ILMN vs TXG vs TECH Stock Comparison

Illumina, 10x Genomics and Bio-Techne Prices as of Oct 28, 2026 Peers: Industry group
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ILMN Illumina, Inc.
$288.79 +6.2% 1M +195.3% 1Y
Market cap
$43.61B
P/E
52.9x
Revenue (TTM)
$4.49B
Div. yield
–
Life Sciences Tools Healthcare
6 wins
TXG 10x Genomics, Inc.
$83.62 -5.5% 1M +526.8% 1Y
Market cap
$10.89B
P/E
–
Revenue (TTM)
$616.91M
Div. yield
–
Life Sciences Tools Healthcare
1 win
TECH BIO-TECHNE Corp
$72.69 +0.2% 1M +13.7% 1Y
Market cap
$11.35B
P/E
62.3x
Revenue (TTM)
$1.22B
Div. yield
0.44%
Life Sciences Tools Healthcare
4 wins

Head to Head

11 decided of 12

Illumina leads on 6 of the 12 questions below (Illumina 6, Bio-Techne 4, 10x Genomics 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionILMNTXGTECHLeader
Larger companyMarket capitalisation $43.61B $10.89B $11.35B ILMN
Cheaper on earningsLower P/E, profitable companies only 52.9x -144.7x 62.3x ILMN
Cheaper on forward earningsLower price / next fiscal year consensus EPS 57.9x — 33.7x TECH
Faster revenue growthRevenue growth, trailing twelve months +4.9% -4.3% -0.4% ILMN
More profitableNet margin, trailing twelve months 18.4% -12.2% 15.0% ILMN
Better return on capitalReturn on invested capital 15.1% — 8.3% ILMN
Less leveragedLower net debt / EBITDA 0.7x — -0.2x TECH
Higher dividend yieldTrailing dividend yield — — 0.44% –
Better 1-year returnPrice return, last 12 months +195.3% +526.8% +13.7% TXG
Better 5-year returnAnnualised price return, 5 years -6.5%/yr -12.3%/yr -11.1%/yr ILMN
Less volatileAnnualised volatility, 1 year 50.4% 74.2% 43.5% TECH
Higher overall scoreMean of the five percentile scores vs peers 65/100 61/100 66/100 TECH

Percentile Scorecard

ILMNTXGTECH

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisILMNTXGTECH
Valuation 50 #115 of 227 44 #128 of 227 59 #94 of 227
Growth 46 #119 of 219 66 #76 of 219 40 #131 of 219
Profitability 97 #8 of 205 62 #78 of 205 94 #14 of 205
Financial Health 51 #116 of 237 68 #77 of 237 87 #32 of 237
Shareholder Returns 83 #24 of 135 68 #44 of 135 52 #66 of 135
Overall 65 61 66
  • ILMN ranked among 247 companies in Medical Devices and Diagnostics
  • TXG ranked among 247 companies in Medical Devices and Diagnostics
  • TECH ranked among 247 companies in Medical Devices and Diagnostics

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodILMNTXGTECHSPY
1 month +6.2%-5.5%+0.2% +0.9%
3 months +48.2%+80.5%+0.9% +5.9%
6 months +139.9%+314.0%+39.9% +8.5%
Year to date +120.2%+412.7%+23.6% +13.3%
1 year +195.3%+526.8%+13.7% +12.4%
3 years +171.8%+129.7%+22.1% +88.1%
3 years, per year +39.6%+32.0%+6.9% +23.5%
5 years -28.5%-48.1%-44.5% +68.2%
5 years, per year -6.5%-12.3%-11.1% +11.0%
10 years +114.2%—+187.8% +263.4%
10 years, per year +7.9%—+11.2% +13.8%

Risk

MeasureILMNTXGTECHSPY
Volatility, 1Y 50.4%74.2%43.5% 12.7%
Downside volatility, 1Y 39.0%66.3%43.6% 12.7%
Beta vs S&P 500, 1Y 0.832.240.77 1.00
Return / volatility, 1Y 3.887.100.31 0.98
Max drawdown, 5Y -82.9%-96.1%-67.0% -25.4%
From 52-week high -1.7%-14.4%0.0% -0.9%
52-week high $293.69$97.74$72.69 $779.14
52-week low $95.03$12.44$43.30 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleILMNTXGTECH
P/E now vs peer median 52.9xmedian 28.8x -144.7xmedian 28.8x 62.3xmedian 28.8x
P/S now vs peer median 9.7xmedian 3.0x 17.7xmedian 3.0x 9.3xmedian 3.0x
EV/EBITDA now vs peer median 38.5xmedian 17.4x -244.2xmedian 17.4x 32.3xmedian 17.4x
P/FCF now vs peer median 46.8xmedian 25.7x 89.7xmedian 25.7x 43.1xmedian 25.7x
P/B now vs peer median 15.4xmedian 2.4x 13.2xmedian 2.4x 5.4xmedian 2.4x
PEG now vs peer median 1.75median 1.03 -5.39median 1.03 -4.77median 1.03

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsILMNTXGTECH
Revenue $4.49B $616.91M $1.22B
Gross profit $2.98B $432.03M $799.07M
Operating income $882.00M -$88.38M $251.89M
Net income $825.00M -$75.13M $181.86M
Free cash flow $931.00M $121.44M $263.22M
R&D $960.00M $226.80M $94.77M
EPS (diluted) $5.39 $-0.58 $1.16
Cash & equivalents $1.04B – $264.71M
Total debt $1.99B – $200.00M
Shares (diluted) 153.00M 129.98M 157.01M
Enterprise value $38.37B $10.70B $10.55B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricILMNTXGTECH
P/E 52.9x -144.7x 62.3x
P/FCF 46.8x 89.7x 43.1x
P/Operating cash flow 39.8x 85.7x 38.8x
P/S 9.7x 17.7x 9.3x
P/B 15.4x 13.2x 5.4x
P/Tangible book 18.0x 14.3x 6.3x
EV/EBITDA 38.5x -244.2x 32.3x
EV/EBIT 50.4x -122.7x 44.8x
EV/Revenue 9.9x 17.6x 9.3x
EV/FCF 47.7x 89.3x 42.9x
EV/Operating cash flow 40.6x 85.3x 38.6x
PEG (3Y EPS CAGR) 1.75 -5.39 -4.77

Growth

14 metrics
MetricILMNTXGTECH
Revenue growth (1Y) 4.9% -4.3% -0.4%
Revenue CAGR (3Y) -1.0% 2.8% 2.2%
Gross profit growth (1Y) 4.6% -3.5% 1.1%
Gross profit CAGR (3Y) 2.9% 1.1% 1.3%
Operating income growth (1Y) -31.8% 12.1% 146.3%
Operating income CAGR (3Y) 28.3% 20.9% -5.5%
Net income growth (1Y) -34.4% 11.2% 147.8%
Net income CAGR (3Y) 30.0% 24.2% -14.0%
EPS growth (1Y) -32.7% 14.9% 152.0%
EPS CAGR (3Y) 30.1% 26.8% -13.1%
Operating cash flow growth (1Y) -5.1% 89.8% 1.6%
Operating cash flow CAGR (3Y) 38.1% 135.5% 4.7%
Free cash flow growth (1Y) -9.7% 113.5% 2.6%
Free cash flow CAGR (3Y) 105.0% 44.7% 6.8%

Profitability

14 metrics
MetricILMNTXGTECH
Gross margin 66.4% 70.0% 65.8%
EBITDA margin 25.7% -7.2% 28.7%
Operating margin 19.6% -14.3% 20.7%
Pretax margin 22.6% -12.1% 19.8%
Net margin 18.4% -12.2% 15.0%
FCF margin 20.7% 19.7% 21.7%
Operating cash flow margin 24.4% 20.6% 24.0%
Return on equity 29.9% -9.2% 8.7%
Return on assets 12.5% -7.3% 7.1%
Return on invested capital 15.1% – 8.3%
Return on capital employed 17.5% -9.8% 10.5%
Asset turnover 0.7x 0.6x 0.5x
Cash conversion (OCF / net income) 1.3x -1.7x 1.6x
Stock comp / revenue 5.9% 16.0% 0.5%

Financial Health

11 metrics
MetricILMNTXGTECH
Debt / assets 29.9% – 7.7%
Debt / equity 0.7x – 0.1x
Net debt / EBITDA 0.7x – -0.2x
Debt / FCF 2.1x – 0.8x
Liabilities / assets 57.3% 19.9% 18.5%
Equity / assets 42.7% 80.1% 81.5%
Interest coverage 8.9x – 26.2x
Current ratio 1.8x 5.7x 4.5x
Quick ratio 1.2x 0.8x 2.9x
Cash ratio 0.7x 0.4x 1.6x
Altman Z-score 8.19 30.83 15.91

Shareholder Returns

7 metrics
MetricILMNTXGTECH
Dividend yield – – 0.4%
Net buyback yield 1.2% -0.1% -0.3%
Shareholder yield 1.2% -0.1% 0.1%
Payout ratio (earnings) – – 27.4%
Payout ratio (FCF) – – 19.0%
Dividend growth (1Y) – – -0.9%
Dividend CAGR (3Y) – – -0.2%

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusILMNTXGTECH
Forward P/E 57.9xFY2026 – 33.7xFY2027
EPS, next fiscal year $4.99FY2026 $-0.79FY2026 $2.16FY2027
EPS growth, next FY +3.1%FY2026 – +11.9%FY2027
EPS growth, the year after +25.7% – +5.1%
Revenue, next fiscal year $4.52BFY2026 $580.42MFY2026 $1.19BFY2027
Revenue growth, next FY +4.1%FY2026 -9.7%FY2026 -2.1%FY2027
Revenue growth, the year after +12.0% +24.6% +13.5%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersILMNTXGTECH
Held by institutions 100.0% 100.0% 100.0%
Institutions holding 933 389 597
Change in shares held, QoQ +0.0% +2.4% -0.6%
Institutions buying 463 197 293
Institutions selling 330 137 241
Buyers to sellers 1.40 1.44 1.22

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

ILMNTXGTECH
ILMN 1.00 0.51 0.22
TXG 0.51 1.00 0.34
TECH 0.22 0.34 1.00

Add a Peer

Largest companies in the same industry

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Frequently Asked Questions

Which is bigger, ILMN, TXG and TECH?

Illumina (ILMN) is the largest by market capitalisation: Illumina (ILMN) $43.61B, 10x Genomics (TXG) $10.89B, Bio-Techne (TECH) $11.35B.

Which stock is cheaper, ILMN, TXG and TECH?

Illumina (ILMN) trades on the lowest price-to-earnings ratio (Illumina (ILMN) 52.9x, 10x Genomics (TXG) -144.7x, Bio-Techne (TECH) 62.3x). On next year's consensus earnings, Bio-Techne (TECH) is cheapest (Illumina (ILMN) 57.9x, Bio-Techne (TECH) 33.7x). A lower multiple can reflect slower expected growth, so read it next to the growth figures.

Which company is growing faster?

Illumina (ILMN) grew revenue fastest over the trailing twelve months: Illumina (ILMN) +4.9%, 10x Genomics (TXG) -4.3%, Bio-Techne (TECH) -0.4%.

Which company is more profitable?

Illumina (ILMN) has the highest net margin (Illumina (ILMN) 18.4%, 10x Genomics (TXG) -12.2%, Bio-Techne (TECH) 15.0%). On return on invested capital, Illumina (ILMN) leads (Illumina (ILMN) 15.1%, Bio-Techne (TECH) 8.3%).

Which stock has performed better?

Over the past year 10x Genomics (TXG) returned the most: Illumina (ILMN) +195.3%, 10x Genomics (TXG) +526.8%, Bio-Techne (TECH) +13.7%. Over five years, Illumina (ILMN) compounded fastest (Illumina (ILMN) -6.5%/yr, 10x Genomics (TXG) -12.3%/yr, Bio-Techne (TECH) -11.1%/yr). Returns are price only, before dividends.

Which pays a higher dividend?

Only one of these companies pays a dividend: Bio-Techne (TECH) 0.44%. Illumina (ILMN) and 10x Genomics (TXG) pays no regular dividend.

Which stock is riskier?

By one-year price volatility, Bio-Techne (TECH) has been the steadiest (Illumina (ILMN) 50.4%, 10x Genomics (TXG) 74.2%, Bio-Techne (TECH) 43.5%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, ILMN, TXG and TECH?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Illumina (ILMN) leads on 6. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.