GRFS vs REGN vs BIIB Stock Comparison

Grifols, Regeneron Pharmaceuticals and Biogen Prices as of Oct 28, 2026 Peers: Industry group
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GRFS Grifols SA
$8.12 +9.6% 1M -13.2% 1Y
Market cap
$5.48B
P/E
12.2x
Revenue (TTM)
—
Div. yield
–
Biotechnology Healthcare
2 wins
BIIB Biogen Inc.
$244.05 +6.7% 1M +63.6% 1Y
Market cap
$37.29B
P/E
107.3x
Revenue (TTM)
$10.30B
Div. yield
–
Biotechnology Healthcare
1 win

Head to Head

11 decided of 12

Regeneron Pharmaceuticals leads on 8 of the 12 questions below (Regeneron Pharmaceuticals 8, Grifols 2, Biogen 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionGRFSREGNBIIBLeader
Larger companyMarket capitalisation $5.48B $83.86B $37.29B REGN
Cheaper on earningsLower P/E, profitable companies only 12.2x 19.4x 107.3x GRFS
Cheaper on forward earningsLower price / next fiscal year consensus EPS 8.6x 14.2x 19.1x GRFS
Faster revenue growthRevenue growth, trailing twelve months — +9.3% +2.3% REGN
More profitableNet margin, trailing twelve months — 27.9% 3.4% REGN
Better return on capitalReturn on invested capital — 9.6% 1.3% REGN
Less leveragedLower net debt / EBITDA — -1.4x 4.5x REGN
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months -13.2% +24.3% +63.6% BIIB
Better 5-year returnAnnualised price return, 5 years -9.1%/yr +4.9%/yr -1.8%/yr REGN
Less volatileAnnualised volatility, 1 year 32.4% 30.9% 34.2% REGN
Higher overall scoreMean of the five percentile scores vs peers 56/100 72/100 59/100 REGN

Percentile Scorecard

GRFSREGNBIIB

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisGRFSREGNBIIB
Valuation 99 #6 of 625 89 #70 of 625 92 #54 of 625
Growth – 42 #352 of 602 26 #446 of 602
Profitability – 90 #54 of 549 87 #73 of 549
Financial Health 14 #564 of 654 74 #173 of 654 33 #437 of 654
Shareholder Returns 56 #162 of 367 65 #129 of 367 –
Overall 56 72 59
  • GRFS ranked among 672 companies in Pharmaceuticals and Biotechnology
  • REGN ranked among 672 companies in Pharmaceuticals and Biotechnology
  • BIIB ranked among 672 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodGRFSREGNBIIBSPY
1 month +9.6%+8.1%+6.7% +0.9%
3 months -0.4%+16.9%+16.6% +5.9%
6 months +2.7%+18.5%+25.6% +8.5%
Year to date -13.2%+5.4%+38.7% +13.3%
1 year -13.2%+24.3%+63.6% +12.4%
3 years +3.6%+4.9%+4.1% +88.1%
3 years, per year +1.2%+1.6%+1.3% +23.5%
5 years -38.1%+27.1%-8.5% +68.2%
5 years, per year -9.1%+4.9%-1.8% +11.0%
10 years -44.0%+128.6%-14.0% +263.4%
10 years, per year -5.6%+8.6%-1.5% +13.8%

Risk

MeasureGRFSREGNBIIBSPY
Volatility, 1Y 32.4%30.9%34.2% 12.7%
Downside volatility, 1Y 34.2%29.9%32.7% 12.7%
Beta vs S&P 500, 1Y 0.950.450.25 1.00
Return / volatility, 1Y -0.410.791.86 0.98
Max drawdown, 5Y -58.8%-59.8%-64.4% -25.4%
From 52-week high -16.5%-4.5%-3.9% -0.9%
52-week high $9.72$852.03$253.84 $779.14
52-week low $7.02$600.66$147.86 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleGRFSREGNBIIB
P/E now vs peer median 12.2xmedian 17.4x 19.3xmedian 17.4x 103.8xmedian 17.4x
P/S now vs peer median 0.7xmedian 9.1x 5.4xmedian 9.1x 3.5xmedian 9.1x
EV/EBITDA now vs peer median —median 17.1x 17.7xmedian 17.1x 31.7xmedian 17.1x
P/FCF now vs peer median 7.8xmedian 19.0x 22.2xmedian 19.0x 17.4xmedian 19.0x
P/B now vs peer median 0.6xmedian 2.2x 2.6xmedian 2.2x 1.9xmedian 2.2x
PEG now vs peer median —median 0.34 7.26median 0.34 -2.70median 0.34

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsGRFSREGNBIIB
Revenue – $15.53B $10.30B
Gross profit – $13.18B $7.62B
Operating income – $3.84B $445.10M
Net income – $4.33B $347.50M
Free cash flow – $3.76B $2.07B
R&D – $6.28B $2.15B
EPS (diluted) – $40.84 $2.35
Cash & equivalents $969.15M $2.46B $1.30B
Total debt $44.00B $1.99B $7.29B
Shares (diluted) 681.57M 106.00M 147.80M
Enterprise value $1.82B $50.06B $26.60B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricGRFSREGNBIIB
P/E 12.2x 19.3x 103.8x
P/FCF 7.8x 22.2x 17.4x
P/Operating cash flow – 17.9x 16.1x
P/S 0.7x 5.4x 3.5x
P/B 0.6x 2.6x 1.9x
P/Tangible book 1.0x 2.7x 6.5x
EV/EBITDA – 17.7x 31.7x
EV/EBIT – 20.2x 94.5x
EV/Revenue – 5.0x 4.1x
EV/FCF – 20.6x 20.3x
EV/Operating cash flow – 16.6x 18.7x
PEG (3Y EPS CAGR) – 7.26 -2.70

Growth

14 metrics
MetricGRFSREGNBIIB
Revenue growth (1Y) – 9.3% 2.3%
Revenue CAGR (3Y) – 7.0% 1.0%
Gross profit growth (1Y) – 8.4% 0.6%
Gross profit CAGR (3Y) – 6.4% 0.5%
Operating income growth (1Y) – 0.1% -76.6%
Operating income CAGR (3Y) – -3.9% -34.8%
Net income growth (1Y) – -2.9% -78.4%
Net income CAGR (3Y) – 0.2% -38.1%
EPS growth (1Y) – -0.5% -78.5%
EPS CAGR (3Y) – 2.7% -38.5%
Operating cash flow growth (1Y) – -1.3% -8.4%
Operating cash flow CAGR (3Y) – -0.4% 18.2%
Free cash flow growth (1Y) – -2.4% -10.1%
Free cash flow CAGR (3Y) – -3.3% 24.9%

Profitability

14 metrics
MetricGRFSREGNBIIB
Gross margin – 84.9% 74.0%
EBITDA margin – 28.1% 12.9%
Operating margin – 24.7% 4.3%
Pretax margin – 33.3% 4.3%
Net margin – 27.9% 3.4%
FCF margin – 24.2% 20.1%
Operating cash flow margin – 30.1% 21.8%
Return on equity – 13.7% 1.8%
Return on assets – 10.5% 1.1%
Return on invested capital – 9.6% 1.3%
Return on capital employed – 10.7% 1.6%
Asset turnover – 0.4x 0.3x
Cash conversion (OCF / net income) – 1.1x 6.5x
Stock comp / revenue – 6.4% 2.9%

Financial Health

11 metrics
MetricGRFSREGNBIIB
Debt / assets 48.9% 4.8% 22.7%
Debt / equity 1.3x 0.1x 0.4x
Net debt / EBITDA – -1.4x 4.5x
Debt / FCF – 0.5x 3.5x
Liabilities / assets 61.4% 24.0% 41.0%
Equity / assets 38.6% 76.0% 59.0%
Interest coverage – 69.4x –
Current ratio 2.5x 3.3x 1.9x
Quick ratio 0.8x 2.6x 0.9x
Cash ratio 0.4x 1.4x 0.3x
Altman Z-score – 7.32 3.07

Shareholder Returns

7 metrics
MetricGRFSREGNBIIB
Dividend yield 1.4% 0.5% –
Net buyback yield – 3.0% –
Shareholder yield 1.4% 3.5% –
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusGRFSREGNBIIB
Forward P/E 8.6xFY2026 14.2xFY2026 19.1xFY2026
EPS, next fiscal year $0.94FY2026 $57.08FY2026 $12.81FY2026
EPS growth, next FY +10.6%FY2026 +28.8%FY2026 -16.2%FY2026
EPS growth, the year after +26.6% +15.5% +36.5%
Revenue, next fiscal year $8.88BFY2026 $17.05BFY2026 $9.96BFY2026
Revenue growth, next FY +0.0%FY2026 +18.9%FY2026 +0.7%FY2026
Revenue growth, the year after +10.3% +13.0% +11.9%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersGRFSREGNBIIB
Held by institutions 21.0% 66.2% 96.4%
Institutions holding 166 1,325 1,036
Change in shares held, QoQ -0.5% +3.8% +6.0%
Institutions buying 73 604 548
Institutions selling 65 534 294
Buyers to sellers 1.12 1.13 1.86

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

GRFSREGNBIIB
GRFS 1.00 0.28 0.11
REGN 0.28 1.00 0.36
BIIB 0.11 0.36 1.00

Add a Peer

Largest companies in the same industry

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Frequently Asked Questions

Which is bigger, GRFS, REGN and BIIB?

Regeneron Pharmaceuticals (REGN) is the largest by market capitalisation: Grifols (GRFS) $5.48B, Regeneron Pharmaceuticals (REGN) $83.86B, Biogen (BIIB) $37.29B.

Which stock is cheaper, GRFS, REGN and BIIB?

Grifols (GRFS) trades on the lowest price-to-earnings ratio (Grifols (GRFS) 12.2x, Regeneron Pharmaceuticals (REGN) 19.4x, Biogen (BIIB) 107.3x). On next year's consensus earnings, Grifols (GRFS) is cheapest (Grifols (GRFS) 8.6x, Regeneron Pharmaceuticals (REGN) 14.2x, Biogen (BIIB) 19.1x). A lower multiple can reflect slower expected growth, so read it next to the growth figures.

Which company is growing faster?

Regeneron Pharmaceuticals (REGN) grew revenue fastest over the trailing twelve months: Regeneron Pharmaceuticals (REGN) +9.3%, Biogen (BIIB) +2.3%.

Which company is more profitable?

Regeneron Pharmaceuticals (REGN) has the highest net margin (Regeneron Pharmaceuticals (REGN) 27.9%, Biogen (BIIB) 3.4%). On return on invested capital, Regeneron Pharmaceuticals (REGN) leads (Regeneron Pharmaceuticals (REGN) 9.6%, Biogen (BIIB) 1.3%).

Which stock has performed better?

Over the past year Biogen (BIIB) returned the most: Grifols (GRFS) -13.2%, Regeneron Pharmaceuticals (REGN) +24.3%, Biogen (BIIB) +63.6%. Over five years, Regeneron Pharmaceuticals (REGN) compounded fastest (Grifols (GRFS) -9.1%/yr, Regeneron Pharmaceuticals (REGN) +4.9%/yr, Biogen (BIIB) -1.8%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Regeneron Pharmaceuticals (REGN) has been the steadiest (Grifols (GRFS) 32.4%, Regeneron Pharmaceuticals (REGN) 30.9%, Biogen (BIIB) 34.2%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, GRFS, REGN and BIIB?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Regeneron Pharmaceuticals (REGN) leads on 8. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.