CRSP vs SLDB vs SLBT Stock Comparison

CRISPR Therapeutics AG, Solid Biosciences and SL Science Holding Prices as of Nov 3, 2026 Peers: Industry group
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CRSP CRISPR Therapeutics AG
$49.99 -9.8% 1M -19.3% 1Y
Market cap
$5.00B
P/E
–
Revenue (TTM)
$25.17M
Div. yield
–
Gene and Cell Therapy Healthcare
4 wins
SLDB Solid Biosciences Inc.
$6.28 -8.3% 1M +20.8% 1Y
Market cap
$931.10M
P/E
–
Revenue (TTM)
—
Div. yield
–
Gene and Cell Therapy Healthcare
1 win

Head to Head

5 decided of 12

CRISPR Therapeutics AG leads on 4 of the 12 questions below (CRISPR Therapeutics AG 4, Solid Biosciences 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionCRSPSLDBSLBTLeader
Larger companyMarket capitalisation $5.00B $931.10M $2.59B CRSP
Cheaper on earningsLower P/E, profitable companies only -11.0x -4.5x — –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — — — –
Faster revenue growthRevenue growth, trailing twelve months -34.3% — — –
More profitableNet margin, trailing twelve months -1,812.1% — — –
Better return on capitalReturn on invested capital -23.3% — — –
Less leveragedLower net debt / EBITDA 3.3x — — –
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months -19.3% +20.8% -88.3% SLDB
Better 5-year returnAnnualised price return, 5 years -11.7%/yr -29.8%/yr — CRSP
Less volatileAnnualised volatility, 1 year 57.4% 78.3% 175.7% CRSP
Higher overall scoreMean of the five percentile scores vs peers 48/100 44/100 — CRSP

Percentile Scorecard

CRSPSLDBSLBT

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisCRSPSLDBSLBT
Valuation 52 #305 of 634 39 #385 of 634 12 #561 of 634
Growth 28 #440 of 607 21 #483 of 607 –
Profitability 37 #350 of 557 51 #275 of 557 –
Financial Health 70 #199 of 654 88 #79 of 654 58 #278 of 654
Shareholder Returns 52 #194 of 401 20 #321 of 401 –
Overall 48 44 –
  • CRSP ranked among 671 companies in Pharmaceuticals and Biotechnology
  • SLDB ranked among 671 companies in Pharmaceuticals and Biotechnology
  • SLBT ranked among 671 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodCRSPSLDBSLBTSPY
1 month -9.8%-8.3%-22.3% -2.0%
3 months -5.8%-27.1%-60.4% -2.2%
6 months -4.6%-9.0%-85.6% +4.2%
Year to date -4.7%+11.3%-88.4% +10.6%
1 year -19.3%+20.8%-88.3% +10.4%
3 years -2.0%+121.1%— +73.6%
3 years, per year -0.7%+30.3%— +20.2%
5 years -46.2%-83.0%— +61.6%
5 years, per year -11.7%-29.8%— +10.1%
10 years +226.3%—— +261.3%
10 years, per year +12.6%—— +13.7%

Risk

MeasureCRSPSLDBSLBTSPY
Volatility, 1Y 57.4%78.3%175.7% 12.8%
Downside volatility, 1Y 54.4%76.2%169.4% 12.8%
Beta vs S&P 500, 1Y 1.872.130.17 1.00
Return / volatility, 1Y -0.340.27-0.50 0.81
Max drawdown, 5Y -66.8%-94.9%-91.0% -25.4%
From 52-week high -19.3%-43.7%-90.5% -3.2%
52-week high $61.97$11.15$12.81 $779.14
52-week low $44.34$3.93$1.15 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleCRSPSLDBSLBT
P/E now vs peer median -10.6xmedian 18.4x -4.4xmedian 18.4x —median 18.4x
P/S now vs peer median 192.6xmedian 9.0x —median 9.0x —median 9.0x
EV/EBITDA now vs peer median -6.2xmedian 16.0x -2.5xmedian 16.0x —median 16.0x
P/FCF now vs peer median -12.9xmedian 21.8x -4.8xmedian 21.8x -1,417xmedian 21.8x
P/B now vs peer median 2.9xmedian 2.1x 2.4xmedian 2.1x 381.5xmedian 2.1x
PEG now vs peer median 5.48median 0.37 -0.14median 0.37 —median 0.37

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsCRSPSLDBSLBT
Revenue $25.17M – –
Operating income -$532.33M -$212.15M –
Net income -$456.14M -$207.10M –
Free cash flow -$376.72M -$187.82M –
R&D $291.14M $167.40M –
EPS (diluted) $-4.72 $-1.44 –
Cash & equivalents $192.03M $159.39M $8.31M
Total debt $586.93M – –
Shares (diluted) 96.74M 143.69M –
Enterprise value -$4.05B -$251.25M $2.58B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricCRSPSLDBSLBT
P/E -10.6x -4.4x –
P/FCF -12.9x -4.8x -1,417x
P/Operating cash flow -12.9x -4.8x –
P/S 192.6x – –
P/B 2.9x 2.4x 381.5x
P/Tangible book 2.9x 2.4x 381.5x
EV/EBITDA -6.2x -2.5x –
EV/EBIT -5.9x -2.5x –
EV/Revenue 125.7x – –
EV/FCF -8.4x -2.8x –
EV/Operating cash flow -8.4x -2.8x –
PEG (3Y EPS CAGR) 5.48 -0.14 –

Growth

14 metrics
MetricCRSPSLDBSLBT
Revenue growth (1Y) -34.3% – –
Revenue CAGR (3Y) -47.1% – –
Gross profit growth (1Y) – – –
Gross profit CAGR (3Y) – – –
Operating income growth (1Y) 7.3% -35.3% –
Operating income CAGR (3Y) -7.9% -22.8% –
Net income growth (1Y) 6.6% -34.4% –
Net income CAGR (3Y) -8.9% -31.9% –
EPS growth (1Y) 11.8% 11.9% –
EPS CAGR (3Y) -1.9% 32.0% –
Operating cash flow growth (1Y) -23.8% -52.4% –
Operating cash flow CAGR (3Y) -10.5% -19.2% –
Free cash flow growth (1Y) -24.3% -52.3% –
Free cash flow CAGR (3Y) -8.8% -18.4% –

Profitability

14 metrics
MetricCRSPSLDBSLBT
Gross margin – – –
EBITDA margin -2,038% – –
Operating margin -2,115% – –
Pretax margin -1,802% – –
Net margin -1,812% – –
FCF margin -1,497% – –
Operating cash flow margin -1,488% – –
Return on equity -26.9% -55.4% –
Return on assets -17.5% -49.1% –
Return on invested capital -23.3% – –
Return on capital employed -21.6% -54.0% –
Asset turnover 0.0x – –
Cash conversion (OCF / net income) 0.8x 0.9x –
Stock comp / revenue 276.8% – –

Financial Health

11 metrics
MetricCRSPSLDBSLBT
Debt / assets 23.0% – –
Debt / equity 0.4x – –
Net debt / EBITDA 3.3x – –
Debt / FCF -1.6x – –
Liabilities / assets 35.5% 11.1% 21.8%
Equity / assets 64.5% 88.9% 78.2%
Interest coverage – – –
Current ratio 16.2x 13.8x 4.4x
Quick ratio 16.1x 13.2x 4.3x
Cash ratio 16.1x 13.2x 4.3x
Altman Z-score 2.29 – –

Shareholder Returns

7 metrics
MetricCRSPSLDBSLBT
Dividend yield – – –
Net buyback yield -2.8% -26.7% –
Shareholder yield -2.8% -26.7% 0.0%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusCRSPSLDBSLBT
EPS, next fiscal year $-4.10FY2026 $-1.63FY2026 –
Revenue, next fiscal year $38.73MFY2026 $0.00FY2026 –
Revenue growth, next FY +1,003.4%FY2026 – –
Revenue growth, the year after +266.1% – –

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersCRSPSLDBSLBT
Held by institutions 78.9% 79.7% –
Institutions holding 520 157 –
Change in shares held, QoQ -1.0% +18.9% –
Institutions buying 238 101 –
Institutions selling 139 37 –
Buyers to sellers 1.71 2.73 –

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

CRSPSLDBSLBT
CRSP 1.00 0.49 -0.04
SLDB 0.49 1.00 -0.02
SLBT -0.04 -0.02 1.00

Add a Peer

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Frequently Asked Questions

Which is bigger, CRSP, SLDB and SLBT?

CRISPR Therapeutics AG (CRSP) is the largest by market capitalisation: CRISPR Therapeutics AG (CRSP) $5.00B, Solid Biosciences (SLDB) $931.10M, SL Science Holding (SLBT) $2.59B.

Which stock has performed better?

Over the past year Solid Biosciences (SLDB) returned the most: CRISPR Therapeutics AG (CRSP) -19.3%, Solid Biosciences (SLDB) +20.8%, SL Science Holding (SLBT) -88.3%. Over five years, CRISPR Therapeutics AG (CRSP) compounded fastest (CRISPR Therapeutics AG (CRSP) -11.7%/yr, Solid Biosciences (SLDB) -29.8%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, CRISPR Therapeutics AG (CRSP) has been the steadiest (CRISPR Therapeutics AG (CRSP) 57.4%, Solid Biosciences (SLDB) 78.3%, SL Science Holding (SLBT) 175.7%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, CRSP, SLDB and SLBT?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, CRISPR Therapeutics AG (CRSP) leads on 4. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.