LEGN vs IOVA vs VCEL Stock Comparison

Legend Biotech, Iovance Biotherapeutics and Vericel Prices as of Nov 5, 2026 Peers: Industry group
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LEGN Legend Biotech Corp
$22.54 +20.4% 1M -29.6% 1Y
Market cap
$4.15B
P/E
–
Revenue (TTM)
$1.27B
Div. yield
–
Gene and Cell Therapy Healthcare
2 wins
VCEL Vericel Corp
$51.78 +29.3% 1M +39.2% 1Y
Market cap
$2.64B
P/E
79.6x
Revenue (TTM)
$324.17M
Div. yield
–
Gene and Cell Therapy Healthcare
4 wins

Head to Head

7 decided of 12

Vericel leads on 4 of the 12 questions below (Vericel 4, Legend Biotech 2, Iovance Biotherapeutics 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionLEGNIOVAVCELLeader
Larger companyMarket capitalisation $4.15B $3.58B $2.64B LEGN
Cheaper on earningsLower P/E, profitable companies only -45.3x -16.0x 79.6x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — — 101.5x –
Faster revenue growthRevenue growth, trailing twelve months +59.5% +51.3% +25.3% LEGN
More profitableNet margin, trailing twelve months -7.2% -58.2% 10.3% VCEL
Better return on capitalReturn on invested capital -4.2% — — –
Less leveragedLower net debt / EBITDA -130.2x — — –
Higher dividend yieldTrailing dividend yield — — — –
Better 1-year returnPrice return, last 12 months -29.6% +327.6% +39.2% IOVA
Better 5-year returnAnnualised price return, 5 years -14.3%/yr -20.9%/yr +2.4%/yr VCEL
Less volatileAnnualised volatility, 1 year 72.7% 109.9% 44.3% VCEL
Higher overall scoreMean of the five percentile scores vs peers 74/100 67/100 81/100 VCEL

Percentile Scorecard

LEGNIOVAVCEL

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisLEGNIOVAVCEL
Valuation 88 #77 of 634 70 #190 of 634 81 #123 of 634
Growth 96 #23 of 608 91 #58 of 608 94 #39 of 608
Profitability 80 #110 of 557 67 #182 of 557 89 #65 of 557
Financial Health 59 #267 of 654 68 #213 of 654 70 #195 of 654
Shareholder Returns 44 #225 of 403 39 #245 of 403 73 #109 of 403
Overall 74 67 81
  • LEGN ranked among 671 companies in Pharmaceuticals and Biotechnology
  • IOVA ranked among 671 companies in Pharmaceuticals and Biotechnology
  • VCEL ranked among 671 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodLEGNIOVAVCELSPY
1 month +20.4%-40.3%+29.3% -5.9%
3 months +16.9%+24.6%+15.7% -4.6%
6 months -21.1%+118.0%+47.4% +0.2%
Year to date +3.7%+183.5%+43.8% +7.5%
1 year -29.6%+327.6%+39.2% +8.2%
3 years -65.8%+79.2%+43.2% +68.3%
3 years, per year -30.1%+21.5%+12.7% +19.0%
5 years -53.7%-69.0%+12.4% +56.5%
5 years, per year -14.3%-20.9%+2.4% +9.4%
10 years —+33.4%+2,308.4% +251.5%
10 years, per year —+2.9%+37.5% +13.4%

Risk

MeasureLEGNIOVAVCELSPY
Volatility, 1Y 72.7%109.9%44.3% 13.6%
Downside volatility, 1Y 62.9%95.6%41.2% 14.2%
Beta vs S&P 500, 1Y 0.501.600.43 1.00
Return / volatility, 1Y -0.412.980.88 0.60
Max drawdown, 5Y -78.2%-93.4%-60.2% -25.4%
From 52-week high -37.9%-47.9%0.0% -5.9%
52-week high $36.28$14.86$51.78 $779.14
52-week low $16.65$1.81$29.34 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleLEGNIOVAVCEL
P/E now vs peer median -45.3xmedian 17.8x -16.0xmedian 17.8x 79.6xmedian 17.8x
P/S now vs peer median 3.3xmedian 8.1x 9.4xmedian 8.1x 8.2xmedian 8.1x
EV/EBITDA now vs peer median 917.1xmedian 15.7x -16.6xmedian 15.7x 60.6xmedian 15.7x
P/FCF now vs peer median -64.3xmedian 21.0x -16.6xmedian 21.0x 45.7xmedian 21.0x
P/B now vs peer median 3.4xmedian 2.0x 4.4xmedian 2.0x 6.9xmedian 2.0x
PEG now vs peer median -0.96median 0.36 -0.46median 0.36 1.13median 0.36

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsLEGNIOVAVCEL
Revenue $1.27B $378.98M $324.17M
Gross profit $727.10M $201.75M $241.41M
Operating income -$55.25M -$230.38M $26.97M
Net income -$80.39M -$220.56M $33.31M
Free cash flow -$64.60M -$216.07M $57.89M
R&D $396.15M $241.88M $29.74M
EPS (diluted) $-0.50 $-0.48 $0.63
Cash & equivalents $672.90M $57.93M $133.50M
Total debt $156.40M – –
Shares (diluted) 184.32M 455.92M 52.96M
Enterprise value $1.65B $2.30B $2.03B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricLEGNIOVAVCEL
P/E -45.3x -16.0x 79.6x
P/FCF -64.3x -16.6x 45.7x
P/Operating cash flow -46.5x -18.9x 40.5x
P/S 3.3x 9.4x 8.2x
P/B 3.4x 4.4x 6.9x
P/Tangible book 3.4x 6.5x 7.0x
EV/EBITDA 917.1x -16.6x 60.6x
EV/EBIT -65.8x -13.9x 91.7x
EV/Revenue 2.9x 8.5x 7.6x
EV/FCF -56.3x -14.8x 42.7x
EV/Operating cash flow -40.7x -16.9x 37.9x
PEG (3Y EPS CAGR) -0.96 -0.46 1.13

Growth

14 metrics
MetricLEGNIOVAVCEL
Revenue growth (1Y) 59.5% 51.3% 25.3%
Revenue CAGR (3Y) 97.6% 712.3% 20.5%
Gross profit growth (1Y) 42.4% 144.4% 26.4%
Gross profit CAGR (3Y) 147.5% – 24.4%
Operating income growth (1Y) 75.3% 44.7% 279.4%
Operating income CAGR (3Y) 49.1% 19.8% 59.5%
Net income growth (1Y) 75.3% 44.5% 154.6%
Net income CAGR (3Y) 46.7% 20.1% 73.8%
EPS growth (1Y) 72.0% 55.7% 149.5%
EPS CAGR (3Y) 47.0% 35.0% 70.1%
Operating cash flow growth (1Y) 67.5% 41.2% 10.4%
Operating cash flow CAGR (3Y) 37.1% 18.9% 26.6%
Free cash flow growth (1Y) 77.8% 38.6% 184.1%
Free cash flow CAGR (3Y) 44.5% 17.0% 45.2%

Profitability

14 metrics
MetricLEGNIOVAVCEL
Gross margin 57.2% 53.2% 74.5%
EBITDA margin 0.3% -50.9% 12.6%
Operating margin -4.3% -60.8% 8.3%
Pretax margin -4.4% -58.5% 10.5%
Net margin -7.2% -58.2% 10.3%
FCF margin -5.1% -57.0% 17.9%
Operating cash flow margin -7.0% -50.1% 20.1%
Return on equity -8.3% -28.5% 9.1%
Return on assets -5.5% -23.1% 6.7%
Return on invested capital -4.2% – –
Return on capital employed -4.3% -27.2% 5.9%
Asset turnover 0.8x 0.4x 0.6x
Cash conversion (OCF / net income) 1.1x 0.9x 2.0x
Stock comp / revenue 5.2% 12.3% 11.3%

Financial Health

11 metrics
MetricLEGNIOVAVCEL
Debt / assets 8.9% – –
Debt / equity 0.1x – –
Net debt / EBITDA -130.2x – –
Debt / FCF -2.4x – –
Liabilities / assets 29.8% 18.0% 25.7%
Equity / assets 70.2% 82.0% 74.3%
Interest coverage -4.8x – 42.0x
Current ratio 3.0x 5.2x 5.1x
Quick ratio 1.7x 4.6x 4.6x
Cash ratio 1.7x 3.6x 3.1x
Altman Z-score 6.95 8.06 12.26

Shareholder Returns

7 metrics
MetricLEGNIOVAVCEL
Dividend yield – – –
Net buyback yield -5.2% -8.2% -0.3%
Shareholder yield -5.2% -8.2% -0.3%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusLEGNIOVAVCEL
Forward P/E – – 101.5xFY2026
EPS, next fiscal year $-0.04FY2026 $-0.47FY2026 $0.51FY2026
EPS growth, next FY – – +59.4%FY2026
EPS growth, the year after – – +74.5%
Revenue, next fiscal year $1.37BFY2026 $435.90MFY2026 $324.56MFY2026
Revenue growth, next FY +32.9%FY2026 +65.4%FY2026 +17.5%FY2026
Revenue growth, the year after +35.9% +33.1% +16.1%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersLEGNIOVAVCEL
Held by institutions 55.9% 63.3% 100.0%
Institutions holding 218 292 319
Change in shares held, QoQ +7.3% +6.5% +0.4%
Institutions buying 117 174 188
Institutions selling 78 66 99
Buyers to sellers 1.50 2.64 1.90

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

LEGNIOVAVCEL
LEGN 1.00 0.14 0.14
IOVA 0.14 1.00 0.09
VCEL 0.14 0.09 1.00

Add a Peer

Largest companies in the same industry

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Frequently Asked Questions

Which is bigger, LEGN, IOVA and VCEL?

Legend Biotech (LEGN) is the largest by market capitalisation: Legend Biotech (LEGN) $4.15B, Iovance Biotherapeutics (IOVA) $3.58B, Vericel (VCEL) $2.64B.

Which company is growing faster?

Legend Biotech (LEGN) grew revenue fastest over the trailing twelve months: Legend Biotech (LEGN) +59.5%, Iovance Biotherapeutics (IOVA) +51.3%, Vericel (VCEL) +25.3%.

Which company is more profitable?

Vericel (VCEL) has the highest net margin (Legend Biotech (LEGN) -7.2%, Iovance Biotherapeutics (IOVA) -58.2%, Vericel (VCEL) 10.3%).

Which stock has performed better?

Over the past year Iovance Biotherapeutics (IOVA) returned the most: Legend Biotech (LEGN) -29.6%, Iovance Biotherapeutics (IOVA) +327.6%, Vericel (VCEL) +39.2%. Over five years, Vericel (VCEL) compounded fastest (Legend Biotech (LEGN) -14.3%/yr, Iovance Biotherapeutics (IOVA) -20.9%/yr, Vericel (VCEL) +2.4%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Vericel (VCEL) has been the steadiest (Legend Biotech (LEGN) 72.7%, Iovance Biotherapeutics (IOVA) 109.9%, Vericel (VCEL) 44.3%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, LEGN, IOVA and VCEL?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Vericel (VCEL) leads on 4. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.