NTLA vs IOVA vs LEGN Stock Comparison

Intellia Therapeutics, Iovance Biotherapeutics and Legend Biotech Prices as of Nov 3, 2026 Peers: Industry group
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LEGN Legend Biotech Corp
$21.48 +15.7% 1M -33.1% 1Y
Market cap
$4.23B
P/E
–
Revenue (TTM)
$1.27B
Div. yield
–
Gene and Cell Therapy Healthcare
6 wins

Head to Head

7 decided of 12

Legend Biotech leads on 6 of the 12 questions below (Legend Biotech 6, Iovance Biotherapeutics 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionNTLAIOVALEGNLeader
Larger companyMarket capitalisation $1.64B $3.95B $4.23B LEGN
Cheaper on earningsLower P/E, profitable companies only -4.1x -13.6x -46.2x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — — — –
Faster revenue growthRevenue growth, trailing twelve months +12.6% +34.5% +59.5% LEGN
More profitableNet margin, trailing twelve months -672.2% -89.1% -7.2% LEGN
Better return on capitalReturn on invested capital — — -4.2% –
Less leveragedLower net debt / EBITDA — — -130.2x –
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months -9.3% +352.8% -33.1% IOVA
Better 5-year returnAnnualised price return, 5 years -38.4%/yr -18.5%/yr -15.1%/yr LEGN
Less volatileAnnualised volatility, 1 year 79.9% 109.4% 72.4% LEGN
Higher overall scoreMean of the five percentile scores vs peers 50/100 63/100 74/100 LEGN

Percentile Scorecard

NTLAIOVALEGN

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisNTLAIOVALEGN
Valuation 37 #402 of 634 65 #224 of 634 88 #75 of 634
Growth 63 #224 of 607 82 #111 of 607 97 #20 of 607
Profitability 39 #339 of 557 63 #205 of 557 80 #112 of 557
Financial Health 72 #187 of 654 62 #250 of 654 60 #262 of 654
Shareholder Returns 39 #245 of 401 41 #238 of 401 44 #227 of 401
Overall 50 63 74
  • NTLA ranked among 671 companies in Pharmaceuticals and Biotechnology
  • IOVA ranked among 671 companies in Pharmaceuticals and Biotechnology
  • LEGN ranked among 671 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodNTLAIOVALEGNSPY
1 month -3.3%-37.9%+15.7% -2.0%
3 months +4.8%+102.5%+12.3% -2.2%
6 months -10.9%+121.9%-24.7% +4.2%
Year to date +31.9%+223.4%-1.2% +10.6%
1 year -9.3%+352.8%-33.1% +10.4%
3 years -58.8%+109.7%-67.4% +73.6%
3 years, per year -25.6%+28.0%-31.2% +20.2%
5 years -91.1%-64.0%-55.9% +61.6%
5 years, per year -38.4%-18.5%-15.1% +10.1%
10 years -9.1%+50.9%— +261.3%
10 years, per year -1.0%+4.2%— +13.7%

Risk

MeasureNTLAIOVALEGNSPY
Volatility, 1Y 79.9%109.4%72.4% 12.8%
Downside volatility, 1Y 81.8%94.7%62.7% 12.8%
Beta vs S&P 500, 1Y 2.461.540.48 1.00
Return / volatility, 1Y -0.123.22-0.46 0.81
Max drawdown, 5Y -95.5%-93.4%-78.2% -25.4%
From 52-week high -33.5%-40.6%-40.8% -3.2%
52-week high $17.84$14.86$36.28 $779.14
52-week low $8.04$1.81$16.65 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleNTLAIOVALEGN
P/E now vs peer median -4.0xmedian 18.4x -13.7xmedian 18.4x -43.2xmedian 18.4x
P/S now vs peer median 27.9xmedian 9.0x 12.3xmedian 9.0x 3.1xmedian 9.0x
EV/EBITDA now vs peer median -3.0xmedian 16.0x -14.0xmedian 16.0x 867.8xmedian 16.0x
P/FCF now vs peer median -4.8xmedian 21.8x -13.5xmedian 21.8x -61.3xmedian 21.8x
P/B now vs peer median 2.3xmedian 2.1x 5.4xmedian 2.1x 3.2xmedian 2.1x
PEG now vs peer median -0.24median 0.37 -0.46median 0.37 -0.92median 0.37

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsNTLAIOVALEGN
Revenue $59.51M $324.97M $1.27B
Gross profit – $157.29M $727.10M
Operating income -$423.48M -$301.31M -$55.25M
Net income -$399.98M -$289.51M -$80.39M
Free cash flow -$348.69M -$296.40M -$64.60M
R&D $346.73M $267.72M $396.15M
EPS (diluted) $-3.00 $-0.64 $-0.50
Cash & equivalents $106.13M $110.80M $672.90M
Total debt – – $156.40M
Shares (diluted) 133.48M 450.19M 184.32M
Enterprise value -$135.54M $2.74B $1.73B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricNTLAIOVALEGN
P/E -4.0x -13.7x -43.2x
P/FCF -4.8x -13.5x -61.3x
P/Operating cash flow -4.8x -15.1x -44.3x
P/S 27.9x 12.3x 3.1x
P/B 2.3x 5.4x 3.2x
P/Tangible book 2.3x 8.5x 3.2x
EV/EBITDA -3.0x -14.0x 867.8x
EV/EBIT -2.9x -12.3x -62.3x
EV/Revenue 20.6x 11.4x 2.7x
EV/FCF -3.5x -12.5x -53.3x
EV/Operating cash flow -3.5x -14.0x -38.5x
PEG (3Y EPS CAGR) -0.24 -0.46 -0.92

Growth

14 metrics
MetricNTLAIOVALEGN
Revenue growth (1Y) 12.6% 34.5% 59.5%
Revenue CAGR (3Y) 3.9% 1,009% 97.6%
Gross profit growth (1Y) – 95.1% 42.4%
Gross profit CAGR (3Y) – – 147.5%
Operating income growth (1Y) 17.3% 26.6% 75.3%
Operating income CAGR (3Y) 2.7% 11.1% 49.1%
Net income growth (1Y) 16.7% 25.8% 75.3%
Net income CAGR (3Y) 4.1% 11.6% 46.7%
EPS growth (1Y) 35.3% 44.8% 72.0%
EPS CAGR (3Y) 16.5% 29.9% 47.0%
Operating cash flow growth (1Y) 17.2% 12.9% 67.5%
Operating cash flow CAGR (3Y) 2.0% 7.6% 37.1%
Free cash flow growth (1Y) 17.3% 8.4% 77.8%
Free cash flow CAGR (3Y) 3.2% 5.8% 44.5%

Profitability

14 metrics
MetricNTLAIOVALEGN
Gross margin – 48.4% 57.2%
EBITDA margin -696.4% -81.4% 0.3%
Operating margin -711.7% -92.7% -4.3%
Pretax margin -671.0% -90.4% -4.4%
Net margin -672.2% -89.1% -7.2%
FCF margin -586.0% -91.2% -5.1%
Operating cash flow margin -582.5% -81.3% -7.0%
Return on equity -59.2% -39.7% -8.3%
Return on assets -49.4% -31.4% -5.5%
Return on invested capital – – -4.2%
Return on capital employed -58.1% -37.0% -4.3%
Asset turnover 0.1x 0.4x 0.8x
Cash conversion (OCF / net income) 0.9x 0.9x 1.1x
Stock comp / revenue 114.1% 14.4% 5.2%

Financial Health

11 metrics
MetricNTLAIOVALEGN
Debt / assets – – 8.9%
Debt / equity – – 0.1x
Net debt / EBITDA – – -130.2x
Debt / FCF – – -2.4x
Liabilities / assets 15.1% 19.6% 29.8%
Equity / assets 84.9% 80.4% 70.2%
Interest coverage – – -4.8x
Current ratio 6.6x 4.3x 3.0x
Quick ratio 5.6x 3.7x 1.7x
Cash ratio 5.5x 2.8x 1.7x
Altman Z-score 2.20 8.67 6.73

Shareholder Returns

7 metrics
MetricNTLAIOVALEGN
Dividend yield – – –
Net buyback yield -7.9% -7.4% -5.4%
Shareholder yield -7.9% -7.4% -5.4%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusNTLAIOVALEGN
EPS, next fiscal year $-3.38FY2026 $-0.47FY2026 $-0.04FY2026
Revenue, next fiscal year $48.94MFY2026 $434.71MFY2026 $1.37BFY2026
Revenue growth, next FY -27.7%FY2026 +65.0%FY2026 +32.9%FY2026
Revenue growth, the year after +158.6% +33.0% +35.9%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersNTLAIOVALEGN
Held by institutions 100.0% 63.3% 55.9%
Institutions holding 329 292 218
Change in shares held, QoQ +30.5% +6.5% +7.3%
Institutions buying 195 174 117
Institutions selling 78 66 78
Buyers to sellers 2.50 2.64 1.50

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

NTLAIOVALEGN
NTLA 1.00 0.25 0.09
IOVA 0.25 1.00 0.15
LEGN 0.09 0.15 1.00

Add a Peer

Largest companies in the same industry

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Frequently Asked Questions

Which is bigger, NTLA, IOVA and LEGN?

Legend Biotech (LEGN) is the largest by market capitalisation: Intellia Therapeutics (NTLA) $1.64B, Iovance Biotherapeutics (IOVA) $3.95B, Legend Biotech (LEGN) $4.23B.

Which company is growing faster?

Legend Biotech (LEGN) grew revenue fastest over the trailing twelve months: Intellia Therapeutics (NTLA) +12.6%, Iovance Biotherapeutics (IOVA) +34.5%, Legend Biotech (LEGN) +59.5%.

Which company is more profitable?

Legend Biotech (LEGN) has the highest net margin (Intellia Therapeutics (NTLA) -672.2%, Iovance Biotherapeutics (IOVA) -89.1%, Legend Biotech (LEGN) -7.2%).

Which stock has performed better?

Over the past year Iovance Biotherapeutics (IOVA) returned the most: Intellia Therapeutics (NTLA) -9.3%, Iovance Biotherapeutics (IOVA) +352.8%, Legend Biotech (LEGN) -33.1%. Over five years, Legend Biotech (LEGN) compounded fastest (Intellia Therapeutics (NTLA) -38.4%/yr, Iovance Biotherapeutics (IOVA) -18.5%/yr, Legend Biotech (LEGN) -15.1%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Legend Biotech (LEGN) has been the steadiest (Intellia Therapeutics (NTLA) 79.9%, Iovance Biotherapeutics (IOVA) 109.4%, Legend Biotech (LEGN) 72.4%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, NTLA, IOVA and LEGN?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Legend Biotech (LEGN) leads on 6. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.