NTLA vs LEGN vs PGEN Stock Comparison

Intellia Therapeutics, Legend Biotech and Precigen Prices as of Nov 4, 2026 Peers: Industry group
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LEGN Legend Biotech Corp
$22.77 +21.3% 1M -29.0% 1Y
Market cap
$4.20B
P/E
–
Revenue (TTM)
$1.27B
Div. yield
–
Gene and Cell Therapy Healthcare
5 wins
PGEN Precigen, Inc.
$5.05 -34.8% 1M +30.2% 1Y
Market cap
$1.81B
P/E
–
Revenue (TTM)
$85.72M
Div. yield
–
Gene and Cell Therapy Healthcare
3 wins

Head to Head

8 decided of 12

Legend Biotech leads on 5 of the 12 questions below (Legend Biotech 5, Precigen 3). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionNTLALEGNPGENLeader
Larger companyMarket capitalisation $1.72B $4.20B $1.81B LEGN
Cheaper on earningsLower P/E, profitable companies only -4.1x -45.8x -5.4x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — — 29.7x –
Faster revenue growthRevenue growth, trailing twelve months +12.6% +59.5% +1,875.0% PGEN
More profitableNet margin, trailing twelve months -672.2% -7.2% -392.8% LEGN
Better return on capitalReturn on invested capital — -4.2% — –
Less leveragedLower net debt / EBITDA — -130.2x -1.6x LEGN
Higher dividend yieldTrailing dividend yield — — — –
Better 1-year returnPrice return, last 12 months +0.9% -29.0% +30.2% PGEN
Better 5-year returnAnnualised price return, 5 years -38.1%/yr -14.1%/yr -0.2%/yr PGEN
Less volatileAnnualised volatility, 1 year 79.7% 72.7% 83.8% LEGN
Higher overall scoreMean of the five percentile scores vs peers 50/100 74/100 54/100 LEGN

Percentile Scorecard

NTLALEGNPGEN

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisNTLALEGNPGEN
Valuation 37 #398 of 634 88 #77 of 634 58 #265 of 634
Growth 63 #225 of 607 97 #21 of 607 48 #317 of 607
Profitability 39 #341 of 557 80 #110 of 557 59 #229 of 557
Financial Health 73 #180 of 654 60 #263 of 654 25 #488 of 654
Shareholder Returns 40 #241 of 400 44 #223 of 400 80 #80 of 400
Overall 50 74 54
  • NTLA ranked among 671 companies in Pharmaceuticals and Biotechnology
  • LEGN ranked among 671 companies in Pharmaceuticals and Biotechnology
  • PGEN ranked among 671 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodNTLALEGNPGENSPY
1 month -3.5%+21.3%-34.8% -1.0%
3 months +12.2%+19.5%-26.7% -0.4%
6 months -11.1%-21.4%+14.8% +4.5%
Year to date +36.9%+4.7%+20.8% +12.4%
1 year +0.9%-29.0%+30.2% +13.6%
3 years -57.2%-65.5%+317.4% +76.4%
3 years, per year -24.7%-29.9%+61.1% +20.8%
5 years -90.9%-53.3%-1.2% +63.7%
5 years, per year -38.1%-14.1%-0.2% +10.4%
10 years -11.6%—-79.9% +267.7%
10 years, per year -1.2%—-14.8% +13.9%

Risk

MeasureNTLALEGNPGENSPY
Volatility, 1Y 79.7%72.7%83.8% 12.8%
Downside volatility, 1Y 81.6%62.9%80.6% 12.7%
Beta vs S&P 500, 1Y 2.430.531.34 1.00
Return / volatility, 1Y 0.01-0.400.36 1.06
Max drawdown, 5Y -95.5%-78.2%-86.9% -25.4%
From 52-week high -31.0%-37.2%-41.0% -1.6%
52-week high $17.84$36.28$8.56 $779.14
52-week low $8.04$16.65$3.10 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleNTLALEGNPGEN
P/E now vs peer median -4.1xmedian 18.0x -45.8xmedian 18.0x -5.4xmedian 18.0x
P/S now vs peer median 29.0xmedian 9.1x 3.3xmedian 9.1x 21.1xmedian 9.1x
EV/EBITDA now vs peer median -3.1xmedian 16.2x 927.8xmedian 16.2x -54.3xmedian 16.2x
P/FCF now vs peer median -4.9xmedian 21.7x -65.0xmedian 21.7x -15.7xmedian 21.7x
P/B now vs peer median 2.4xmedian 2.2x 3.4xmedian 2.2x 41.5xmedian 2.2x
PEG now vs peer median -0.25median 0.38 -0.97median 0.38 0.04median 0.38

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsNTLALEGNPGEN
Revenue $59.51M $1.27B $85.72M
Gross profit – $727.10M $77.72M
Operating income -$423.48M -$55.25M -$39.50M
Net income -$399.98M -$80.39M -$157.71M
Free cash flow -$348.69M -$64.60M -$115.22M
R&D $346.73M $396.15M $32.29M
EPS (diluted) $-3.00 $-0.50 $-0.81
Cash & equivalents $106.13M $672.90M $16.33M
Total debt – $156.40M $93.88M
Shares (diluted) 133.48M 184.32M 413.69M
Enterprise value -$51.05M $1.70B $1.49B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricNTLALEGNPGEN
P/E -4.1x -45.8x -5.4x
P/FCF -4.9x -65.0x -15.7x
P/Operating cash flow -5.0x -46.9x -15.8x
P/S 29.0x 3.3x 21.1x
P/B 2.4x 3.4x 41.5x
P/Tangible book 2.4x 3.4x 44.1x
EV/EBITDA -3.1x 927.8x -54.3x
EV/EBIT -3.0x -66.6x -47.2x
EV/Revenue 21.6x 2.9x 21.7x
EV/FCF -3.7x -57.0x -16.2x
EV/Operating cash flow -3.7x -41.2x -16.3x
PEG (3Y EPS CAGR) -0.25 -0.97 0.04

Growth

14 metrics
MetricNTLALEGNPGEN
Revenue growth (1Y) 12.6% 59.5% 1,875%
Revenue CAGR (3Y) 3.9% 97.6% 57.1%
Gross profit growth (1Y) – 42.4% 259,173%
Gross profit CAGR (3Y) – 147.5% 69.2%
Operating income growth (1Y) 17.3% 75.3% 62.1%
Operating income CAGR (3Y) 2.7% 49.1% 18.9%
Net income growth (1Y) 16.7% 75.3% -26.7%
Net income CAGR (3Y) 4.1% 46.7% -108.9%
EPS growth (1Y) 35.3% 72.0% -93.8%
EPS CAGR (3Y) 16.5% 47.0% -123.2%
Operating cash flow growth (1Y) 17.2% 67.5% -72.3%
Operating cash flow CAGR (3Y) 2.0% 37.1% -15.9%
Free cash flow growth (1Y) 17.3% 77.8% -65.1%
Free cash flow CAGR (3Y) 3.2% 44.5% -15.3%

Profitability

14 metrics
MetricNTLALEGNPGEN
Gross margin – 57.2% 90.7%
EBITDA margin -696.4% 0.3% -40.0%
Operating margin -711.7% -4.3% -46.1%
Pretax margin -671.0% -4.4% -184.0%
Net margin -672.2% -7.2% -392.8%
FCF margin -586.0% -5.1% -134.4%
Operating cash flow margin -582.5% -7.0% -133.2%
Return on equity -59.2% -8.3% -494.3%
Return on assets -49.4% -5.5% -102.1%
Return on invested capital – -4.2% –
Return on capital employed -58.1% -4.3% -31.6%
Asset turnover 0.1x 0.8x 0.6x
Cash conversion (OCF / net income) 0.9x 1.1x 0.7x
Stock comp / revenue 114.1% 5.2% 15.3%

Financial Health

11 metrics
MetricNTLALEGNPGEN
Debt / assets – 8.9% 55.1%
Debt / equity – 0.1x 2.2x
Net debt / EBITDA – -130.2x -1.6x
Debt / FCF – -2.4x -0.8x
Liabilities / assets 15.1% 29.8% 74.4%
Equity / assets 84.9% 70.2% 25.6%
Interest coverage – -4.8x -4.1x
Current ratio 6.6x 3.0x 4.6x
Quick ratio 5.6x 1.7x 3.8x
Cash ratio 5.5x 1.7x 1.3x
Altman Z-score 2.49 7.00 -10.11

Shareholder Returns

7 metrics
MetricNTLALEGNPGEN
Dividend yield – – –
Net buyback yield -7.6% -5.1% -0.1%
Shareholder yield -7.6% -5.1% -0.1%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusNTLALEGNPGEN
Forward P/E – – 29.7xFY2026
EPS, next fiscal year $-3.38FY2026 $-0.04FY2026 $0.17FY2026
EPS growth, the year after – – +288.2%
Revenue, next fiscal year $48.94MFY2026 $1.37BFY2026 $249.17MFY2026
Revenue growth, next FY -27.7%FY2026 +32.9%FY2026 +2,474.1%FY2026
Revenue growth, the year after +158.6% +35.9% +82.3%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersNTLALEGNPGEN
Held by institutions 100.0% 55.9% 39.2%
Institutions holding 329 218 211
Change in shares held, QoQ +30.5% +7.3% +4.9%
Institutions buying 195 117 123
Institutions selling 78 78 46
Buyers to sellers 2.50 1.50 2.67

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

NTLALEGNPGEN
NTLA 1.00 0.09 0.25
LEGN 0.09 1.00 0.07
PGEN 0.25 0.07 1.00

Add a Peer

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Frequently Asked Questions

Which is bigger, NTLA, LEGN and PGEN?

Legend Biotech (LEGN) is the largest by market capitalisation: Intellia Therapeutics (NTLA) $1.72B, Legend Biotech (LEGN) $4.20B, Precigen (PGEN) $1.81B.

Which company is growing faster?

Precigen (PGEN) grew revenue fastest over the trailing twelve months: Intellia Therapeutics (NTLA) +12.6%, Legend Biotech (LEGN) +59.5%, Precigen (PGEN) +1,875.0%.

Which company is more profitable?

Legend Biotech (LEGN) has the highest net margin (Intellia Therapeutics (NTLA) -672.2%, Legend Biotech (LEGN) -7.2%, Precigen (PGEN) -392.8%).

Which stock has performed better?

Over the past year Precigen (PGEN) returned the most: Intellia Therapeutics (NTLA) +0.9%, Legend Biotech (LEGN) -29.0%, Precigen (PGEN) +30.2%. Over five years, Precigen (PGEN) compounded fastest (Intellia Therapeutics (NTLA) -38.1%/yr, Legend Biotech (LEGN) -14.1%/yr, Precigen (PGEN) -0.2%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Legend Biotech (LEGN) has been the steadiest (Intellia Therapeutics (NTLA) 79.7%, Legend Biotech (LEGN) 72.7%, Precigen (PGEN) 83.8%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, NTLA, LEGN and PGEN?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Legend Biotech (LEGN) leads on 5. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.