NGNE vs LEGN Stock Comparison

Neurogene and Legend Biotech Prices as of Oct 26, 2026 Peers: Industry group
NGNE Neurogene Inc.
$23.54 -16.8% 1M -21.2% 1Y
Market cap
$608.90M
P/E
–
Revenue (TTM)
—
Div. yield
–
Gene and Cell Therapy Healthcare
1 win
LEGN Legend Biotech Corp
$20.39 +6.7% 1M -36.0% 1Y
Market cap
$3.99B
P/E
–
Revenue (TTM)
$1.27B
Div. yield
–
Gene and Cell Therapy Healthcare
4 wins

Head to Head

5 decided of 12

Legend Biotech leads on 4 of the 12 questions below (Legend Biotech 4, Neurogene 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionNGNELEGNLeader
Larger companyMarket capitalisation $608.90M $3.99B LEGN
Cheaper on earningsLower P/E, profitable companies only -5.5x -43.5x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — — –
Faster revenue growthRevenue growth, trailing twelve months — +59.5% –
More profitableNet margin, trailing twelve months — -7.2% –
Better return on capitalReturn on invested capital — -4.2% –
Less leveragedLower net debt / EBITDA — 28.0x –
Higher dividend yieldTrailing dividend yield 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months -21.2% -36.0% NGNE
Better 5-year returnAnnualised price return, 5 years -29.1%/yr -17.0%/yr LEGN
Less volatileAnnualised volatility, 1 year 77.0% 72.1% LEGN
Higher overall scoreMean of the five percentile scores vs peers 46/100 72/100 LEGN

Percentile Scorecard

NGNELEGN

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisNGNELEGN
Valuation 44 #352 of 626 89 #71 of 626
Growth 21 #475 of 604 97 #21 of 604
Profitability 53 #260 of 555 80 #114 of 555
Financial Health 72 #186 of 658 54 #306 of 658
Shareholder Returns 40 #220 of 368 43 #212 of 368
Overall 46 72
  • NGNE ranked among 673 companies in Pharmaceuticals and Biotechnology
  • LEGN ranked among 673 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodNGNELEGNSPY
1 month -16.8%+6.7% -0.8%
3 months -32.0%+5.8% +3.5%
6 months -13.0%-13.8% +7.0%
Year to date +14.3%-6.2% +12.2%
1 year -21.2%-36.0% +13.0%
3 years +68.1%-68.0% +86.3%
3 years, per year +18.9%-31.6% +23.1%
5 years -82.1%-60.6% +68.6%
5 years, per year -29.1%-17.0% +11.0%
10 years -88.9%— +258.0%
10 years, per year -19.7%— +13.6%

Risk

MeasureNGNELEGNSPY
Volatility, 1Y 77.0%72.1% 12.7%
Downside volatility, 1Y 76.4%62.7% 12.7%
Beta vs S&P 500, 1Y 1.520.41 1.00
Return / volatility, 1Y -0.28-0.50 1.02
Max drawdown, 5Y -95.3%-78.2% -25.4%
From 52-week high -45.1%-43.8% -1.8%
52-week high $42.84$36.28 $779.14
52-week low $16.37$16.65 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleNGNELEGN
P/E now vs peer median -4.8xmedian 17.1x -41.0xmedian 17.1x
P/S now vs peer median —median 8.8x 3.0xmedian 8.8x
EV/EBITDA now vs peer median -2.6xmedian 17.1x -175.9xmedian 17.1x
P/FCF now vs peer median -6.0xmedian 18.0x -58.2xmedian 18.0x
P/B now vs peer median 2.4xmedian 2.1x 3.1xmedian 2.1x
PEG now vs peer median -0.14median 0.31 -0.87median 0.31

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsNGNELEGN
Revenue – $1.27B
Gross profit – $727.10M
Operating income -$121.35M -$55.25M
Net income -$111.16M -$80.39M
Free cash flow -$87.75M -$64.60M
R&D $88.50M $396.15M
EPS (diluted) $-4.93 $-0.50
Cash & equivalents $112.49M $672.90M
Total debt – $1.06B
Shares (diluted) 22.55M 184.32M
Enterprise value -$394.09M $1.48B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricNGNELEGN
P/E -4.8x -41.0x
P/FCF -6.0x -58.2x
P/Operating cash flow -6.1x -42.0x
P/S – 3.0x
P/B 2.4x 3.1x
P/Tangible book 2.4x 3.1x
EV/EBITDA -2.6x -175.9x
EV/EBIT -2.5x -58.7x
EV/Revenue – 2.6x
EV/FCF -3.5x -50.2x
EV/Operating cash flow -3.5x -36.3x
PEG (3Y EPS CAGR) -0.14 -0.87

Growth

14 metrics
MetricNGNELEGN
Revenue growth (1Y) – 59.5%
Revenue CAGR (3Y) – 97.6%
Gross profit growth (1Y) – 42.4%
Gross profit CAGR (3Y) – 147.5%
Operating income growth (1Y) -26.8% 75.3%
Operating income CAGR (3Y) -33.6% 49.1%
Net income growth (1Y) -31.7% 75.3%
Net income CAGR (3Y) -32.0% 46.7%
EPS growth (1Y) -23.0% 72.0%
EPS CAGR (3Y) 34.1% 47.0%
Operating cash flow growth (1Y) -18.5% 67.5%
Operating cash flow CAGR (3Y) -19.9% 37.1%
Free cash flow growth (1Y) -17.8% 77.8%
Free cash flow CAGR (3Y) -19.1% 44.5%

Profitability

14 metrics
MetricNGNELEGN
Gross margin – 57.2%
EBITDA margin – -1.5%
Operating margin – -4.3%
Pretax margin – -4.4%
Net margin – -7.2%
FCF margin – -5.1%
Operating cash flow margin – -7.0%
Return on equity -49.1% -8.3%
Return on assets -44.0% -5.5%
Return on invested capital – -4.2%
Return on capital employed -52.2% -4.3%
Asset turnover – 0.8x
Cash conversion (OCF / net income) 0.8x 1.1x
Stock comp / revenue – 5.2%

Financial Health

11 metrics
MetricNGNELEGN
Debt / assets – 8.9%
Debt / equity – 0.1x
Net debt / EBITDA – 28.0x
Debt / FCF – -2.4x
Liabilities / assets 11.1% 29.8%
Equity / assets 88.9% 70.2%
Interest coverage -60,673x -4.8x
Current ratio 10.6x 3.0x
Quick ratio 10.5x 1.7x
Cash ratio 10.5x 1.7x
Altman Z-score – 6.50

Shareholder Returns

7 metrics
MetricNGNELEGN
Dividend yield – –
Net buyback yield -6.9% -5.7%
Shareholder yield -6.9% -5.7%
Payout ratio (earnings) – –
Payout ratio (FCF) – –
Dividend growth (1Y) – –
Dividend CAGR (3Y) – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusNGNELEGN
EPS, next fiscal year $-5.76FY2026 $-0.04FY2026
Revenue, next fiscal year $0.00FY2026 $1.37BFY2026
Revenue growth, next FY – +32.9%FY2026
Revenue growth, the year after – +35.9%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersNGNELEGN
Held by institutions 76.8% 55.9%
Institutions holding 113 218
Change in shares held, QoQ +2.0% +7.3%
Institutions buying 61 117
Institutions selling 31 78
Buyers to sellers 1.97 1.50

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

NGNELEGN
NGNE 1.00 0.16
LEGN 0.16 1.00

Add a Peer

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Frequently Asked Questions

Which is bigger, NGNE and LEGN?

Legend Biotech (LEGN) is the largest by market capitalisation: Neurogene (NGNE) $608.90M, Legend Biotech (LEGN) $3.99B.

Which stock has performed better?

Over the past year Neurogene (NGNE) returned the most: Neurogene (NGNE) -21.2%, Legend Biotech (LEGN) -36.0%. Over five years, Legend Biotech (LEGN) compounded fastest (Neurogene (NGNE) -29.1%/yr, Legend Biotech (LEGN) -17.0%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Legend Biotech (LEGN) has been the steadiest (Neurogene (NGNE) 77.0%, Legend Biotech (LEGN) 72.1%). Volatility measures how widely the price swings, not the risk of the business.

Do NGNE and LEGN move together?

Their daily returns over the past year have a correlation of 0.16, a weak relationship. Holding both diversifies more than two closely linked stocks would.

Which is the better stock, NGNE and LEGN?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Legend Biotech (LEGN) leads on 4. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.