CRSP vs PGEN vs SRPT Stock Comparison

CRISPR Therapeutics AG, Precigen and Sarepta Therapeutics Prices as of Nov 5, 2026 Peers: Industry group
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CRSP CRISPR Therapeutics AG
$48.56 -10.1% 1M -14.8% 1Y
Market cap
$4.71B
P/E
–
Revenue (TTM)
$25.17M
Div. yield
–
Gene and Cell Therapy Healthcare
2 wins
PGEN Precigen, Inc.
$4.22 -44.1% 1M +5.8% 1Y
Market cap
$1.51B
P/E
61.9x
Revenue (TTM)
$156.94M
Div. yield
–
Gene and Cell Therapy Healthcare
6 wins

Head to Head

10 decided of 12

Precigen leads on 6 of the 12 questions below (Precigen 6, CRISPR Therapeutics AG 2, Sarepta Therapeutics 2). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionCRSPPGENSRPTLeader
Larger companyMarket capitalisation $4.71B $1.51B $1.88B CRSP
Cheaper on earningsLower P/E, profitable companies only -10.3x 61.9x -19.6x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — 24.8x 6.1x SRPT
Faster revenue growthRevenue growth, trailing twelve months -34.3% +2,387.6% -18.9% PGEN
More profitableNet margin, trailing twelve months -1,812.1% 15.6% -4.8% PGEN
Better return on capitalReturn on invested capital -23.3% 21.1% -2.1% PGEN
Less leveragedLower net debt / EBITDA 3.3x 1.2x 1.3x PGEN
Higher dividend yieldTrailing dividend yield — — — –
Better 1-year returnPrice return, last 12 months -14.8% +5.8% -6.0% PGEN
Better 5-year returnAnnualised price return, 5 years -11.7%/yr -3.8%/yr -27.7%/yr PGEN
Less volatileAnnualised volatility, 1 year 57.1% 85.7% 68.7% CRSP
Higher overall scoreMean of the five percentile scores vs peers 47/100 72/100 76/100 SRPT

Percentile Scorecard

CRSPPGENSRPT

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisCRSPPGENSRPT
Valuation 51 #310 of 634 68 #206 of 634 98 #17 of 634
Growth 27 #445 of 608 90 #59 of 608 84 #101 of 608
Profitability 37 #354 of 557 86 #81 of 557 81 #108 of 557
Financial Health 69 #202 of 654 38 #409 of 654 33 #438 of 654
Shareholder Returns 51 #198 of 403 77 #92 of 403 87 #53 of 403
Overall 47 72 76
  • CRSP ranked among 671 companies in Pharmaceuticals and Biotechnology
  • PGEN ranked among 671 companies in Pharmaceuticals and Biotechnology
  • SRPT ranked among 671 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodCRSPPGENSRPTSPY
1 month -10.1%-44.1%+1.4% -5.9%
3 months -6.0%-38.9%+4.6% -4.6%
6 months -7.4%+1.7%-15.6% +0.2%
Year to date -7.4%+1.0%-18.4% +7.5%
1 year -14.8%+5.8%-6.0% +8.2%
3 years -5.9%+263.8%-78.1% +68.3%
3 years, per year -2.0%+53.8%-39.7% +19.0%
5 years -46.2%-17.4%-80.3% +56.5%
5 years, per year -11.7%-3.8%-27.7% +9.4%
10 years +219.5%-83.2%-55.2% +251.5%
10 years, per year +12.3%-16.4%-7.7% +13.4%

Risk

MeasureCRSPPGENSRPTSPY
Volatility, 1Y 57.1%85.7%68.7% 13.6%
Downside volatility, 1Y 53.6%84.2%64.0% 14.2%
Beta vs S&P 500, 1Y 1.781.631.75 1.00
Return / volatility, 1Y -0.260.07-0.09 0.60
Max drawdown, 5Y -66.8%-86.5%-92.7% -25.4%
From 52-week high -21.5%-50.7%-26.4% -5.9%
52-week high $61.89$8.56$23.83 $779.14
52-week low $44.34$3.10$14.86 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleCRSPPGENSRPT
P/E now vs peer median -10.3xmedian 17.8x 61.9xmedian 17.8x -19.6xmedian 17.8x
P/S now vs peer median 187.1xmedian 8.1x 9.6xmedian 8.1x 1.0xmedian 8.1x
EV/EBITDA now vs peer median -5.9xmedian 15.7x 39.6xmedian 15.7x -111.1xmedian 15.7x
P/FCF now vs peer median -12.5xmedian 21.0x -20.4xmedian 21.0x 10.7xmedian 21.0x
P/B now vs peer median 2.9xmedian 2.0x 18.1xmedian 2.0x 1.2xmedian 2.0x
PEG now vs peer median 5.33median 0.36 2.10median 0.36 -0.38median 0.36

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsCRSPPGENSRPT
Revenue $25.17M $156.94M $1.96B
Gross profit – $143.48M $1.11B
Operating income -$532.33M $33.63M -$48.90M
Net income -$456.14M $24.41M -$114.62M
Free cash flow -$376.72M -$74.32M $176.40M
R&D $291.14M $26.54M $653.10M
EPS (diluted) $-4.72 $0.06 $-0.89
Cash & equivalents $192.03M $14.96M $472.80M
Total debt $586.93M $94.26M $857.36M
Shares (diluted) 96.74M 421.16M 105.93M
Enterprise value -$4.34B $1.27B -$1.38B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricCRSPPGENSRPT
P/E -10.3x 61.9x -19.6x
P/FCF -12.5x -20.4x 10.7x
P/Operating cash flow -12.6x -20.7x 10.1x
P/S 187.1x 9.6x 1.0x
P/B 2.9x 18.1x 1.2x
P/Tangible book 2.9x 18.5x 1.3x
EV/EBITDA -5.9x 39.6x -111.1x
EV/EBIT -5.7x 46.4x -38.0x
EV/Revenue 120.2x 9.9x 1.0x
EV/FCF -8.0x -21.0x 10.5x
EV/Operating cash flow -8.1x -21.3x 10.0x
PEG (3Y EPS CAGR) 5.33 2.10 -0.38

Growth

14 metrics
MetricCRSPPGENSRPT
Revenue growth (1Y) -34.3% 2,388% -18.9%
Revenue CAGR (3Y) -47.1% 185.3% 21.0%
Gross profit growth (1Y) – 7,400% -39.6%
Gross profit CAGR (3Y) – 478.3% 4.7%
Operating income growth (1Y) 7.3% 128.7% 61.3%
Operating income CAGR (3Y) -7.9% 33.6% 50.3%
Net income growth (1Y) 6.6% 109.9% 19.4%
Net income CAGR (3Y) -8.9% 31.8% 45.1%
EPS growth (1Y) 11.8% 104.2% 26.5%
EPS CAGR (3Y) -1.9% 29.5% 51.4%
Operating cash flow growth (1Y) -23.8% -0.8% 175.9%
Operating cash flow CAGR (3Y) -10.5% -3.2% 32.8%
Free cash flow growth (1Y) -24.3% 1.7% 146.3%
Free cash flow CAGR (3Y) -8.8% -3.5% 31.9%

Profitability

14 metrics
MetricCRSPPGENSRPT
Gross margin – 91.4% 56.8%
EBITDA margin -2,038% 25.1% -0.9%
Operating margin -2,115% 21.4% -2.5%
Pretax margin -1,802% 15.7% -4.7%
Net margin -1,812% 15.6% -4.8%
FCF margin -1,497% -47.4% 9.0%
Operating cash flow margin -1,488% -46.6% 9.5%
Return on equity -26.9% 38.3% -7.5%
Return on assets -17.5% 12.8% -3.6%
Return on invested capital -23.3% 21.1% -2.1%
Return on capital employed -21.6% 21.0% -1.9%
Asset turnover 0.0x 0.8x 0.6x
Cash conversion (OCF / net income) 0.8x -3.0x -1.6x
Stock comp / revenue 276.8% 8.0% 7.0%

Financial Health

11 metrics
MetricCRSPPGENSRPT
Debt / assets 23.0% 44.4% 27.1%
Debt / equity 0.4x 1.1x 0.6x
Net debt / EBITDA 3.3x 1.2x 1.3x
Debt / FCF -1.6x -1.3x 4.9x
Liabilities / assets 35.5% 60.5% 51.7%
Equity / assets 64.5% 39.5% 48.3%
Interest coverage – 2.8x –
Current ratio 16.2x 5.6x 3.5x
Quick ratio 16.1x 4.6x 2.0x
Cash ratio 16.1x 1.5x 1.3x
Altman Z-score 2.20 -6.00 -0.16

Shareholder Returns

7 metrics
MetricCRSPPGENSRPT
Dividend yield – – –
Net buyback yield -2.9% -0.2% 0.0%
Shareholder yield -2.9% -0.2% 0.0%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusCRSPPGENSRPT
Forward P/E – 24.8xFY2026 6.1xFY2026
EPS, next fiscal year $-4.27FY2026 $0.17FY2026 $2.88FY2026
EPS growth, the year after – +288.2% -88.5%
Revenue, next fiscal year $33.04MFY2026 $249.16MFY2026 $1.76BFY2026
Revenue growth, next FY +841.2%FY2026 +2,474.0%FY2026 -20.1%FY2026
Revenue growth, the year after +271.8% +82.3% -21.5%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersCRSPPGENSRPT
Held by institutions 78.9% 39.2% 100.0%
Institutions holding 520 211 326
Change in shares held, QoQ -1.0% +4.9% +4.5%
Institutions buying 238 123 148
Institutions selling 139 46 117
Buyers to sellers 1.71 2.67 1.26

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

CRSPPGENSRPT
CRSP 1.00 0.34 0.37
PGEN 0.34 1.00 0.21
SRPT 0.37 0.21 1.00

Add a Peer

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Frequently Asked Questions

Which is bigger, CRSP, PGEN and SRPT?

CRISPR Therapeutics AG (CRSP) is the largest by market capitalisation: CRISPR Therapeutics AG (CRSP) $4.71B, Precigen (PGEN) $1.51B, Sarepta Therapeutics (SRPT) $1.88B.

Which company is growing faster?

Precigen (PGEN) grew revenue fastest over the trailing twelve months: CRISPR Therapeutics AG (CRSP) -34.3%, Precigen (PGEN) +2,387.6%, Sarepta Therapeutics (SRPT) -18.9%.

Which company is more profitable?

Precigen (PGEN) has the highest net margin (CRISPR Therapeutics AG (CRSP) -1,812.1%, Precigen (PGEN) 15.6%, Sarepta Therapeutics (SRPT) -4.8%). On return on invested capital, Precigen (PGEN) leads (CRISPR Therapeutics AG (CRSP) -23.3%, Precigen (PGEN) 21.1%, Sarepta Therapeutics (SRPT) -2.1%).

Which stock has performed better?

Over the past year Precigen (PGEN) returned the most: CRISPR Therapeutics AG (CRSP) -14.8%, Precigen (PGEN) +5.8%, Sarepta Therapeutics (SRPT) -6.0%. Over five years, Precigen (PGEN) compounded fastest (CRISPR Therapeutics AG (CRSP) -11.7%/yr, Precigen (PGEN) -3.8%/yr, Sarepta Therapeutics (SRPT) -27.7%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, CRISPR Therapeutics AG (CRSP) has been the steadiest (CRISPR Therapeutics AG (CRSP) 57.1%, Precigen (PGEN) 85.7%, Sarepta Therapeutics (SRPT) 68.7%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, CRSP, PGEN and SRPT?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Precigen (PGEN) leads on 6. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.