
Revenue CAGR (3Y) – 21.0% 712.3%
Gross profit growth (1Y) – -39.6% 144.4%
Gross profit CAGR (3Y) – 4.7% –
Operating income growth (1Y) – 61.3% 44.7%
Operating income CAGR (3Y) – 50.3% 19.8%
Net income growth (1Y) – 19.4% 44.5%
Net income CAGR (3Y) – 45.1% 20.1%
EPS growth (1Y) – 26.5% 55.7%
EPS CAGR (3Y) – 51.4% 35.0%
Operating cash flow growth (1Y) – 175.9% 41.2%
Operating cash flow CAGR (3Y) – 32.8% 18.9%
Free cash flow growth (1Y) – 146.3% 38.6%
Free cash flow CAGR (3Y) – 31.9% 17.0%

Profitability

14 metrics
MetricSLBTSRPTIOVA
Gross margin – 56.8% 53.2%
EBITDA margin – -0.9% -50.9%
Operating margin – -2.5% -60.8%
Pretax margin – -4.7% -58.5%
Net margin – -4.8% -58.2%
FCF margin – 9.0% -57.0%
Operating cash flow margin – 9.5% -50.1%
Return on equity – -7.5% -28.5%
Return on assets – -3.6% -23.1%
Return on invested capital – -2.1% –
Return on capital employed – -1.9% -27.2%
Asset turnover – 0.6x 0.4x
Cash conversion (OCF / net income) – -1.6x 0.9x
Stock comp / revenue – 7.0% 12.3%

Financial Health

11 metrics
MetricSLBTSRPTIOVA
Debt / assets – 27.1% –
Debt / equity – 0.6x –
Net debt / EBITDA – 1.3x –
Debt / FCF – 4.9x –
Liabilities / assets 21.8% 51.7% 18.0%
Equity / assets 78.2% 48.3% 82.0%
Interest coverage – – –
Current ratio 4.4x 3.5x 5.2x
Quick ratio 4.3x 2.0x 4.6x
Cash ratio 4.3x 1.3x 3.6x
Altman Z-score – -0.16 8.06

Shareholder Returns

7 metrics
MetricSLBTSRPTIOVA
Dividend yield – – –
Net buyback yield – 0.0% -8.2%
Shareholder yield 0.0% 0.0% -8.2%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusSLBTSRPTIOVA
Forward P/E – 6.1xFY2026 –
EPS, next fiscal year – $2.88FY2026 $-0.47FY2026
EPS growth, the year after – -88.5% –
Revenue, next fiscal year – $1.76BFY2026 $435.90MFY2026
Revenue growth, next FY – -20.1%FY2026 +65.4%FY2026
Revenue growth, the year after – -21.5% +33.1%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersSLBTSRPTIOVA
Held by institutions – 100.0% 63.3%
Institutions holding – 326 292
Change in shares held, QoQ – +4.5% +6.5%
Institutions buying – 148 174
Institutions selling – 117 66
Buyers to sellers – 1.26 2.64

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

SLBTSRPTIOVA
SLBT 1.00 0.01 0.02
SRPT 0.01 1.00 0.31
IOVA 0.02 0.31 1.00

Add a Peer

Largest companies in the same industry

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Frequently Asked Questions

Which is bigger, SLBT, SRPT and IOVA?

Iovance Biotherapeutics (IOVA) is the largest by market capitalisation: SL Science Holding (SLBT) $1.96B, Sarepta Therapeutics (SRPT) $1.88B, Iovance Biotherapeutics (IOVA) $3.58B.

Which company is growing faster?

Iovance Biotherapeutics (IOVA) grew revenue fastest over the trailing twelve months: Sarepta Therapeutics (SRPT) -18.9%, Iovance Biotherapeutics (IOVA) +51.3%.

Which company is more profitable?

Sarepta Therapeutics (SRPT) has the highest net margin (Sarepta Therapeutics (SRPT) -4.8%, Iovance Biotherapeutics (IOVA) -58.2%).

Which stock has performed better?

Over the past year Iovance Biotherapeutics (IOVA) returned the most: SL Science Holding (SLBT) -91.3%, Sarepta Therapeutics (SRPT) -6.0%, Iovance Biotherapeutics (IOVA) +327.6%. Over five years, Iovance Biotherapeutics (IOVA) compounded fastest (Sarepta Therapeutics (SRPT) -27.7%/yr, Iovance Biotherapeutics (IOVA) -20.9%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Sarepta Therapeutics (SRPT) has been the steadiest (SL Science Holding (SLBT) 177.0%, Sarepta Therapeutics (SRPT) 68.7%, Iovance Biotherapeutics (IOVA) 109.9%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, SLBT, SRPT and IOVA?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Iovance Biotherapeutics (IOVA) leads on 4. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.