CRSP vs VCEL vs PGEN Stock Comparison

CRISPR Therapeutics AG, Vericel and Precigen Prices as of Oct 23, 2026 Peers: Industry group
CRSP CRISPR Therapeutics AG
$49.39 -11.4% 1M -26.5% 1Y
Market cap
$4.73B
P/E
–
Revenue (TTM)
$13.39M
Div. yield
–
Gene and Cell Therapy Healthcare
1 win
VCEL Vericel Corp
$42.53 +9.6% 1M +18.2% 1Y
Market cap
$2.20B
P/E
90.8x
Revenue (TTM)
$306.30M
Div. yield
–
Gene and Cell Therapy Healthcare
3 wins
PGEN Precigen, Inc.
$6.19 -16.8% 1M +45.6% 1Y
Market cap
$2.16B
P/E
–
Revenue (TTM)
$85.72M
Div. yield
–
Gene and Cell Therapy Healthcare
5 wins

Head to Head

9 decided of 12

Precigen leads on 5 of the 12 questions below (Precigen 5, Vericel 3, CRISPR Therapeutics AG 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionCRSPVCELPGENLeader
Larger companyMarket capitalisation $4.73B $2.20B $2.16B CRSP
Cheaper on earningsLower P/E, profitable companies only -10.5x 90.8x -6.4x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — 83.4x 34.4x PGEN
Faster revenue growthRevenue growth, trailing twelve months -64.8% +23.0% +1,875.0% PGEN
More profitableNet margin, trailing twelve months -3,368.7% 7.9% -392.8% VCEL
Better return on capitalReturn on invested capital -22.6% — — –
Less leveragedLower net debt / EBITDA 3.4x — -1.6x PGEN
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months -26.5% +18.2% +45.6% PGEN
Better 5-year returnAnnualised price return, 5 years -12.4%/yr -3.7%/yr +6.2%/yr PGEN
Less volatileAnnualised volatility, 1 year 57.0% 40.8% 77.9% VCEL
Higher overall scoreMean of the five percentile scores vs peers 44/100 81/100 55/100 VCEL

Percentile Scorecard

CRSPVCELPGEN

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisCRSPVCELPGEN
Valuation 48 #324 of 624 81 #118 of 624 58 #261 of 624
Growth 32 #413 of 603 94 #37 of 603 48 #312 of 603
Profitability 32 #379 of 555 88 #67 of 555 59 #229 of 555
Financial Health 71 #190 of 657 69 #207 of 657 26 #484 of 657
Shareholder Returns 37 #232 of 370 73 #102 of 370 82 #66 of 370
Overall 44 81 55
  • CRSP ranked among 671 companies in Pharmaceuticals and Biotechnology
  • VCEL ranked among 671 companies in Pharmaceuticals and Biotechnology
  • PGEN ranked among 671 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodCRSPVCELPGENSPY
1 month -11.4%+9.6%-16.8% -1.0%
3 months +6.1%-5.6%+14.6% +2.9%
6 months +1.2%+19.3%+49.9% +6.4%
Year to date -5.8%+18.1%+48.1% +11.4%
1 year -26.5%+18.2%+45.6% +13.1%
3 years +19.0%+20.0%+457.7% +79.4%
3 years, per year +6.0%+6.3%+77.4% +21.5%
5 years -48.3%-17.1%+34.9% +67.7%
5 years, per year -12.4%-3.7%+6.2% +10.9%
10 years +257.4%+1,635.9%-76.5% +255.2%
10 years, per year +13.6%+33.0%-13.5% +13.5%

Risk

MeasureCRSPVCELPGENSPY
Volatility, 1Y 57.0%40.8%77.9% 12.7%
Downside volatility, 1Y 53.8%40.1%69.3% 12.7%
Beta vs S&P 500, 1Y 1.790.731.42 1.00
Return / volatility, 1Y -0.460.450.59 1.03
Max drawdown, 5Y -67.7%-65.4%-87.8% -25.4%
From 52-week high -26.9%-12.0%-27.7% -2.5%
52-week high $67.61$48.31$8.56 $779.14
52-week low $44.34$29.34$3.10 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleCRSPVCELPGEN
P/E now vs peer median -10.6xmedian 17.2x 89.7xmedian 17.2x -6.6xmedian 17.2x
P/S now vs peer median 356.5xmedian 8.8x 7.1xmedian 8.8x 25.9xmedian 8.8x
EV/EBITDA now vs peer median -5.8xmedian 16.0x 64.2xmedian 16.0x -66.2xmedian 16.0x
P/FCF now vs peer median -12.9xmedian 17.8x 35.3xmedian 17.8x -19.2xmedian 17.8x
P/B now vs peer median 2.7xmedian 2.1x 5.9xmedian 2.1x 50.9xmedian 2.1x
PEG now vs peer median -2.74median 0.32 1.65median 0.32 0.05median 0.32

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsCRSPVCELPGEN
Revenue $13.39M $306.30M $85.72M
Gross profit – $228.38M $77.72M
Operating income -$534.34M $18.24M -$39.50M
Net income -$451.14M $24.22M -$157.71M
Free cash flow -$371.33M $61.66M -$115.22M
R&D $278.15M $29.17M $32.29M
EPS (diluted) $-4.67 $0.46 $-0.81
Cash & equivalents $291.34M $125.40M $16.33M
Total debt $586.20M – $93.88M
Shares (diluted) 96.51M 52.31M 413.69M
Enterprise value -$3.97B $1.62B $1.84B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricCRSPVCELPGEN
P/E -10.6x 89.7x -6.6x
P/FCF -12.9x 35.3x -19.2x
P/Operating cash flow -12.9x 31.2x -19.4x
P/S 356.5x 7.1x 25.9x
P/B 2.7x 5.9x 50.9x
P/Tangible book 2.7x 6.0x 54.0x
EV/EBITDA -5.8x 64.2x -66.2x
EV/EBIT -5.6x 110.4x -57.5x
EV/Revenue 223.7x 6.6x 26.5x
EV/FCF -8.1x 32.7x -19.7x
EV/Operating cash flow -8.1x 28.9x -19.9x
PEG (3Y EPS CAGR) -2.74 1.65 0.05

Growth

14 metrics
MetricCRSPVCELPGEN
Revenue growth (1Y) -64.8% 23.0% 1,875%
Revenue CAGR (3Y) -57.1% 19.8% 57.1%
Gross profit growth (1Y) – 24.8% 259,173%
Gross profit CAGR (3Y) – 23.9% 69.2%
Operating income growth (1Y) 3.3% 1,428% 62.1%
Operating income CAGR (3Y) -4.1% 47.8% 18.9%
Net income growth (1Y) 3.6% 240.8% -26.7%
Net income CAGR (3Y) -2.7% 56.6% -108.9%
EPS growth (1Y) 13.0% 228.1% -93.8%
EPS CAGR (3Y) 3.9% 54.3% -123.2%
Operating cash flow growth (1Y) -13.8% 47.5% -72.3%
Operating cash flow CAGR (3Y) -2.5% 33.7% -15.9%
Free cash flow growth (1Y) -14.1% 842.9% -65.1%
Free cash flow CAGR (3Y) -0.9% 43.2% -15.3%

Profitability

14 metrics
MetricCRSPVCELPGEN
Gross margin – 74.6% 90.7%
EBITDA margin -3,850% 10.2% -40.0%
Operating margin -3,990% 6.0% -46.1%
Pretax margin -3,346% 8.2% -184.0%
Net margin -3,369% 7.9% -392.8%
FCF margin -2,773% 20.1% -134.4%
Operating cash flow margin -2,760% 22.7% -133.2%
Return on equity -25.3% 6.9% -494.3%
Return on assets -16.8% 5.1% -102.1%
Return on invested capital -22.6% – –
Return on capital employed -20.9% 4.1% -31.6%
Asset turnover 0.0x 0.6x 0.6x
Cash conversion (OCF / net income) 0.8x 2.9x 0.7x
Stock comp / revenue 510.2% 12.2% 15.3%

Financial Health

11 metrics
MetricCRSPVCELPGEN
Debt / assets 22.1% – 55.1%
Debt / equity 0.3x – 2.2x
Net debt / EBITDA 3.4x – -1.6x
Debt / FCF -1.6x – -0.8x
Liabilities / assets 34.1% 26.4% 74.4%
Equity / assets 65.9% 73.6% 25.6%
Interest coverage – 28.5x -4.1x
Current ratio 17.8x 5.0x 4.6x
Quick ratio 17.8x 4.5x 3.8x
Cash ratio 17.8x 3.1x 1.3x
Altman Z-score 2.38 10.01 -8.18

Shareholder Returns

7 metrics
MetricCRSPVCELPGEN
Dividend yield – – –
Net buyback yield -8.9% -0.3% -0.1%
Shareholder yield -8.9% -0.3% -0.1%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusCRSPVCELPGEN
Forward P/E – 83.4xFY2026 34.4xFY2026
EPS, next fiscal year $-4.12FY2026 $0.51FY2026 $0.18FY2026
EPS growth, next FY – +59.4%FY2026 –
EPS growth, the year after – +72.5% +277.8%
Revenue, next fiscal year $38.73MFY2026 $324.56MFY2026 $252.29MFY2026
Revenue growth, next FY +1,003.4%FY2026 +17.5%FY2026 +2,506.3%FY2026
Revenue growth, the year after +259.5% +16.1% +82.7%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersCRSPVCELPGEN
Held by institutions 78.9% 100.0% 39.2%
Institutions holding 518 317 210
Change in shares held, QoQ -1.0% +0.4% +4.9%
Institutions buying 237 187 123
Institutions selling 139 98 46
Buyers to sellers 1.71 1.91 2.67

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

CRSPVCELPGEN
CRSP 1.00 0.35 0.37
VCEL 0.35 1.00 0.16
PGEN 0.37 0.16 1.00

Add a Peer

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Frequently Asked Questions

Which is bigger, CRSP, VCEL and PGEN?

CRISPR Therapeutics AG (CRSP) is the largest by market capitalisation: CRISPR Therapeutics AG (CRSP) $4.73B, Vericel (VCEL) $2.20B, Precigen (PGEN) $2.16B.

Which company is growing faster?

Precigen (PGEN) grew revenue fastest over the trailing twelve months: CRISPR Therapeutics AG (CRSP) -64.8%, Vericel (VCEL) +23.0%, Precigen (PGEN) +1,875.0%.

Which company is more profitable?

Vericel (VCEL) has the highest net margin (CRISPR Therapeutics AG (CRSP) -3,368.7%, Vericel (VCEL) 7.9%, Precigen (PGEN) -392.8%).

Which stock has performed better?

Over the past year Precigen (PGEN) returned the most: CRISPR Therapeutics AG (CRSP) -26.5%, Vericel (VCEL) +18.2%, Precigen (PGEN) +45.6%. Over five years, Precigen (PGEN) compounded fastest (CRISPR Therapeutics AG (CRSP) -12.4%/yr, Vericel (VCEL) -3.7%/yr, Precigen (PGEN) +6.2%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Vericel (VCEL) has been the steadiest (CRISPR Therapeutics AG (CRSP) 57.0%, Vericel (VCEL) 40.8%, Precigen (PGEN) 77.9%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, CRSP, VCEL and PGEN?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Precigen (PGEN) leads on 5. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.