ILMN vs QGEN vs RGEN Stock Comparison

Illumina, Qiagen and Repligen Prices as of Oct 29, 2026 Peers: Industry group
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ILMN Illumina, Inc.
$290.06 +6.6% 1M +205.2% 1Y
Market cap
$35.66B
P/E
39.8x
Revenue (TTM)
$4.54B
Div. yield
–
Life Sciences Tools Healthcare
2 wins
QGEN Qiagen N.V.
$50.38 +13.5% 1M +1.4% 1Y
Market cap
$10.93B
P/E
26.7x
Revenue (TTM)
$2.10B
Div. yield
–
Life Sciences Tools Healthcare
5 wins
RGEN Repligen Corp
$188.64 -3.0% 1M +27.0% 1Y
Market cap
$9.83B
P/E
–
Revenue (TTM)
$805.61M
Div. yield
–
Life Sciences Tools Healthcare
1 win

Head to Head

8 decided of 12

Qiagen leads on 5 of the 12 questions below (Qiagen 5, Illumina 2, Repligen 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionILMNQGENRGENLeader
Larger companyMarket capitalisation $35.66B $10.93B $9.83B ILMN
Cheaper on earningsLower P/E, profitable companies only 39.8x 26.7x -833.0x QGEN
Cheaper on forward earningsLower price / next fiscal year consensus EPS 58.1x 21.4x 97.2x QGEN
Faster revenue growthRevenue growth, trailing twelve months +5.8% +3.0% +13.8% RGEN
More profitableNet margin, trailing twelve months — 19.5% — –
Better return on capitalReturn on invested capital — 7.9% — –
Less leveragedLower net debt / EBITDA — 1.3x — –
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months +205.2% +1.4% +27.0% ILMN
Better 5-year returnAnnualised price return, 5 years -6.4%/yr -4.1%/yr -8.3%/yr QGEN
Less volatileAnnualised volatility, 1 year 50.3% 35.7% 46.1% QGEN
Higher overall scoreMean of the five percentile scores vs peers 68/100 71/100 57/100 QGEN

Percentile Scorecard

ILMNQGENRGEN

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisILMNQGENRGEN
Valuation 41 #134 of 227 77 #54 of 227 42 #132 of 227
Growth 63 #81 of 218 31 #151 of 218 32 #149 of 218
Profitability 100 #1 of 202 93 #16 of 202 69 #63 of 202
Financial Health – 63 #87 of 233 84 #39 of 233
Shareholder Returns – 93 #10 of 130 –
Overall 68 71 57
  • ILMN ranked among 247 companies in Medical Devices and Diagnostics
  • QGEN ranked among 247 companies in Medical Devices and Diagnostics
  • RGEN ranked among 247 companies in Medical Devices and Diagnostics

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodILMNQGENRGENSPY
1 month +6.6%+13.5%-3.0% +0.7%
3 months +41.4%+21.5%+31.4% +3.7%
6 months +128.9%+45.7%+59.4% +7.1%
Year to date +121.1%+6.4%+15.1% +12.8%
1 year +205.2%+1.4%+27.0% +11.9%
3 years +176.4%+27.0%+65.2% +85.2%
3 years, per year +40.4%+8.3%+18.2% +22.8%
5 years -28.2%-19.1%-35.1% +67.6%
5 years, per year -6.4%-4.1%-8.3% +10.9%
10 years +115.1%+75.8%+560.0% +262.0%
10 years, per year +8.0%+5.8%+20.8% +13.7%

Risk

MeasureILMNQGENRGENSPY
Volatility, 1Y 50.3%35.7%46.1% 12.7%
Downside volatility, 1Y 39.0%30.5%46.2% 12.6%
Beta vs S&P 500, 1Y 0.830.471.22 1.00
Return / volatility, 1Y 4.080.040.59 0.94
Max drawdown, 5Y -82.9%-48.2%-66.2% -25.4%
From 52-week high -1.2%-9.5%-3.0% -1.2%
52-week high $293.69$55.66$194.57 $779.14
52-week low $95.03$32.63$102.87 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleILMNQGENRGEN
P/E now vs peer median 48.9xmedian 28.7x 26.7xmedian 28.7x -901.6xmedian 28.7x
P/S now vs peer median 9.7xmedian 3.0x 5.2xmedian 3.0x 13.2xmedian 3.0x
EV/EBITDA now vs peer median —median 17.8x 18.1xmedian 17.8x —median 17.8x
P/FCF now vs peer median 43.8xmedian 26.4x 11.0xmedian 26.4x 98.1xmedian 26.4x
P/B now vs peer median 13.9xmedian 2.4x 3.3xmedian 2.4x 5.1xmedian 2.4x
PEG now vs peer median 1.18median 0.99 3.62median 0.99 31.72median 0.99

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsILMNQGENRGEN
Revenue $4.54B $2.10B $805.61M
Gross profit $3.08B $1.31B –
Operating income $960.00M $445.43M $18.24M
Net income – $409.32M $26.59M
Free cash flow – $991.33M –
R&D $975.00M $194.67M $56.43M
EPS (diluted) $5.85 $1.87 $-0.21
Cash & equivalents $1.29B $768.50M $726.96M
Total debt – $6.86B –
Shares (diluted) 153.00M 218.88M 56.64M
Enterprise value $35.66B $6.70B $9.83B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricILMNQGENRGEN
P/E 48.9x 26.7x -901.6x
P/FCF 43.8x 11.0x 98.1x
P/Operating cash flow 35.6x 16.7x 82.0x
P/S 9.7x 5.2x 13.2x
P/B 13.9x 3.3x 5.1x
P/Tangible book 15.9x 3.6x 6.0x
EV/EBITDA – 18.1x –
EV/EBIT – 26.4x –
EV/Revenue 9.7x 5.6x 13.2x
EV/FCF – 11.9x –
EV/Operating cash flow 35.6x 18.0x 82.0x
PEG (3Y EPS CAGR) 1.18 3.62 31.72

Growth

14 metrics
MetricILMNQGENRGEN
Revenue growth (1Y) 5.8% 3.0% 13.8%
Revenue CAGR (3Y) -0.7% 2.0% 7.3%
Gross profit growth (1Y) 8.5% 1.7% –
Gross profit CAGR (3Y) 4.4% 1.3% –
Operating income growth (1Y) 23.1% -4.9% 2,185%
Operating income CAGR (3Y) 30.0% 3.3% -40.5%
Net income growth (1Y) – 143.9% 1,430%
Net income CAGR (3Y) – 6.7% -35.9%
EPS growth (1Y) 28.3% 12.5% -777.9%
EPS CAGR (3Y) 41.3% 7.4% -28.4%
Operating cash flow growth (1Y) 9.6% -3.0% -0.8%
Operating cash flow CAGR (3Y) 47.5% 8.0% -4.0%
Free cash flow growth (1Y) – 2.3% –
Free cash flow CAGR (3Y) – 10.5% –

Profitability

14 metrics
MetricILMNQGENRGEN
Gross margin – 62.2% –
EBITDA margin – 31.0% –
Operating margin – 21.2% –
Pretax margin – 22.0% –
Net margin – 19.5% –
FCF margin – 47.2% –
Operating cash flow margin 27.1% 31.2% 16.1%
Return on equity 29.9% 12.2% 1.3%
Return on assets 13.3% 7.0% 0.9%
Return on invested capital – 7.9% –
Return on capital employed – 8.5% –
Asset turnover 0.7x 0.4x 0.3x
Cash conversion (OCF / net income) – 1.6x 4.9x
Stock comp / revenue – 2.1% 4.2%

Financial Health

11 metrics
MetricILMNQGENRGEN
Debt / assets – 27.9% –
Debt / equity – 0.5x –
Net debt / EBITDA – 1.3x –
Debt / FCF – 1.7x –
Liabilities / assets – 43.0% 28.5%
Equity / assets 46.2% 57.0% 71.5%
Interest coverage – 11.3x –
Current ratio 2.6x 2.8x 9.9x
Quick ratio – 2.0x –
Cash ratio – 1.4x –
Altman Z-score – 4.08 –

Shareholder Returns

7 metrics
MetricILMNQGENRGEN
Dividend yield – 5.2% –
Net buyback yield – 0.6% –
Shareholder yield – 5.8% –
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusILMNQGENRGEN
Forward P/E 58.1xFY2026 21.4xFY2026 97.2xFY2026
EPS, next fiscal year $4.99FY2026 $2.35FY2026 $1.94FY2026
EPS growth, next FY +3.1%FY2026 -1.3%FY2026 +13.5%FY2026
EPS growth, the year after +25.7% +17.4% +29.4%
Revenue, next fiscal year $4.52BFY2026 $2.25BFY2026 $773.94MFY2026
Revenue growth, next FY +4.1%FY2026 +7.8%FY2026 +4.8%FY2026
Revenue growth, the year after +12.0% -2.8% +35.9%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersILMNQGENRGEN
Held by institutions 100.0% 67.3% 100.0%
Institutions holding 934 338 483
Change in shares held, QoQ +0.0% +16.5% +1.2%
Institutions buying 464 216 273
Institutions selling 330 86 141
Buyers to sellers 1.41 2.51 1.94

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

ILMNQGENRGEN
ILMN 1.00 0.39 0.42
QGEN 0.39 1.00 0.38
RGEN 0.42 0.38 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, ILMN, QGEN and RGEN?

Illumina (ILMN) is the largest by market capitalisation: Illumina (ILMN) $35.66B, Qiagen (QGEN) $10.93B, Repligen (RGEN) $9.83B.

Which stock is cheaper, ILMN, QGEN and RGEN?

Qiagen (QGEN) trades on the lowest price-to-earnings ratio (Illumina (ILMN) 39.8x, Qiagen (QGEN) 26.7x, Repligen (RGEN) -833.0x). On next year's consensus earnings, Qiagen (QGEN) is cheapest (Illumina (ILMN) 58.1x, Qiagen (QGEN) 21.4x, Repligen (RGEN) 97.2x). A lower multiple can reflect slower expected growth, so read it next to the growth figures.

Which company is growing faster?

Repligen (RGEN) grew revenue fastest over the trailing twelve months: Illumina (ILMN) +5.8%, Qiagen (QGEN) +3.0%, Repligen (RGEN) +13.8%.

Which stock has performed better?

Over the past year Illumina (ILMN) returned the most: Illumina (ILMN) +205.2%, Qiagen (QGEN) +1.4%, Repligen (RGEN) +27.0%. Over five years, Qiagen (QGEN) compounded fastest (Illumina (ILMN) -6.4%/yr, Qiagen (QGEN) -4.1%/yr, Repligen (RGEN) -8.3%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Qiagen (QGEN) has been the steadiest (Illumina (ILMN) 50.3%, Qiagen (QGEN) 35.7%, Repligen (RGEN) 46.1%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, ILMN, QGEN and RGEN?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Qiagen (QGEN) leads on 5. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.