IOVA vs NGNE Stock Comparison

Iovance Biotherapeutics and Neurogene Prices as of Oct 27, 2026 Peers: Industry group
NGNE Neurogene Inc.
$26.99 -4.7% 1M -15.8% 1Y
Market cap
$608.68M
P/E
–
Revenue (TTM)
—
Div. yield
–
Gene and Cell Therapy Healthcare
1 win

Head to Head

5 decided of 12

Iovance Biotherapeutics leads on 4 of the 12 questions below (Iovance Biotherapeutics 4, Neurogene 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionIOVANGNELeader
Larger companyMarket capitalisation $6.60B $608.68M IOVA
Cheaper on earningsLower P/E, profitable companies only -22.7x -5.5x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — — –
Faster revenue growthRevenue growth, trailing twelve months +34.5% — –
More profitableNet margin, trailing twelve months -89.1% — –
Better return on capitalReturn on invested capital — — –
Less leveragedLower net debt / EBITDA — — –
Higher dividend yieldTrailing dividend yield — — –
Better 1-year returnPrice return, last 12 months +531.2% -15.8% IOVA
Better 5-year returnAnnualised price return, 5 years -10.4%/yr -27.8%/yr IOVA
Less volatileAnnualised volatility, 1 year 99.2% 78.1% NGNE
Higher overall scoreMean of the five percentile scores vs peers 64/100 47/100 IOVA

Percentile Scorecard

IOVANGNE

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisIOVANGNE
Valuation 67 #209 of 625 47 #331 of 625
Growth 81 #114 of 602 22 #473 of 602
Profitability 62 #210 of 551 54 #256 of 551
Financial Health 64 #238 of 656 72 #185 of 656
Shareholder Returns 44 #205 of 365 41 #216 of 365
Overall 64 47
  • IOVA ranked among 672 companies in Pharmaceuticals and Biotechnology
  • NGNE ranked among 672 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodIOVANGNESPY
1 month +32.5%-4.7% -0.2%
3 months +210.2%-18.8% +3.9%
6 months +331.4%-1.7% +8.2%
Year to date +434.1%+31.0% +12.9%
1 year +531.2%-15.8% +12.3%
3 years +316.6%+92.8% +87.4%
3 years, per year +61.0%+24.5% +23.3%
5 years -42.3%-80.3% +67.9%
5 years, per year -10.4%-27.8% +10.9%
10 years +143.0%-87.4% +261.1%
10 years, per year +9.3%-18.7% +13.7%

Risk

MeasureIOVANGNESPY
Volatility, 1Y 99.2%78.1% 12.7%
Downside volatility, 1Y 71.2%76.4% 12.7%
Beta vs S&P 500, 1Y 1.281.56 1.00
Return / volatility, 1Y 5.36-0.20 0.97
Max drawdown, 5Y -93.4%-95.3% -25.4%
From 52-week high -1.9%-37.0% -1.2%
52-week high $14.86$42.84 $779.14
52-week low $1.81$16.37 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleIOVANGNE
P/E now vs peer median -22.7xmedian 17.2x -5.5xmedian 17.2x
P/S now vs peer median 20.3xmedian 9.0x —median 9.0x
EV/EBITDA now vs peer median -23.9xmedian 16.3x -3.2xmedian 16.3x
P/FCF now vs peer median -22.3xmedian 18.7x -6.9xmedian 18.7x
P/B now vs peer median 9.0xmedian 2.2x 2.8xmedian 2.2x
PEG now vs peer median -0.76median 0.33 -0.16median 0.33

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsIOVANGNE
Revenue $324.97M –
Gross profit $157.29M –
Operating income -$301.31M -$121.35M
Net income -$289.51M -$111.16M
Free cash flow -$296.40M -$87.75M
R&D $267.72M $88.50M
EPS (diluted) $-0.64 $-4.93
Cash & equivalents $110.80M $112.49M
Shares (diluted) 450.19M 22.55M
Enterprise value $5.40B -$394.32M

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricIOVANGNE
P/E -22.7x -5.5x
P/FCF -22.3x -6.9x
P/Operating cash flow -25.0x -7.0x
P/S 20.3x –
P/B 9.0x 2.8x
P/Tangible book 14.0x 2.8x
EV/EBITDA -23.9x -3.2x
EV/EBIT -20.9x -3.2x
EV/Revenue 19.4x –
EV/FCF -21.3x -4.4x
EV/Operating cash flow -23.9x -4.4x
PEG (3Y EPS CAGR) -0.76 -0.16

Growth

14 metrics
MetricIOVANGNE
Revenue growth (1Y) 34.5% –
Revenue CAGR (3Y) 1,009% –
Gross profit growth (1Y) 95.1% –
Gross profit CAGR (3Y) – –
Operating income growth (1Y) 26.6% -26.8%
Operating income CAGR (3Y) 11.1% -33.6%
Net income growth (1Y) 25.8% -31.7%
Net income CAGR (3Y) 11.6% -32.0%
EPS growth (1Y) 44.8% -23.0%
EPS CAGR (3Y) 29.9% 34.1%
Operating cash flow growth (1Y) 12.9% -18.5%
Operating cash flow CAGR (3Y) 7.6% -19.9%
Free cash flow growth (1Y) 8.4% -17.8%
Free cash flow CAGR (3Y) 5.8% -19.1%

Profitability

14 metrics
MetricIOVANGNE
Gross margin 48.4% –
EBITDA margin -81.4% –
Operating margin -92.7% –
Pretax margin -90.4% –
Net margin -89.1% –
FCF margin -91.2% –
Operating cash flow margin -81.3% –
Return on equity -39.7% -49.1%
Return on assets -31.4% -44.0%
Return on invested capital – –
Return on capital employed -37.0% -52.2%
Asset turnover 0.4x –
Cash conversion (OCF / net income) 0.9x 0.8x
Stock comp / revenue 14.4% –

Financial Health

11 metrics
MetricIOVANGNE
Debt / assets – –
Debt / equity – –
Net debt / EBITDA – –
Debt / FCF – –
Liabilities / assets 19.6% 11.1%
Equity / assets 80.4% 88.9%
Interest coverage – -60,673x
Current ratio 4.3x 10.6x
Quick ratio 3.7x 10.5x
Cash ratio 2.8x 10.5x
Altman Z-score 17.38 –

Shareholder Returns

7 metrics
MetricIOVANGNE
Dividend yield – –
Net buyback yield -4.5% -6.1%
Shareholder yield -4.5% -6.1%
Payout ratio (earnings) – –
Payout ratio (FCF) – –
Dividend growth (1Y) – –
Dividend CAGR (3Y) – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusIOVANGNE
EPS, next fiscal year $-0.47FY2026 $-5.76FY2026
Revenue, next fiscal year $434.71MFY2026 $0.00FY2026
Revenue growth, next FY +65.0%FY2026 –
Revenue growth, the year after +33.0% –

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersIOVANGNE
Held by institutions 63.3% 76.8%
Institutions holding 292 113
Change in shares held, QoQ +6.5% +2.0%
Institutions buying 174 61
Institutions selling 66 31
Buyers to sellers 2.64 1.97

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

IOVANGNE
IOVA 1.00 0.25
NGNE 0.25 1.00

Add a Peer

Largest companies in the same industry

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Frequently Asked Questions

Which is bigger, IOVA and NGNE?

Iovance Biotherapeutics (IOVA) is the largest by market capitalisation: Iovance Biotherapeutics (IOVA) $6.60B, Neurogene (NGNE) $608.68M.

Which stock has performed better?

Over the past year Iovance Biotherapeutics (IOVA) returned the most: Iovance Biotherapeutics (IOVA) +531.2%, Neurogene (NGNE) -15.8%. Over five years, Iovance Biotherapeutics (IOVA) compounded fastest (Iovance Biotherapeutics (IOVA) -10.4%/yr, Neurogene (NGNE) -27.8%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Neurogene (NGNE) has been the steadiest (Iovance Biotherapeutics (IOVA) 99.2%, Neurogene (NGNE) 78.1%). Volatility measures how widely the price swings, not the risk of the business.

Do IOVA and NGNE move together?

Their daily returns over the past year have a correlation of 0.25, a weak relationship. Holding both diversifies more than two closely linked stocks would.

Which is the better stock, IOVA and NGNE?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Iovance Biotherapeutics (IOVA) leads on 4. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.