NGNE vs LEGN vs BEAM Stock Comparison

Neurogene, Legend Biotech and Beam Therapeutics Prices as of Oct 28, 2026 Peers: Industry group
NGNE Neurogene Inc.
$30.42 +6.8% 1M -1.9% 1Y
Market cap
$686.03M
P/E
–
Revenue (TTM)
—
Div. yield
–
Gene and Cell Therapy Healthcare
LEGN Legend Biotech Corp
$22.53 +21.0% 1M -30.8% 1Y
Market cap
$4.15B
P/E
–
Revenue (TTM)
$1.27B
Div. yield
–
Gene and Cell Therapy Healthcare
4 wins
BEAM Beam Therapeutics Inc.
$28.78 +18.8% 1M +8.9% 1Y
Market cap
$2.97B
P/E
–
Revenue (TTM)
$156.04M
Div. yield
–
Gene and Cell Therapy Healthcare
4 wins

Head to Head

8 decided of 12

Legend Biotech leads on 4 of the 12 questions below (Legend Biotech 4, Beam Therapeutics 4). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionNGNELEGNBEAMLeader
Larger companyMarket capitalisation $686.03M $4.15B $2.97B LEGN
Cheaper on earningsLower P/E, profitable companies only -6.2x -45.3x -35.1x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — — — –
Faster revenue growthRevenue growth, trailing twelve months — +59.5% +158.9% BEAM
More profitableNet margin, trailing twelve months — -7.2% -54.7% LEGN
Better return on capitalReturn on invested capital — -4.2% — –
Less leveragedLower net debt / EBITDA — 28.0x 3.0x BEAM
Higher dividend yieldTrailing dividend yield — — 0.00% –
Better 1-year returnPrice return, last 12 months -1.9% -30.8% +8.9% BEAM
Better 5-year returnAnnualised price return, 5 years -27.0%/yr -15.6%/yr -20.2%/yr LEGN
Less volatileAnnualised volatility, 1 year 78.9% 72.3% 70.7% BEAM
Higher overall scoreMean of the five percentile scores vs peers 48/100 73/100 69/100 LEGN

Percentile Scorecard

NGNELEGNBEAM

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisNGNELEGNBEAM
Valuation 51 #308 of 625 89 #72 of 625 57 #272 of 625
Growth 22 #473 of 602 96 #23 of 602 77 #139 of 602
Profitability 53 #257 of 549 80 #109 of 549 64 #197 of 549
Financial Health 72 #184 of 654 54 #299 of 654 81 #123 of 654
Shareholder Returns 43 #209 of 367 44 #206 of 367 68 #119 of 367
Overall 48 73 69
  • NGNE ranked among 672 companies in Pharmaceuticals and Biotechnology
  • LEGN ranked among 672 companies in Pharmaceuticals and Biotechnology
  • BEAM ranked among 672 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodNGNELEGNBEAMSPY
1 month +6.8%+21.0%+18.8% +0.9%
3 months -9.6%+19.5%+10.6% +5.9%
6 months +14.9%-1.1%-2.0% +8.5%
Year to date +47.7%+3.6%+3.8% +13.3%
1 year -1.9%-30.8%+8.9% +12.4%
3 years +117.3%-64.6%+54.6% +88.1%
3 years, per year +29.5%-29.3%+15.6% +23.5%
5 years -79.2%-57.1%-67.6% +68.2%
5 years, per year -27.0%-15.6%-20.2% +11.0%
10 years -85.7%—— +263.4%
10 years, per year -17.7%—— +13.8%

Risk

MeasureNGNELEGNBEAMSPY
Volatility, 1Y 78.9%72.3%70.7% 12.7%
Downside volatility, 1Y 76.5%62.7%64.0% 12.7%
Beta vs S&P 500, 1Y 1.590.442.09 1.00
Return / volatility, 1Y -0.02-0.430.13 0.98
Max drawdown, 5Y -95.3%-78.2%-85.3% -25.4%
From 52-week high -29.0%-37.9%-24.1% -0.9%
52-week high $42.84$36.28$37.92 $779.14
52-week low $16.37$16.65$20.60 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleNGNELEGNBEAM
P/E now vs peer median -6.2xmedian 17.4x -45.3xmedian 17.4x -35.1xmedian 17.4x
P/S now vs peer median —median 9.1x 3.3xmedian 9.1x 19.0xmedian 9.1x
EV/EBITDA now vs peer median -3.9xmedian 17.1x -197.3xmedian 17.1x -5.4xmedian 17.1x
P/FCF now vs peer median -7.8xmedian 19.0x -64.3xmedian 19.0x -8.0xmedian 19.0x
P/B now vs peer median 3.2xmedian 2.2x 3.4xmedian 2.2x 2.8xmedian 2.2x
PEG now vs peer median -0.18median 0.34 -0.96median 0.34 -0.83median 0.34

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsNGNELEGNBEAM
Revenue – $1.27B $156.04M
Gross profit – $727.10M –
Operating income -$121.35M -$55.25M -$378.02M
Net income -$111.16M -$80.39M -$86.52M
Free cash flow -$87.75M -$64.60M -$372.77M
R&D $88.50M $396.15M $408.66M
EPS (diluted) $-4.93 $-0.50 $-0.82
Cash & equivalents $112.49M $672.90M $219.83M
Total debt – $1.06B $100.26M
Shares (diluted) 22.55M 184.32M 104.33M
Enterprise value -$316.96M $1.65B -$1.71B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricNGNELEGNBEAM
P/E -6.2x -45.3x -35.1x
P/FCF -7.8x -64.3x -8.0x
P/Operating cash flow -7.9x -46.5x -8.3x
P/S – 3.3x 19.0x
P/B 3.2x 3.4x 2.8x
P/Tangible book 3.2x 3.4x 2.8x
EV/EBITDA -3.9x -197.3x -5.4x
EV/EBIT -3.8x -65.8x -5.1x
EV/Revenue – 2.9x 12.3x
EV/FCF -5.2x -56.3x -5.1x
EV/Operating cash flow -5.3x -40.7x -5.3x
PEG (3Y EPS CAGR) -0.18 -0.96 -0.83

Growth

14 metrics
MetricNGNELEGNBEAM
Revenue growth (1Y) – 59.5% 158.9%
Revenue CAGR (3Y) – 97.6% 24.9%
Gross profit growth (1Y) – 42.4% –
Gross profit CAGR (3Y) – 147.5% –
Operating income growth (1Y) -26.8% 75.3% 15.2%
Operating income CAGR (3Y) -33.6% 49.1% 0.3%
Net income growth (1Y) -31.7% 75.3% 78.2%
Net income CAGR (3Y) -32.0% 46.7% 35.8%
EPS growth (1Y) -23.0% 72.0% 79.0%
EPS CAGR (3Y) 34.1% 47.0% 42.4%
Operating cash flow growth (1Y) -18.5% 67.5% -4.2%
Operating cash flow CAGR (3Y) -19.9% 37.1% -2.0%
Free cash flow growth (1Y) -17.8% 77.8% -4.8%
Free cash flow CAGR (3Y) -19.1% 44.5% 0.7%

Profitability

14 metrics
MetricNGNELEGNBEAM
Gross margin – 57.2% –
EBITDA margin – -1.5% -228.0%
Operating margin – -4.3% -242.3%
Pretax margin – -4.4% -54.4%
Net margin – -7.2% -54.7%
FCF margin – -5.1% -238.9%
Operating cash flow margin – -7.0% -230.3%
Return on equity -49.1% -8.3% -7.6%
Return on assets -44.0% -5.5% -5.9%
Return on invested capital – -4.2% –
Return on capital employed -52.2% -4.3% -27.9%
Asset turnover – 0.8x 0.1x
Cash conversion (OCF / net income) 0.8x 1.1x 4.2x
Stock comp / revenue – 5.2% 52.2%

Financial Health

11 metrics
MetricNGNELEGNBEAM
Debt / assets – 8.9% 7.2%
Debt / equity – 0.1x 0.1x
Net debt / EBITDA – 28.0x 3.0x
Debt / FCF – -2.4x -0.3x
Liabilities / assets 11.1% 29.8% 23.0%
Equity / assets 88.9% 70.2% 77.0%
Interest coverage -60,673x -4.8x –
Current ratio 10.6x 3.0x 14.6x
Quick ratio 10.5x 1.7x 14.3x
Cash ratio 10.5x 1.7x 14.3x
Altman Z-score – 6.95 3.84

Shareholder Returns

7 metrics
MetricNGNELEGNBEAM
Dividend yield – – –
Net buyback yield -5.4% -5.2% -0.5%
Shareholder yield -5.4% -5.2% -0.5%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusNGNELEGNBEAM
EPS, next fiscal year $-5.76FY2026 $-0.04FY2026 $-4.22FY2026
Revenue, next fiscal year $0.00FY2026 $1.37BFY2026 $49.46MFY2026
Revenue growth, next FY – +32.9%FY2026 -64.6%FY2026
Revenue growth, the year after – +35.9% +23.6%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersNGNELEGNBEAM
Held by institutions 76.8% 55.9% 100.0%
Institutions holding 113 218 277
Change in shares held, QoQ +2.0% +7.3% +1.0%
Institutions buying 61 117 154
Institutions selling 31 78 75
Buyers to sellers 1.97 1.50 2.05

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

NGNELEGNBEAM
NGNE 1.00 0.18 0.35
LEGN 0.18 1.00 0.09
BEAM 0.35 0.09 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, NGNE, LEGN and BEAM?

Legend Biotech (LEGN) is the largest by market capitalisation: Neurogene (NGNE) $686.03M, Legend Biotech (LEGN) $4.15B, Beam Therapeutics (BEAM) $2.97B.

Which company is growing faster?

Beam Therapeutics (BEAM) grew revenue fastest over the trailing twelve months: Legend Biotech (LEGN) +59.5%, Beam Therapeutics (BEAM) +158.9%.

Which company is more profitable?

Legend Biotech (LEGN) has the highest net margin (Legend Biotech (LEGN) -7.2%, Beam Therapeutics (BEAM) -54.7%).

Which stock has performed better?

Over the past year Beam Therapeutics (BEAM) returned the most: Neurogene (NGNE) -1.9%, Legend Biotech (LEGN) -30.8%, Beam Therapeutics (BEAM) +8.9%. Over five years, Legend Biotech (LEGN) compounded fastest (Neurogene (NGNE) -27.0%/yr, Legend Biotech (LEGN) -15.6%/yr, Beam Therapeutics (BEAM) -20.2%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Beam Therapeutics (BEAM) has been the steadiest (Neurogene (NGNE) 78.9%, Legend Biotech (LEGN) 72.3%, Beam Therapeutics (BEAM) 70.7%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, NGNE, LEGN and BEAM?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Legend Biotech (LEGN) leads on 4. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.