PGEN vs BEAM vs MESO Stock Comparison

Precigen, Beam Therapeutics and Mesoblast Prices as of Oct 27, 2026 Peers: Industry group
PGEN Precigen, Inc.
$6.15 -20.6% 1M +43.0% 1Y
Market cap
$2.20B
P/E
–
Revenue (TTM)
$85.72M
Div. yield
–
Gene and Cell Therapy Healthcare
4 wins
BEAM Beam Therapeutics Inc.
$24.90 +2.6% 1M -6.8% 1Y
Market cap
$2.57B
P/E
–
Revenue (TTM)
$156.04M
Div. yield
–
Gene and Cell Therapy Healthcare
3 wins
MESO Mesoblast Ltd
$13.18 -12.8% 1M -21.1% 1Y
Market cap
$1.71B
P/E
–
Revenue (TTM)
—
Div. yield
–
Gene and Cell Therapy Healthcare
1 win

Head to Head

8 decided of 12

Precigen leads on 4 of the 12 questions below (Precigen 4, Beam Therapeutics 3, Mesoblast 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionPGENBEAMMESOLeader
Larger companyMarket capitalisation $2.20B $2.57B $1.71B BEAM
Cheaper on earningsLower P/E, profitable companies only -6.5x -30.4x -29.7x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS 36.2x — — –
Faster revenue growthRevenue growth, trailing twelve months +1,875.0% +158.9% — PGEN
More profitableNet margin, trailing twelve months -392.8% -54.7% — BEAM
Better return on capitalReturn on invested capital — — — –
Less leveragedLower net debt / EBITDA -1.6x 3.0x — PGEN
Higher dividend yieldTrailing dividend yield — 0.00% — –
Better 1-year returnPrice return, last 12 months +43.0% -6.8% -21.1% PGEN
Better 5-year returnAnnualised price return, 5 years +4.4%/yr -23.4%/yr +1.9%/yr PGEN
Less volatileAnnualised volatility, 1 year 77.9% 69.2% 54.8% MESO
Higher overall scoreMean of the five percentile scores vs peers 55/100 69/100 — BEAM

Percentile Scorecard

PGENBEAMMESO

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisPGENBEAMMESO
Valuation 59 #258 of 625 54 #286 of 625 70 #189 of 625
Growth 49 #310 of 602 77 #137 of 602 –
Profitability 59 #227 of 551 64 #198 of 551 –
Financial Health 27 #482 of 656 81 #128 of 656 44 #365 of 656
Shareholder Returns 83 #63 of 365 67 #123 of 365 –
Overall 55 69 –
  • PGEN ranked among 672 companies in Pharmaceuticals and Biotechnology
  • BEAM ranked among 672 companies in Pharmaceuticals and Biotechnology
  • MESO ranked among 672 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodPGENBEAMMESOSPY
1 month -20.6%+2.6%-12.8% -0.2%
3 months +11.2%-5.3%-8.8% +3.9%
6 months +53.0%-18.5%-13.4% +8.2%
Year to date +47.1%-10.2%-26.9% +12.9%
1 year +43.0%-6.8%-21.1% +12.3%
3 years +508.9%+33.7%+463.2% +87.4%
3 years, per year +82.7%+10.2%+78.0% +23.3%
5 years +24.0%-73.6%+9.7% +67.9%
5 years, per year +4.4%-23.4%+1.9% +10.9%
10 years -76.2%—+56.2% +261.1%
10 years, per year -13.4%—+4.6% +13.7%

Risk

MeasurePGENBEAMMESOSPY
Volatility, 1Y 77.9%69.2%54.8% 12.7%
Downside volatility, 1Y 69.4%63.8%54.9% 12.7%
Beta vs S&P 500, 1Y 1.432.061.52 1.00
Return / volatility, 1Y 0.55-0.10-0.39 0.97
Max drawdown, 5Y -87.8%-85.3%-87.9% -25.4%
From 52-week high -28.2%-34.3%-37.1% -1.2%
52-week high $8.56$37.92$20.96 $779.14
52-week low $3.10$20.60$11.95 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultiplePGENBEAMMESO
P/E now vs peer median -6.5xmedian 17.2x -30.4xmedian 17.2x -29.7xmedian 17.2x
P/S now vs peer median 25.7xmedian 9.0x 16.5xmedian 9.0x 14.2xmedian 9.0x
EV/EBITDA now vs peer median -65.8xmedian 16.3x -4.3xmedian 16.3x —median 16.3x
P/FCF now vs peer median -19.1xmedian 18.7x -6.9xmedian 18.7x -38.2xmedian 18.7x
P/B now vs peer median 50.5xmedian 2.2x 2.4xmedian 2.2x 3.0xmedian 2.2x
PEG now vs peer median 0.05median 0.33 -0.72median 0.33 —median 0.33

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsPGENBEAMMESO
Revenue $85.72M $156.04M –
Gross profit $77.72M – –
Operating income -$39.50M -$378.02M –
Net income -$157.71M -$86.52M –
Free cash flow -$115.22M -$372.77M –
R&D $32.29M $408.66M –
EPS (diluted) $-0.81 $-0.82 –
Cash & equivalents $16.33M $219.83M $102.91M
Total debt $93.88M $100.26M $119.24M
Shares (diluted) 413.69M 104.33M 129.49M
Enterprise value $1.89B -$2.11B $1.27B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricPGENBEAMMESO
P/E -6.5x -30.4x -29.7x
P/FCF -19.1x -6.9x -38.2x
P/Operating cash flow -19.3x -7.2x –
P/S 25.7x 16.5x 14.2x
P/B 50.5x 2.4x 3.0x
P/Tangible book 53.7x 2.4x 3.0x
EV/EBITDA -65.8x -4.3x –
EV/EBIT -57.2x -4.0x –
EV/Revenue 26.3x 9.7x –
EV/FCF -19.6x -4.1x –
EV/Operating cash flow -19.8x -4.2x –
PEG (3Y EPS CAGR) 0.05 -0.72 –

Growth

14 metrics
MetricPGENBEAMMESO
Revenue growth (1Y) 1,875% 158.9% –
Revenue CAGR (3Y) 57.1% 24.9% –
Gross profit growth (1Y) 259,173% – –
Gross profit CAGR (3Y) 69.2% – –
Operating income growth (1Y) 62.1% 15.2% –
Operating income CAGR (3Y) 18.9% 0.3% –
Net income growth (1Y) -26.7% 78.2% –
Net income CAGR (3Y) -108.9% 35.8% –
EPS growth (1Y) -93.8% 79.0% –
EPS CAGR (3Y) -123.2% 42.4% –
Operating cash flow growth (1Y) -72.3% -4.2% –
Operating cash flow CAGR (3Y) -15.9% -2.0% –
Free cash flow growth (1Y) -65.1% -4.8% –
Free cash flow CAGR (3Y) -15.3% 0.7% –

Profitability

14 metrics
MetricPGENBEAMMESO
Gross margin 90.7% – –
EBITDA margin -40.0% -228.0% –
Operating margin -46.1% -242.3% –
Pretax margin -184.0% -54.4% –
Net margin -392.8% -54.7% –
FCF margin -134.4% -238.9% –
Operating cash flow margin -133.2% -230.3% –
Return on equity -494.3% -7.6% –
Return on assets -102.1% -5.9% –
Return on invested capital – – –
Return on capital employed -31.6% -27.9% –
Asset turnover 0.6x 0.1x –
Cash conversion (OCF / net income) 0.7x 4.2x –
Stock comp / revenue 15.3% 52.2% –

Financial Health

11 metrics
MetricPGENBEAMMESO
Debt / assets 55.1% 7.2% 15.4%
Debt / equity 2.2x 0.1x 0.2x
Net debt / EBITDA -1.6x 3.0x –
Debt / FCF -0.8x -0.3x –
Liabilities / assets 74.4% 23.0% 26.5%
Equity / assets 25.6% 77.0% 73.5%
Interest coverage -4.1x – –
Current ratio 4.6x 14.6x 2.4x
Quick ratio 3.8x 14.3x 2.0x
Cash ratio 1.3x 14.3x 1.3x
Altman Z-score -8.25 3.08 –

Shareholder Returns

7 metrics
MetricPGENBEAMMESO
Dividend yield – – –
Net buyback yield -0.1% -0.6% –
Shareholder yield -0.1% -0.6% –
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusPGENBEAMMESO
Forward P/E 36.2xFY2026 – –
EPS, next fiscal year $0.17FY2026 $-4.22FY2026 $-0.15FY2027
EPS growth, the year after +288.2% – –
Revenue, next fiscal year $249.17MFY2026 $49.46MFY2026 $188.99MFY2027
Revenue growth, next FY +2,474.1%FY2026 -64.6%FY2026 +57.2%FY2027
Revenue growth, the year after +82.3% +23.6% +110.3%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersPGENBEAMMESO
Held by institutions 39.2% 100.0% 3.0%
Institutions holding 210 277 73
Change in shares held, QoQ +4.9% +1.0% +17.7%
Institutions buying 123 154 34
Institutions selling 46 75 20
Buyers to sellers 2.67 2.05 1.70

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

PGENBEAMMESO
PGEN 1.00 0.26 0.20
BEAM 0.26 1.00 0.14
MESO 0.20 0.14 1.00

Add a Peer

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Frequently Asked Questions

Which is bigger, PGEN, BEAM and MESO?

Beam Therapeutics (BEAM) is the largest by market capitalisation: Precigen (PGEN) $2.20B, Beam Therapeutics (BEAM) $2.57B, Mesoblast (MESO) $1.71B.

Which company is growing faster?

Precigen (PGEN) grew revenue fastest over the trailing twelve months: Precigen (PGEN) +1,875.0%, Beam Therapeutics (BEAM) +158.9%.

Which company is more profitable?

Beam Therapeutics (BEAM) has the highest net margin (Precigen (PGEN) -392.8%, Beam Therapeutics (BEAM) -54.7%).

Which stock has performed better?

Over the past year Precigen (PGEN) returned the most: Precigen (PGEN) +43.0%, Beam Therapeutics (BEAM) -6.8%, Mesoblast (MESO) -21.1%. Over five years, Precigen (PGEN) compounded fastest (Precigen (PGEN) +4.4%/yr, Beam Therapeutics (BEAM) -23.4%/yr, Mesoblast (MESO) +1.9%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Mesoblast (MESO) has been the steadiest (Precigen (PGEN) 77.9%, Beam Therapeutics (BEAM) 69.2%, Mesoblast (MESO) 54.8%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, PGEN, BEAM and MESO?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Precigen (PGEN) leads on 4. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.