CRL vs MEDP vs DNA Stock Comparison

Charles River Laboratories International, Medpace Holdings and Ginkgo Bioworks Holdings Prices as of Nov 3, 2026 Peers: Industry group
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MEDP Medpace Holdings, Inc.
$663.49 +10.7% 1M +11.7% 1Y
Market cap
$18.33B
P/E
35.4x
Revenue (TTM)
$2.84B
Div. yield
–
Contract Research Healthcare
6 wins

Head to Head

8 decided of 12

Medpace Holdings leads on 6 of the 12 questions below (Medpace Holdings 6, Charles River Laboratories International 2). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionCRLMEDPDNALeader
Larger companyMarket capitalisation $15.79B $18.33B $729.92M MEDP
Cheaper on earningsLower P/E, profitable companies only -66.2x 35.4x -2.5x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS 32.3x 37.3x — CRL
Faster revenue growthRevenue growth, trailing twelve months -0.7% +20.4% -46.8% MEDP
More profitableNet margin, trailing twelve months -6.0% 18.2% -260.0% MEDP
Better return on capitalReturn on invested capital 1.6% — — –
Less leveragedLower net debt / EBITDA 6.3x — — –
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months +96.7% +11.7% -15.8% CRL
Better 5-year returnAnnualised price return, 5 years -1.5%/yr +23.9%/yr -54.9%/yr MEDP
Less volatileAnnualised volatility, 1 year 46.5% 45.8% 104.5% MEDP
Higher overall scoreMean of the five percentile scores vs peers 48/100 78/100 43/100 MEDP

Percentile Scorecard

CRLMEDPDNA

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisCRLMEDPDNA
Valuation 70 #4 of 11 60 #5 of 11 10 #10 of 11
Growth 10 #10 of 11 100 #1 of 11 50 #6 of 11
Profitability 70 #4 of 11 100 #1 of 11 10 #10 of 11
Financial Health 42 #8 of 13 50 #7 of 13 100 #1 of 13
Shareholder Returns – – –
Overall 48 78 43
  • CRL ranked among 13 companies in Pharma Services
  • MEDP ranked among 13 companies in Pharma Services
  • DNA ranked among 13 companies in Pharma Services

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodCRLMEDPDNASPY
1 month +21.3%+10.7%-12.7% -2.0%
3 months +50.0%+15.4%+14.8% -2.2%
6 months +89.8%+54.2%+10.9% +4.2%
Year to date +76.4%+18.1%+29.6% +10.6%
1 year +96.7%+11.7%-15.8% +10.4%
3 years +93.4%+142.0%-83.6% +73.6%
3 years, per year +24.6%+34.3%-45.3% +20.2%
5 years -7.2%+191.7%-98.1% +61.6%
5 years, per year -1.5%+23.9%-54.9% +10.1%
10 years +422.1%+2,182.4%— +261.3%
10 years, per year +18.0%+36.7%— +13.7%

Risk

MeasureCRLMEDPDNASPY
Volatility, 1Y 46.5%45.8%104.5% 12.8%
Downside volatility, 1Y 43.9%54.0%106.4% 12.8%
Beta vs S&P 500, 1Y 1.340.723.21 1.00
Return / volatility, 1Y 2.080.26-0.15 0.81
Max drawdown, 5Y -74.7%-42.9%-99.1% -25.4%
From 52-week high -6.4%-4.2%-28.1% -3.2%
52-week high $375.83$692.68$14.98 $779.14
52-week low $149.93$393.42$5.48 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleCRLMEDPDNA
P/E now vs peer median -70.9xmedian 35.6x 35.8xmedian 35.6x -2.3xmedian 35.6x
P/S now vs peer median 4.2xmedian 2.5x 6.5xmedian 2.5x 6.1xmedian 2.5x
EV/EBITDA now vs peer median 49.5xmedian 29.7x 28.1xmedian 29.7x -2.5xmedian 29.7x
P/FCF now vs peer median 45.3xmedian 20.8x 27.8xmedian 20.8x -3.9xmedian 20.8x
P/B now vs peer median 5.9xmedian 2.8x 31.7xmedian 2.8x 1.6xmedian 2.8x
PEG now vs peer median 1.96median 1.97 1.26median 1.97 0.02median 1.97

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsCRLMEDPDNA
Revenue $4.00B $2.84B $111.86M
Gross profit $1.31B $827.16M $92.92M
Operating income $90.14M $607.14M -$290.69M
Net income -$239.23M $517.83M -$290.80M
Free cash flow $370.61M $667.63M -$174.80M
R&D – – $215.61M
EPS (diluted) $-4.97 $18.25 $-5.24
Cash & equivalents $192.03M $705.32M $84.54M
Total debt $2.62B – –
Shares (diluted) 48.02M 28.37M 55.46M
Enterprise value $14.99B $15.97B -$32.16M

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricCRLMEDPDNA
P/E -70.9x 35.8x -2.3x
P/FCF 45.3x 27.8x -3.9x
P/Operating cash flow 28.8x 25.7x -4.0x
P/S 4.2x 6.5x 6.1x
P/B 5.9x 31.7x 1.6x
P/Tangible book 6.5x 33.6x 1.8x
EV/EBITDA 49.5x 28.1x -2.5x
EV/EBIT 213.2x 29.4x -2.1x
EV/Revenue 4.8x 6.3x 5.4x
EV/FCF 51.9x 26.7x -3.4x
EV/Operating cash flow 33.0x 24.7x -3.5x
PEG (3Y EPS CAGR) 1.96 1.26 0.02

Growth

14 metrics
MetricCRLMEDPDNA
Revenue growth (1Y) -0.7% 20.4% -46.8%
Revenue CAGR (3Y) -1.5% 16.8% -30.0%
Gross profit growth (1Y) -0.1% 12.8% -49.3%
Gross profit CAGR (3Y) -5.5% 18.0% -28.2%
Operating income growth (1Y) -27.6% 19.7% 2.4%
Operating income CAGR (3Y) -48.2% 23.0% 39.1%
Net income growth (1Y) -268.7% 19.6% 7.7%
Net income CAGR (3Y) -35.5% 23.8% 38.0%
EPS growth (1Y) -253.8% 21.5% 8.7%
EPS CAGR (3Y) -36.2% 28.5% -102.3%
Operating cash flow growth (1Y) -26.1% 1.7% 28.4%
Operating cash flow CAGR (3Y) -2.3% 20.5% 16.9%
Free cash flow growth (1Y) -35.9% -1.4% 36.2%
Free cash flow CAGR (3Y) 8.6% 20.9% 22.1%

Profitability

14 metrics
MetricCRLMEDPDNA
Gross margin 32.7% 29.1% 83.1%
EBITDA margin 9.7% 22.4% -211.6%
Operating margin 2.3% 21.4% -259.9%
Pretax margin -4.6% 22.1% -264.1%
Net margin -6.0% 18.2% -260.0%
FCF margin 9.3% 23.5% -156.3%
Operating cash flow margin 14.6% 25.5% -152.2%
Return on equity -8.2% 101.7% -67.4%
Return on assets -3.1% 23.8% -28.7%
Return on invested capital 1.6% – –
Return on capital employed 1.4% 88.8% -31.0%
Asset turnover 0.5x 1.3x 0.1x
Cash conversion (OCF / net income) -2.4x 1.4x 0.6x
Stock comp / revenue 2.1% 0.8% 61.5%

Financial Health

11 metrics
MetricCRLMEDPDNA
Debt / assets 34.8% – –
Debt / equity 0.9x – –
Net debt / EBITDA 6.3x – –
Debt / FCF 7.1x – –
Liabilities / assets 62.2% 74.6% 57.5%
Equity / assets 37.8% 25.4% 42.5%
Interest coverage 0.8x – –
Current ratio 1.3x 0.8x 4.6x
Quick ratio 0.8x 0.8x 1.4x
Cash ratio 0.2x 0.5x 1.2x
Altman Z-score 3.04 8.23 -8.70

Shareholder Returns

7 metrics
MetricCRLMEDPDNA
Dividend yield – – –
Net buyback yield 1.9% 1.3% –
Shareholder yield 1.9% 1.3% –
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusCRLMEDPDNA
Forward P/E 32.3xFY2026 37.3xFY2026 –
EPS, next fiscal year $10.90FY2026 $17.80FY2026 $-4.06FY2026
EPS growth, next FY +6.0%FY2026 +16.5%FY2026 –
EPS growth, the year after +20.5% +6.2% –
Revenue, next fiscal year $3.82BFY2026 $2.94BFY2026 $88.21MFY2026
Revenue growth, next FY -4.9%FY2026 +16.4%FY2026 -48.2%FY2026
Revenue growth, the year after +0.7% +6.0% +5.8%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersCRLMEDPDNA
Held by institutions 100.0% 87.8% 67.2%
Institutions holding 571 695 183
Change in shares held, QoQ -0.7% +3.2% +12.3%
Institutions buying 271 279 100
Institutions selling 204 304 39
Buyers to sellers 1.33 0.92 2.56

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

CRLMEDPDNA
CRL 1.00 0.59 0.38
MEDP 0.59 1.00 0.31
DNA 0.38 0.31 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, CRL, MEDP and DNA?

Medpace Holdings (MEDP) is the largest by market capitalisation: Charles River Laboratories International (CRL) $15.79B, Medpace Holdings (MEDP) $18.33B, Ginkgo Bioworks Holdings (DNA) $729.92M.

Which company is growing faster?

Medpace Holdings (MEDP) grew revenue fastest over the trailing twelve months: Charles River Laboratories International (CRL) -0.7%, Medpace Holdings (MEDP) +20.4%, Ginkgo Bioworks Holdings (DNA) -46.8%.

Which company is more profitable?

Medpace Holdings (MEDP) has the highest net margin (Charles River Laboratories International (CRL) -6.0%, Medpace Holdings (MEDP) 18.2%, Ginkgo Bioworks Holdings (DNA) -260.0%).

Which stock has performed better?

Over the past year Charles River Laboratories International (CRL) returned the most: Charles River Laboratories International (CRL) +96.7%, Medpace Holdings (MEDP) +11.7%, Ginkgo Bioworks Holdings (DNA) -15.8%. Over five years, Medpace Holdings (MEDP) compounded fastest (Charles River Laboratories International (CRL) -1.5%/yr, Medpace Holdings (MEDP) +23.9%/yr, Ginkgo Bioworks Holdings (DNA) -54.9%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Medpace Holdings (MEDP) has been the steadiest (Charles River Laboratories International (CRL) 46.5%, Medpace Holdings (MEDP) 45.8%, Ginkgo Bioworks Holdings (DNA) 104.5%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, CRL, MEDP and DNA?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Medpace Holdings (MEDP) leads on 6. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.