NGNE vs CRSP vs PGEN Stock Comparison

Neurogene, CRISPR Therapeutics AG and Precigen Prices as of Oct 29, 2026 Peers: Industry group
NGNE Neurogene Inc.
$28.82 +1.5% 1M -11.8% 1Y
Market cap
$617.93M
P/E
–
Revenue (TTM)
—
Div. yield
–
Gene and Cell Therapy Healthcare
CRSP CRISPR Therapeutics AG
$54.26 -3.1% 1M -13.3% 1Y
Market cap
$4.94B
P/E
–
Revenue (TTM)
$13.39M
Div. yield
–
Gene and Cell Therapy Healthcare
2 wins
PGEN Precigen, Inc.
$6.64 -17.5% 1M +65.6% 1Y
Market cap
$2.49B
P/E
–
Revenue (TTM)
$85.72M
Div. yield
–
Gene and Cell Therapy Healthcare
6 wins

Head to Head

8 decided of 12

Precigen leads on 6 of the 12 questions below (Precigen 6, CRISPR Therapeutics AG 2). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionNGNECRSPPGENLeader
Larger companyMarket capitalisation $617.93M $4.94B $2.49B CRSP
Cheaper on earningsLower P/E, profitable companies only -5.6x -11.0x -7.4x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — — 39.1x –
Faster revenue growthRevenue growth, trailing twelve months — -64.8% +1,875.0% PGEN
More profitableNet margin, trailing twelve months — -3,368.7% -392.8% PGEN
Better return on capitalReturn on invested capital — -22.6% — –
Less leveragedLower net debt / EBITDA — 3.4x -1.6x PGEN
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months -11.8% -13.3% +65.6% PGEN
Better 5-year returnAnnualised price return, 5 years -27.8%/yr -9.9%/yr +6.6%/yr PGEN
Less volatileAnnualised volatility, 1 year 79.0% 57.3% 78.1% CRSP
Higher overall scoreMean of the five percentile scores vs peers 48/100 45/100 55/100 PGEN

Percentile Scorecard

NGNECRSPPGEN

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisNGNECRSPPGEN
Valuation 50 #315 of 624 51 #308 of 624 60 #252 of 624
Growth 22 #471 of 601 32 #412 of 601 48 #314 of 601
Profitability 54 #250 of 541 32 #367 of 541 59 #224 of 541
Financial Health 72 #183 of 647 71 #188 of 647 27 #475 of 647
Shareholder Returns 43 #205 of 359 38 #222 of 359 82 #67 of 359
Overall 48 45 55
  • NGNE ranked among 671 companies in Pharmaceuticals and Biotechnology
  • CRSP ranked among 671 companies in Pharmaceuticals and Biotechnology
  • PGEN ranked among 671 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodNGNECRSPPGENSPY
1 month +1.5%-3.1%-17.5% +0.7%
3 months -14.2%+12.0%+11.8% +3.7%
6 months +10.5%+3.7%+59.6% +7.1%
Year to date +39.9%+3.5%+58.9% +12.8%
1 year -11.8%-13.3%+65.6% +11.9%
3 years +117.0%+39.4%+520.6% +85.2%
3 years, per year +29.5%+11.7%+83.8% +22.8%
5 years -80.3%-40.6%+37.5% +67.6%
5 years, per year -27.8%-9.9%+6.6% +10.9%
10 years -86.4%+224.1%-74.2% +262.0%
10 years, per year -18.1%+12.5%-12.7% +13.7%

Risk

MeasureNGNECRSPPGENSPY
Volatility, 1Y 79.0%57.3%78.1% 12.7%
Downside volatility, 1Y 76.6%53.8%69.2% 12.6%
Beta vs S&P 500, 1Y 1.601.841.41 1.00
Return / volatility, 1Y -0.15-0.230.84 0.94
Max drawdown, 5Y -95.3%-67.7%-87.8% -25.4%
From 52-week high -32.7%-15.2%-22.4% -1.2%
52-week high $42.84$63.99$8.56 $779.14
52-week low $16.37$44.34$3.10 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleNGNECRSPPGEN
P/E now vs peer median -5.8xmedian 17.8x -11.6xmedian 17.8x -7.0xmedian 17.8x
P/S now vs peer median —median 9.1x 391.6xmedian 9.1x 27.7xmedian 9.1x
EV/EBITDA now vs peer median -3.6xmedian 15.0x -6.7xmedian 15.0x -70.9xmedian 15.0x
P/FCF now vs peer median -7.4xmedian 21.7x -14.1xmedian 21.7x -20.6xmedian 21.7x
P/B now vs peer median 3.0xmedian 2.2x 3.0xmedian 2.2x 54.6xmedian 2.2x
PEG now vs peer median -0.17median 0.35 -3.01median 0.35 0.06median 0.35

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsNGNECRSPPGEN
Revenue – $13.39M $85.72M
Gross profit – – $77.72M
Operating income -$121.35M -$534.34M -$39.50M
Net income -$111.16M -$451.14M -$157.71M
Free cash flow -$87.75M -$371.33M -$115.22M
R&D $88.50M $278.15M $32.29M
EPS (diluted) $-4.93 $-4.67 $-0.81
Cash & equivalents $112.49M $291.34M $16.33M
Total debt – $586.20M $93.88M
Shares (diluted) 22.55M 96.51M 413.69M
Enterprise value -$385.07M -$3.76B $2.17B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricNGNECRSPPGEN
P/E -5.8x -11.6x -7.0x
P/FCF -7.4x -14.1x -20.6x
P/Operating cash flow -7.5x -14.2x -20.8x
P/S – 391.6x 27.7x
P/B 3.0x 3.0x 54.6x
P/Tangible book 3.0x 3.0x 57.9x
EV/EBITDA -3.6x -6.7x -70.9x
EV/EBIT -3.5x -6.5x -61.6x
EV/Revenue – 258.9x 28.4x
EV/FCF -4.8x -9.3x -21.1x
EV/Operating cash flow -4.9x -9.4x -21.3x
PEG (3Y EPS CAGR) -0.17 -3.01 0.06

Growth

14 metrics
MetricNGNECRSPPGEN
Revenue growth (1Y) – -64.8% 1,875%
Revenue CAGR (3Y) – -57.1% 57.1%
Gross profit growth (1Y) – – 259,173%
Gross profit CAGR (3Y) – – 69.2%
Operating income growth (1Y) -26.8% 3.3% 62.1%
Operating income CAGR (3Y) -33.6% -4.1% 18.9%
Net income growth (1Y) -31.7% 3.6% -26.7%
Net income CAGR (3Y) -32.0% -2.7% -108.9%
EPS growth (1Y) -23.0% 13.0% -93.8%
EPS CAGR (3Y) 34.1% 3.9% -123.2%
Operating cash flow growth (1Y) -18.5% -13.8% -72.3%
Operating cash flow CAGR (3Y) -19.9% -2.5% -15.9%
Free cash flow growth (1Y) -17.8% -14.1% -65.1%
Free cash flow CAGR (3Y) -19.1% -0.9% -15.3%

Profitability

14 metrics
MetricNGNECRSPPGEN
Gross margin – – 90.7%
EBITDA margin – -3,850% -40.0%
Operating margin – -3,990% -46.1%
Pretax margin – -3,346% -184.0%
Net margin – -3,369% -392.8%
FCF margin – -2,773% -134.4%
Operating cash flow margin – -2,760% -133.2%
Return on equity -49.1% -25.3% -494.3%
Return on assets -44.0% -16.8% -102.1%
Return on invested capital – -22.6% –
Return on capital employed -52.2% -20.9% -31.6%
Asset turnover – 0.0x 0.6x
Cash conversion (OCF / net income) 0.8x 0.8x 0.7x
Stock comp / revenue – 510.2% 15.3%

Financial Health

11 metrics
MetricNGNECRSPPGEN
Debt / assets – 22.1% 55.1%
Debt / equity – 0.3x 2.2x
Net debt / EBITDA – 3.4x -1.6x
Debt / FCF – -1.6x -0.8x
Liabilities / assets 11.1% 34.1% 74.4%
Equity / assets 88.9% 65.9% 25.6%
Interest coverage -60,673x – -4.1x
Current ratio 10.6x 17.8x 4.6x
Quick ratio 10.5x 17.8x 3.8x
Cash ratio 10.5x 17.8x 1.3x
Altman Z-score – 2.69 -7.41

Shareholder Returns

7 metrics
MetricNGNECRSPPGEN
Dividend yield – – –
Net buyback yield -5.7% -8.1% -0.1%
Shareholder yield -5.7% -8.1% -0.1%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusNGNECRSPPGEN
Forward P/E – – 39.1xFY2026
EPS, next fiscal year $-5.76FY2026 $-4.10FY2026 $0.17FY2026
EPS growth, the year after – – +288.2%
Revenue, next fiscal year $0.00FY2026 $38.73MFY2026 $249.17MFY2026
Revenue growth, next FY – +1,003.4%FY2026 +2,474.1%FY2026
Revenue growth, the year after – +266.1% +82.3%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersNGNECRSPPGEN
Held by institutions 76.8% 78.9% 39.2%
Institutions holding 113 519 211
Change in shares held, QoQ +2.0% -1.0% +4.9%
Institutions buying 61 238 123
Institutions selling 31 139 46
Buyers to sellers 1.97 1.71 2.67

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

NGNECRSPPGEN
NGNE 1.00 0.33 0.10
CRSP 0.33 1.00 0.36
PGEN 0.10 0.36 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, NGNE, CRSP and PGEN?

CRISPR Therapeutics AG (CRSP) is the largest by market capitalisation: Neurogene (NGNE) $617.93M, CRISPR Therapeutics AG (CRSP) $4.94B, Precigen (PGEN) $2.49B.

Which company is growing faster?

Precigen (PGEN) grew revenue fastest over the trailing twelve months: CRISPR Therapeutics AG (CRSP) -64.8%, Precigen (PGEN) +1,875.0%.

Which company is more profitable?

Precigen (PGEN) has the highest net margin (CRISPR Therapeutics AG (CRSP) -3,368.7%, Precigen (PGEN) -392.8%).

Which stock has performed better?

Over the past year Precigen (PGEN) returned the most: Neurogene (NGNE) -11.8%, CRISPR Therapeutics AG (CRSP) -13.3%, Precigen (PGEN) +65.6%. Over five years, Precigen (PGEN) compounded fastest (Neurogene (NGNE) -27.8%/yr, CRISPR Therapeutics AG (CRSP) -9.9%/yr, Precigen (PGEN) +6.6%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, CRISPR Therapeutics AG (CRSP) has been the steadiest (Neurogene (NGNE) 79.0%, CRISPR Therapeutics AG (CRSP) 57.3%, Precigen (PGEN) 78.1%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, NGNE, CRSP and PGEN?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Precigen (PGEN) leads on 6. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.