CRSP vs LEGN vs BEAM Stock Comparison

CRISPR Therapeutics AG, Legend Biotech and Beam Therapeutics Prices as of Nov 3, 2026 Peers: Industry group
1 more company in this comparison (MESO) Create a free account to keep reading and compare up to 10 companies.
CRSP CRISPR Therapeutics AG
$49.99 -9.8% 1M -19.3% 1Y
Market cap
$5.00B
P/E
–
Revenue (TTM)
$25.17M
Div. yield
–
Gene and Cell Therapy Healthcare
3 wins
LEGN Legend Biotech Corp
$21.48 +15.7% 1M -33.1% 1Y
Market cap
$4.23B
P/E
–
Revenue (TTM)
$1.27B
Div. yield
–
Gene and Cell Therapy Healthcare
4 wins
BEAM Beam Therapeutics Inc.
$26.33 +7.5% 1M +8.6% 1Y
Market cap
$2.88B
P/E
–
Revenue (TTM)
$156.04M
Div. yield
–
Gene and Cell Therapy Healthcare
2 wins

Head to Head

9 decided of 12

Legend Biotech leads on 4 of the 12 questions below (Legend Biotech 4, CRISPR Therapeutics AG 3, Beam Therapeutics 2). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionCRSPLEGNBEAMLeader
Larger companyMarket capitalisation $5.00B $4.23B $2.88B CRSP
Cheaper on earningsLower P/E, profitable companies only -11.0x -46.2x -33.7x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — — — –
Faster revenue growthRevenue growth, trailing twelve months -34.3% +59.5% +158.9% BEAM
More profitableNet margin, trailing twelve months -1,812.1% -7.2% -54.7% LEGN
Better return on capitalReturn on invested capital -23.3% -4.2% — LEGN
Less leveragedLower net debt / EBITDA 3.3x -130.2x 3.0x LEGN
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months -19.3% -33.1% +8.6% BEAM
Better 5-year returnAnnualised price return, 5 years -11.7%/yr -15.1%/yr -22.4%/yr CRSP
Less volatileAnnualised volatility, 1 year 57.4% 72.4% 70.5% CRSP
Higher overall scoreMean of the five percentile scores vs peers 48/100 74/100 69/100 LEGN

Percentile Scorecard

CRSPLEGNBEAM

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisCRSPLEGNBEAM
Valuation 52 #305 of 634 88 #75 of 634 56 #277 of 634
Growth 28 #440 of 607 97 #20 of 607 78 #137 of 607
Profitability 37 #350 of 557 80 #112 of 557 65 #196 of 557
Financial Health 70 #199 of 654 60 #262 of 654 81 #127 of 654
Shareholder Returns 52 #194 of 401 44 #227 of 401 67 #135 of 401
Overall 48 74 69
  • CRSP ranked among 671 companies in Pharmaceuticals and Biotechnology
  • LEGN ranked among 671 companies in Pharmaceuticals and Biotechnology
  • BEAM ranked among 671 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodCRSPLEGNBEAMSPY
1 month -9.8%+15.7%+7.5% -2.0%
3 months -5.8%+12.3%-7.1% -2.2%
6 months -4.6%-24.7%-8.9% +4.2%
Year to date -4.7%-1.2%-5.0% +10.6%
1 year -19.3%-33.1%+8.6% +10.4%
3 years -2.0%-67.4%+7.5% +73.6%
3 years, per year -0.7%-31.2%+2.4% +20.2%
5 years -46.2%-55.9%-71.8% +61.6%
5 years, per year -11.7%-15.1%-22.4% +10.1%
10 years +226.3%—— +261.3%
10 years, per year +12.6%—— +13.7%

Risk

MeasureCRSPLEGNBEAMSPY
Volatility, 1Y 57.4%72.4%70.5% 12.8%
Downside volatility, 1Y 54.4%62.7%64.1% 12.8%
Beta vs S&P 500, 1Y 1.870.482.11 1.00
Return / volatility, 1Y -0.34-0.460.12 0.81
Max drawdown, 5Y -66.8%-78.2%-85.3% -25.4%
From 52-week high -19.3%-40.8%-30.6% -3.2%
52-week high $61.97$36.28$37.92 $779.14
52-week low $44.34$16.65$20.60 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleCRSPLEGNBEAM
P/E now vs peer median -10.6xmedian 18.4x -43.2xmedian 18.4x -32.2xmedian 18.4x
P/S now vs peer median 192.6xmedian 9.0x 3.1xmedian 9.0x 17.4xmedian 9.0x
EV/EBITDA now vs peer median -6.2xmedian 16.0x 867.8xmedian 16.0x -4.7xmedian 16.0x
P/FCF now vs peer median -12.9xmedian 21.8x -61.3xmedian 21.8x -7.3xmedian 21.8x
P/B now vs peer median 2.9xmedian 2.1x 3.2xmedian 2.1x 2.5xmedian 2.1x
PEG now vs peer median 5.48median 0.37 -0.92median 0.37 -0.76median 0.37

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsCRSPLEGNBEAM
Revenue $25.17M $1.27B $156.04M
Gross profit – $727.10M –
Operating income -$532.33M -$55.25M -$378.02M
Net income -$456.14M -$80.39M -$86.52M
Free cash flow -$376.72M -$64.60M -$372.77M
R&D $291.14M $396.15M $408.66M
EPS (diluted) $-4.72 $-0.50 $-0.82
Cash & equivalents $192.03M $672.90M $219.83M
Total debt $586.93M $156.40M $100.26M
Shares (diluted) 96.74M 184.32M 104.33M
Enterprise value -$4.05B $1.73B -$1.81B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricCRSPLEGNBEAM
P/E -10.6x -43.2x -32.2x
P/FCF -12.9x -61.3x -7.3x
P/Operating cash flow -12.9x -44.3x -7.6x
P/S 192.6x 3.1x 17.4x
P/B 2.9x 3.2x 2.5x
P/Tangible book 2.9x 3.2x 2.5x
EV/EBITDA -6.2x 867.8x -4.7x
EV/EBIT -5.9x -62.3x -4.4x
EV/Revenue 125.7x 2.7x 10.7x
EV/FCF -8.4x -53.3x -4.5x
EV/Operating cash flow -8.4x -38.5x -4.6x
PEG (3Y EPS CAGR) 5.48 -0.92 -0.76

Growth

14 metrics
MetricCRSPLEGNBEAM
Revenue growth (1Y) -34.3% 59.5% 158.9%
Revenue CAGR (3Y) -47.1% 97.6% 24.9%
Gross profit growth (1Y) – 42.4% –
Gross profit CAGR (3Y) – 147.5% –
Operating income growth (1Y) 7.3% 75.3% 15.2%
Operating income CAGR (3Y) -7.9% 49.1% 0.3%
Net income growth (1Y) 6.6% 75.3% 78.2%
Net income CAGR (3Y) -8.9% 46.7% 35.8%
EPS growth (1Y) 11.8% 72.0% 79.0%
EPS CAGR (3Y) -1.9% 47.0% 42.4%
Operating cash flow growth (1Y) -23.8% 67.5% -4.2%
Operating cash flow CAGR (3Y) -10.5% 37.1% -2.0%
Free cash flow growth (1Y) -24.3% 77.8% -4.8%
Free cash flow CAGR (3Y) -8.8% 44.5% 0.7%

Profitability

14 metrics
MetricCRSPLEGNBEAM
Gross margin – 57.2% –
EBITDA margin -2,038% 0.3% -228.0%
Operating margin -2,115% -4.3% -242.3%
Pretax margin -1,802% -4.4% -54.4%
Net margin -1,812% -7.2% -54.7%
FCF margin -1,497% -5.1% -238.9%
Operating cash flow margin -1,488% -7.0% -230.3%
Return on equity -26.9% -8.3% -7.6%
Return on assets -17.5% -5.5% -5.9%
Return on invested capital -23.3% -4.2% –
Return on capital employed -21.6% -4.3% -27.9%
Asset turnover 0.0x 0.8x 0.1x
Cash conversion (OCF / net income) 0.8x 1.1x 4.2x
Stock comp / revenue 276.8% 5.2% 52.2%

Financial Health

11 metrics
MetricCRSPLEGNBEAM
Debt / assets 23.0% 8.9% 7.2%
Debt / equity 0.4x 0.1x 0.1x
Net debt / EBITDA 3.3x -130.2x 3.0x
Debt / FCF -1.6x -2.4x -0.3x
Liabilities / assets 35.5% 29.8% 23.0%
Equity / assets 64.5% 70.2% 77.0%
Interest coverage – -4.8x –
Current ratio 16.2x 3.0x 14.6x
Quick ratio 16.1x 1.7x 14.3x
Cash ratio 16.1x 1.7x 14.3x
Altman Z-score 2.29 6.73 3.36

Shareholder Returns

7 metrics
MetricCRSPLEGNBEAM
Dividend yield – – –
Net buyback yield -2.8% -5.4% -0.5%
Shareholder yield -2.8% -5.4% -0.5%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusCRSPLEGNBEAM
EPS, next fiscal year $-4.10FY2026 $-0.04FY2026 $-4.22FY2026
Revenue, next fiscal year $38.73MFY2026 $1.37BFY2026 $49.46MFY2026
Revenue growth, next FY +1,003.4%FY2026 +32.9%FY2026 -64.6%FY2026
Revenue growth, the year after +266.1% +35.9% +23.6%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersCRSPLEGNBEAM
Held by institutions 78.9% 55.9% 100.0%
Institutions holding 520 218 277
Change in shares held, QoQ -1.0% +7.3% +1.0%
Institutions buying 238 117 154
Institutions selling 139 78 75
Buyers to sellers 1.71 1.50 2.05

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

CRSPLEGNBEAM
CRSP 1.00 0.06 0.76
LEGN 0.06 1.00 0.10
BEAM 0.76 0.10 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, CRSP, LEGN and BEAM?

CRISPR Therapeutics AG (CRSP) is the largest by market capitalisation: CRISPR Therapeutics AG (CRSP) $5.00B, Legend Biotech (LEGN) $4.23B, Beam Therapeutics (BEAM) $2.88B.

Which company is growing faster?

Beam Therapeutics (BEAM) grew revenue fastest over the trailing twelve months: CRISPR Therapeutics AG (CRSP) -34.3%, Legend Biotech (LEGN) +59.5%, Beam Therapeutics (BEAM) +158.9%.

Which company is more profitable?

Legend Biotech (LEGN) has the highest net margin (CRISPR Therapeutics AG (CRSP) -1,812.1%, Legend Biotech (LEGN) -7.2%, Beam Therapeutics (BEAM) -54.7%). On return on invested capital, Legend Biotech (LEGN) leads (CRISPR Therapeutics AG (CRSP) -23.3%, Legend Biotech (LEGN) -4.2%).

Which stock has performed better?

Over the past year Beam Therapeutics (BEAM) returned the most: CRISPR Therapeutics AG (CRSP) -19.3%, Legend Biotech (LEGN) -33.1%, Beam Therapeutics (BEAM) +8.6%. Over five years, CRISPR Therapeutics AG (CRSP) compounded fastest (CRISPR Therapeutics AG (CRSP) -11.7%/yr, Legend Biotech (LEGN) -15.1%/yr, Beam Therapeutics (BEAM) -22.4%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, CRISPR Therapeutics AG (CRSP) has been the steadiest (CRISPR Therapeutics AG (CRSP) 57.4%, Legend Biotech (LEGN) 72.4%, Beam Therapeutics (BEAM) 70.5%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, CRSP, LEGN and BEAM?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Legend Biotech (LEGN) leads on 4. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.