EW vs ISRG vs SKYA Stock Comparison

Edwards Lifesciences, Intuitive Surgical and SkyAI Prices as of Oct 29, 2026 Peers: Industry group
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EW Edwards Lifesciences Corp
$94.40 +7.1% 1M +14.2% 1Y
Market cap
$54.43B
P/E
54.1x
Revenue (TTM)
$6.51B
Div. yield
–
Medical Devices Healthcare
2 wins
ISRG Intuitive Surgical Inc
$448.76 +8.9% 1M -16.5% 1Y
Market cap
$155.54B
P/E
53.0x
Revenue (TTM)
$11.58B
Div. yield
–
Medical Devices Healthcare
5 wins
SKYA SkyAI, Inc.
$2.93 +60.1% 1M -40.9% 1Y
Market cap
$211.23M
P/E
–
Revenue (TTM)
$194.22K
Div. yield
–
Medical Supplies Healthcare
2 wins

Head to Head

9 decided of 12

Intuitive Surgical leads on 5 of the 12 questions below (Intuitive Surgical 5, SkyAI 2, Edwards Lifesciences 2). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionEWISRGSKYALeader
Larger companyMarket capitalisation $54.43B $155.54B $211.23M ISRG
Cheaper on earningsLower P/E, profitable companies only 54.1x 53.0x -0.7x ISRG
Cheaper on forward earningsLower price / next fiscal year consensus EPS 33.4x 39.1x 0.0x SKYA
Faster revenue growthRevenue growth, trailing twelve months +14.6% +20.5% +108.9% SKYA
More profitableNet margin, trailing twelve months 15.4% 25.5% -158,431.4% ISRG
Better return on capitalReturn on invested capital 9.0% — — –
Less leveragedLower net debt / EBITDA -2.3x — — –
Higher dividend yieldTrailing dividend yield — — — –
Better 1-year returnPrice return, last 12 months +14.2% -16.5% -40.9% EW
Better 5-year returnAnnualised price return, 5 years -4.7%/yr +4.4%/yr — ISRG
Less volatileAnnualised volatility, 1 year 24.8% 34.6% 105.8% EW
Higher overall scoreMean of the five percentile scores vs peers 77/100 80/100 26/100 ISRG

Percentile Scorecard

EWISRGSKYA

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisEWISRGSKYA
Valuation 64 #83 of 227 53 #107 of 227 2 #222 of 227
Growth 54 #101 of 218 80 #44 of 218 7 #203 of 218
Profitability 95 #11 of 202 98 #6 of 202 1 #200 of 202
Financial Health 87 #31 of 233 77 #54 of 233 94 #14 of 233
Shareholder Returns 87 #18 of 130 91 #13 of 130 –
Overall 77 80 26
  • EW ranked among 247 companies in Medical Devices and Diagnostics
  • ISRG ranked among 247 companies in Medical Devices and Diagnostics
  • SKYA ranked among 247 companies in Medical Devices and Diagnostics

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodEWISRGSKYASPY
1 month +7.1%+8.9%+60.1% +0.7%
3 months +8.6%+27.1%+118.7% +3.7%
6 months +13.1%-1.9%+64.1% +7.1%
Year to date +10.7%-20.8%+44.3% +12.8%
1 year +14.2%-16.5%-40.9% +11.9%
3 years +51.4%+73.6%-99.9% +85.2%
3 years, per year +14.8%+20.2%-90.2% +22.8%
5 years -21.2%+24.3%— +67.6%
5 years, per year -4.7%+4.4%— +10.9%
10 years +194.5%+505.9%— +262.0%
10 years, per year +11.4%+19.7%— +13.7%

Risk

MeasureEWISRGSKYASPY
Volatility, 1Y 24.8%34.6%105.8% 12.7%
Downside volatility, 1Y 24.5%37.5%104.6% 12.6%
Beta vs S&P 500, 1Y 0.570.892.59 1.00
Return / volatility, 1Y 0.57-0.48-0.39 0.94
Max drawdown, 5Y -54.3%-49.9%-100.0% -25.4%
From 52-week high -0.8%-24.3%-40.9% -1.2%
52-week high $95.17$592.85$4.96 $779.14
52-week low $75.87$332.02$0.95 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleEWISRGSKYA
P/E now vs peer median 54.1xmedian 28.7x 53.0xmedian 28.7x -0.7xmedian 28.7x
P/S now vs peer median 8.4xmedian 3.0x 13.4xmedian 3.0x 1,088xmedian 3.0x
EV/EBITDA now vs peer median 31.5xmedian 17.8x 37.0xmedian 17.8x —median 17.8x
P/FCF now vs peer median 38.0xmedian 26.4x 43.2xmedian 26.4x —median 26.4x
P/B now vs peer median 5.1xmedian 2.4x 9.7xmedian 2.4x 1.3xmedian 2.4x
PEG now vs peer median -6.31median 0.99 2.06median 0.99 0.01median 0.99

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsEWISRGSKYA
Revenue $6.51B $11.58B $194.22K
Gross profit $5.07B $7.78B $321.93K
Operating income $1.45B $3.28B -$289.52M
Net income $1.00B $2.97B -$307.71M
Free cash flow $1.43B $3.60B –
R&D $1.09B $1.49B $399.91K
EPS (diluted) $1.74 $8.41 $-4.27
Cash & equivalents $2.91B $2.98B $12.07M
Total debt $598.70M – –
Shares (diluted) 577.60M 351.60M 72.09M
Enterprise value $38.55B $135.96B $169.94M

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricEWISRGSKYA
P/E 54.1x 53.0x -0.7x
P/FCF 38.0x 43.2x –
P/Operating cash flow 31.6x 38.0x –
P/S 8.4x 13.4x 1,088x
P/B 5.1x 9.7x 1.3x
P/Tangible book 5.8x 10.4x 16.3x
EV/EBITDA 31.5x 37.0x –
EV/EBIT 35.0x 46.1x -0.7x
EV/Revenue 7.8x 13.1x 1,025x
EV/FCF 35.4x 42.1x –
EV/Operating cash flow 29.5x 37.0x –
PEG (3Y EPS CAGR) -6.31 2.06 0.01

Growth

14 metrics
MetricEWISRGSKYA
Revenue growth (1Y) 14.6% 20.5% 108.9%
Revenue CAGR (3Y) 15.3% 19.1% 23.8%
Gross profit growth (1Y) 13.0% 21.9% –
Gross profit CAGR (3Y) 11.9% 19.5% –
Operating income growth (1Y) -1.4% 16.6% -5,525%
Operating income CAGR (3Y) 5.0% 24.8% -212.8%
Net income growth (1Y) -75.8% 7.5% -42,440%
Net income CAGR (3Y) -10.2% 24.4% -238.0%
EPS growth (1Y) -75.3% 10.8% -487.2%
EPS CAGR (3Y) -8.6% 25.7% -84.2%
Operating cash flow growth (1Y) 116.4% 38.1% –
Operating cash flow CAGR (3Y) 22.3% 26.4% –
Free cash flow growth (1Y) 143.9% 58.4% –
Free cash flow CAGR (3Y) 26.9% 42.0% –

Profitability

14 metrics
MetricEWISRGSKYA
Gross margin 77.8% 67.2% 165.8%
EBITDA margin 24.8% 35.3% –
Operating margin 22.3% 28.4% -149,065%
Pretax margin 21.8% 31.3% -151,352%
Net margin 15.4% 25.5% -158,431%
FCF margin 22.0% 31.1% –
Operating cash flow margin 26.4% 35.3% –
Return on equity 9.5% 17.3% -140.2%
Return on assets 7.4% 14.8% -137.6%
Return on invested capital 9.0% – –
Return on capital employed 12.0% 18.7% -136.7%
Asset turnover 0.5x 0.6x 0.0x
Cash conversion (OCF / net income) 1.7x 1.4x –
Stock comp / revenue 2.6% 7.2% 48,037%

Financial Health

11 metrics
MetricEWISRGSKYA
Debt / assets 4.3% – –
Debt / equity 0.1x – –
Net debt / EBITDA -2.3x – –
Debt / FCF 0.4x – –
Liabilities / assets 22.7% 16.7% 1.9%
Equity / assets 77.3% 83.3% 98.1%
Interest coverage – – –
Current ratio 4.5x 3.3x 5.3x
Quick ratio 3.5x 2.3x 4.4x
Cash ratio 2.8x 1.6x 4.2x
Altman Z-score 13.17 30.73 31.69

Shareholder Returns

7 metrics
MetricEWISRGSKYA
Dividend yield – – –
Net buyback yield 1.9% 2.7% –
Shareholder yield 1.9% 2.7% –
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusEWISRGSKYA
Forward P/E 33.4xFY2026 39.1xFY2026 0.0xFY2026
EPS, next fiscal year $2.83FY2026 $11.47FY2026 $2,362.06FY2026
EPS growth, next FY +10.5%FY2026 +28.4%FY2026 –
EPS growth, the year after +12.7% +4.5% –
Revenue, next fiscal year $7.24BFY2026 $11.60BFY2026 $70.01MFY2026
Revenue growth, next FY +19.2%FY2026 +15.3%FY2026 +34,200.1%FY2026
Revenue growth, the year after -2.6% +11.3% +17.5%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersEWISRGSKYA
Held by institutions 90.6% 86.2% –
Institutions holding 1,324 2,237 –
Change in shares held, QoQ +20.4% +4.6% –
Institutions buying 641 1,072 –
Institutions selling 454 877 –
Buyers to sellers 1.41 1.22 –

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

EWISRGSKYA
EW 1.00 0.45 0.02
ISRG 0.45 1.00 0.15
SKYA 0.02 0.15 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, EW, ISRG and SKYA?

Intuitive Surgical (ISRG) is the largest by market capitalisation: Edwards Lifesciences (EW) $54.43B, Intuitive Surgical (ISRG) $155.54B, SkyAI (SKYA) $211.23M.

Which stock is cheaper, EW, ISRG and SKYA?

Intuitive Surgical (ISRG) trades on the lowest price-to-earnings ratio (Edwards Lifesciences (EW) 54.1x, Intuitive Surgical (ISRG) 53.0x, SkyAI (SKYA) -0.7x). On next year's consensus earnings, SkyAI (SKYA) is cheapest (Edwards Lifesciences (EW) 33.4x, Intuitive Surgical (ISRG) 39.1x, SkyAI (SKYA) 0.0x). A lower multiple can reflect slower expected growth, so read it next to the growth figures.

Which company is growing faster?

SkyAI (SKYA) grew revenue fastest over the trailing twelve months: Edwards Lifesciences (EW) +14.6%, Intuitive Surgical (ISRG) +20.5%, SkyAI (SKYA) +108.9%.

Which company is more profitable?

Intuitive Surgical (ISRG) has the highest net margin (Edwards Lifesciences (EW) 15.4%, Intuitive Surgical (ISRG) 25.5%, SkyAI (SKYA) -158,431.4%).

Which stock has performed better?

Over the past year Edwards Lifesciences (EW) returned the most: Edwards Lifesciences (EW) +14.2%, Intuitive Surgical (ISRG) -16.5%, SkyAI (SKYA) -40.9%. Over five years, Intuitive Surgical (ISRG) compounded fastest (Edwards Lifesciences (EW) -4.7%/yr, Intuitive Surgical (ISRG) +4.4%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Edwards Lifesciences (EW) has been the steadiest (Edwards Lifesciences (EW) 24.8%, Intuitive Surgical (ISRG) 34.6%, SkyAI (SKYA) 105.8%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, EW, ISRG and SKYA?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Intuitive Surgical (ISRG) leads on 5. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.