PGEN vs VCEL vs IOVA Stock Comparison

Precigen, Vericel and Iovance Biotherapeutics Prices as of Nov 3, 2026 Peers: Industry group
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PGEN Precigen, Inc.
$5.25 -38.5% 1M +26.2% 1Y
Market cap
$1.82B
P/E
–
Revenue (TTM)
$85.72M
Div. yield
–
Gene and Cell Therapy Healthcare
3 wins
VCEL Vericel Corp
$41.09 +2.3% 1M +11.9% 1Y
Market cap
$2.32B
P/E
95.9x
Revenue (TTM)
$306.30M
Div. yield
–
Gene and Cell Therapy Healthcare
3 wins

Head to Head

8 decided of 12

Precigen leads on 3 of the 12 questions below (Precigen 3, Vericel 3, Iovance Biotherapeutics 2). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionPGENVCELIOVALeader
Larger companyMarket capitalisation $1.82B $2.32B $3.95B IOVA
Cheaper on earningsLower P/E, profitable companies only -5.4x 95.9x -13.6x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS 30.9x 80.6x — PGEN
Faster revenue growthRevenue growth, trailing twelve months +1,875.0% +23.0% +34.5% PGEN
More profitableNet margin, trailing twelve months -392.8% 7.9% -89.1% VCEL
Better return on capitalReturn on invested capital — — — –
Less leveragedLower net debt / EBITDA -1.6x — — –
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months +26.2% +11.9% +352.8% IOVA
Better 5-year returnAnnualised price return, 5 years 0.0%/yr -3.3%/yr -18.5%/yr PGEN
Less volatileAnnualised volatility, 1 year 84.0% 41.3% 109.4% VCEL
Higher overall scoreMean of the five percentile scores vs peers 54/100 81/100 63/100 VCEL

Percentile Scorecard

PGENVCELIOVA

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisPGENVCELIOVA
Valuation 58 #266 of 634 82 #113 of 634 65 #224 of 634
Growth 48 #318 of 607 94 #37 of 607 82 #111 of 607
Profitability 59 #229 of 557 89 #65 of 557 63 #205 of 557
Financial Health 26 #485 of 654 68 #208 of 654 62 #250 of 654
Shareholder Returns 81 #78 of 401 72 #115 of 401 41 #238 of 401
Overall 54 81 63
  • PGEN ranked among 671 companies in Pharmaceuticals and Biotechnology
  • VCEL ranked among 671 companies in Pharmaceuticals and Biotechnology
  • IOVA ranked among 671 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodPGENVCELIOVASPY
1 month -38.5%+2.3%-37.9% -2.0%
3 months -19.6%-11.3%+102.5% -2.2%
6 months +21.2%+11.6%+121.9% +4.2%
Year to date +25.6%+14.1%+223.4% +10.6%
1 year +26.2%+11.9%+352.8% +10.4%
3 years +333.9%+11.5%+109.7% +73.6%
3 years, per year +63.2%+3.7%+28.0% +20.2%
5 years -0.2%-15.6%-64.0% +61.6%
5 years, per year 0.0%-3.3%-18.5% +10.1%
10 years -78.4%+1,856.7%+50.9% +261.3%
10 years, per year -14.2%+34.6%+4.2% +13.7%

Risk

MeasurePGENVCELIOVASPY
Volatility, 1Y 84.0%41.3%109.4% 12.8%
Downside volatility, 1Y 81.1%41.1%94.7% 12.8%
Beta vs S&P 500, 1Y 1.440.771.54 1.00
Return / volatility, 1Y 0.310.293.22 0.81
Max drawdown, 5Y -87.3%-63.7%-93.4% -25.4%
From 52-week high -38.7%-14.9%-40.6% -3.2%
52-week high $8.56$48.31$14.86 $779.14
52-week low $3.10$29.34$1.81 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultiplePGENVCELIOVA
P/E now vs peer median -5.6xmedian 18.4x 86.6xmedian 18.4x -13.7xmedian 18.4x
P/S now vs peer median 21.9xmedian 9.0x 6.9xmedian 9.0x 12.3xmedian 9.0x
EV/EBITDA now vs peer median -56.4xmedian 16.0x 61.8xmedian 16.0x -14.0xmedian 16.0x
P/FCF now vs peer median -16.3xmedian 21.8x 34.1xmedian 21.8x -13.5xmedian 21.8x
P/B now vs peer median 43.1xmedian 2.1x 5.7xmedian 2.1x 5.4xmedian 2.1x
PEG now vs peer median 0.05median 0.37 1.60median 0.37 -0.46median 0.37

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsPGENVCELIOVA
Revenue $85.72M $306.30M $324.97M
Gross profit $77.72M $228.38M $157.29M
Operating income -$39.50M $18.24M -$301.31M
Net income -$157.71M $24.22M -$289.51M
Free cash flow -$115.22M $61.66M -$296.40M
R&D $32.29M $29.17M $267.72M
EPS (diluted) $-0.81 $0.46 $-0.64
Cash & equivalents $16.33M $125.40M $110.80M
Total debt $93.88M – –
Shares (diluted) 413.69M 52.31M 450.19M
Enterprise value $1.51B $1.74B $2.74B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricPGENVCELIOVA
P/E -5.6x 86.6x -13.7x
P/FCF -16.3x 34.1x -13.5x
P/Operating cash flow -16.5x 30.2x -15.1x
P/S 21.9x 6.9x 12.3x
P/B 43.1x 5.7x 5.4x
P/Tangible book 45.8x 5.8x 8.5x
EV/EBITDA -56.4x 61.8x -14.0x
EV/EBIT -49.0x 106.4x -12.3x
EV/Revenue 22.6x 6.3x 11.4x
EV/FCF -16.8x 31.5x -12.5x
EV/Operating cash flow -17.0x 27.8x -14.0x
PEG (3Y EPS CAGR) 0.05 1.60 -0.46

Growth

14 metrics
MetricPGENVCELIOVA
Revenue growth (1Y) 1,875% 23.0% 34.5%
Revenue CAGR (3Y) 57.1% 19.8% 1,009%
Gross profit growth (1Y) 259,173% 24.8% 95.1%
Gross profit CAGR (3Y) 69.2% 23.9% –
Operating income growth (1Y) 62.1% 1,428% 26.6%
Operating income CAGR (3Y) 18.9% 47.8% 11.1%
Net income growth (1Y) -26.7% 240.8% 25.8%
Net income CAGR (3Y) -108.9% 56.6% 11.6%
EPS growth (1Y) -93.8% 228.1% 44.8%
EPS CAGR (3Y) -123.2% 54.3% 29.9%
Operating cash flow growth (1Y) -72.3% 47.5% 12.9%
Operating cash flow CAGR (3Y) -15.9% 33.7% 7.6%
Free cash flow growth (1Y) -65.1% 842.9% 8.4%
Free cash flow CAGR (3Y) -15.3% 43.2% 5.8%

Profitability

14 metrics
MetricPGENVCELIOVA
Gross margin 90.7% 74.6% 48.4%
EBITDA margin -40.0% 10.2% -81.4%
Operating margin -46.1% 6.0% -92.7%
Pretax margin -184.0% 8.2% -90.4%
Net margin -392.8% 7.9% -89.1%
FCF margin -134.4% 20.1% -91.2%
Operating cash flow margin -133.2% 22.7% -81.3%
Return on equity -494.3% 6.9% -39.7%
Return on assets -102.1% 5.1% -31.4%
Return on invested capital – – –
Return on capital employed -31.6% 4.1% -37.0%
Asset turnover 0.6x 0.6x 0.4x
Cash conversion (OCF / net income) 0.7x 2.9x 0.9x
Stock comp / revenue 15.3% 12.2% 14.4%

Financial Health

11 metrics
MetricPGENVCELIOVA
Debt / assets 55.1% – –
Debt / equity 2.2x – –
Net debt / EBITDA -1.6x – –
Debt / FCF -0.8x – –
Liabilities / assets 74.4% 26.4% 19.6%
Equity / assets 25.6% 73.6% 80.4%
Interest coverage -4.1x 28.5x –
Current ratio 4.6x 5.0x 4.3x
Quick ratio 3.8x 4.5x 3.7x
Cash ratio 1.3x 3.1x 2.8x
Altman Z-score -9.77 9.67 8.67

Shareholder Returns

7 metrics
MetricPGENVCELIOVA
Dividend yield – – –
Net buyback yield -0.1% -0.3% -7.4%
Shareholder yield -0.1% -0.3% -7.4%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusPGENVCELIOVA
Forward P/E 30.9xFY2026 80.6xFY2026 –
EPS, next fiscal year $0.17FY2026 $0.51FY2026 $-0.47FY2026
EPS growth, next FY – +59.4%FY2026 –
EPS growth, the year after +288.2% +74.5% –
Revenue, next fiscal year $249.17MFY2026 $324.56MFY2026 $434.71MFY2026
Revenue growth, next FY +2,474.1%FY2026 +17.5%FY2026 +65.0%FY2026
Revenue growth, the year after +82.3% +16.1% +33.0%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersPGENVCELIOVA
Held by institutions 39.2% 100.0% 63.3%
Institutions holding 211 319 292
Change in shares held, QoQ +4.9% +0.4% +6.5%
Institutions buying 123 188 174
Institutions selling 46 99 66
Buyers to sellers 2.67 1.90 2.64

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

PGENVCELIOVA
PGEN 1.00 0.14 0.20
VCEL 0.14 1.00 0.15
IOVA 0.20 0.15 1.00

Add a Peer

Largest companies in the same industry

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Frequently Asked Questions

Which is bigger, PGEN, VCEL and IOVA?

Iovance Biotherapeutics (IOVA) is the largest by market capitalisation: Precigen (PGEN) $1.82B, Vericel (VCEL) $2.32B, Iovance Biotherapeutics (IOVA) $3.95B.

Which company is growing faster?

Precigen (PGEN) grew revenue fastest over the trailing twelve months: Precigen (PGEN) +1,875.0%, Vericel (VCEL) +23.0%, Iovance Biotherapeutics (IOVA) +34.5%.

Which company is more profitable?

Vericel (VCEL) has the highest net margin (Precigen (PGEN) -392.8%, Vericel (VCEL) 7.9%, Iovance Biotherapeutics (IOVA) -89.1%).

Which stock has performed better?

Over the past year Iovance Biotherapeutics (IOVA) returned the most: Precigen (PGEN) +26.2%, Vericel (VCEL) +11.9%, Iovance Biotherapeutics (IOVA) +352.8%. Over five years, Precigen (PGEN) compounded fastest (Precigen (PGEN) 0.0%/yr, Vericel (VCEL) -3.3%/yr, Iovance Biotherapeutics (IOVA) -18.5%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Vericel (VCEL) has been the steadiest (Precigen (PGEN) 84.0%, Vericel (VCEL) 41.3%, Iovance Biotherapeutics (IOVA) 109.4%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, PGEN, VCEL and IOVA?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Precigen (PGEN) leads on 3. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.