MDGL vs NXTS vs AMGN Stock Comparison

Madrigal Pharmaceuticals, Nexentis Technologies and Amgen Prices as of Oct 26, 2026 Peers: Industry group
AMGN Amgen Inc
$444.63 +7.2% 1M +52.4% 1Y
Market cap
$241.32B
P/E
27.6x
Revenue (TTM)
$38.10B
Div. yield
0.02%
Biotechnology Healthcare
4 wins

Head to Head

8 decided of 12

Amgen leads on 4 of the 12 questions below (Amgen 4, Madrigal Pharmaceuticals 4). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionMDGLNXTSAMGNLeader
Larger companyMarket capitalisation $12.81B $453.69K $241.32B AMGN
Cheaper on earningsLower P/E, profitable companies only -39.4x 0.0x 27.6x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — — 20.4x –
Faster revenue growthRevenue growth, trailing twelve months +149.0% — +9.1% MDGL
More profitableNet margin, trailing twelve months -25.3% — 23.0% AMGN
Better return on capitalReturn on invested capital — — 14.3% –
Less leveragedLower net debt / EBITDA 1.6x 1.6x 2.7x MDGL
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.02% –
Better 1-year returnPrice return, last 12 months +3.9% -97.9% +52.4% AMGN
Better 5-year returnAnnualised price return, 5 years +42.6%/yr -86.1%/yr +16.6%/yr MDGL
Less volatileAnnualised volatility, 1 year 43.6% 169.1% 29.7% AMGN
Higher overall scoreMean of the five percentile scores vs peers 66/100 32/100 66/100 MDGL

Percentile Scorecard

MDGLNXTSAMGN

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisMDGLNXTSAMGN
Valuation 74 #161 of 626 – 85 #94 of 626
Growth 68 #194 of 604 13 #526 of 604 61 #234 of 604
Profitability 74 #146 of 555 40 #333 of 555 94 #33 of 555
Financial Health 41 #391 of 658 44 #372 of 658 22 #512 of 658
Shareholder Returns 75 #92 of 368 – 68 #117 of 368
Overall 66 32 66
  • MDGL ranked among 673 companies in Pharmaceuticals and Biotechnology
  • NXTS ranked among 673 companies in Pharmaceuticals and Biotechnology
  • AMGN ranked among 673 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodMDGLNXTSAMGNSPY
1 month -15.3%-61.9%+7.2% -0.8%
3 months -20.6%-66.5%+18.2% +3.5%
6 months -15.8%-88.4%+30.7% +7.0%
Year to date -24.8%-95.2%+35.8% +12.2%
1 year +3.9%-97.9%+52.4% +13.0%
3 years +263.6%-99.9%+70.0% +86.3%
3 years, per year +53.8%-89.6%+19.4% +23.1%
5 years +489.7%-100.0%+115.2% +68.6%
5 years, per year +42.6%-86.1%+16.6% +11.0%
10 years +2,473.4%-100.0%+179.7% +258.0%
10 years, per year +38.4%-66.6%+10.8% +13.6%

Risk

MeasureMDGLNXTSAMGNSPY
Volatility, 1Y 43.6%169.1%29.7% 12.7%
Downside volatility, 1Y 41.4%153.3%27.9% 12.7%
Beta vs S&P 500, 1Y 0.302.310.45 1.00
Return / volatility, 1Y 0.09-0.581.76 1.02
Max drawdown, 5Y -61.4%-100.0%-26.7% -25.4%
From 52-week high -27.4%-97.8%-0.6% -1.8%
52-week high $602.83$26.04$447.28 $779.14
52-week low $412.35$0.53$291.16 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleMDGLNXTSAMGN
P/E now vs peer median -39.2xmedian 17.1x 0.0xmedian 17.1x 27.5xmedian 17.1x
P/S now vs peer median 9.9xmedian 8.8x —median 8.8x 6.3xmedian 8.8x
EV/EBITDA now vs peer median -38.4xmedian 17.1x 1.5xmedian 17.1x 17.6xmedian 17.1x
P/FCF now vs peer median -61.8xmedian 18.0x —median 18.0x 23.6xmedian 18.0x
P/B now vs peer median 24.4xmedian 2.1x 0.2xmedian 2.1x 20.6xmedian 2.1x
PEG now vs peer median -2.66median 0.31 0.00median 0.31 10.36median 0.31

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsMDGLNXTSAMGN
Revenue $1.28B – $38.10B
Gross profit – – $26.48B
Operating income -$322.62M -$5.28M $11.43B
Net income -$325.11M -$14.06M $8.74B
Free cash flow -$206.29M – $10.18B
R&D $490.14M $532.00K $7.63B
EPS (diluted) $-11.15 $-17.10 $16.07
Cash & equivalents $292.73M $7.62M $13.99B
Total debt $340.79M $3.22M $57.30B
Shares (diluted) 29.15M 816.14K 544.00M
Enterprise value $9.07B -$22.19M $196.72B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricMDGLNXTSAMGN
P/E -39.2x 0.0x 27.5x
P/FCF -61.8x – 23.6x
P/Operating cash flow -64.5x – 19.3x
P/S 9.9x – 6.3x
P/B 24.4x 0.2x 20.6x
P/Tangible book 24.7x -0.2x -27.3x
EV/EBITDA -38.4x 1.5x 17.6x
EV/EBIT -38.0x 1.5x 24.8x
EV/Revenue 9.5x – 7.4x
EV/FCF -59.4x – 27.9x
EV/Operating cash flow -62.0x – 22.7x
PEG (3Y EPS CAGR) -2.66 0.00 10.36

Growth

14 metrics
MetricMDGLNXTSAMGN
Revenue growth (1Y) 149.0% – 9.1%
Revenue CAGR (3Y) – – 12.7%
Gross profit growth (1Y) – – 17.6%
Gross profit CAGR (3Y) – – 10.3%
Operating income growth (1Y) -4.1% -7.7% 39.5%
Operating income CAGR (3Y) 0.8% 3.0% 6.4%
Net income growth (1Y) -15.3% -48.2% 32.1%
Net income CAGR (3Y) 0.5% -35.8% 3.1%
EPS growth (1Y) 12.1% -567.8% 31.4%
EPS CAGR (3Y) 14.8% -45.2% 2.7%
Operating cash flow growth (1Y) 35.7% – 3.9%
Operating cash flow CAGR (3Y) 10.6% – 4.9%
Free cash flow growth (1Y) 33.1% – -4.1%
Free cash flow CAGR (3Y) 9.4% – 1.7%

Profitability

14 metrics
MetricMDGLNXTSAMGN
Gross margin – – 69.5%
EBITDA margin -24.9% – 42.2%
Operating margin -25.1% – 30.0%
Pretax margin -24.8% – 27.0%
Net margin -25.3% – 23.0%
FCF margin -16.1% – 26.7%
Operating cash flow margin -15.4% – 32.8%
Return on equity -59.8% -157.0% 83.8%
Return on assets -25.8% -71.9% 9.3%
Return on invested capital – – 14.3%
Return on capital employed -37.4% -31.5% 16.7%
Asset turnover 1.0x – 0.4x
Cash conversion (OCF / net income) 0.6x – 1.4x
Stock comp / revenue 9.5% – 1.3%

Financial Health

11 metrics
MetricMDGLNXTSAMGN
Debt / assets 27.4% 2.3% 59.9%
Debt / equity 0.7x 0.2x 4.9x
Net debt / EBITDA 1.6x 1.6x 2.7x
Debt / FCF -1.7x – 5.6x
Liabilities / assets 57.9% 89.8% 87.8%
Equity / assets 42.1% 10.2% 12.2%
Interest coverage -10.2x – 4.3x
Current ratio 3.2x 3.7x 1.4x
Quick ratio 2.8x 3.2x 0.9x
Cash ratio 2.2x 3.2x 0.5x
Altman Z-score 9.07 – 2.30

Shareholder Returns

7 metrics
MetricMDGLNXTSAMGN
Dividend yield – – 2.2%
Net buyback yield -0.3% – –
Shareholder yield -0.3% – 2.2%
Payout ratio (earnings) – – 60.4%
Payout ratio (FCF) – – 51.9%
Dividend growth (1Y) – – 6.3%
Dividend CAGR (3Y) – – 6.7%

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusMDGLNXTSAMGN
Forward P/E – – 20.4xFY2026
EPS, next fiscal year $-6.25FY2026 – $21.81FY2026
EPS growth, next FY – – -0.1%FY2026
EPS growth, the year after – – +7.2%
Revenue, next fiscal year $1.46BFY2026 – $41.51BFY2026
Revenue growth, next FY +52.7%FY2026 – +12.9%FY2026
Revenue growth, the year after +36.3% – +2.3%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersMDGLNXTSAMGN
Held by institutions 80.9% – 82.7%
Institutions holding 412 – 3,159
Change in shares held, QoQ -0.6% – +4.5%
Institutions buying 225 – 1,451
Institutions selling 128 – 1,217
Buyers to sellers 1.76 – 1.19

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

MDGLNXTSAMGN
MDGL 1.00 0.03 0.24
NXTS 0.03 1.00 0.02
AMGN 0.24 0.02 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, MDGL, NXTS and AMGN?

Amgen (AMGN) is the largest by market capitalisation: Madrigal Pharmaceuticals (MDGL) $12.81B, Nexentis Technologies (NXTS) $453.69K, Amgen (AMGN) $241.32B.

Which company is growing faster?

Madrigal Pharmaceuticals (MDGL) grew revenue fastest over the trailing twelve months: Madrigal Pharmaceuticals (MDGL) +149.0%, Amgen (AMGN) +9.1%.

Which company is more profitable?

Amgen (AMGN) has the highest net margin (Madrigal Pharmaceuticals (MDGL) -25.3%, Amgen (AMGN) 23.0%).

Which stock has performed better?

Over the past year Amgen (AMGN) returned the most: Madrigal Pharmaceuticals (MDGL) +3.9%, Nexentis Technologies (NXTS) -97.9%, Amgen (AMGN) +52.4%. Over five years, Madrigal Pharmaceuticals (MDGL) compounded fastest (Madrigal Pharmaceuticals (MDGL) +42.6%/yr, Nexentis Technologies (NXTS) -86.1%/yr, Amgen (AMGN) +16.6%/yr). Returns are price only, before dividends.

Which pays a higher dividend?

Only one of these companies pays a dividend: Madrigal Pharmaceuticals (MDGL) 0.00%, Nexentis Technologies (NXTS) 0.00%, Amgen (AMGN) 0.02%. Madrigal Pharmaceuticals (MDGL) and Nexentis Technologies (NXTS) pays no regular dividend.

Which stock is riskier?

By one-year price volatility, Amgen (AMGN) has been the steadiest (Madrigal Pharmaceuticals (MDGL) 43.6%, Nexentis Technologies (NXTS) 169.1%, Amgen (AMGN) 29.7%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, MDGL, NXTS and AMGN?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Amgen (AMGN) leads on 4. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.