SHC vs NEO vs CSTL Stock Comparison

Sotera Health, Neogenomics and Castle Biosciences Prices as of Nov 5, 2026 Peers: Industry group
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SHC Sotera Health Co
$15.87 -13.0% 1M +0.4% 1Y
Market cap
$4.53B
P/E
26.2x
Revenue (TTM)
$1.23B
Div. yield
–
Diagnostic Labs Healthcare
8 wins
NEO Neogenomics Inc
$16.49 -0.1% 1M +58.1% 1Y
Market cap
$2.13B
P/E
–
Revenue (TTM)
$787.75M
Div. yield
–
Diagnostic Labs Healthcare
2 wins

Head to Head

10 decided of 12

Sotera Health leads on 8 of the 12 questions below (Sotera Health 8, Neogenomics 2). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionSHCNEOCSTLLeader
Larger companyMarket capitalisation $4.53B $2.13B $1.05B SHC
Cheaper on earningsLower P/E, profitable companies only 26.2x -65.7x -45.5x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS 17.1x 78.5x — SHC
Faster revenue growthRevenue growth, trailing twelve months +6.9% +11.1% +9.8% NEO
More profitableNet margin, trailing twelve months 14.1% -4.1% -6.1% SHC
Better return on capitalReturn on invested capital 9.2% — -5.8% SHC
Less leveragedLower net debt / EBITDA 3.1x — 22.2x SHC
Higher dividend yieldTrailing dividend yield — — — –
Better 1-year returnPrice return, last 12 months +0.4% +58.1% +1.9% NEO
Better 5-year returnAnnualised price return, 5 years -10.1%/yr -16.8%/yr -10.5%/yr SHC
Less volatileAnnualised volatility, 1 year 30.4% 53.8% 55.5% SHC
Higher overall scoreMean of the five percentile scores vs peers 62/100 42/100 47/100 SHC

Percentile Scorecard

SHCNEOCSTL

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisSHCNEOCSTL
Valuation 57 #41 of 95 28 #69 of 95 42 #56 of 95
Growth 72 #25 of 88 59 #37 of 88 49 #45 of 88
Profitability 85 #14 of 87 33 #59 of 87 37 #55 of 87
Financial Health 34 #66 of 100 70 #31 of 100 86 #15 of 100
Shareholder Returns – 20 #48 of 60 22 #47 of 60
Overall 62 42 47
  • SHC ranked among 102 companies in Healthcare Providers
  • NEO ranked among 102 companies in Healthcare Providers
  • CSTL ranked among 102 companies in Healthcare Providers

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodSHCNEOCSTLSPY
1 month -13.0%-0.1%+2.5% -5.9%
3 months -16.1%+6.0%+12.2% -4.6%
6 months +1.3%+81.8%+77.8% +0.2%
Year to date -10.0%+40.2%-12.1% +7.5%
1 year +0.4%+58.1%+1.9% +8.2%
3 years +18.5%+12.6%+89.4% +68.3%
3 years, per year +5.8%+4.0%+23.7% +19.0%
5 years -41.1%-60.1%-42.6% +56.5%
5 years, per year -10.1%-16.8%-10.5% +9.4%
10 years —+105.9%— +251.5%
10 years, per year —+7.5%— +13.4%

Risk

MeasureSHCNEOCSTLSPY
Volatility, 1Y 30.4%53.8%55.5% 13.6%
Downside volatility, 1Y 31.1%53.1%62.0% 14.2%
Beta vs S&P 500, 1Y 1.001.071.14 1.00
Return / volatility, 1Y 0.011.080.03 0.60
Max drawdown, 5Y -78.2%-88.9%-81.0% -25.4%
From 52-week high -18.9%-17.2%-20.5% -5.9%
52-week high $19.57$19.91$43.04 $779.14
52-week low $13.13$7.19$18.15 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleSHCNEOCSTL
P/E now vs peer median 26.2xmedian 24.8x -65.7xmedian 24.8x -45.5xmedian 24.8x
P/S now vs peer median 3.7xmedian 1.6x 2.7xmedian 1.6x 2.8xmedian 1.6x
EV/EBITDA now vs peer median 11.4xmedian 15.9x 119.3xmedian 15.9x -65.0xmedian 15.9x
P/FCF now vs peer median 33.5xmedian 20.9x -74.5xmedian 20.9x 265.6xmedian 20.9x
P/B now vs peer median 6.2xmedian 3.3x 2.7xmedian 3.3x 2.2xmedian 3.3x
PEG now vs peer median 0.71median 0.88 -2.11median 0.88 -1.28median 0.88

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsSHCNEOCSTL
Revenue $1.23B $787.75M $377.13M
Gross profit $671.74M $352.67M $290.66M
Operating income $413.72M -$49.37M -$28.04M
Net income $173.47M -$32.30M -$23.01M
Free cash flow $135.43M -$28.58M $3.96M
R&D – $39.33M $58.29M
EPS (diluted) $0.60 $-0.25 $-0.75
Cash & equivalents $412.38M $139.28M $78.00M
Total debt $2.14B – $10.08M
Shares (diluted) 289.22M 128.59M 30.63M
Enterprise value $3.11B $1.54B -$53.36M

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricSHCNEOCSTL
P/E 26.2x -65.7x -45.5x
P/FCF 33.5x -74.5x 265.6x
P/Operating cash flow 13.7x 497.4x 26.5x
P/S 3.7x 2.7x 2.8x
P/B 6.2x 2.7x 2.2x
P/Tangible book 9.7x 4.0x 2.2x
EV/EBITDA 11.4x 119.3x -65.0x
EV/EBIT 15.1x -40.3x -28.0x
EV/Revenue 5.1x 2.5x 2.1x
EV/FCF 46.2x -69.6x 198.0x
EV/Operating cash flow 18.9x 464.9x 19.7x
PEG (3Y EPS CAGR) 0.71 -2.11 -1.28

Growth

14 metrics
MetricSHCNEOCSTL
Revenue growth (1Y) 6.9% 11.1% 9.8%
Revenue CAGR (3Y) 7.5% 11.1% 25.2%
Gross profit growth (1Y) 4.3% 14.4% 5.8%
Gross profit CAGR (3Y) 7.6% 14.7% 24.7%
Operating income growth (1Y) 11.4% 59.2% 19.7%
Operating income CAGR (3Y) 21.1% 24.7% 30.9%
Net income growth (1Y) 213.0% 71.5% -88.1%
Net income CAGR (3Y) 36.9% 30.5% 32.7%
EPS growth (1Y) 210.3% 71.6% -78.5%
EPS CAGR (3Y) 36.6% 31.1% 35.6%
Operating cash flow growth (1Y) 38.3% -68.7% -35.7%
Operating cash flow CAGR (3Y) 59.9% 29.7% 49.1%
Free cash flow growth (1Y) 56.4% -67.7% -84.4%
Free cash flow CAGR (3Y) 33.1% 16.8% 28.0%

Profitability

14 metrics
MetricSHCNEOCSTL
Gross margin 54.6% 44.8% 77.1%
EBITDA margin 44.7% 2.1% -3.2%
Operating margin 33.6% -6.3% -7.4%
Pretax margin 22.4% -4.6% -6.0%
Net margin 14.1% -4.1% -6.1%
FCF margin 11.0% -3.6% 1.1%
Operating cash flow margin 27.0% 0.5% 10.5%
Return on equity 24.8% -4.1% -4.9%
Return on assets 5.2% -2.4% -4.0%
Return on invested capital 9.2% – -5.8%
Return on capital employed 13.2% -4.0% -5.6%
Asset turnover 0.4x 0.6x 0.7x
Cash conversion (OCF / net income) 1.9x -0.1x -1.7x
Stock comp / revenue 3.0% 4.4% 11.7%

Financial Health

11 metrics
MetricSHCNEOCSTL
Debt / assets 63.1% – 1.7%
Debt / equity 2.9x – 0.0x
Net debt / EBITDA 3.1x – 22.2x
Debt / FCF 15.8x – 2.5x
Liabilities / assets 78.4% 41.9% 17.4%
Equity / assets 21.6% 58.1% 82.6%
Interest coverage – -15.2x -51.2x
Current ratio 3.1x 3.5x 5.3x
Quick ratio 2.7x 3.0x 4.9x
Cash ratio 1.8x 1.2x 4.1x
Altman Z-score 1.80 2.46 6.75

Shareholder Returns

7 metrics
MetricSHCNEOCSTL
Dividend yield – – –
Net buyback yield – -0.7% -0.7%
Shareholder yield – -0.7% -0.7%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusSHCNEOCSTL
Forward P/E 17.1xFY2026 78.5xFY2026 –
EPS, next fiscal year $0.93FY2026 $0.21FY2026 $-1.30FY2026
EPS growth, next FY +8.1%FY2026 +75.0%FY2026 –
EPS growth, the year after +22.6% +61.9% –
Revenue, next fiscal year $1.33BFY2026 $781.24MFY2026 $386.63MFY2026
Revenue growth, next FY +14.8%FY2026 +7.4%FY2026 +12.3%FY2026
Revenue growth, the year after -4.2% +6.4% +3.9%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersSHCNEOCSTL
Held by institutions 100.0% 100.0% 89.6%
Institutions holding 316 266 177
Change in shares held, QoQ +5.9% +8.1% -1.0%
Institutions buying 220 156 104
Institutions selling 64 62 55
Buyers to sellers 3.44 2.52 1.89

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

SHCNEOCSTL
SHC 1.00 0.42 0.37
NEO 0.42 1.00 0.51
CSTL 0.37 0.51 1.00

Add a Peer

Largest companies in the same industry

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Frequently Asked Questions

Which is bigger, SHC, NEO and CSTL?

Sotera Health (SHC) is the largest by market capitalisation: Sotera Health (SHC) $4.53B, Neogenomics (NEO) $2.13B, Castle Biosciences (CSTL) $1.05B.

Which company is growing faster?

Neogenomics (NEO) grew revenue fastest over the trailing twelve months: Sotera Health (SHC) +6.9%, Neogenomics (NEO) +11.1%, Castle Biosciences (CSTL) +9.8%.

Which company is more profitable?

Sotera Health (SHC) has the highest net margin (Sotera Health (SHC) 14.1%, Neogenomics (NEO) -4.1%, Castle Biosciences (CSTL) -6.1%). On return on invested capital, Sotera Health (SHC) leads (Sotera Health (SHC) 9.2%, Castle Biosciences (CSTL) -5.8%).

Which stock has performed better?

Over the past year Neogenomics (NEO) returned the most: Sotera Health (SHC) +0.4%, Neogenomics (NEO) +58.1%, Castle Biosciences (CSTL) +1.9%. Over five years, Sotera Health (SHC) compounded fastest (Sotera Health (SHC) -10.1%/yr, Neogenomics (NEO) -16.8%/yr, Castle Biosciences (CSTL) -10.5%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Sotera Health (SHC) has been the steadiest (Sotera Health (SHC) 30.4%, Neogenomics (NEO) 53.8%, Castle Biosciences (CSTL) 55.5%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, SHC, NEO and CSTL?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Sotera Health (SHC) leads on 8. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.