CRSP vs SRPT vs VCEL Stock Comparison

CRISPR Therapeutics AG, Sarepta Therapeutics and Vericel Prices as of Nov 3, 2026 Peers: Industry group
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CRSP CRISPR Therapeutics AG
$49.99 -9.8% 1M -19.3% 1Y
Market cap
$5.00B
P/E
–
Revenue (TTM)
$25.17M
Div. yield
–
Gene and Cell Therapy Healthcare
1 win
VCEL Vericel Corp
$41.09 +2.3% 1M +11.9% 1Y
Market cap
$2.32B
P/E
95.9x
Revenue (TTM)
$306.30M
Div. yield
–
Gene and Cell Therapy Healthcare
6 wins

Head to Head

10 decided of 12

Vericel leads on 6 of the 12 questions below (Vericel 6, Sarepta Therapeutics 3, CRISPR Therapeutics AG 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionCRSPSRPTVCELLeader
Larger companyMarket capitalisation $5.00B $2.00B $2.32B CRSP
Cheaper on earningsLower P/E, profitable companies only -11.0x -17.1x 95.9x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — 6.4x 80.6x SRPT
Faster revenue growthRevenue growth, trailing twelve months -34.3% -20.4% +23.0% VCEL
More profitableNet margin, trailing twelve months -1,812.1% -5.9% 7.9% VCEL
Better return on capitalReturn on invested capital -23.3% -6.1% — SRPT
Less leveragedLower net debt / EBITDA 3.3x -0.6x — SRPT
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months -19.3% -24.2% +11.9% VCEL
Better 5-year returnAnnualised price return, 5 years -11.7%/yr -26.6%/yr -3.3%/yr VCEL
Less volatileAnnualised volatility, 1 year 57.4% 81.1% 41.3% VCEL
Higher overall scoreMean of the five percentile scores vs peers 48/100 67/100 81/100 VCEL

Percentile Scorecard

CRSPSRPTVCEL

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisCRSPSRPTVCEL
Valuation 52 #305 of 634 96 #24 of 634 82 #113 of 634
Growth 28 #440 of 607 64 #222 of 607 94 #37 of 607
Profitability 37 #350 of 557 80 #114 of 557 89 #65 of 557
Financial Health 70 #199 of 654 34 #434 of 654 68 #208 of 654
Shareholder Returns 52 #194 of 401 61 #156 of 401 72 #115 of 401
Overall 48 67 81
  • CRSP ranked among 671 companies in Pharmaceuticals and Biotechnology
  • SRPT ranked among 671 companies in Pharmaceuticals and Biotechnology
  • VCEL ranked among 671 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodCRSPSRPTVCELSPY
1 month -9.8%+5.9%+2.3% -2.0%
3 months -5.8%+13.1%-11.3% -2.2%
6 months -4.6%-14.9%+11.6% +4.2%
Year to date -4.7%-13.8%+14.1% +10.6%
1 year -19.3%-24.2%+11.9% +10.4%
3 years -2.0%-76.2%+11.5% +73.6%
3 years, per year -0.7%-38.1%+3.7% +20.2%
5 years -46.2%-78.7%-15.6% +61.6%
5 years, per year -11.7%-26.6%-3.3% +10.1%
10 years +226.3%-50.1%+1,856.7% +261.3%
10 years, per year +12.6%-6.7%+34.6% +13.7%

Risk

MeasureCRSPSRPTVCELSPY
Volatility, 1Y 57.4%81.1%41.3% 12.8%
Downside volatility, 1Y 54.4%85.6%41.1% 12.8%
Beta vs S&P 500, 1Y 1.872.080.77 1.00
Return / volatility, 1Y -0.34-0.300.29 0.81
Max drawdown, 5Y -66.8%-92.7%-63.7% -25.4%
From 52-week high -19.3%-24.2%-14.9% -3.2%
52-week high $61.97$24.45$48.31 $779.14
52-week low $44.34$14.86$29.34 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleCRSPSRPTVCEL
P/E now vs peer median -10.6xmedian 18.4x -16.7xmedian 18.4x 86.6xmedian 18.4x
P/S now vs peer median 192.6xmedian 9.0x 1.0xmedian 9.0x 6.9xmedian 9.0x
EV/EBITDA now vs peer median -6.2xmedian 16.0x -20.5xmedian 16.0x 61.8xmedian 16.0x
P/FCF now vs peer median -12.9xmedian 21.8x 23.9xmedian 21.8x 34.1xmedian 21.8x
P/B now vs peer median 2.9xmedian 2.1x 1.3xmedian 2.1x 5.7xmedian 2.1x
PEG now vs peer median 5.48median 0.37 -0.32median 0.37 1.60median 0.37

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsCRSPSRPTVCEL
Revenue $25.17M $1.97B $306.30M
Gross profit – $1.17B $228.38M
Operating income -$532.33M -$143.25M $18.24M
Net income -$456.14M -$136.73M $24.22M
Free cash flow -$376.72M $81.85M $61.66M
R&D $291.14M $789.44M $29.17M
EPS (diluted) $-4.72 $-1.11 $0.46
Cash & equivalents $192.03M $571.15M $125.40M
Total debt $586.93M $847.62M –
Shares (diluted) 96.74M 105.43M 52.31M
Enterprise value -$4.05B -$1.23B $1.74B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricCRSPSRPTVCEL
P/E -10.6x -16.7x 86.6x
P/FCF -12.9x 23.9x 34.1x
P/Operating cash flow -12.9x 17.6x 30.2x
P/S 192.6x 1.0x 6.9x
P/B 2.9x 1.3x 5.7x
P/Tangible book 2.9x 1.3x 5.8x
EV/EBITDA -6.2x -20.5x 61.8x
EV/EBIT -5.9x -14.1x 106.4x
EV/Revenue 125.7x 1.0x 6.3x
EV/FCF -8.4x 24.6x 31.5x
EV/Operating cash flow -8.4x 18.2x 27.8x
PEG (3Y EPS CAGR) 5.48 -0.32 1.60

Growth

14 metrics
MetricCRSPSRPTVCEL
Revenue growth (1Y) -34.3% -20.4% 23.0%
Revenue CAGR (3Y) -47.1% 25.3% 19.8%
Gross profit growth (1Y) – -40.7% 24.8%
Gross profit CAGR (3Y) – 10.6% 23.9%
Operating income growth (1Y) 7.3% -15,270% 1,428%
Operating income CAGR (3Y) -7.9% 34.5% 47.8%
Net income growth (1Y) 6.6% -135.9% 240.8%
Net income CAGR (3Y) -8.9% 46.8% 56.6%
EPS growth (1Y) 11.8% -215.7% 228.1%
EPS CAGR (3Y) -1.9% 52.3% 54.3%
Operating cash flow growth (1Y) -23.8% 136.9% 47.5%
Operating cash flow CAGR (3Y) -10.5% 30.6% 33.7%
Free cash flow growth (1Y) -24.3% 118.1% 842.9%
Free cash flow CAGR (3Y) -8.8% 29.1% 43.2%

Profitability

14 metrics
MetricCRSPSRPTVCEL
Gross margin – 59.1% 74.6%
EBITDA margin -2,038% -5.0% 10.2%
Operating margin -2,115% -7.3% 6.0%
Pretax margin -1,802% -6.6% 8.2%
Net margin -1,812% -5.9% 7.9%
FCF margin -1,497% 4.1% 20.1%
Operating cash flow margin -1,488% 5.6% 22.7%
Return on equity -26.9% -9.0% 6.9%
Return on assets -17.5% -4.3% 5.1%
Return on invested capital -23.3% -6.1% –
Return on capital employed -21.6% -5.3% 4.1%
Asset turnover 0.0x 0.6x 0.6x
Cash conversion (OCF / net income) 0.8x -0.8x 2.9x
Stock comp / revenue 276.8% 6.3% 12.2%

Financial Health

11 metrics
MetricCRSPSRPTVCEL
Debt / assets 23.0% 26.6% –
Debt / equity 0.4x 0.6x –
Net debt / EBITDA 3.3x -0.6x –
Debt / FCF -1.6x 10.4x –
Liabilities / assets 35.5% 52.1% 26.4%
Equity / assets 64.5% 47.9% 73.6%
Interest coverage – – 28.5x
Current ratio 16.2x 4.4x 5.0x
Quick ratio 16.1x 2.4x 4.5x
Cash ratio 16.1x 1.6x 3.1x
Altman Z-score 2.29 -0.17 9.67

Shareholder Returns

7 metrics
MetricCRSPSRPTVCEL
Dividend yield – – –
Net buyback yield -2.8% -1.1% -0.3%
Shareholder yield -2.8% -1.1% -0.3%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusCRSPSRPTVCEL
Forward P/E – 6.4xFY2026 80.6xFY2026
EPS, next fiscal year $-4.10FY2026 $2.88FY2026 $0.51FY2026
EPS growth, next FY – – +59.4%FY2026
EPS growth, the year after – -88.5% +74.5%
Revenue, next fiscal year $38.73MFY2026 $1.76BFY2026 $324.56MFY2026
Revenue growth, next FY +1,003.4%FY2026 -20.1%FY2026 +17.5%FY2026
Revenue growth, the year after +266.1% -21.5% +16.1%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersCRSPSRPTVCEL
Held by institutions 78.9% 100.0% 100.0%
Institutions holding 520 326 319
Change in shares held, QoQ -1.0% +4.5% +0.4%
Institutions buying 238 148 188
Institutions selling 139 117 99
Buyers to sellers 1.71 1.26 1.90

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

CRSPSRPTVCEL
CRSP 1.00 0.36 0.35
SRPT 0.36 1.00 0.20
VCEL 0.35 0.20 1.00

Add a Peer

Largest companies in the same industry

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Frequently Asked Questions

Which is bigger, CRSP, SRPT and VCEL?

CRISPR Therapeutics AG (CRSP) is the largest by market capitalisation: CRISPR Therapeutics AG (CRSP) $5.00B, Sarepta Therapeutics (SRPT) $2.00B, Vericel (VCEL) $2.32B.

Which company is growing faster?

Vericel (VCEL) grew revenue fastest over the trailing twelve months: CRISPR Therapeutics AG (CRSP) -34.3%, Sarepta Therapeutics (SRPT) -20.4%, Vericel (VCEL) +23.0%.

Which company is more profitable?

Vericel (VCEL) has the highest net margin (CRISPR Therapeutics AG (CRSP) -1,812.1%, Sarepta Therapeutics (SRPT) -5.9%, Vericel (VCEL) 7.9%). On return on invested capital, Sarepta Therapeutics (SRPT) leads (CRISPR Therapeutics AG (CRSP) -23.3%, Sarepta Therapeutics (SRPT) -6.1%).

Which stock has performed better?

Over the past year Vericel (VCEL) returned the most: CRISPR Therapeutics AG (CRSP) -19.3%, Sarepta Therapeutics (SRPT) -24.2%, Vericel (VCEL) +11.9%. Over five years, Vericel (VCEL) compounded fastest (CRISPR Therapeutics AG (CRSP) -11.7%/yr, Sarepta Therapeutics (SRPT) -26.6%/yr, Vericel (VCEL) -3.3%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Vericel (VCEL) has been the steadiest (CRISPR Therapeutics AG (CRSP) 57.4%, Sarepta Therapeutics (SRPT) 81.1%, Vericel (VCEL) 41.3%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, CRSP, SRPT and VCEL?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Vericel (VCEL) leads on 6. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.