CRSP vs IMMX vs PGEN Stock Comparison

CRISPR Therapeutics AG, Immix Biopharma and Precigen Prices as of Oct 27, 2026 Peers: Industry group
CRSP CRISPR Therapeutics AG
$51.47 -5.1% 1M -21.7% 1Y
Market cap
$5.16B
P/E
–
Revenue (TTM)
$13.39M
Div. yield
–
Gene and Cell Therapy Healthcare
2 wins
IMMX Immix Biopharma, Inc.
$8.05 -26.6% 1M +137.5% 1Y
Market cap
$513.36M
P/E
–
Revenue (TTM)
—
Div. yield
–
Gene and Cell Therapy Healthcare
1 win
PGEN Precigen, Inc.
$6.15 -20.6% 1M +43.0% 1Y
Market cap
$2.18B
P/E
–
Revenue (TTM)
$85.72M
Div. yield
–
Gene and Cell Therapy Healthcare
5 wins

Head to Head

8 decided of 12

Precigen leads on 5 of the 12 questions below (Precigen 5, CRISPR Therapeutics AG 2, Immix Biopharma 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionCRSPIMMXPGENLeader
Larger companyMarket capitalisation $5.16B $513.36M $2.18B CRSP
Cheaper on earningsLower P/E, profitable companies only -11.4x -12.9x -6.5x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — — 36.2x –
Faster revenue growthRevenue growth, trailing twelve months -64.8% — +1,875.0% PGEN
More profitableNet margin, trailing twelve months -3,368.7% — -392.8% PGEN
Better return on capitalReturn on invested capital -22.6% — — –
Less leveragedLower net debt / EBITDA 3.4x — -1.6x PGEN
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months -21.7% +137.5% +43.0% IMMX
Better 5-year returnAnnualised price return, 5 years -11.4%/yr — +4.4%/yr PGEN
Less volatileAnnualised volatility, 1 year 57.2% 83.9% 77.9% CRSP
Higher overall scoreMean of the five percentile scores vs peers 44/100 53/100 55/100 PGEN

Percentile Scorecard

CRSPIMMXPGEN

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisCRSPIMMXPGEN
Valuation 49 #322 of 625 73 #169 of 625 59 #258 of 625
Growth 32 #411 of 602 6 #569 of 602 49 #310 of 602
Profitability 32 #375 of 551 79 #118 of 551 59 #227 of 551
Financial Health 71 #190 of 656 97 #18 of 656 27 #482 of 656
Shareholder Returns 38 #228 of 365 10 #329 of 365 83 #63 of 365
Overall 44 53 55
  • CRSP ranked among 672 companies in Pharmaceuticals and Biotechnology
  • IMMX ranked among 672 companies in Pharmaceuticals and Biotechnology
  • PGEN ranked among 672 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodCRSPIMMXPGENSPY
1 month -5.1%-26.6%-20.6% -0.2%
3 months +8.2%-4.6%+11.2% +3.9%
6 months -1.1%-6.4%+53.0% +8.2%
Year to date -1.8%+53.9%+47.1% +12.9%
1 year -21.7%+137.5%+43.0% +12.3%
3 years +32.9%+137.5%+508.9% +87.4%
3 years, per year +9.9%+33.4%+82.7% +23.3%
5 years -45.2%—+24.0% +67.9%
5 years, per year -11.4%—+4.4% +10.9%
10 years +225.3%—-76.2% +261.1%
10 years, per year +12.5%—-13.4% +13.7%

Risk

MeasureCRSPIMMXPGENSPY
Volatility, 1Y 57.2%83.9%77.9% 12.7%
Downside volatility, 1Y 53.7%76.3%69.4% 12.7%
Beta vs S&P 500, 1Y 1.831.591.43 1.00
Return / volatility, 1Y -0.381.640.55 0.97
Max drawdown, 5Y -67.7%-88.9%-87.8% -25.4%
From 52-week high -21.7%-44.4%-28.2% -1.2%
52-week high $65.72$14.47$8.56 $779.14
52-week low $44.34$3.03$3.10 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleCRSPIMMXPGEN
P/E now vs peer median -11.0xmedian 17.2x -12.9xmedian 17.2x -6.5xmedian 17.2x
P/S now vs peer median 371.5xmedian 9.0x —median 9.0x 25.7xmedian 9.0x
EV/EBITDA now vs peer median -6.2xmedian 16.3x -8.3xmedian 16.3x -65.8xmedian 16.3x
P/FCF now vs peer median -13.4xmedian 18.7x -14.7xmedian 18.7x -19.1xmedian 18.7x
P/B now vs peer median 2.8xmedian 2.2x 2.5xmedian 2.2x 50.5xmedian 2.2x
PEG now vs peer median -2.86median 0.33 -2.08median 0.33 0.05median 0.33

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsCRSPIMMXPGEN
Revenue $13.39M – $85.72M
Gross profit – – $77.72M
Operating income -$534.34M -$41.82M -$39.50M
Net income -$451.14M -$39.88M -$157.71M
Free cash flow -$371.33M -$39.09M -$115.22M
R&D $278.15M $21.62M $32.29M
EPS (diluted) $-4.67 $-0.63 $-0.81
Cash & equivalents $291.34M $225.49M $16.33M
Total debt $586.20M – $93.88M
Shares (diluted) 96.51M 63.77M 413.69M
Enterprise value -$3.54B $281.26M $1.87B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricCRSPIMMXPGEN
P/E -11.0x -12.9x -6.5x
P/FCF -13.4x -14.7x -19.1x
P/Operating cash flow -13.5x -15.0x -19.3x
P/S 371.5x – 25.7x
P/B 2.8x 2.5x 50.5x
P/Tangible book 2.8x 2.5x 53.7x
EV/EBITDA -6.2x -8.3x -65.8x
EV/EBIT -6.0x -8.2x -57.2x
EV/Revenue 238.7x – 26.3x
EV/FCF -8.6x -8.8x -19.6x
EV/Operating cash flow -8.7x -8.9x -19.8x
PEG (3Y EPS CAGR) -2.86 -2.08 0.05

Growth

14 metrics
MetricCRSPIMMXPGEN
Revenue growth (1Y) -64.8% – 1,875%
Revenue CAGR (3Y) -57.1% – 57.1%
Gross profit growth (1Y) – – 259,173%
Gross profit CAGR (3Y) – – 69.2%
Operating income growth (1Y) 3.3% -75.8% 62.1%
Operating income CAGR (3Y) -4.1% -53.5% 18.9%
Net income growth (1Y) 3.6% -72.4% -26.7%
Net income CAGR (3Y) -2.7% -51.7% -108.9%
EPS growth (1Y) 13.0% 18.9% -93.8%
EPS CAGR (3Y) 3.9% 6.2% -123.2%
Operating cash flow growth (1Y) -13.8% -207.8% -72.3%
Operating cash flow CAGR (3Y) -2.5% -51.9% -15.9%
Free cash flow growth (1Y) -14.1% -190.0% -65.1%
Free cash flow CAGR (3Y) -0.9% -52.7% -15.3%

Profitability

14 metrics
MetricCRSPIMMXPGEN
Gross margin – – 90.7%
EBITDA margin -3,850% – -40.0%
Operating margin -3,990% – -46.1%
Pretax margin -3,346% – -184.0%
Net margin -3,369% – -392.8%
FCF margin -2,773% – -134.4%
Operating cash flow margin -2,760% – -133.2%
Return on equity -25.3% -25.5% -494.3%
Return on assets -16.8% -23.8% -102.1%
Return on invested capital -22.6% – –
Return on capital employed -20.9% -26.4% -31.6%
Asset turnover 0.0x – 0.6x
Cash conversion (OCF / net income) 0.8x 1.0x 0.7x
Stock comp / revenue 510.2% – 15.3%

Financial Health

11 metrics
MetricCRSPIMMXPGEN
Debt / assets 22.1% – 55.1%
Debt / equity 0.3x – 2.2x
Net debt / EBITDA 3.4x – -1.6x
Debt / FCF -1.6x – -0.8x
Liabilities / assets 34.1% 4.3% 74.4%
Equity / assets 65.9% 95.7% 25.6%
Interest coverage – – -4.1x
Current ratio 17.8x 25.1x 4.6x
Quick ratio 17.8x 25.0x 3.8x
Cash ratio 17.8x 25.0x 1.3x
Altman Z-score 2.51 – -8.25

Shareholder Returns

7 metrics
MetricCRSPIMMXPGEN
Dividend yield – – –
Net buyback yield -8.6% -43.2% -0.1%
Shareholder yield -8.6% -43.2% -0.1%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusCRSPIMMXPGEN
Forward P/E – – 36.2xFY2026
EPS, next fiscal year $-4.10FY2026 $-0.70FY2026 $0.17FY2026
EPS growth, the year after – – +288.2%
Revenue, next fiscal year $38.73MFY2026 $0.00FY2026 $249.17MFY2026
Revenue growth, next FY +1,003.4%FY2026 – +2,474.1%FY2026
Revenue growth, the year after +266.1% – +82.3%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersCRSPIMMXPGEN
Held by institutions 78.9% 78.6% 39.2%
Institutions holding 518 110 210
Change in shares held, QoQ -1.0% +107.6% +4.9%
Institutions buying 237 81 123
Institutions selling 139 13 46
Buyers to sellers 1.71 6.23 2.67

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

CRSPIMMXPGEN
CRSP 1.00 0.32 0.37
IMMX 0.32 1.00 0.27
PGEN 0.37 0.27 1.00

Add a Peer

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Frequently Asked Questions

Which is bigger, CRSP, IMMX and PGEN?

CRISPR Therapeutics AG (CRSP) is the largest by market capitalisation: CRISPR Therapeutics AG (CRSP) $5.16B, Immix Biopharma (IMMX) $513.36M, Precigen (PGEN) $2.18B.

Which company is growing faster?

Precigen (PGEN) grew revenue fastest over the trailing twelve months: CRISPR Therapeutics AG (CRSP) -64.8%, Precigen (PGEN) +1,875.0%.

Which company is more profitable?

Precigen (PGEN) has the highest net margin (CRISPR Therapeutics AG (CRSP) -3,368.7%, Precigen (PGEN) -392.8%).

Which stock has performed better?

Over the past year Immix Biopharma (IMMX) returned the most: CRISPR Therapeutics AG (CRSP) -21.7%, Immix Biopharma (IMMX) +137.5%, Precigen (PGEN) +43.0%. Over five years, Precigen (PGEN) compounded fastest (CRISPR Therapeutics AG (CRSP) -11.4%/yr, Precigen (PGEN) +4.4%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, CRISPR Therapeutics AG (CRSP) has been the steadiest (CRISPR Therapeutics AG (CRSP) 57.2%, Immix Biopharma (IMMX) 83.9%, Precigen (PGEN) 77.9%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, CRSP, IMMX and PGEN?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Precigen (PGEN) leads on 5. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.