CSTL vs NTRA vs LH Stock Comparison

Castle Biosciences, Natera and Labcorp Holdings Prices as of Nov 2, 2026 Peers: Industry group
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NTRA Natera, Inc.
$378.92 -7.7% 1M +90.5% 1Y
Market cap
$54.42B
P/E
–
Revenue (TTM)
$2.71B
Div. yield
–
Diagnostic Labs Healthcare
4 wins
LH Labcorp Holdings Inc.
$355.65 +15.3% 1M +40.0% 1Y
Market cap
$28.77B
P/E
28.9x
Revenue (TTM)
$14.59B
Div. yield
0.81%
Diagnostic Labs Healthcare
5 wins

Head to Head

9 decided of 12

Labcorp Holdings leads on 5 of the 12 questions below (Labcorp Holdings 5, Natera 4). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionCSTLNTRALHLeader
Larger companyMarket capitalisation $1.07B $54.42B $28.77B NTRA
Cheaper on earningsLower P/E, profitable companies only -54.7x -282.2x 28.9x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — — 20.8x –
Faster revenue growthRevenue growth, trailing twelve months +3.2% +37.8% +6.0% NTRA
More profitableNet margin, trailing twelve months -5.4% -7.1% 6.9% LH
Better return on capitalReturn on invested capital -6.7% -11.7% 8.5% LH
Less leveragedLower net debt / EBITDA 15.5x 4.5x 2.5x LH
Higher dividend yieldTrailing dividend yield — — 0.81% –
Better 1-year returnPrice return, last 12 months +37.0% +90.5% +40.0% NTRA
Better 5-year returnAnnualised price return, 5 years -10.9%/yr +27.6%/yr +7.6%/yr NTRA
Less volatileAnnualised volatility, 1 year 59.1% 49.1% 24.4% LH
Higher overall scoreMean of the five percentile scores vs peers 50/100 50/100 57/100 LH

Percentile Scorecard

CSTLNTRALH

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisCSTLNTRALH
Valuation 43 #54 of 94 16 #79 of 94 61 #37 of 94
Growth 51 #43 of 87 70 #27 of 87 35 #57 of 87
Profitability 39 #53 of 86 32 #59 of 86 71 #26 of 86
Financial Health 93 #8 of 99 86 #15 of 99 45 #55 of 99
Shareholder Returns 24 #43 of 56 46 #31 of 56 71 #17 of 56
Overall 50 50 57
  • CSTL ranked among 102 companies in Healthcare Providers
  • NTRA ranked among 102 companies in Healthcare Providers
  • LH ranked among 102 companies in Healthcare Providers

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodCSTLNTRALHSPY
1 month -1.7%-7.7%+15.3% -2.3%
3 months +15.0%+40.2%+15.6% -0.7%
6 months +36.9%+79.1%+40.6% +4.8%
Year to date -10.2%+65.4%+41.8% +10.3%
1 year +37.0%+90.5%+40.0% +10.3%
3 years +94.3%+786.6%+69.2% +73.0%
3 years, per year +24.8%+107.1%+19.2% +20.1%
5 years -43.7%+238.6%+44.0% +61.9%
5 years, per year -10.9%+27.6%+7.6% +10.1%
10 years —+4,624.7%+233.8% +258.6%
10 years, per year —+47.0%+12.8% +13.6%

Risk

MeasureCSTLNTRALHSPY
Volatility, 1Y 59.1%49.1%24.4% 12.8%
Downside volatility, 1Y 61.9%46.9%21.8% 12.8%
Beta vs S&P 500, 1Y 1.011.300.39 1.00
Return / volatility, 1Y 0.631.841.64 0.80
Max drawdown, 5Y -81.2%-75.9%-35.0% -25.4%
From 52-week high -18.8%-13.1%-3.4% -3.5%
52-week high $43.04$436.00$368.15 $779.14
52-week low $18.15$182.65$246.64 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleCSTLNTRALH
P/E now vs peer median -54.7xmedian 25.3x -282.2xmedian 25.3x 28.9xmedian 25.3x
P/S now vs peer median 3.0xmedian 1.5x 20.1xmedian 1.5x 2.0xmedian 1.5x
EV/EBITDA now vs peer median -49.0xmedian 14.6x -238.2xmedian 14.6x 15.5xmedian 14.6x
P/FCF now vs peer median -2,180xmedian 21.6x 646.3xmedian 21.6x 22.4xmedian 21.6x
P/B now vs peer median 2.3xmedian 3.1x 29.9xmedian 3.1x 3.3xmedian 3.1x
PEG now vs peer median -1.29median 0.83 -8.50median 0.83 1.68median 0.83

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsCSTLNTRALH
Revenue $357.28M $2.71B $14.59B
Gross profit $276.03M $1.71B $4.23B
Operating income -$32.11M -$289.67M $1.50B
Net income -$19.42M -$192.36M $1.00B
Free cash flow -$489.00K $84.20M $1.29B
R&D $55.45M $787.38M –
EPS (diluted) $-0.64 $-1.34 $12.24
Cash & equivalents $62.12M $1.10B $261.80M
Total debt $10.08M $80.29M $5.85B
Shares (diluted) 30.40M 143.28M 82.00M
Enterprise value -$49.67M $50.10B $26.87B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricCSTLNTRALH
P/E -54.7x -282.2x 28.9x
P/FCF -2,180x 646.3x 22.4x
P/Operating cash flow 25.0x 238.4x 15.9x
P/S 3.0x 20.1x 2.0x
P/B 2.3x 29.9x 3.3x
P/Tangible book 2.3x 37.2x 5.6x
EV/EBITDA -49.0x -238.2x 15.5x
EV/EBIT -25.2x -184.3x 22.9x
EV/Revenue 2.3x 19.7x 2.4x
EV/FCF -1,655x 634.2x 26.7x
EV/Operating cash flow 19.0x 234.0x 18.9x
PEG (3Y EPS CAGR) -1.29 -8.50 1.68

Growth

14 metrics
MetricCSTLNTRALH
Revenue growth (1Y) 3.2% 37.8% 6.0%
Revenue CAGR (3Y) 28.7% 42.7% 6.6%
Gross profit growth (1Y) -1.6% 43.6% 8.0%
Gross profit CAGR (3Y) 29.2% 68.1% 8.2%
Operating income growth (1Y) -39.3% 1.3% 12.6%
Operating income CAGR (3Y) 30.8% 17.3% 19.7%
Net income growth (1Y) -105.1% 24.0% 17.4%
Net income CAGR (3Y) 39.8% 27.8% 14.9%
EPS growth (1Y) -99.3% 27.7% 19.8%
EPS CAGR (3Y) 42.3% 33.2% 17.2%
Operating cash flow growth (1Y) -31.8% 22.2% 0.6%
Operating cash flow CAGR (3Y) 45.1% 38.6% 9.0%
Free cash flow growth (1Y) -101.4% -26.8% -6.8%
Free cash flow CAGR (3Y) 78.8% 30.4% 8.2%

Profitability

14 metrics
MetricCSTLNTRALH
Gross margin 77.3% 63.2% 29.0%
EBITDA margin -4.6% -8.3% 15.1%
Operating margin -9.0% -10.7% 10.3%
Pretax margin -5.4% -9.3% 8.4%
Net margin -5.4% -7.1% 6.9%
FCF margin -0.1% 3.1% 8.8%
Operating cash flow margin 11.9% 8.4% 12.4%
Return on equity -4.2% -10.7% 11.5%
Return on assets -3.5% -7.3% 5.4%
Return on invested capital -6.7% -11.7% 8.5%
Return on capital employed -6.4% -13.9% 9.4%
Asset turnover 0.6x 1.0x 0.8x
Cash conversion (OCF / net income) -2.2x -1.2x 1.8x
Stock comp / revenue 12.6% 14.1% 0.9%

Financial Health

11 metrics
MetricCSTLNTRALH
Debt / assets 1.8% 3.0% 30.9%
Debt / equity 0.0x 0.0x 0.7x
Net debt / EBITDA 15.5x 4.5x 2.5x
Debt / FCF -20.6x 1.0x 4.5x
Liabilities / assets 16.2% 31.5% 53.2%
Equity / assets 83.8% 68.5% 46.8%
Interest coverage -85.6x -75.9x 6.5x
Current ratio 6.0x 3.0x 1.4x
Quick ratio 5.6x 2.8x 1.0x
Cash ratio 4.7x 2.0x 0.1x
Altman Z-score 7.47 38.67 3.48

Shareholder Returns

7 metrics
MetricCSTLNTRALH
Dividend yield – – 0.8%
Net buyback yield -0.5% -0.1% 2.1%
Shareholder yield -0.5% -0.1% 2.9%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusCSTLNTRALH
Forward P/E – – 20.8xFY2026
EPS, next fiscal year $-1.31FY2026 $-1.48FY2026 $17.07FY2026
EPS growth, next FY – – +3.8%FY2026
EPS growth, the year after – – +9.3%
Revenue, next fiscal year $385.85MFY2026 $3.07BFY2026 $14.31BFY2026
Revenue growth, next FY +12.1%FY2026 +32.8%FY2026 +2.6%FY2026
Revenue growth, the year after +2.3% +7.2% +11.9%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersCSTLNTRALH
Held by institutions 89.6% 95.5% 97.0%
Institutions holding 177 849 1,053
Change in shares held, QoQ -1.0% +2.7% +1.6%
Institutions buying 104 515 466
Institutions selling 55 240 393
Buyers to sellers 1.89 2.15 1.19

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

CSTLNTRALH
CSTL 1.00 0.46 0.23
NTRA 0.46 1.00 0.26
LH 0.23 0.26 1.00

Add a Peer

Largest companies in the same industry

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Frequently Asked Questions

Which is bigger, CSTL, NTRA and LH?

Natera (NTRA) is the largest by market capitalisation: Castle Biosciences (CSTL) $1.07B, Natera (NTRA) $54.42B, Labcorp Holdings (LH) $28.77B.

Which company is growing faster?

Natera (NTRA) grew revenue fastest over the trailing twelve months: Castle Biosciences (CSTL) +3.2%, Natera (NTRA) +37.8%, Labcorp Holdings (LH) +6.0%.

Which company is more profitable?

Labcorp Holdings (LH) has the highest net margin (Castle Biosciences (CSTL) -5.4%, Natera (NTRA) -7.1%, Labcorp Holdings (LH) 6.9%). On return on invested capital, Labcorp Holdings (LH) leads (Castle Biosciences (CSTL) -6.7%, Natera (NTRA) -11.7%, Labcorp Holdings (LH) 8.5%).

Which stock has performed better?

Over the past year Natera (NTRA) returned the most: Castle Biosciences (CSTL) +37.0%, Natera (NTRA) +90.5%, Labcorp Holdings (LH) +40.0%. Over five years, Natera (NTRA) compounded fastest (Castle Biosciences (CSTL) -10.9%/yr, Natera (NTRA) +27.6%/yr, Labcorp Holdings (LH) +7.6%/yr). Returns are price only, before dividends.

Which pays a higher dividend?

Only one of these companies pays a dividend: Labcorp Holdings (LH) 0.81%. Castle Biosciences (CSTL) and Natera (NTRA) pays no regular dividend.

Which stock is riskier?

By one-year price volatility, Labcorp Holdings (LH) has been the steadiest (Castle Biosciences (CSTL) 59.1%, Natera (NTRA) 49.1%, Labcorp Holdings (LH) 24.4%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, CSTL, NTRA and LH?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Labcorp Holdings (LH) leads on 5. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.