CRSP vs NTLA Stock Comparison

CRISPR Therapeutics AG and Intellia Therapeutics Prices as of Oct 27, 2026 Peers: Industry group
CRSP CRISPR Therapeutics AG
$51.47 -5.1% 1M -21.7% 1Y
Market cap
$5.13B
P/E
–
Revenue (TTM)
$13.39M
Div. yield
–
Gene and Cell Therapy Healthcare
3 wins

Head to Head

7 decided of 12

Intellia Therapeutics leads on 4 of the 12 questions below (Intellia Therapeutics 4, CRISPR Therapeutics AG 3). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionCRSPNTLALeader
Larger companyMarket capitalisation $5.13B $1.74B CRSP
Cheaper on earningsLower P/E, profitable companies only -11.4x -4.4x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — — –
Faster revenue growthRevenue growth, trailing twelve months -64.8% +12.6% NTLA
More profitableNet margin, trailing twelve months -3,368.7% -672.2% NTLA
Better return on capitalReturn on invested capital -22.6% — –
Less leveragedLower net debt / EBITDA 3.4x — –
Higher dividend yieldTrailing dividend yield 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months -21.7% -17.0% NTLA
Better 5-year returnAnnualised price return, 5 years -11.4%/yr -38.2%/yr CRSP
Less volatileAnnualised volatility, 1 year 57.2% 79.8% CRSP
Higher overall scoreMean of the five percentile scores vs peers 44/100 49/100 NTLA

Percentile Scorecard

CRSPNTLA

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisCRSPNTLA
Valuation 49 #322 of 625 34 #415 of 625
Growth 32 #411 of 602 63 #221 of 602
Profitability 32 #375 of 551 39 #338 of 551
Financial Health 71 #190 of 656 72 #186 of 656
Shareholder Returns 38 #228 of 365 39 #223 of 365
Overall 44 49
  • CRSP ranked among 672 companies in Pharmaceuticals and Biotechnology
  • NTLA ranked among 672 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodCRSPNTLASPY
1 month -5.1%+4.5% -0.2%
3 months +8.2%+12.8% +3.9%
6 months -1.1%-7.0% +8.2%
Year to date -1.8%+36.6% +12.9%
1 year -21.7%-17.0% +12.3%
3 years +32.9%-47.0% +87.4%
3 years, per year +9.9%-19.1% +23.3%
5 years -45.2%-91.0% +67.9%
5 years, per year -11.4%-38.2% +10.9%
10 years +225.3%-4.8% +261.1%
10 years, per year +12.5%-0.5% +13.7%

Risk

MeasureCRSPNTLASPY
Volatility, 1Y 57.2%79.8% 12.7%
Downside volatility, 1Y 53.7%82.3% 12.7%
Beta vs S&P 500, 1Y 1.832.44 1.00
Return / volatility, 1Y -0.38-0.21 0.97
Max drawdown, 5Y -67.7%-95.5% -25.4%
From 52-week high -21.7%-31.2% -1.2%
52-week high $65.72$17.84 $779.14
52-week low $44.34$8.04 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleCRSPNTLA
P/E now vs peer median -11.0xmedian 17.2x -4.1xmedian 17.2x
P/S now vs peer median 371.5xmedian 9.0x 28.9xmedian 9.0x
EV/EBITDA now vs peer median -6.2xmedian 16.3x -3.1xmedian 16.3x
P/FCF now vs peer median -13.4xmedian 18.7x -4.9xmedian 18.7x
P/B now vs peer median 2.8xmedian 2.2x 2.4xmedian 2.2x
PEG now vs peer median -2.86median 0.33 -0.25median 0.33

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsCRSPNTLA
Revenue $13.39M $59.51M
Operating income -$534.34M -$423.48M
Net income -$451.14M -$399.98M
Free cash flow -$371.33M -$348.69M
R&D $278.15M $346.73M
EPS (diluted) $-4.67 $-3.00
Cash & equivalents $291.34M $106.13M
Total debt $586.20M –
Shares (diluted) 96.51M 133.48M
Enterprise value -$3.57B -$31.04M

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricCRSPNTLA
P/E -11.0x -4.1x
P/FCF -13.4x -4.9x
P/Operating cash flow -13.5x -5.0x
P/S 371.5x 28.9x
P/B 2.8x 2.4x
P/Tangible book 2.8x 2.4x
EV/EBITDA -6.2x -3.1x
EV/EBIT -6.0x -3.0x
EV/Revenue 238.7x 21.5x
EV/FCF -8.6x -3.7x
EV/Operating cash flow -8.7x -3.7x
PEG (3Y EPS CAGR) -2.86 -0.25

Growth

14 metrics
MetricCRSPNTLA
Revenue growth (1Y) -64.8% 12.6%
Revenue CAGR (3Y) -57.1% 3.9%
Gross profit growth (1Y) – –
Gross profit CAGR (3Y) – –
Operating income growth (1Y) 3.3% 17.3%
Operating income CAGR (3Y) -4.1% 2.7%
Net income growth (1Y) 3.6% 16.7%
Net income CAGR (3Y) -2.7% 4.1%
EPS growth (1Y) 13.0% 35.3%
EPS CAGR (3Y) 3.9% 16.5%
Operating cash flow growth (1Y) -13.8% 17.2%
Operating cash flow CAGR (3Y) -2.5% 2.0%
Free cash flow growth (1Y) -14.1% 17.3%
Free cash flow CAGR (3Y) -0.9% 3.2%

Profitability

14 metrics
MetricCRSPNTLA
Gross margin – –
EBITDA margin -3,850% -696.4%
Operating margin -3,990% -711.7%
Pretax margin -3,346% -671.0%
Net margin -3,369% -672.2%
FCF margin -2,773% -586.0%
Operating cash flow margin -2,760% -582.5%
Return on equity -25.3% -59.2%
Return on assets -16.8% -49.4%
Return on invested capital -22.6% –
Return on capital employed -20.9% -58.1%
Asset turnover 0.0x 0.1x
Cash conversion (OCF / net income) 0.8x 0.9x
Stock comp / revenue 510.2% 114.1%

Financial Health

11 metrics
MetricCRSPNTLA
Debt / assets 22.1% –
Debt / equity 0.3x –
Net debt / EBITDA 3.4x –
Debt / FCF -1.6x –
Liabilities / assets 34.1% 15.1%
Equity / assets 65.9% 84.9%
Interest coverage – –
Current ratio 17.8x 6.6x
Quick ratio 17.8x 5.6x
Cash ratio 17.8x 5.5x
Altman Z-score 2.51 2.47

Shareholder Returns

7 metrics
MetricCRSPNTLA
Dividend yield – –
Net buyback yield -8.6% -7.7%
Shareholder yield -8.6% -7.7%
Payout ratio (earnings) – –
Payout ratio (FCF) – –
Dividend growth (1Y) – –
Dividend CAGR (3Y) – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusCRSPNTLA
EPS, next fiscal year $-4.10FY2026 $-3.38FY2026
Revenue, next fiscal year $38.73MFY2026 $48.94MFY2026
Revenue growth, next FY +1,003.4%FY2026 -27.7%FY2026
Revenue growth, the year after +266.1% +158.6%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersCRSPNTLA
Held by institutions 78.9% 100.0%
Institutions holding 518 329
Change in shares held, QoQ -1.0% +30.5%
Institutions buying 237 195
Institutions selling 139 78
Buyers to sellers 1.71 2.50

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

CRSPNTLA
CRSP 1.00 0.69
NTLA 0.69 1.00

Add a Peer

Largest companies in the same industry

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Frequently Asked Questions

Which is bigger, CRSP and NTLA?

CRISPR Therapeutics AG (CRSP) is the largest by market capitalisation: CRISPR Therapeutics AG (CRSP) $5.13B, Intellia Therapeutics (NTLA) $1.74B.

Which company is growing faster?

Intellia Therapeutics (NTLA) grew revenue fastest over the trailing twelve months: CRISPR Therapeutics AG (CRSP) -64.8%, Intellia Therapeutics (NTLA) +12.6%.

Which company is more profitable?

Intellia Therapeutics (NTLA) has the highest net margin (CRISPR Therapeutics AG (CRSP) -3,368.7%, Intellia Therapeutics (NTLA) -672.2%).

Which stock has performed better?

Over the past year Intellia Therapeutics (NTLA) returned the most: CRISPR Therapeutics AG (CRSP) -21.7%, Intellia Therapeutics (NTLA) -17.0%. Over five years, CRISPR Therapeutics AG (CRSP) compounded fastest (CRISPR Therapeutics AG (CRSP) -11.4%/yr, Intellia Therapeutics (NTLA) -38.2%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, CRISPR Therapeutics AG (CRSP) has been the steadiest (CRISPR Therapeutics AG (CRSP) 57.2%, Intellia Therapeutics (NTLA) 79.8%). Volatility measures how widely the price swings, not the risk of the business.

Do CRSP and NTLA move together?

Their daily returns over the past year have a correlation of 0.69, a moderate positive relationship. Holding both diversifies more than two closely linked stocks would.

Which is the better stock, CRSP and NTLA?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Intellia Therapeutics (NTLA) leads on 4. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.