CRSP vs NGNE Stock Comparison

CRISPR Therapeutics AG and Neurogene Prices as of Oct 27, 2026 Peers: Industry group
CRSP CRISPR Therapeutics AG
$51.47 -5.1% 1M -21.7% 1Y
Market cap
$4.98B
P/E
–
Revenue (TTM)
$13.39M
Div. yield
–
Gene and Cell Therapy Healthcare
3 wins
NGNE Neurogene Inc.
$26.99 -4.7% 1M -15.8% 1Y
Market cap
$608.68M
P/E
–
Revenue (TTM)
—
Div. yield
–
Gene and Cell Therapy Healthcare
2 wins

Head to Head

5 decided of 12

CRISPR Therapeutics AG leads on 3 of the 12 questions below (CRISPR Therapeutics AG 3, Neurogene 2). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionCRSPNGNELeader
Larger companyMarket capitalisation $4.98B $608.68M CRSP
Cheaper on earningsLower P/E, profitable companies only -11.0x -5.5x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — — –
Faster revenue growthRevenue growth, trailing twelve months -64.8% — –
More profitableNet margin, trailing twelve months -3,368.7% — –
Better return on capitalReturn on invested capital -22.6% — –
Less leveragedLower net debt / EBITDA 3.4x — –
Higher dividend yieldTrailing dividend yield — — –
Better 1-year returnPrice return, last 12 months -21.7% -15.8% NGNE
Better 5-year returnAnnualised price return, 5 years -11.4%/yr -27.8%/yr CRSP
Less volatileAnnualised volatility, 1 year 57.2% 78.1% CRSP
Higher overall scoreMean of the five percentile scores vs peers 44/100 47/100 NGNE

Percentile Scorecard

CRSPNGNE

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisCRSPNGNE
Valuation 49 #322 of 625 47 #331 of 625
Growth 32 #411 of 602 22 #473 of 602
Profitability 32 #375 of 551 54 #256 of 551
Financial Health 71 #190 of 656 72 #185 of 656
Shareholder Returns 38 #228 of 365 41 #216 of 365
Overall 44 47
  • CRSP ranked among 672 companies in Pharmaceuticals and Biotechnology
  • NGNE ranked among 672 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodCRSPNGNESPY
1 month -5.1%-4.7% -0.2%
3 months +8.2%-18.8% +3.9%
6 months -1.1%-1.7% +8.2%
Year to date -1.8%+31.0% +12.9%
1 year -21.7%-15.8% +12.3%
3 years +32.9%+92.8% +87.4%
3 years, per year +9.9%+24.5% +23.3%
5 years -45.2%-80.3% +67.9%
5 years, per year -11.4%-27.8% +10.9%
10 years +225.3%-87.4% +261.1%
10 years, per year +12.5%-18.7% +13.7%

Risk

MeasureCRSPNGNESPY
Volatility, 1Y 57.2%78.1% 12.7%
Downside volatility, 1Y 53.7%76.4% 12.7%
Beta vs S&P 500, 1Y 1.831.56 1.00
Return / volatility, 1Y -0.38-0.20 0.97
Max drawdown, 5Y -67.7%-95.3% -25.4%
From 52-week high -21.7%-37.0% -1.2%
52-week high $65.72$42.84 $779.14
52-week low $44.34$16.37 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleCRSPNGNE
P/E now vs peer median -11.0xmedian 17.2x -5.5xmedian 17.2x
P/S now vs peer median 371.5xmedian 9.0x —median 9.0x
EV/EBITDA now vs peer median -6.2xmedian 16.3x -3.2xmedian 16.3x
P/FCF now vs peer median -13.4xmedian 18.7x -6.9xmedian 18.7x
P/B now vs peer median 2.8xmedian 2.2x 2.8xmedian 2.2x
PEG now vs peer median -2.86median 0.33 -0.16median 0.33

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsCRSPNGNE
Revenue $13.39M –
Operating income -$534.34M -$121.35M
Net income -$451.14M -$111.16M
Free cash flow -$371.33M -$87.75M
R&D $278.15M $88.50M
EPS (diluted) $-4.67 $-4.93
Cash & equivalents $291.34M $112.49M
Total debt $586.20M –
Shares (diluted) 96.51M 22.55M
Enterprise value -$3.72B -$394.32M

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricCRSPNGNE
P/E -11.0x -5.5x
P/FCF -13.4x -6.9x
P/Operating cash flow -13.5x -7.0x
P/S 371.5x –
P/B 2.8x 2.8x
P/Tangible book 2.8x 2.8x
EV/EBITDA -6.2x -3.2x
EV/EBIT -6.0x -3.2x
EV/Revenue 238.7x –
EV/FCF -8.6x -4.4x
EV/Operating cash flow -8.7x -4.4x
PEG (3Y EPS CAGR) -2.86 -0.16

Growth

14 metrics
MetricCRSPNGNE
Revenue growth (1Y) -64.8% –
Revenue CAGR (3Y) -57.1% –
Gross profit growth (1Y) – –
Gross profit CAGR (3Y) – –
Operating income growth (1Y) 3.3% -26.8%
Operating income CAGR (3Y) -4.1% -33.6%
Net income growth (1Y) 3.6% -31.7%
Net income CAGR (3Y) -2.7% -32.0%
EPS growth (1Y) 13.0% -23.0%
EPS CAGR (3Y) 3.9% 34.1%
Operating cash flow growth (1Y) -13.8% -18.5%
Operating cash flow CAGR (3Y) -2.5% -19.9%
Free cash flow growth (1Y) -14.1% -17.8%
Free cash flow CAGR (3Y) -0.9% -19.1%

Profitability

14 metrics
MetricCRSPNGNE
Gross margin – –
EBITDA margin -3,850% –
Operating margin -3,990% –
Pretax margin -3,346% –
Net margin -3,369% –
FCF margin -2,773% –
Operating cash flow margin -2,760% –
Return on equity -25.3% -49.1%
Return on assets -16.8% -44.0%
Return on invested capital -22.6% –
Return on capital employed -20.9% -52.2%
Asset turnover 0.0x –
Cash conversion (OCF / net income) 0.8x 0.8x
Stock comp / revenue 510.2% –

Financial Health

11 metrics
MetricCRSPNGNE
Debt / assets 22.1% –
Debt / equity 0.3x –
Net debt / EBITDA 3.4x –
Debt / FCF -1.6x –
Liabilities / assets 34.1% 11.1%
Equity / assets 65.9% 88.9%
Interest coverage – -60,673x
Current ratio 17.8x 10.6x
Quick ratio 17.8x 10.5x
Cash ratio 17.8x 10.5x
Altman Z-score 2.51 –

Shareholder Returns

7 metrics
MetricCRSPNGNE
Dividend yield – –
Net buyback yield -8.6% -6.1%
Shareholder yield -8.6% -6.1%
Payout ratio (earnings) – –
Payout ratio (FCF) – –
Dividend growth (1Y) – –
Dividend CAGR (3Y) – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusCRSPNGNE
EPS, next fiscal year $-4.10FY2026 $-5.76FY2026
Revenue, next fiscal year $38.73MFY2026 $0.00FY2026
Revenue growth, next FY +1,003.4%FY2026 –
Revenue growth, the year after +266.1% –

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersCRSPNGNE
Held by institutions 78.9% 76.8%
Institutions holding 518 113
Change in shares held, QoQ -1.0% +2.0%
Institutions buying 237 61
Institutions selling 139 31
Buyers to sellers 1.71 1.97

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

CRSPNGNE
CRSP 1.00 0.32
NGNE 0.32 1.00

Add a Peer

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Frequently Asked Questions

Which is bigger, CRSP and NGNE?

CRISPR Therapeutics AG (CRSP) is the largest by market capitalisation: CRISPR Therapeutics AG (CRSP) $4.98B, Neurogene (NGNE) $608.68M.

Which stock has performed better?

Over the past year Neurogene (NGNE) returned the most: CRISPR Therapeutics AG (CRSP) -21.7%, Neurogene (NGNE) -15.8%. Over five years, CRISPR Therapeutics AG (CRSP) compounded fastest (CRISPR Therapeutics AG (CRSP) -11.4%/yr, Neurogene (NGNE) -27.8%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, CRISPR Therapeutics AG (CRSP) has been the steadiest (CRISPR Therapeutics AG (CRSP) 57.2%, Neurogene (NGNE) 78.1%). Volatility measures how widely the price swings, not the risk of the business.

Do CRSP and NGNE move together?

Their daily returns over the past year have a correlation of 0.32, a weak relationship. Holding both diversifies more than two closely linked stocks would.

Which is the better stock, CRSP and NGNE?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, CRISPR Therapeutics AG (CRSP) leads on 3. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.