SLBT vs SLDB vs CRSP Stock Comparison

SL Science Holding, Solid Biosciences and CRISPR Therapeutics AG Prices as of Oct 29, 2026 Peers: Industry group
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SLDB Solid Biosciences Inc.
$6.39 -10.8% 1M +16.4% 1Y
Market cap
$888.71M
P/E
–
Revenue (TTM)
—
Div. yield
–
Gene and Cell Therapy Healthcare
1 win
CRSP CRISPR Therapeutics AG
$54.26 -3.1% 1M -13.3% 1Y
Market cap
$4.94B
P/E
–
Revenue (TTM)
$13.39M
Div. yield
–
Gene and Cell Therapy Healthcare
4 wins

Head to Head

5 decided of 12

CRISPR Therapeutics AG leads on 4 of the 12 questions below (CRISPR Therapeutics AG 4, Solid Biosciences 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionSLBTSLDBCRSPLeader
Larger companyMarket capitalisation $2.82B $888.71M $4.94B CRSP
Cheaper on earningsLower P/E, profitable companies only — -4.3x -11.0x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — — — –
Faster revenue growthRevenue growth, trailing twelve months — — -64.8% –
More profitableNet margin, trailing twelve months — — -3,368.7% –
Better return on capitalReturn on invested capital — — -22.6% –
Less leveragedLower net debt / EBITDA — — 3.4x –
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months -88.7% +16.4% -13.3% SLDB
Better 5-year returnAnnualised price return, 5 years — -26.8%/yr -9.9%/yr CRSP
Less volatileAnnualised volatility, 1 year 175.5% 78.2% 57.3% CRSP
Higher overall scoreMean of the five percentile scores vs peers — 42/100 45/100 CRSP

Percentile Scorecard

SLBTSLDBCRSP

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisSLBTSLDBCRSP
Valuation 11 #556 of 624 35 #408 of 624 51 #308 of 624
Growth – 20 #484 of 601 32 #412 of 601
Profitability – 50 #273 of 541 32 #367 of 541
Financial Health 58 #271 of 647 88 #77 of 647 71 #188 of 647
Shareholder Returns – 19 #292 of 359 38 #222 of 359
Overall – 42 45
  • SLBT ranked among 671 companies in Pharmaceuticals and Biotechnology
  • SLDB ranked among 671 companies in Pharmaceuticals and Biotechnology
  • CRSP ranked among 671 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodSLBTSLDBCRSPSPY
1 month -36.1%-10.8%-3.1% +0.7%
3 months -56.5%-24.7%+12.0% +3.7%
6 months -87.4%-12.0%+3.7% +7.1%
Year to date -88.9%+13.3%+3.5% +12.8%
1 year -88.7%+16.4%-13.3% +11.9%
3 years —+208.7%+39.4% +85.2%
3 years, per year —+45.6%+11.7% +22.8%
5 years —-79.0%-40.6% +67.6%
5 years, per year —-26.8%-9.9% +10.9%
10 years ——+224.1% +262.0%
10 years, per year ——+12.5% +13.7%

Risk

MeasureSLBTSLDBCRSPSPY
Volatility, 1Y 175.5%78.2%57.3% 12.7%
Downside volatility, 1Y 170.0%76.3%53.8% 12.6%
Beta vs S&P 500, 1Y 0.242.131.84 1.00
Return / volatility, 1Y -0.510.21-0.23 0.94
Max drawdown, 5Y -91.0%-94.9%-67.7% -25.4%
From 52-week high -90.9%-42.7%-15.2% -1.2%
52-week high $12.81$11.15$63.99 $779.14
52-week low $1.15$3.93$44.34 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleSLBTSLDBCRSP
P/E now vs peer median —median 17.8x -4.4xmedian 17.8x -11.6xmedian 17.8x
P/S now vs peer median —median 9.1x —median 9.1x 391.6xmedian 9.1x
EV/EBITDA now vs peer median —median 15.0x -2.6xmedian 15.0x -6.7xmedian 15.0x
P/FCF now vs peer median -1,359xmedian 21.7x -4.9xmedian 21.7x -14.1xmedian 21.7x
P/B now vs peer median 365.9xmedian 2.2x 2.5xmedian 2.2x 3.0xmedian 2.2x
PEG now vs peer median —median 0.35 -0.14median 0.35 -3.01median 0.35

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsSLBTSLDBCRSP
Revenue – – $13.39M
Operating income – -$212.15M -$534.34M
Net income – -$207.10M -$451.14M
Free cash flow – -$187.82M -$371.33M
R&D – $167.40M $278.15M
EPS (diluted) – $-1.44 $-4.67
Cash & equivalents $8.31M $159.39M $291.34M
Total debt – – $586.20M
Shares (diluted) – 143.69M 96.51M
Enterprise value $2.80B -$293.64M -$3.76B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricSLBTSLDBCRSP
P/E – -4.4x -11.6x
P/FCF -1,359x -4.9x -14.1x
P/Operating cash flow – -4.9x -14.2x
P/S – – 391.6x
P/B 365.9x 2.5x 3.0x
P/Tangible book 365.9x 2.5x 3.0x
EV/EBITDA – -2.6x -6.7x
EV/EBIT – -2.5x -6.5x
EV/Revenue – – 258.9x
EV/FCF – -2.9x -9.3x
EV/Operating cash flow – -2.9x -9.4x
PEG (3Y EPS CAGR) – -0.14 -3.01

Growth

14 metrics
MetricSLBTSLDBCRSP
Revenue growth (1Y) – – -64.8%
Revenue CAGR (3Y) – – -57.1%
Gross profit growth (1Y) – – –
Gross profit CAGR (3Y) – – –
Operating income growth (1Y) – -35.3% 3.3%
Operating income CAGR (3Y) – -22.8% -4.1%
Net income growth (1Y) – -34.4% 3.6%
Net income CAGR (3Y) – -31.9% -2.7%
EPS growth (1Y) – 11.9% 13.0%
EPS CAGR (3Y) – 32.0% 3.9%
Operating cash flow growth (1Y) – -52.4% -13.8%
Operating cash flow CAGR (3Y) – -19.2% -2.5%
Free cash flow growth (1Y) – -52.3% -14.1%
Free cash flow CAGR (3Y) – -18.4% -0.9%

Profitability

14 metrics
MetricSLBTSLDBCRSP
Gross margin – – –
EBITDA margin – – -3,850%
Operating margin – – -3,990%
Pretax margin – – -3,346%
Net margin – – -3,369%
FCF margin – – -2,773%
Operating cash flow margin – – -2,760%
Return on equity – -55.4% -25.3%
Return on assets – -49.1% -16.8%
Return on invested capital – – -22.6%
Return on capital employed – -54.0% -20.9%
Asset turnover – – 0.0x
Cash conversion (OCF / net income) – 0.9x 0.8x
Stock comp / revenue – – 510.2%

Financial Health

11 metrics
MetricSLBTSLDBCRSP
Debt / assets – – 22.1%
Debt / equity – – 0.3x
Net debt / EBITDA – – 3.4x
Debt / FCF – – -1.6x
Liabilities / assets 21.8% 11.1% 34.1%
Equity / assets 78.2% 88.9% 65.9%
Interest coverage – – –
Current ratio 4.4x 13.8x 17.8x
Quick ratio 4.3x 13.2x 17.8x
Cash ratio 4.3x 13.2x 17.8x
Altman Z-score – – 2.69

Shareholder Returns

7 metrics
MetricSLBTSLDBCRSP
Dividend yield – – –
Net buyback yield – -26.2% -8.1%
Shareholder yield 0.0% -26.2% -8.1%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusSLBTSLDBCRSP
EPS, next fiscal year – $-1.63FY2026 $-4.10FY2026
Revenue, next fiscal year – $0.00FY2026 $38.73MFY2026
Revenue growth, next FY – – +1,003.4%FY2026
Revenue growth, the year after – – +266.1%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersSLBTSLDBCRSP
Held by institutions – 79.7% 78.9%
Institutions holding – 157 519
Change in shares held, QoQ – +18.9% -1.0%
Institutions buying – 101 238
Institutions selling – 37 139
Buyers to sellers – 2.73 1.71

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

SLBTSLDBCRSP
SLBT 1.00 -0.02 -0.04
SLDB -0.02 1.00 0.50
CRSP -0.04 0.50 1.00

Add a Peer

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Frequently Asked Questions

Which is bigger, SLBT, SLDB and CRSP?

CRISPR Therapeutics AG (CRSP) is the largest by market capitalisation: SL Science Holding (SLBT) $2.82B, Solid Biosciences (SLDB) $888.71M, CRISPR Therapeutics AG (CRSP) $4.94B.

Which stock has performed better?

Over the past year Solid Biosciences (SLDB) returned the most: SL Science Holding (SLBT) -88.7%, Solid Biosciences (SLDB) +16.4%, CRISPR Therapeutics AG (CRSP) -13.3%. Over five years, CRISPR Therapeutics AG (CRSP) compounded fastest (Solid Biosciences (SLDB) -26.8%/yr, CRISPR Therapeutics AG (CRSP) -9.9%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, CRISPR Therapeutics AG (CRSP) has been the steadiest (SL Science Holding (SLBT) 175.5%, Solid Biosciences (SLDB) 78.2%, CRISPR Therapeutics AG (CRSP) 57.3%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, SLBT, SLDB and CRSP?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, CRISPR Therapeutics AG (CRSP) leads on 4. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.