CRSP vs MESO vs BEAM Stock Comparison

CRISPR Therapeutics AG, Mesoblast and Beam Therapeutics Prices as of Oct 26, 2026 Peers: Industry group
CRSP CRISPR Therapeutics AG
$49.01 -9.6% 1M -27.5% 1Y
Market cap
$4.97B
P/E
–
Revenue (TTM)
$13.39M
Div. yield
–
Gene and Cell Therapy Healthcare
1 win
MESO Mesoblast Ltd
$12.39 -18.1% 1M -26.3% 1Y
Market cap
$1.71B
P/E
–
Revenue (TTM)
—
Div. yield
–
Gene and Cell Therapy Healthcare
2 wins
BEAM Beam Therapeutics Inc.
$23.79 -2.0% 1M -14.9% 1Y
Market cap
$2.60B
P/E
–
Revenue (TTM)
$156.04M
Div. yield
–
Gene and Cell Therapy Healthcare
5 wins

Head to Head

8 decided of 12

Beam Therapeutics leads on 5 of the 12 questions below (Beam Therapeutics 5, Mesoblast 2, CRISPR Therapeutics AG 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionCRSPMESOBEAMLeader
Larger companyMarket capitalisation $4.97B $1.71B $2.60B CRSP
Cheaper on earningsLower P/E, profitable companies only -11.0x -27.9x -30.4x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — — — –
Faster revenue growthRevenue growth, trailing twelve months -64.8% — +158.9% BEAM
More profitableNet margin, trailing twelve months -3,368.7% — -54.7% BEAM
Better return on capitalReturn on invested capital -22.6% — — –
Less leveragedLower net debt / EBITDA 3.4x — 3.0x BEAM
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months -27.5% -26.3% -14.9% BEAM
Better 5-year returnAnnualised price return, 5 years -12.0%/yr +0.4%/yr -23.7%/yr MESO
Less volatileAnnualised volatility, 1 year 57.1% 54.6% 69.2% MESO
Higher overall scoreMean of the five percentile scores vs peers 44/100 — 69/100 BEAM

Percentile Scorecard

CRSPMESOBEAM

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisCRSPMESOBEAM
Valuation 48 #327 of 626 71 #183 of 626 55 #284 of 626
Growth 32 #414 of 604 – 77 #138 of 604
Profitability 32 #379 of 555 – 64 #200 of 555
Financial Health 71 #191 of 658 44 #366 of 658 81 #127 of 658
Shareholder Returns 38 #230 of 368 – 66 #125 of 368
Overall 44 – 69
  • CRSP ranked among 673 companies in Pharmaceuticals and Biotechnology
  • MESO ranked among 673 companies in Pharmaceuticals and Biotechnology
  • BEAM ranked among 673 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodCRSPMESOBEAMSPY
1 month -9.6%-18.1%-2.0% -0.8%
3 months +4.9%-14.9%-5.1% +3.5%
6 months -3.9%-19.2%-18.4% +7.0%
Year to date -6.5%-31.3%-14.2% +12.2%
1 year -27.5%-26.3%-14.9% +13.0%
3 years +26.5%+429.5%+27.8% +86.3%
3 years, per year +8.2%+74.4%+8.5% +23.1%
5 years -47.2%+2.2%-74.1% +68.6%
5 years, per year -12.0%+0.4%-23.7% +11.0%
10 years +231.1%+52.6%— +258.0%
10 years, per year +12.7%+4.3%— +13.6%

Risk

MeasureCRSPMESOBEAMSPY
Volatility, 1Y 57.1%54.6%69.2% 12.7%
Downside volatility, 1Y 53.7%54.9%63.8% 12.7%
Beta vs S&P 500, 1Y 1.821.502.05 1.00
Return / volatility, 1Y -0.48-0.48-0.22 1.02
Max drawdown, 5Y -67.7%-87.9%-85.3% -25.4%
From 52-week high -25.4%-40.9%-37.3% -1.8%
52-week high $65.72$20.96$37.92 $779.14
52-week low $44.34$11.95$20.60 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleCRSPMESOBEAM
P/E now vs peer median -10.5xmedian 17.1x -27.9xmedian 17.1x -29.1xmedian 17.1x
P/S now vs peer median 353.7xmedian 8.8x 13.3xmedian 8.8x 15.7xmedian 8.8x
EV/EBITDA now vs peer median -5.7xmedian 17.1x —median 17.1x -3.9xmedian 17.1x
P/FCF now vs peer median -12.8xmedian 18.0x -35.9xmedian 18.0x -6.6xmedian 18.0x
P/B now vs peer median 2.7xmedian 2.1x 2.8xmedian 2.1x 2.3xmedian 2.1x
PEG now vs peer median -2.72median 0.31 —median 0.31 -0.69median 0.31

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsCRSPMESOBEAM
Revenue $13.39M – $156.04M
Operating income -$534.34M – -$378.02M
Net income -$451.14M – -$86.52M
Free cash flow -$371.33M – -$372.77M
R&D $278.15M – $408.66M
EPS (diluted) $-4.67 – $-0.82
Cash & equivalents $291.34M $102.91M $219.83M
Total debt $586.20M $119.24M $100.26M
Shares (diluted) 96.51M 129.49M 104.33M
Enterprise value -$3.73B $1.27B -$2.08B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricCRSPMESOBEAM
P/E -10.5x -27.9x -29.1x
P/FCF -12.8x -35.9x -6.6x
P/Operating cash flow -12.8x – -6.8x
P/S 353.7x 13.3x 15.7x
P/B 2.7x 2.8x 2.3x
P/Tangible book 2.7x 2.8x 2.3x
EV/EBITDA -5.7x – -3.9x
EV/EBIT -5.5x – -3.7x
EV/Revenue 221.0x – 9.0x
EV/FCF -8.0x – -3.8x
EV/Operating cash flow -8.0x – -3.9x
PEG (3Y EPS CAGR) -2.72 – -0.69

Growth

14 metrics
MetricCRSPMESOBEAM
Revenue growth (1Y) -64.8% – 158.9%
Revenue CAGR (3Y) -57.1% – 24.9%
Gross profit growth (1Y) – – –
Gross profit CAGR (3Y) – – –
Operating income growth (1Y) 3.3% – 15.2%
Operating income CAGR (3Y) -4.1% – 0.3%
Net income growth (1Y) 3.6% – 78.2%
Net income CAGR (3Y) -2.7% – 35.8%
EPS growth (1Y) 13.0% – 79.0%
EPS CAGR (3Y) 3.9% – 42.4%
Operating cash flow growth (1Y) -13.8% – -4.2%
Operating cash flow CAGR (3Y) -2.5% – -2.0%
Free cash flow growth (1Y) -14.1% – -4.8%
Free cash flow CAGR (3Y) -0.9% – 0.7%

Profitability

14 metrics
MetricCRSPMESOBEAM
Gross margin – – –
EBITDA margin -3,850% – -228.0%
Operating margin -3,990% – -242.3%
Pretax margin -3,346% – -54.4%
Net margin -3,369% – -54.7%
FCF margin -2,773% – -238.9%
Operating cash flow margin -2,760% – -230.3%
Return on equity -25.3% – -7.6%
Return on assets -16.8% – -5.9%
Return on invested capital -22.6% – –
Return on capital employed -20.9% – -27.9%
Asset turnover 0.0x – 0.1x
Cash conversion (OCF / net income) 0.8x – 4.2x
Stock comp / revenue 510.2% – 52.2%

Financial Health

11 metrics
MetricCRSPMESOBEAM
Debt / assets 22.1% 15.4% 7.2%
Debt / equity 0.3x 0.2x 0.1x
Net debt / EBITDA 3.4x – 3.0x
Debt / FCF -1.6x – -0.3x
Liabilities / assets 34.1% 26.5% 23.0%
Equity / assets 65.9% 73.5% 77.0%
Interest coverage – – –
Current ratio 17.8x 2.4x 14.6x
Quick ratio 17.8x 2.0x 14.3x
Cash ratio 17.8x 1.3x 14.3x
Altman Z-score 2.36 – 2.87

Shareholder Returns

7 metrics
MetricCRSPMESOBEAM
Dividend yield – – –
Net buyback yield -9.0% – -0.6%
Shareholder yield -9.0% – -0.6%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusCRSPMESOBEAM
EPS, next fiscal year $-4.10FY2026 $-0.15FY2027 $-4.22FY2026
Revenue, next fiscal year $38.73MFY2026 $188.99MFY2027 $49.46MFY2026
Revenue growth, next FY +1,003.4%FY2026 +57.2%FY2027 -64.6%FY2026
Revenue growth, the year after +266.1% +110.3% +23.6%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersCRSPMESOBEAM
Held by institutions 78.9% 3.0% 100.0%
Institutions holding 518 73 277
Change in shares held, QoQ -1.0% +17.7% +1.0%
Institutions buying 237 34 154
Institutions selling 139 20 75
Buyers to sellers 1.71 1.70 2.05

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

CRSPMESOBEAM
CRSP 1.00 0.22 0.76
MESO 0.22 1.00 0.13
BEAM 0.76 0.13 1.00

Add a Peer

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Frequently Asked Questions

Which is bigger, CRSP, MESO and BEAM?

CRISPR Therapeutics AG (CRSP) is the largest by market capitalisation: CRISPR Therapeutics AG (CRSP) $4.97B, Mesoblast (MESO) $1.71B, Beam Therapeutics (BEAM) $2.60B.

Which company is growing faster?

Beam Therapeutics (BEAM) grew revenue fastest over the trailing twelve months: CRISPR Therapeutics AG (CRSP) -64.8%, Beam Therapeutics (BEAM) +158.9%.

Which company is more profitable?

Beam Therapeutics (BEAM) has the highest net margin (CRISPR Therapeutics AG (CRSP) -3,368.7%, Beam Therapeutics (BEAM) -54.7%).

Which stock has performed better?

Over the past year Beam Therapeutics (BEAM) returned the most: CRISPR Therapeutics AG (CRSP) -27.5%, Mesoblast (MESO) -26.3%, Beam Therapeutics (BEAM) -14.9%. Over five years, Mesoblast (MESO) compounded fastest (CRISPR Therapeutics AG (CRSP) -12.0%/yr, Mesoblast (MESO) +0.4%/yr, Beam Therapeutics (BEAM) -23.7%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Mesoblast (MESO) has been the steadiest (CRISPR Therapeutics AG (CRSP) 57.1%, Mesoblast (MESO) 54.6%, Beam Therapeutics (BEAM) 69.2%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, CRSP, MESO and BEAM?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Beam Therapeutics (BEAM) leads on 5. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.