MDGL vs REGN vs ROIV Stock Comparison

Madrigal Pharmaceuticals, Regeneron Pharmaceuticals and Roivant Sciences Prices as of Oct 26, 2026 Peers: Industry group
ROIV Roivant Sciences Ltd.
$36.05 +0.7% 1M +97.9% 1Y
Market cap
$26.36B
P/E
–
Revenue (TTM)
$7.53M
Div. yield
–
Biotechnology Healthcare
1 win

Head to Head

8 decided of 12

Regeneron Pharmaceuticals leads on 5 of the 12 questions below (Regeneron Pharmaceuticals 5, Madrigal Pharmaceuticals 2, Roivant Sciences 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionMDGLREGNROIVLeader
Larger companyMarket capitalisation $12.83B $83.80B $26.36B REGN
Cheaper on earningsLower P/E, profitable companies only -39.5x 19.4x -99.0x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — 14.1x — –
Faster revenue growthRevenue growth, trailing twelve months +149.0% +9.3% -67.6% MDGL
More profitableNet margin, trailing twelve months -25.3% 27.9% -3,535.0% REGN
Better return on capitalReturn on invested capital — 9.6% — –
Less leveragedLower net debt / EBITDA 1.6x -1.4x — REGN
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months +3.9% +39.7% +97.9% ROIV
Better 5-year returnAnnualised price return, 5 years +42.6%/yr +6.5%/yr +36.1%/yr MDGL
Less volatileAnnualised volatility, 1 year 43.6% 32.9% 45.3% REGN
Higher overall scoreMean of the five percentile scores vs peers 66/100 72/100 65/100 REGN

Percentile Scorecard

MDGLREGNROIV

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisMDGLREGNROIV
Valuation 74 #161 of 626 89 #72 of 626 64 #229 of 626
Growth 68 #194 of 604 42 #353 of 604 49 #308 of 604
Profitability 74 #146 of 555 90 #55 of 555 30 #387 of 555
Financial Health 41 #391 of 658 74 #172 of 658 93 #47 of 658
Shareholder Returns 75 #92 of 368 65 #129 of 368 91 #36 of 368
Overall 66 72 65
  • MDGL ranked among 673 companies in Pharmaceuticals and Biotechnology
  • REGN ranked among 673 companies in Pharmaceuticals and Biotechnology
  • ROIV ranked among 673 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodMDGLREGNROIVSPY
1 month -15.3%+2.5%+0.7% -0.8%
3 months -20.6%+21.1%+3.8% +3.5%
6 months -15.8%+8.5%+29.4% +7.0%
Year to date -24.8%+4.6%+66.1% +12.2%
1 year +3.9%+39.7%+97.9% +13.0%
3 years +263.6%+4.2%+330.2% +86.3%
3 years, per year +53.8%+1.4%+62.7% +23.1%
5 years +489.7%+37.0%+365.8% +68.6%
5 years, per year +42.6%+6.5%+36.1% +11.0%
10 years +2,473.4%+122.4%— +258.0%
10 years, per year +38.4%+8.3%— +13.6%

Risk

MeasureMDGLREGNROIVSPY
Volatility, 1Y 43.6%32.9%45.3% 12.7%
Downside volatility, 1Y 41.4%30.0%32.6% 12.7%
Beta vs S&P 500, 1Y 0.300.460.97 1.00
Return / volatility, 1Y 0.091.212.16 1.02
Max drawdown, 5Y -61.4%-59.8%-79.2% -25.4%
From 52-week high -27.4%-5.2%-13.8% -1.8%
52-week high $602.83$852.03$41.81 $779.14
52-week low $412.35$585.31$18.41 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleMDGLREGNROIV
P/E now vs peer median -39.2xmedian 17.1x 19.2xmedian 17.1x -97.6xmedian 17.1x
P/S now vs peer median 9.9xmedian 8.8x 5.3xmedian 8.8x 3,459xmedian 8.8x
EV/EBITDA now vs peer median -38.4xmedian 17.1x 17.6xmedian 17.1x -37.4xmedian 17.1x
P/FCF now vs peer median -61.8xmedian 18.0x 22.1xmedian 18.0x -31.7xmedian 18.0x
P/B now vs peer median 24.4xmedian 2.1x 2.6xmedian 2.1x 5.3xmedian 2.1x
PEG now vs peer median -2.66median 0.31 7.21median 0.31 -2.88median 0.31

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsMDGLREGNROIV
Revenue $1.28B $15.53B $7.53M
Gross profit – $13.18B $6.12M
Operating income -$322.62M $3.84B -$596.14M
Net income -$325.11M $4.33B -$414.60M
Free cash flow -$206.29M $3.76B -$821.06M
R&D $490.14M $6.28B $730.91M
EPS (diluted) $-11.15 $40.84 $-0.37
Cash & equivalents $292.73M $2.46B $1.25B
Total debt $340.79M $1.99B –
Shares (diluted) 29.15M 106.00M 720.78M
Enterprise value $9.09B $50.01B $9.31B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricMDGLREGNROIV
P/E -39.2x 19.2x -97.6x
P/FCF -61.8x 22.1x -31.7x
P/Operating cash flow -64.5x 17.7x -31.9x
P/S 9.9x 5.3x 3,459x
P/B 24.4x 2.6x 5.3x
P/Tangible book 24.7x 2.7x 5.3x
EV/EBITDA -38.4x 17.6x -37.4x
EV/EBIT -38.0x 20.0x -37.3x
EV/Revenue 9.5x 5.0x 2,949x
EV/FCF -59.4x 20.5x -27.1x
EV/Operating cash flow -62.0x 16.5x -27.2x
PEG (3Y EPS CAGR) -2.66 7.21 -2.88

Growth

14 metrics
MetricMDGLREGNROIV
Revenue growth (1Y) 149.0% 9.3% -67.6%
Revenue CAGR (3Y) – 7.0% -46.4%
Gross profit growth (1Y) – 8.4% -72.7%
Gross profit CAGR (3Y) – 6.4% -47.9%
Operating income growth (1Y) -4.1% 0.1% 49.7%
Operating income CAGR (3Y) 0.8% -3.9% 12.9%
Net income growth (1Y) -15.3% -2.9% 34.9%
Net income CAGR (3Y) 0.5% 0.2% 26.5%
EPS growth (1Y) 12.1% -0.5% 48.8%
EPS CAGR (3Y) 14.8% 2.7% 33.9%
Operating cash flow growth (1Y) 35.7% -1.3% 4.1%
Operating cash flow CAGR (3Y) 10.6% -0.4% 1.0%
Free cash flow growth (1Y) 33.1% -2.4% 4.4%
Free cash flow CAGR (3Y) 9.4% -3.3% 1.0%

Profitability

14 metrics
MetricMDGLREGNROIV
Gross margin – 84.9% 81.2%
EBITDA margin -24.9% 28.1% -7,877%
Operating margin -25.1% 24.7% -7,915%
Pretax margin -24.8% 33.3% -3,849%
Net margin -25.3% 27.9% -3,535%
FCF margin -16.1% 24.2% -10,901%
Operating cash flow margin -15.4% 30.1% -10,840%
Return on equity -59.8% 13.7% -8.1%
Return on assets -25.8% 10.5% -7.5%
Return on invested capital – 9.6% –
Return on capital employed -37.4% 10.7% -11.4%
Asset turnover 1.0x 0.4x 0.0x
Cash conversion (OCF / net income) 0.6x 1.1x 2.0x
Stock comp / revenue 9.5% 6.4% 4,611%

Financial Health

11 metrics
MetricMDGLREGNROIV
Debt / assets 27.4% 4.8% –
Debt / equity 0.7x 0.1x –
Net debt / EBITDA 1.6x -1.4x –
Debt / FCF -1.7x 0.5x –
Liabilities / assets 57.9% 24.0% 7.2%
Equity / assets 42.1% 76.0% 92.8%
Interest coverage -10.2x 69.4x –
Current ratio 3.2x 3.3x 16.7x
Quick ratio 2.8x 2.6x 13.5x
Cash ratio 2.2x 1.4x 13.5x
Altman Z-score 9.07 7.28 41.04

Shareholder Returns

7 metrics
MetricMDGLREGNROIV
Dividend yield – 0.5% –
Net buyback yield -0.3% 3.1% 0.0%
Shareholder yield -0.3% 3.5% 0.0%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusMDGLREGNROIV
Forward P/E – 14.1xFY2026 –
EPS, next fiscal year $-6.25FY2026 $57.08FY2026 $-1.43FY2026
EPS growth, next FY – +28.8%FY2026 –
EPS growth, the year after – +15.5% –
Revenue, next fiscal year $1.46BFY2026 $17.05BFY2026 $55.64MFY2026
Revenue growth, next FY +52.7%FY2026 +18.9%FY2026 +573.6%FY2026
Revenue growth, the year after +36.3% +13.0% +681.6%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersMDGLREGNROIV
Held by institutions 80.9% 66.2% 77.0%
Institutions holding 412 1,325 498
Change in shares held, QoQ -0.6% +3.8% +5.1%
Institutions buying 225 604 303
Institutions selling 128 534 138
Buyers to sellers 1.76 1.13 2.20

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

MDGLREGNROIV
MDGL 1.00 0.15 0.21
REGN 0.15 1.00 0.21
ROIV 0.21 0.21 1.00

Add a Peer

Largest companies in the same industry

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Frequently Asked Questions

Which is bigger, MDGL, REGN and ROIV?

Regeneron Pharmaceuticals (REGN) is the largest by market capitalisation: Madrigal Pharmaceuticals (MDGL) $12.83B, Regeneron Pharmaceuticals (REGN) $83.80B, Roivant Sciences (ROIV) $26.36B.

Which company is growing faster?

Madrigal Pharmaceuticals (MDGL) grew revenue fastest over the trailing twelve months: Madrigal Pharmaceuticals (MDGL) +149.0%, Regeneron Pharmaceuticals (REGN) +9.3%, Roivant Sciences (ROIV) -67.6%.

Which company is more profitable?

Regeneron Pharmaceuticals (REGN) has the highest net margin (Madrigal Pharmaceuticals (MDGL) -25.3%, Regeneron Pharmaceuticals (REGN) 27.9%, Roivant Sciences (ROIV) -3,535.0%).

Which stock has performed better?

Over the past year Roivant Sciences (ROIV) returned the most: Madrigal Pharmaceuticals (MDGL) +3.9%, Regeneron Pharmaceuticals (REGN) +39.7%, Roivant Sciences (ROIV) +97.9%. Over five years, Madrigal Pharmaceuticals (MDGL) compounded fastest (Madrigal Pharmaceuticals (MDGL) +42.6%/yr, Regeneron Pharmaceuticals (REGN) +6.5%/yr, Roivant Sciences (ROIV) +36.1%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Regeneron Pharmaceuticals (REGN) has been the steadiest (Madrigal Pharmaceuticals (MDGL) 43.6%, Regeneron Pharmaceuticals (REGN) 32.9%, Roivant Sciences (ROIV) 45.3%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, MDGL, REGN and ROIV?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Regeneron Pharmaceuticals (REGN) leads on 5. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.