CRSP vs VCEL vs LEGN Stock Comparison

CRISPR Therapeutics AG, Vericel and Legend Biotech Prices as of Oct 29, 2026 Peers: Industry group
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CRSP CRISPR Therapeutics AG
$54.26 -3.1% 1M -13.3% 1Y
Market cap
$4.94B
P/E
–
Revenue (TTM)
$13.39M
Div. yield
–
Gene and Cell Therapy Healthcare
2 wins
VCEL Vericel Corp
$42.91 +5.7% 1M +23.0% 1Y
Market cap
$2.05B
P/E
84.7x
Revenue (TTM)
$306.30M
Div. yield
–
Gene and Cell Therapy Healthcare
5 wins
LEGN Legend Biotech Corp
$22.30 +18.5% 1M -30.6% 1Y
Market cap
$3.98B
P/E
–
Revenue (TTM)
$1.27B
Div. yield
–
Gene and Cell Therapy Healthcare
2 wins

Head to Head

9 decided of 12

Vericel leads on 5 of the 12 questions below (Vericel 5, CRISPR Therapeutics AG 2, Legend Biotech 2). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionCRSPVCELLEGNLeader
Larger companyMarket capitalisation $4.94B $2.05B $3.98B CRSP
Cheaper on earningsLower P/E, profitable companies only -11.0x 84.7x -43.4x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — 84.1x — –
Faster revenue growthRevenue growth, trailing twelve months -64.8% +23.0% +59.5% LEGN
More profitableNet margin, trailing twelve months -3,368.7% 7.9% -7.2% VCEL
Better return on capitalReturn on invested capital -22.6% — -4.2% LEGN
Less leveragedLower net debt / EBITDA 3.4x — 28.0x CRSP
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months -13.3% +23.0% -30.6% VCEL
Better 5-year returnAnnualised price return, 5 years -9.9%/yr -1.4%/yr -15.7%/yr VCEL
Less volatileAnnualised volatility, 1 year 57.3% 41.0% 72.3% VCEL
Higher overall scoreMean of the five percentile scores vs peers 45/100 81/100 73/100 VCEL

Percentile Scorecard

CRSPVCELLEGN

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisCRSPVCELLEGN
Valuation 51 #308 of 624 82 #115 of 624 89 #70 of 624
Growth 32 #412 of 601 94 #36 of 601 97 #20 of 601
Profitability 32 #367 of 541 88 #64 of 541 80 #108 of 541
Financial Health 71 #188 of 647 69 #203 of 647 54 #299 of 647
Shareholder Returns 38 #222 of 359 73 #99 of 359 44 #201 of 359
Overall 45 81 73
  • CRSP ranked among 671 companies in Pharmaceuticals and Biotechnology
  • VCEL ranked among 671 companies in Pharmaceuticals and Biotechnology
  • LEGN ranked among 671 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodCRSPVCELLEGNSPY
1 month -3.1%+5.7%+18.5% +0.7%
3 months +12.0%-9.9%+17.1% +3.7%
6 months +3.7%+23.6%-5.2% +7.1%
Year to date +3.5%+19.2%+2.6% +12.8%
1 year -13.3%+23.0%-30.6% +11.9%
3 years +39.4%+24.8%-66.0% +85.2%
3 years, per year +11.7%+7.7%-30.2% +22.8%
5 years -40.6%-6.8%-57.5% +67.6%
5 years, per year -9.9%-1.4%-15.7% +10.9%
10 years +224.1%+1,726.0%— +262.0%
10 years, per year +12.5%+33.7%— +13.7%

Risk

MeasureCRSPVCELLEGNSPY
Volatility, 1Y 57.3%41.0%72.3% 12.7%
Downside volatility, 1Y 53.8%40.0%62.7% 12.6%
Beta vs S&P 500, 1Y 1.840.710.44 1.00
Return / volatility, 1Y -0.230.56-0.42 0.94
Max drawdown, 5Y -67.7%-64.7%-78.2% -25.4%
From 52-week high -15.2%-11.2%-38.5% -1.2%
52-week high $63.99$48.31$36.28 $779.14
52-week low $44.34$29.34$16.65 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleCRSPVCELLEGN
P/E now vs peer median -11.6xmedian 17.8x 90.5xmedian 17.8x -44.8xmedian 17.8x
P/S now vs peer median 391.6xmedian 9.1x 7.2xmedian 9.1x 3.2xmedian 9.1x
EV/EBITDA now vs peer median -6.7xmedian 15.0x 64.8xmedian 15.0x -195.0xmedian 15.0x
P/FCF now vs peer median -14.1xmedian 21.7x 35.6xmedian 21.7x -63.6xmedian 21.7x
P/B now vs peer median 3.0xmedian 2.2x 5.9xmedian 2.2x 3.3xmedian 2.2x
PEG now vs peer median -3.01median 0.35 1.67median 0.35 -0.95median 0.35

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsCRSPVCELLEGN
Revenue $13.39M $306.30M $1.27B
Gross profit – $228.38M $727.10M
Operating income -$534.34M $18.24M -$55.25M
Net income -$451.14M $24.22M -$80.39M
Free cash flow -$371.33M $61.66M -$64.60M
R&D $278.15M $29.17M $396.15M
EPS (diluted) $-4.67 $0.46 $-0.50
Cash & equivalents $291.34M $125.40M $672.90M
Total debt $586.20M – $1.06B
Shares (diluted) 96.51M 52.31M 184.32M
Enterprise value -$3.76B $1.47B $1.48B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricCRSPVCELLEGN
P/E -11.6x 90.5x -44.8x
P/FCF -14.1x 35.6x -63.6x
P/Operating cash flow -14.2x 31.5x -46.0x
P/S 391.6x 7.2x 3.2x
P/B 3.0x 5.9x 3.3x
P/Tangible book 3.0x 6.0x 3.3x
EV/EBITDA -6.7x 64.8x -195.0x
EV/EBIT -6.5x 111.5x -65.0x
EV/Revenue 258.9x 6.6x 2.8x
EV/FCF -9.3x 33.0x -55.6x
EV/Operating cash flow -9.4x 29.2x -40.2x
PEG (3Y EPS CAGR) -3.01 1.67 -0.95

Growth

14 metrics
MetricCRSPVCELLEGN
Revenue growth (1Y) -64.8% 23.0% 59.5%
Revenue CAGR (3Y) -57.1% 19.8% 97.6%
Gross profit growth (1Y) – 24.8% 42.4%
Gross profit CAGR (3Y) – 23.9% 147.5%
Operating income growth (1Y) 3.3% 1,428% 75.3%
Operating income CAGR (3Y) -4.1% 47.8% 49.1%
Net income growth (1Y) 3.6% 240.8% 75.3%
Net income CAGR (3Y) -2.7% 56.6% 46.7%
EPS growth (1Y) 13.0% 228.1% 72.0%
EPS CAGR (3Y) 3.9% 54.3% 47.0%
Operating cash flow growth (1Y) -13.8% 47.5% 67.5%
Operating cash flow CAGR (3Y) -2.5% 33.7% 37.1%
Free cash flow growth (1Y) -14.1% 842.9% 77.8%
Free cash flow CAGR (3Y) -0.9% 43.2% 44.5%

Profitability

14 metrics
MetricCRSPVCELLEGN
Gross margin – 74.6% 57.2%
EBITDA margin -3,850% 10.2% -1.5%
Operating margin -3,990% 6.0% -4.3%
Pretax margin -3,346% 8.2% -4.4%
Net margin -3,369% 7.9% -7.2%
FCF margin -2,773% 20.1% -5.1%
Operating cash flow margin -2,760% 22.7% -7.0%
Return on equity -25.3% 6.9% -8.3%
Return on assets -16.8% 5.1% -5.5%
Return on invested capital -22.6% – -4.2%
Return on capital employed -20.9% 4.1% -4.3%
Asset turnover 0.0x 0.6x 0.8x
Cash conversion (OCF / net income) 0.8x 2.9x 1.1x
Stock comp / revenue 510.2% 12.2% 5.2%

Financial Health

11 metrics
MetricCRSPVCELLEGN
Debt / assets 22.1% – 8.9%
Debt / equity 0.3x – 0.1x
Net debt / EBITDA 3.4x – 28.0x
Debt / FCF -1.6x – -2.4x
Liabilities / assets 34.1% 26.4% 29.8%
Equity / assets 65.9% 73.6% 70.2%
Interest coverage – 28.5x -4.8x
Current ratio 17.8x 5.0x 3.0x
Quick ratio 17.8x 4.5x 1.7x
Cash ratio 17.8x 3.1x 1.7x
Altman Z-score 2.69 10.09 6.90

Shareholder Returns

7 metrics
MetricCRSPVCELLEGN
Dividend yield – – –
Net buyback yield -8.1% -0.3% -5.2%
Shareholder yield -8.1% -0.3% -5.2%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusCRSPVCELLEGN
Forward P/E – 84.1xFY2026 –
EPS, next fiscal year $-4.10FY2026 $0.51FY2026 $-0.04FY2026
EPS growth, next FY – +59.4%FY2026 –
EPS growth, the year after – +74.5% –
Revenue, next fiscal year $38.73MFY2026 $324.56MFY2026 $1.37BFY2026
Revenue growth, next FY +1,003.4%FY2026 +17.5%FY2026 +32.9%FY2026
Revenue growth, the year after +266.1% +16.1% +35.9%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersCRSPVCELLEGN
Held by institutions 78.9% 100.0% 55.9%
Institutions holding 519 318 218
Change in shares held, QoQ -1.0% +0.4% +7.3%
Institutions buying 238 188 117
Institutions selling 139 98 78
Buyers to sellers 1.71 1.92 1.50

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

CRSPVCELLEGN
CRSP 1.00 0.34 0.05
VCEL 0.34 1.00 0.13
LEGN 0.05 0.13 1.00

Add a Peer

Largest companies in the same industry

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Frequently Asked Questions

Which is bigger, CRSP, VCEL and LEGN?

CRISPR Therapeutics AG (CRSP) is the largest by market capitalisation: CRISPR Therapeutics AG (CRSP) $4.94B, Vericel (VCEL) $2.05B, Legend Biotech (LEGN) $3.98B.

Which company is growing faster?

Legend Biotech (LEGN) grew revenue fastest over the trailing twelve months: CRISPR Therapeutics AG (CRSP) -64.8%, Vericel (VCEL) +23.0%, Legend Biotech (LEGN) +59.5%.

Which company is more profitable?

Vericel (VCEL) has the highest net margin (CRISPR Therapeutics AG (CRSP) -3,368.7%, Vericel (VCEL) 7.9%, Legend Biotech (LEGN) -7.2%). On return on invested capital, Legend Biotech (LEGN) leads (CRISPR Therapeutics AG (CRSP) -22.6%, Legend Biotech (LEGN) -4.2%).

Which stock has performed better?

Over the past year Vericel (VCEL) returned the most: CRISPR Therapeutics AG (CRSP) -13.3%, Vericel (VCEL) +23.0%, Legend Biotech (LEGN) -30.6%. Over five years, Vericel (VCEL) compounded fastest (CRISPR Therapeutics AG (CRSP) -9.9%/yr, Vericel (VCEL) -1.4%/yr, Legend Biotech (LEGN) -15.7%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Vericel (VCEL) has been the steadiest (CRISPR Therapeutics AG (CRSP) 57.3%, Vericel (VCEL) 41.0%, Legend Biotech (LEGN) 72.3%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, CRSP, VCEL and LEGN?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Vericel (VCEL) leads on 5. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.