CRSP vs BEAM vs PGEN Stock Comparison

CRISPR Therapeutics AG, Beam Therapeutics and Precigen Prices as of Oct 27, 2026 Peers: Industry group
CRSP CRISPR Therapeutics AG
$51.47 -5.1% 1M -21.7% 1Y
Market cap
$4.98B
P/E
–
Revenue (TTM)
$13.39M
Div. yield
–
Gene and Cell Therapy Healthcare
2 wins
BEAM Beam Therapeutics Inc.
$24.90 +2.6% 1M -6.8% 1Y
Market cap
$2.57B
P/E
–
Revenue (TTM)
$156.04M
Div. yield
–
Gene and Cell Therapy Healthcare
2 wins
PGEN Precigen, Inc.
$6.15 -20.6% 1M +43.0% 1Y
Market cap
$2.20B
P/E
–
Revenue (TTM)
$85.72M
Div. yield
–
Gene and Cell Therapy Healthcare
4 wins

Head to Head

8 decided of 12

Precigen leads on 4 of the 12 questions below (Precigen 4, CRISPR Therapeutics AG 2, Beam Therapeutics 2). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionCRSPBEAMPGENLeader
Larger companyMarket capitalisation $4.98B $2.57B $2.20B CRSP
Cheaper on earningsLower P/E, profitable companies only -11.0x -30.4x -6.5x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — — 36.2x –
Faster revenue growthRevenue growth, trailing twelve months -64.8% +158.9% +1,875.0% PGEN
More profitableNet margin, trailing twelve months -3,368.7% -54.7% -392.8% BEAM
Better return on capitalReturn on invested capital -22.6% — — –
Less leveragedLower net debt / EBITDA 3.4x 3.0x -1.6x PGEN
Higher dividend yieldTrailing dividend yield — 0.00% — –
Better 1-year returnPrice return, last 12 months -21.7% -6.8% +43.0% PGEN
Better 5-year returnAnnualised price return, 5 years -11.4%/yr -23.4%/yr +4.4%/yr PGEN
Less volatileAnnualised volatility, 1 year 57.2% 69.2% 77.9% CRSP
Higher overall scoreMean of the five percentile scores vs peers 44/100 69/100 55/100 BEAM

Percentile Scorecard

CRSPBEAMPGEN

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisCRSPBEAMPGEN
Valuation 49 #322 of 625 54 #286 of 625 59 #258 of 625
Growth 32 #411 of 602 77 #137 of 602 49 #310 of 602
Profitability 32 #375 of 551 64 #198 of 551 59 #227 of 551
Financial Health 71 #190 of 656 81 #128 of 656 27 #482 of 656
Shareholder Returns 38 #228 of 365 67 #123 of 365 83 #63 of 365
Overall 44 69 55
  • CRSP ranked among 672 companies in Pharmaceuticals and Biotechnology
  • BEAM ranked among 672 companies in Pharmaceuticals and Biotechnology
  • PGEN ranked among 672 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodCRSPBEAMPGENSPY
1 month -5.1%+2.6%-20.6% -0.2%
3 months +8.2%-5.3%+11.2% +3.9%
6 months -1.1%-18.5%+53.0% +8.2%
Year to date -1.8%-10.2%+47.1% +12.9%
1 year -21.7%-6.8%+43.0% +12.3%
3 years +32.9%+33.7%+508.9% +87.4%
3 years, per year +9.9%+10.2%+82.7% +23.3%
5 years -45.2%-73.6%+24.0% +67.9%
5 years, per year -11.4%-23.4%+4.4% +10.9%
10 years +225.3%—-76.2% +261.1%
10 years, per year +12.5%—-13.4% +13.7%

Risk

MeasureCRSPBEAMPGENSPY
Volatility, 1Y 57.2%69.2%77.9% 12.7%
Downside volatility, 1Y 53.7%63.8%69.4% 12.7%
Beta vs S&P 500, 1Y 1.832.061.43 1.00
Return / volatility, 1Y -0.38-0.100.55 0.97
Max drawdown, 5Y -67.7%-85.3%-87.8% -25.4%
From 52-week high -21.7%-34.3%-28.2% -1.2%
52-week high $65.72$37.92$8.56 $779.14
52-week low $44.34$20.60$3.10 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleCRSPBEAMPGEN
P/E now vs peer median -11.0xmedian 17.2x -30.4xmedian 17.2x -6.5xmedian 17.2x
P/S now vs peer median 371.5xmedian 9.0x 16.5xmedian 9.0x 25.7xmedian 9.0x
EV/EBITDA now vs peer median -6.2xmedian 16.3x -4.3xmedian 16.3x -65.8xmedian 16.3x
P/FCF now vs peer median -13.4xmedian 18.7x -6.9xmedian 18.7x -19.1xmedian 18.7x
P/B now vs peer median 2.8xmedian 2.2x 2.4xmedian 2.2x 50.5xmedian 2.2x
PEG now vs peer median -2.86median 0.33 -0.72median 0.33 0.05median 0.33

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsCRSPBEAMPGEN
Revenue $13.39M $156.04M $85.72M
Gross profit – – $77.72M
Operating income -$534.34M -$378.02M -$39.50M
Net income -$451.14M -$86.52M -$157.71M
Free cash flow -$371.33M -$372.77M -$115.22M
R&D $278.15M $408.66M $32.29M
EPS (diluted) $-4.67 $-0.82 $-0.81
Cash & equivalents $291.34M $219.83M $16.33M
Total debt $586.20M $100.26M $93.88M
Shares (diluted) 96.51M 104.33M 413.69M
Enterprise value -$3.72B -$2.11B $1.89B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricCRSPBEAMPGEN
P/E -11.0x -30.4x -6.5x
P/FCF -13.4x -6.9x -19.1x
P/Operating cash flow -13.5x -7.2x -19.3x
P/S 371.5x 16.5x 25.7x
P/B 2.8x 2.4x 50.5x
P/Tangible book 2.8x 2.4x 53.7x
EV/EBITDA -6.2x -4.3x -65.8x
EV/EBIT -6.0x -4.0x -57.2x
EV/Revenue 238.7x 9.7x 26.3x
EV/FCF -8.6x -4.1x -19.6x
EV/Operating cash flow -8.7x -4.2x -19.8x
PEG (3Y EPS CAGR) -2.86 -0.72 0.05

Growth

14 metrics
MetricCRSPBEAMPGEN
Revenue growth (1Y) -64.8% 158.9% 1,875%
Revenue CAGR (3Y) -57.1% 24.9% 57.1%
Gross profit growth (1Y) – – 259,173%
Gross profit CAGR (3Y) – – 69.2%
Operating income growth (1Y) 3.3% 15.2% 62.1%
Operating income CAGR (3Y) -4.1% 0.3% 18.9%
Net income growth (1Y) 3.6% 78.2% -26.7%
Net income CAGR (3Y) -2.7% 35.8% -108.9%
EPS growth (1Y) 13.0% 79.0% -93.8%
EPS CAGR (3Y) 3.9% 42.4% -123.2%
Operating cash flow growth (1Y) -13.8% -4.2% -72.3%
Operating cash flow CAGR (3Y) -2.5% -2.0% -15.9%
Free cash flow growth (1Y) -14.1% -4.8% -65.1%
Free cash flow CAGR (3Y) -0.9% 0.7% -15.3%

Profitability

14 metrics
MetricCRSPBEAMPGEN
Gross margin – – 90.7%
EBITDA margin -3,850% -228.0% -40.0%
Operating margin -3,990% -242.3% -46.1%
Pretax margin -3,346% -54.4% -184.0%
Net margin -3,369% -54.7% -392.8%
FCF margin -2,773% -238.9% -134.4%
Operating cash flow margin -2,760% -230.3% -133.2%
Return on equity -25.3% -7.6% -494.3%
Return on assets -16.8% -5.9% -102.1%
Return on invested capital -22.6% – –
Return on capital employed -20.9% -27.9% -31.6%
Asset turnover 0.0x 0.1x 0.6x
Cash conversion (OCF / net income) 0.8x 4.2x 0.7x
Stock comp / revenue 510.2% 52.2% 15.3%

Financial Health

11 metrics
MetricCRSPBEAMPGEN
Debt / assets 22.1% 7.2% 55.1%
Debt / equity 0.3x 0.1x 2.2x
Net debt / EBITDA 3.4x 3.0x -1.6x
Debt / FCF -1.6x -0.3x -0.8x
Liabilities / assets 34.1% 23.0% 74.4%
Equity / assets 65.9% 77.0% 25.6%
Interest coverage – – -4.1x
Current ratio 17.8x 14.6x 4.6x
Quick ratio 17.8x 14.3x 3.8x
Cash ratio 17.8x 14.3x 1.3x
Altman Z-score 2.51 3.08 -8.25

Shareholder Returns

7 metrics
MetricCRSPBEAMPGEN
Dividend yield – – –
Net buyback yield -8.6% -0.6% -0.1%
Shareholder yield -8.6% -0.6% -0.1%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusCRSPBEAMPGEN
Forward P/E – – 36.2xFY2026
EPS, next fiscal year $-4.10FY2026 $-4.22FY2026 $0.17FY2026
EPS growth, the year after – – +288.2%
Revenue, next fiscal year $38.73MFY2026 $49.46MFY2026 $249.17MFY2026
Revenue growth, next FY +1,003.4%FY2026 -64.6%FY2026 +2,474.1%FY2026
Revenue growth, the year after +266.1% +23.6% +82.3%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersCRSPBEAMPGEN
Held by institutions 78.9% 100.0% 39.2%
Institutions holding 518 277 210
Change in shares held, QoQ -1.0% +1.0% +4.9%
Institutions buying 237 154 123
Institutions selling 139 75 46
Buyers to sellers 1.71 2.05 2.67

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

CRSPBEAMPGEN
CRSP 1.00 0.76 0.37
BEAM 0.76 1.00 0.26
PGEN 0.37 0.26 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, CRSP, BEAM and PGEN?

CRISPR Therapeutics AG (CRSP) is the largest by market capitalisation: CRISPR Therapeutics AG (CRSP) $4.98B, Beam Therapeutics (BEAM) $2.57B, Precigen (PGEN) $2.20B.

Which company is growing faster?

Precigen (PGEN) grew revenue fastest over the trailing twelve months: CRISPR Therapeutics AG (CRSP) -64.8%, Beam Therapeutics (BEAM) +158.9%, Precigen (PGEN) +1,875.0%.

Which company is more profitable?

Beam Therapeutics (BEAM) has the highest net margin (CRISPR Therapeutics AG (CRSP) -3,368.7%, Beam Therapeutics (BEAM) -54.7%, Precigen (PGEN) -392.8%).

Which stock has performed better?

Over the past year Precigen (PGEN) returned the most: CRISPR Therapeutics AG (CRSP) -21.7%, Beam Therapeutics (BEAM) -6.8%, Precigen (PGEN) +43.0%. Over five years, Precigen (PGEN) compounded fastest (CRISPR Therapeutics AG (CRSP) -11.4%/yr, Beam Therapeutics (BEAM) -23.4%/yr, Precigen (PGEN) +4.4%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, CRISPR Therapeutics AG (CRSP) has been the steadiest (CRISPR Therapeutics AG (CRSP) 57.2%, Beam Therapeutics (BEAM) 69.2%, Precigen (PGEN) 77.9%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, CRSP, BEAM and PGEN?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Precigen (PGEN) leads on 4. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.