MDGL vs ARGX vs MRNA Stock Comparison

Madrigal Pharmaceuticals, Argenx Se and Moderna Prices as of Oct 27, 2026 Peers: Industry group
ARGX Argenx Se
$882.48 -8.0% 1M +6.3% 1Y
Market cap
$54.62B
P/E
29.1x
Revenue (TTM)
$5.82B
Div. yield
–
Biotechnology Healthcare
3 wins
MRNA Moderna, Inc.
$207.97 +4.6% 1M +680.1% 1Y
Market cap
$85.10B
P/E
–
Revenue (TTM)
$2.23B
Div. yield
–
Biotechnology Healthcare
3 wins

Head to Head

8 decided of 12

Moderna leads on 3 of the 12 questions below (Moderna 3, Argenx Se 3, Madrigal Pharmaceuticals 2). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionMDGLARGXMRNALeader
Larger companyMarket capitalisation $12.52B $54.62B $85.10B MRNA
Cheaper on earningsLower P/E, profitable companies only -38.5x 29.1x -27.0x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — 28.8x — –
Faster revenue growthRevenue growth, trailing twelve months +149.0% +61.5% -27.6% MDGL
More profitableNet margin, trailing twelve months -25.3% 32.3% -141.4% ARGX
Better return on capitalReturn on invested capital — — -43.3% –
Less leveragedLower net debt / EBITDA 1.6x — 1.5x MRNA
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months +1.0% +6.3% +680.1% MRNA
Better 5-year returnAnnualised price return, 5 years +41.0%/yr +25.8%/yr -9.8%/yr MDGL
Less volatileAnnualised volatility, 1 year 43.5% 36.9% 130.8% ARGX
Higher overall scoreMean of the five percentile scores vs peers 66/100 92/100 57/100 ARGX

Percentile Scorecard

MDGLARGXMRNA

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisMDGLARGXMRNA
Valuation 74 #163 of 625 84 #99 of 625 69 #193 of 625
Growth 68 #194 of 602 94 #35 of 602 18 #493 of 602
Profitability 74 #144 of 551 98 #11 of 551 57 #239 of 551
Financial Health 41 #389 of 656 – 55 #298 of 656
Shareholder Returns 75 #91 of 365 – 85 #57 of 365
Overall 66 92 57
  • MDGL ranked among 672 companies in Pharmaceuticals and Biotechnology
  • ARGX ranked among 672 companies in Pharmaceuticals and Biotechnology
  • MRNA ranked among 672 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodMDGLARGXMRNASPY
1 month -14.8%-8.0%+4.6% -0.2%
3 months -18.3%+1.2%+272.6% +3.9%
6 months -14.8%+13.9%+341.2% +8.2%
Year to date -24.4%+4.9%+605.2% +12.9%
1 year +1.0%+6.3%+680.1% +12.3%
3 years +265.7%+91.9%+189.2% +87.4%
3 years, per year +54.1%+24.3%+42.5% +23.3%
5 years +457.5%+214.2%-40.2% +67.9%
5 years, per year +41.0%+25.8%-9.8% +10.9%
10 years +2,491.7%—— +261.1%
10 years, per year +38.5%—— +13.7%

Risk

MeasureMDGLARGXMRNASPY
Volatility, 1Y 43.5%36.9%130.8% 12.7%
Downside volatility, 1Y 41.4%34.6%79.5% 12.7%
Beta vs S&P 500, 1Y 0.300.392.15 1.00
Return / volatility, 1Y 0.020.175.20 0.97
Max drawdown, 5Y -61.4%-38.2%-93.9% -25.4%
From 52-week high -27.0%-16.7%-15.4% -1.2%
52-week high $602.83$1,058.90$245.81 $779.14
52-week low $412.35$663.93$22.36 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleMDGLARGXMRNA
P/E now vs peer median -39.5xmedian 17.2x 28.8xmedian 17.2x -26.3xmedian 17.2x
P/S now vs peer median 10.0xmedian 9.0x 9.4xmedian 9.0x 37.2xmedian 9.0x
EV/EBITDA now vs peer median -38.6xmedian 16.3x —median 16.3x -25.5xmedian 16.3x
P/FCF now vs peer median -62.2xmedian 18.7x —median 18.7x -66.7xmedian 18.7x
P/B now vs peer median 24.5xmedian 2.2x —median 2.2x 12.3xmedian 2.2x
PEG now vs peer median -2.67median 0.33 0.27median 0.33 0.40median 0.33

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsMDGLARGXMRNA
Revenue $1.28B $5.82B $2.23B
Gross profit – $5.24B $521.00M
Operating income -$322.62M $1.74B -$3.32B
Net income -$325.11M $1.88B -$3.15B
Free cash flow -$206.29M – -$1.24B
R&D $490.14M $1.80B $2.88B
EPS (diluted) $-11.15 $28.43 $-7.92
Cash & equivalents $292.73M – $1.72B
Total debt $340.79M – $591.00M
Shares (diluted) 29.15M 66.03M 398.00M
Enterprise value $8.77B $54.62B $64.46B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricMDGLARGXMRNA
P/E -39.5x 28.8x -26.3x
P/FCF -62.2x – -66.7x
P/Operating cash flow -64.9x – -77.3x
P/S 10.0x 9.4x 37.2x
P/B 24.5x – 12.3x
P/Tangible book 24.8x – 12.3x
EV/EBITDA -38.6x – -25.5x
EV/EBIT -38.2x 31.4x -23.6x
EV/Revenue 9.6x 9.4x 35.2x
EV/FCF -59.8x – -63.0x
EV/Operating cash flow -62.4x – -73.1x
PEG (3Y EPS CAGR) -2.67 0.27 0.40

Growth

14 metrics
MetricMDGLARGXMRNA
Revenue growth (1Y) 149.0% 61.5% -27.6%
Revenue CAGR (3Y) – 80.5% -40.6%
Gross profit growth (1Y) – 62.2% -67.8%
Gross profit CAGR (3Y) – 80.0% -56.0%
Operating income growth (1Y) -4.1% 120.6% -1.4%
Operating income CAGR (3Y) 0.8% 85.1% -103.9%
Net income growth (1Y) -15.3% 22.5% -8.5%
Net income CAGR (3Y) 0.5% 115.5% -66.4%
EPS growth (1Y) 12.1% 20.9% -5.8%
EPS CAGR (3Y) 14.8% 104.8% -65.1%
Operating cash flow growth (1Y) 35.7% – 60.2%
Operating cash flow CAGR (3Y) 10.6% – -68.1%
Free cash flow growth (1Y) 33.1% – 64.4%
Free cash flow CAGR (3Y) 9.4% – -18.2%

Profitability

14 metrics
MetricMDGLARGXMRNA
Gross margin – 90.0% 23.4%
EBITDA margin -24.9% – -138.2%
Operating margin -25.1% 29.9% -149.0%
Pretax margin -24.8% 32.6% -138.6%
Net margin -25.3% 32.3% -141.4%
FCF margin -16.1% – -55.8%
Operating cash flow margin -15.4% – -48.2%
Return on equity -59.8% – -44.5%
Return on assets -25.8% – -28.1%
Return on invested capital – – -43.3%
Return on capital employed -37.4% – -38.2%
Asset turnover 1.0x – 0.2x
Cash conversion (OCF / net income) 0.6x – 0.3x
Stock comp / revenue 9.5% – 20.7%

Financial Health

11 metrics
MetricMDGLARGXMRNA
Debt / assets 27.4% – 5.4%
Debt / equity 0.7x – 0.1x
Net debt / EBITDA 1.6x – 1.5x
Debt / FCF -1.7x – -0.5x
Liabilities / assets 57.9% – 38.3%
Equity / assets 42.1% – 61.7%
Interest coverage -10.2x 10,120x –
Current ratio 3.2x – 2.3x
Quick ratio 2.8x – 2.0x
Cash ratio 2.2x – 2.0x
Altman Z-score 9.13 – 12.07

Shareholder Returns

7 metrics
MetricMDGLARGXMRNA
Dividend yield – – –
Net buyback yield -0.3% – -0.1%
Shareholder yield -0.3% – -0.1%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusMDGLARGXMRNA
Forward P/E – 28.8xFY2026 –
EPS, next fiscal year $-6.25FY2026 $30.63FY2026 $-8.02FY2026
EPS growth, next FY – +56.5%FY2026 –
EPS growth, the year after – +26.9% –
Revenue, next fiscal year $1.46BFY2026 $6.08BFY2026 $2.04BFY2026
Revenue growth, next FY +52.7%FY2026 +43.1%FY2026 +5.1%FY2026
Revenue growth, the year after +36.3% +22.9% +26.8%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersMDGLARGXMRNA
Held by institutions 80.9% 46.1% 80.2%
Institutions holding 412 504 784
Change in shares held, QoQ -0.6% -2.0% +3.4%
Institutions buying 225 264 402
Institutions selling 128 160 238
Buyers to sellers 1.76 1.65 1.69

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

MDGLARGXMRNA
MDGL 1.00 0.29 0.13
ARGX 0.29 1.00 0.17
MRNA 0.13 0.17 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, MDGL, ARGX and MRNA?

Moderna (MRNA) is the largest by market capitalisation: Madrigal Pharmaceuticals (MDGL) $12.52B, Argenx Se (ARGX) $54.62B, Moderna (MRNA) $85.10B.

Which company is growing faster?

Madrigal Pharmaceuticals (MDGL) grew revenue fastest over the trailing twelve months: Madrigal Pharmaceuticals (MDGL) +149.0%, Argenx Se (ARGX) +61.5%, Moderna (MRNA) -27.6%.

Which company is more profitable?

Argenx Se (ARGX) has the highest net margin (Madrigal Pharmaceuticals (MDGL) -25.3%, Argenx Se (ARGX) 32.3%, Moderna (MRNA) -141.4%).

Which stock has performed better?

Over the past year Moderna (MRNA) returned the most: Madrigal Pharmaceuticals (MDGL) +1.0%, Argenx Se (ARGX) +6.3%, Moderna (MRNA) +680.1%. Over five years, Madrigal Pharmaceuticals (MDGL) compounded fastest (Madrigal Pharmaceuticals (MDGL) +41.0%/yr, Argenx Se (ARGX) +25.8%/yr, Moderna (MRNA) -9.8%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Argenx Se (ARGX) has been the steadiest (Madrigal Pharmaceuticals (MDGL) 43.5%, Argenx Se (ARGX) 36.9%, Moderna (MRNA) 130.8%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, MDGL, ARGX and MRNA?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Moderna (MRNA) leads on 3. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.