SLBT vs BEAM vs KRYS Stock Comparison

SL Science Holding, Beam Therapeutics and Krystal Biotech Prices as of Oct 27, 2026 Peers: Industry group
BEAM Beam Therapeutics Inc.
$24.90 +2.6% 1M -6.8% 1Y
Market cap
$2.57B
P/E
–
Revenue (TTM)
$156.04M
Div. yield
–
Gene and Cell Therapy Healthcare
1 win
KRYS Krystal Biotech, Inc.
$320.58 -7.3% 1M +68.8% 1Y
Market cap
$9.49B
P/E
39.2x
Revenue (TTM)
$440.53M
Div. yield
–
Gene and Cell Therapy Healthcare
6 wins

Head to Head

7 decided of 12

Krystal Biotech leads on 6 of the 12 questions below (Krystal Biotech 6, Beam Therapeutics 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionSLBTBEAMKRYSLeader
Larger companyMarket capitalisation $2.59B $2.57B $9.49B KRYS
Cheaper on earningsLower P/E, profitable companies only — -30.4x 39.2x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — — 46.2x –
Faster revenue growthRevenue growth, trailing twelve months — +158.9% +22.6% BEAM
More profitableNet margin, trailing twelve months — -54.7% 54.8% KRYS
Better return on capitalReturn on invested capital — — — –
Less leveragedLower net debt / EBITDA — 3.0x — –
Higher dividend yieldTrailing dividend yield 0.00% 0.00% — –
Better 1-year returnPrice return, last 12 months -88.5% -6.8% +68.8% KRYS
Better 5-year returnAnnualised price return, 5 years — -23.4%/yr +43.0%/yr KRYS
Less volatileAnnualised volatility, 1 year 175.4% 69.2% 38.1% KRYS
Higher overall scoreMean of the five percentile scores vs peers — 69/100 85/100 KRYS

Percentile Scorecard

SLBTBEAMKRYS

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisSLBTBEAMKRYS
Valuation 11 #555 of 625 54 #286 of 625 79 #131 of 625
Growth – 77 #137 of 602 93 #43 of 602
Profitability – 64 #198 of 551 96 #22 of 551
Financial Health 58 #279 of 656 81 #128 of 656 84 #105 of 656
Shareholder Returns – 67 #123 of 365 70 #109 of 365
Overall – 69 85
  • SLBT ranked among 672 companies in Pharmaceuticals and Biotechnology
  • BEAM ranked among 672 companies in Pharmaceuticals and Biotechnology
  • KRYS ranked among 672 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodSLBTBEAMKRYSSPY
1 month -24.2%+2.6%-7.3% -0.2%
3 months -56.7%-5.3%-12.0% +3.9%
6 months -84.9%-18.5%+19.1% +8.2%
Year to date -88.7%-10.2%+30.0% +12.9%
1 year -88.5%-6.8%+68.8% +12.3%
3 years —+33.7%+180.8% +87.4%
3 years, per year —+10.2%+41.1% +23.3%
5 years —-73.6%+496.2% +67.9%
5 years, per year —-23.4%+43.0% +10.9%

Risk

MeasureSLBTBEAMKRYSSPY
Volatility, 1Y 175.4%69.2%38.1% 12.7%
Downside volatility, 1Y 170.6%63.8%37.3% 12.7%
Beta vs S&P 500, 1Y 0.232.060.69 1.00
Return / volatility, 1Y -0.50-0.101.81 0.97
Max drawdown, 5Y -91.0%-85.3%-44.5% -25.4%
From 52-week high -90.7%-34.3%-15.2% -1.2%
52-week high $12.81$37.92$378.15 $779.14
52-week low $1.15$20.60$185.05 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleSLBTBEAMKRYS
P/E now vs peer median —median 17.2x -30.4xmedian 17.2x 39.2xmedian 17.2x
P/S now vs peer median —median 9.0x 16.5xmedian 9.0x 21.5xmedian 9.0x
EV/EBITDA now vs peer median —median 16.3x -4.3xmedian 16.3x 42.4xmedian 16.3x
P/FCF now vs peer median -1,382xmedian 18.7x -6.9xmedian 18.7x 36.8xmedian 18.7x
P/B now vs peer median 372.2xmedian 2.2x 2.4xmedian 2.2x 7.0xmedian 2.2x
PEG now vs peer median —median 0.33 -0.72median 0.33 0.76median 0.33

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsSLBTBEAMKRYS
Revenue – $156.04M $440.53M
Gross profit – – $416.91M
Operating income – -$378.02M $197.75M
Net income – -$86.52M $241.47M
Free cash flow – -$372.77M $257.78M
R&D – $408.66M $59.23M
EPS (diluted) – $-0.82 $7.88
Cash & equivalents $8.31M $219.83M $427.74M
Total debt – $100.26M –
Shares (diluted) – 104.33M 30.66M
Enterprise value $2.58B -$2.11B $6.26B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricSLBTBEAMKRYS
P/E – -30.4x 39.2x
P/FCF -1,382x -6.9x 36.8x
P/Operating cash flow – -7.2x 34.8x
P/S – 16.5x 21.5x
P/B 372.2x 2.4x 7.0x
P/Tangible book 372.2x 2.4x 7.0x
EV/EBITDA – -4.3x 42.4x
EV/EBIT – -4.0x 43.7x
EV/Revenue – 9.7x 19.6x
EV/FCF – -4.1x 33.5x
EV/Operating cash flow – -4.2x 31.7x
PEG (3Y EPS CAGR) – -0.72 0.76

Growth

14 metrics
MetricSLBTBEAMKRYS
Revenue growth (1Y) – 158.9% 22.6%
Revenue CAGR (3Y) – 24.9% –
Gross profit growth (1Y) – – 24.3%
Gross profit CAGR (3Y) – – –
Operating income growth (1Y) – 15.2% 41.8%
Operating income CAGR (3Y) – 0.3% 48.8%
Net income growth (1Y) – 78.2% 64.6%
Net income CAGR (3Y) – 35.8% 54.9%
EPS growth (1Y) – 79.0% 59.7%
EPS CAGR (3Y) – 42.4% 51.8%
Operating cash flow growth (1Y) – -4.2% 39.4%
Operating cash flow CAGR (3Y) – -2.0% 67.0%
Free cash flow growth (1Y) – -4.8% 39.0%
Free cash flow CAGR (3Y) – 0.7% 58.6%

Profitability

14 metrics
MetricSLBTBEAMKRYS
Gross margin – – 94.6%
EBITDA margin – -228.0% 46.2%
Operating margin – -242.3% 44.9%
Pretax margin – -54.4% 51.4%
Net margin – -54.7% 54.8%
FCF margin – -238.9% 58.5%
Operating cash flow margin – -230.3% 61.8%
Return on equity – -7.6% 18.3%
Return on assets – -5.9% 16.7%
Return on invested capital – – –
Return on capital employed – -27.9% 15.0%
Asset turnover – 0.1x 0.3x
Cash conversion (OCF / net income) – 4.2x 1.1x
Stock comp / revenue – 52.2% 12.4%

Financial Health

11 metrics
MetricSLBTBEAMKRYS
Debt / assets – 7.2% –
Debt / equity – 0.1x –
Net debt / EBITDA – 3.0x –
Debt / FCF – -0.3x –
Liabilities / assets 21.8% 23.0% 9.4%
Equity / assets 78.2% 77.0% 90.6%
Interest coverage – – –
Current ratio 4.4x 14.6x 8.3x
Quick ratio 4.3x 14.3x 7.7x
Cash ratio 4.3x 14.3x 6.6x
Altman Z-score – 3.08 41.82

Shareholder Returns

7 metrics
MetricSLBTBEAMKRYS
Dividend yield – – –
Net buyback yield – -0.6% -0.4%
Shareholder yield 0.0% -0.6% -0.4%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusSLBTBEAMKRYS
Forward P/E – – 46.2xFY2026
EPS, next fiscal year – $-4.22FY2026 $6.94FY2026
EPS growth, next FY – – +1.5%FY2026
EPS growth, the year after – – +25.5%
Revenue, next fiscal year – $49.46MFY2026 $514.54MFY2026
Revenue growth, next FY – -64.6%FY2026 +32.2%FY2026
Revenue growth, the year after – +23.6% +33.4%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersSLBTBEAMKRYS
Held by institutions – 100.0% 99.8%
Institutions holding – 277 421
Change in shares held, QoQ – +1.0% +4.6%
Institutions buying – 154 271
Institutions selling – 75 106
Buyers to sellers – 2.05 2.56

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

SLBTBEAMKRYS
SLBT 1.00 0.00 -0.07
BEAM 0.00 1.00 0.35
KRYS -0.07 0.35 1.00

Add a Peer

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Frequently Asked Questions

Which is bigger, SLBT, BEAM and KRYS?

Krystal Biotech (KRYS) is the largest by market capitalisation: SL Science Holding (SLBT) $2.59B, Beam Therapeutics (BEAM) $2.57B, Krystal Biotech (KRYS) $9.49B.

Which company is growing faster?

Beam Therapeutics (BEAM) grew revenue fastest over the trailing twelve months: Beam Therapeutics (BEAM) +158.9%, Krystal Biotech (KRYS) +22.6%.

Which company is more profitable?

Krystal Biotech (KRYS) has the highest net margin (Beam Therapeutics (BEAM) -54.7%, Krystal Biotech (KRYS) 54.8%).

Which stock has performed better?

Over the past year Krystal Biotech (KRYS) returned the most: SL Science Holding (SLBT) -88.5%, Beam Therapeutics (BEAM) -6.8%, Krystal Biotech (KRYS) +68.8%. Over five years, Krystal Biotech (KRYS) compounded fastest (Beam Therapeutics (BEAM) -23.4%/yr, Krystal Biotech (KRYS) +43.0%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Krystal Biotech (KRYS) has been the steadiest (SL Science Holding (SLBT) 175.4%, Beam Therapeutics (BEAM) 69.2%, Krystal Biotech (KRYS) 38.1%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, SLBT, BEAM and KRYS?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Krystal Biotech (KRYS) leads on 6. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.