IMMX vs CRSP vs IOVA Stock Comparison

Immix Biopharma, CRISPR Therapeutics AG and Iovance Biotherapeutics Prices as of Nov 5, 2026 Peers: Industry group
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IMMX Immix Biopharma, Inc.
$7.20 -25.3% 1M +136.1% 1Y
Market cap
$514.63M
P/E
–
Revenue (TTM)
—
Div. yield
–
Gene and Cell Therapy Healthcare
CRSP CRISPR Therapeutics AG
$48.56 -10.1% 1M -14.8% 1Y
Market cap
$4.82B
P/E
–
Revenue (TTM)
$25.17M
Div. yield
–
Gene and Cell Therapy Healthcare
3 wins

Head to Head

7 decided of 12

Iovance Biotherapeutics leads on 4 of the 12 questions below (Iovance Biotherapeutics 4, CRISPR Therapeutics AG 3). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionIMMXCRSPIOVALeader
Larger companyMarket capitalisation $514.63M $4.82B $3.68B CRSP
Cheaper on earningsLower P/E, profitable companies only -12.9x -10.6x -16.7x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — — — –
Faster revenue growthRevenue growth, trailing twelve months — -34.3% +51.3% IOVA
More profitableNet margin, trailing twelve months — -1,812.1% -58.2% IOVA
Better return on capitalReturn on invested capital — -23.3% — –
Less leveragedLower net debt / EBITDA — 3.3x — –
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months +136.1% -14.8% +327.6% IOVA
Better 5-year returnAnnualised price return, 5 years — -11.7%/yr -20.9%/yr CRSP
Less volatileAnnualised volatility, 1 year 82.7% 57.1% 109.9% CRSP
Higher overall scoreMean of the five percentile scores vs peers 52/100 47/100 67/100 IOVA

Percentile Scorecard

IMMXCRSPIOVA

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisIMMXCRSPIOVA
Valuation 73 #175 of 634 51 #310 of 634 70 #190 of 634
Growth 5 #576 of 608 27 #445 of 608 91 #58 of 608
Profitability 78 #122 of 557 37 #354 of 557 67 #182 of 557
Financial Health 97 #21 of 654 69 #202 of 654 68 #213 of 654
Shareholder Returns 8 #373 of 403 51 #198 of 403 39 #245 of 403
Overall 52 47 67
  • IMMX ranked among 671 companies in Pharmaceuticals and Biotechnology
  • CRSP ranked among 671 companies in Pharmaceuticals and Biotechnology
  • IOVA ranked among 671 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodIMMXCRSPIOVASPY
1 month -25.3%-10.1%-40.3% -5.9%
3 months -28.4%-6.0%+24.6% -4.6%
6 months -24.5%-7.4%+118.0% +0.2%
Year to date +37.7%-7.4%+183.5% +7.5%
1 year +136.1%-14.8%+327.6% +8.2%
3 years +67.1%-5.9%+79.2% +68.3%
3 years, per year +18.7%-2.0%+21.5% +19.0%
5 years —-46.2%-69.0% +56.5%
5 years, per year —-11.7%-20.9% +9.4%
10 years —+219.5%+33.4% +251.5%
10 years, per year —+12.3%+2.9% +13.4%

Risk

MeasureIMMXCRSPIOVASPY
Volatility, 1Y 82.7%57.1%109.9% 13.6%
Downside volatility, 1Y 76.0%53.6%95.6% 14.2%
Beta vs S&P 500, 1Y 1.671.781.60 1.00
Return / volatility, 1Y 1.65-0.262.98 0.60
Max drawdown, 5Y -88.9%-66.8%-93.4% -25.4%
From 52-week high -50.2%-21.5%-47.9% -5.9%
52-week high $14.47$61.89$14.86 $779.14
52-week low $3.03$44.34$1.81 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleIMMXCRSPIOVA
P/E now vs peer median -11.5xmedian 17.8x -10.3xmedian 17.8x -16.0xmedian 17.8x
P/S now vs peer median —median 8.1x 187.1xmedian 8.1x 9.4xmedian 8.1x
EV/EBITDA now vs peer median -6.8xmedian 15.7x -5.9xmedian 15.7x -16.6xmedian 15.7x
P/FCF now vs peer median -13.2xmedian 21.0x -12.5xmedian 21.0x -16.6xmedian 21.0x
P/B now vs peer median 2.2xmedian 2.0x 2.9xmedian 2.0x 4.4xmedian 2.0x
PEG now vs peer median -1.86median 0.36 5.33median 0.36 -0.46median 0.36

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsIMMXCRSPIOVA
Revenue – $25.17M $378.98M
Gross profit – – $201.75M
Operating income -$41.82M -$532.33M -$230.38M
Net income -$39.88M -$456.14M -$220.56M
Free cash flow -$39.09M -$376.72M -$216.07M
R&D $21.62M $291.14M $241.88M
EPS (diluted) $-0.63 $-4.72 $-0.48
Cash & equivalents $225.49M $192.03M $57.93M
Total debt – $586.93M –
Shares (diluted) 63.77M 96.74M 455.92M
Enterprise value $282.53M -$4.23B $2.40B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricIMMXCRSPIOVA
P/E -11.5x -10.3x -16.0x
P/FCF -13.2x -12.5x -16.6x
P/Operating cash flow -13.4x -12.6x -18.9x
P/S – 187.1x 9.4x
P/B 2.2x 2.9x 4.4x
P/Tangible book 2.2x 2.9x 6.5x
EV/EBITDA -6.8x -5.9x -16.6x
EV/EBIT -6.8x -5.7x -13.9x
EV/Revenue – 120.2x 8.5x
EV/FCF -7.2x -8.0x -14.8x
EV/Operating cash flow -7.3x -8.1x -16.9x
PEG (3Y EPS CAGR) -1.86 5.33 -0.46

Growth

14 metrics
MetricIMMXCRSPIOVA
Revenue growth (1Y) – -34.3% 51.3%
Revenue CAGR (3Y) – -47.1% 712.3%
Gross profit growth (1Y) – – 144.4%
Gross profit CAGR (3Y) – – –
Operating income growth (1Y) -75.8% 7.3% 44.7%
Operating income CAGR (3Y) -53.5% -7.9% 19.8%
Net income growth (1Y) -72.4% 6.6% 44.5%
Net income CAGR (3Y) -51.7% -8.9% 20.1%
EPS growth (1Y) 18.9% 11.8% 55.7%
EPS CAGR (3Y) 6.2% -1.9% 35.0%
Operating cash flow growth (1Y) -207.8% -23.8% 41.2%
Operating cash flow CAGR (3Y) -51.9% -10.5% 18.9%
Free cash flow growth (1Y) -190.0% -24.3% 38.6%
Free cash flow CAGR (3Y) -52.7% -8.8% 17.0%

Profitability

14 metrics
MetricIMMXCRSPIOVA
Gross margin – – 53.2%
EBITDA margin – -2,038% -50.9%
Operating margin – -2,115% -60.8%
Pretax margin – -1,802% -58.5%
Net margin – -1,812% -58.2%
FCF margin – -1,497% -57.0%
Operating cash flow margin – -1,488% -50.1%
Return on equity -25.5% -26.9% -28.5%
Return on assets -23.8% -17.5% -23.1%
Return on invested capital – -23.3% –
Return on capital employed -26.4% -21.6% -27.2%
Asset turnover – 0.0x 0.4x
Cash conversion (OCF / net income) 1.0x 0.8x 0.9x
Stock comp / revenue – 276.8% 12.3%

Financial Health

11 metrics
MetricIMMXCRSPIOVA
Debt / assets – 23.0% –
Debt / equity – 0.4x –
Net debt / EBITDA – 3.3x –
Debt / FCF – -1.6x –
Liabilities / assets 4.3% 35.5% 18.0%
Equity / assets 95.7% 64.5% 82.0%
Interest coverage – – –
Current ratio 25.1x 16.2x 5.2x
Quick ratio 25.0x 16.1x 4.6x
Cash ratio 25.0x 16.1x 3.6x
Altman Z-score – 2.20 8.06

Shareholder Returns

7 metrics
MetricIMMXCRSPIOVA
Dividend yield – – –
Net buyback yield -48.3% -2.9% -8.2%
Shareholder yield -48.3% -2.9% -8.2%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusIMMXCRSPIOVA
EPS, next fiscal year $-0.70FY2026 $-4.27FY2026 $-0.47FY2026
Revenue, next fiscal year $0.00FY2026 $33.04MFY2026 $435.90MFY2026
Revenue growth, next FY – +841.2%FY2026 +65.4%FY2026
Revenue growth, the year after – +271.8% +33.1%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersIMMXCRSPIOVA
Held by institutions 78.6% 78.9% 63.3%
Institutions holding 110 520 292
Change in shares held, QoQ +107.6% -1.0% +6.5%
Institutions buying 81 238 174
Institutions selling 13 139 66
Buyers to sellers 6.23 1.71 2.64

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

IMMXCRSPIOVA
IMMX 1.00 0.32 0.26
CRSP 0.32 1.00 0.35
IOVA 0.26 0.35 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, IMMX, CRSP and IOVA?

CRISPR Therapeutics AG (CRSP) is the largest by market capitalisation: Immix Biopharma (IMMX) $514.63M, CRISPR Therapeutics AG (CRSP) $4.82B, Iovance Biotherapeutics (IOVA) $3.68B.

Which company is growing faster?

Iovance Biotherapeutics (IOVA) grew revenue fastest over the trailing twelve months: CRISPR Therapeutics AG (CRSP) -34.3%, Iovance Biotherapeutics (IOVA) +51.3%.

Which company is more profitable?

Iovance Biotherapeutics (IOVA) has the highest net margin (CRISPR Therapeutics AG (CRSP) -1,812.1%, Iovance Biotherapeutics (IOVA) -58.2%).

Which stock has performed better?

Over the past year Iovance Biotherapeutics (IOVA) returned the most: Immix Biopharma (IMMX) +136.1%, CRISPR Therapeutics AG (CRSP) -14.8%, Iovance Biotherapeutics (IOVA) +327.6%. Over five years, CRISPR Therapeutics AG (CRSP) compounded fastest (CRISPR Therapeutics AG (CRSP) -11.7%/yr, Iovance Biotherapeutics (IOVA) -20.9%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, CRISPR Therapeutics AG (CRSP) has been the steadiest (Immix Biopharma (IMMX) 82.7%, CRISPR Therapeutics AG (CRSP) 57.1%, Iovance Biotherapeutics (IOVA) 109.9%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, IMMX, CRSP and IOVA?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Iovance Biotherapeutics (IOVA) leads on 4. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.