CAI vs GH vs IQV Stock Comparison

Caris Life Sciences, Guardant Health and Iqvia Holdings Prices as of Nov 4, 2026 Peers: Industry group
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GH Guardant Health, Inc.
$168.58 -10.0% 1M +71.8% 1Y
Market cap
$22.52B
P/E
–
Revenue (TTM)
$1.18B
Div. yield
–
Diagnostic Labs Healthcare
2 wins
IQV Iqvia Holdings Inc.
$263.73 -0.9% 1M +25.0% 1Y
Market cap
$43.46B
P/E
31.2x
Revenue (TTM)
$17.31B
Div. yield
–
Contract Research Healthcare
5 wins

Head to Head

11 decided of 12

Iqvia Holdings leads on 5 of the 12 questions below (Iqvia Holdings 5, Caris Life Sciences 4, Guardant Health 2). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionCAIGHIQVLeader
Larger companyMarket capitalisation $9.52B $22.52B $43.46B IQV
Cheaper on earningsLower P/E, profitable companies only 98.2x -49.4x 31.2x IQV
Cheaper on forward earningsLower price / next fiscal year consensus EPS 302.0x — 21.7x IQV
Faster revenue growthRevenue growth, trailing twelve months +61.5% +42.7% +8.8% CAI
More profitableNet margin, trailing twelve months 9.2% -38.3% 8.1% CAI
Better return on capitalReturn on invested capital 13.7% — 8.2% CAI
Less leveragedLower net debt / EBITDA -2.3x — 3.9x CAI
Higher dividend yieldTrailing dividend yield 0.00% — — –
Better 1-year returnPrice return, last 12 months +6.5% +71.8% +25.0% GH
Better 5-year returnAnnualised price return, 5 years — +8.9%/yr +1.3%/yr GH
Less volatileAnnualised volatility, 1 year 69.8% 52.0% 40.7% IQV
Higher overall scoreMean of the five percentile scores vs peers 65/100 28/100 71/100 IQV

Percentile Scorecard

CAIGHIQV

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisCAIGHIQV
Valuation 22 #74 of 95 17 #79 of 95 80 #3 of 11
Growth 99 #2 of 88 45 #49 of 88 80 #3 of 11
Profitability 71 #26 of 87 7 #81 of 87 90 #2 of 11
Financial Health 79 #22 of 100 58 #43 of 100 33 #9 of 13
Shareholder Returns 56 #26 of 58 14 #50 of 58 –
Overall 65 28 71
  • CAI ranked among 102 companies in Healthcare Providers
  • GH ranked among 102 companies in Healthcare Providers
  • IQV ranked among 13 companies in Pharma Services

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodCAIGHIQVSPY
1 month +9.3%-10.0%-0.9% -1.0%
3 months +101.9%+3.3%+11.8% -0.4%
6 months +73.7%+82.7%+49.4% +4.5%
Year to date +23.1%+65.0%+17.0% +12.4%
1 year +6.5%+71.8%+25.0% +13.6%
3 years —+488.0%+33.7% +76.4%
3 years, per year —+80.6%+10.2% +20.8%
5 years —+53.0%+6.7% +63.7%
5 years, per year —+8.9%+1.3% +10.4%
10 years ——+263.3% +267.7%
10 years, per year ——+13.8% +13.9%

Risk

MeasureCAIGHIQVSPY
Volatility, 1Y 69.8%52.0%40.7% 12.8%
Downside volatility, 1Y 70.3%49.5%40.0% 12.7%
Beta vs S&P 500, 1Y 1.551.190.76 1.00
Return / volatility, 1Y 0.091.380.62 1.06
Max drawdown, 5Y -63.0%-85.4%-51.5% -25.4%
From 52-week high -8.1%-10.0%-5.6% -1.6%
52-week high $36.14$187.22$279.38 $779.14
52-week low $14.55$78.60$156.66 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleCAIGHIQV
P/E now vs peer median 98.2xmedian 25.6x -49.4xmedian 25.6x 31.2xmedian 35.4x
P/S now vs peer median 9.1xmedian 1.6x 19.0xmedian 1.6x 2.5xmedian 2.5x
EV/EBITDA now vs peer median 55.0xmedian 16.0x -49.7xmedian 16.0x 16.5xmedian 29.5x
P/FCF now vs peer median 329.5xmedian 21.6x -93.6xmedian 21.6x 20.9xmedian 20.9x
P/B now vs peer median 14.9xmedian 3.4x -101.1xmedian 3.4x 6.4xmedian 2.8x
PEG now vs peer median —median 0.74 -4.97median 0.74 2.70median 1.97

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsCAIGHIQV
Revenue $1.05B $1.18B $17.31B
Gross profit $724.14M $769.16M $5.72B
Operating income $139.94M -$470.26M $2.22B
Net income $96.06M -$453.44M $1.40B
Free cash flow $28.91M -$240.72M $2.08B
R&D $129.36M $375.79M –
EPS (diluted) $0.33 $-3.41 $8.35
Cash & equivalents $665.32M $1.05B $2.25B
Total debt $393.27M – $16.07B
Shares (diluted) 295.14M 132.87M 167.00M
Enterprise value $6.34B $18.59B $34.85B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricCAIGHIQV
P/E 98.2x -49.4x 31.2x
P/FCF 329.5x -93.6x 20.9x
P/Operating cash flow 113.5x -121.6x 15.9x
P/S 9.1x 19.0x 2.5x
P/B 14.9x -101.1x 6.4x
P/Tangible book 14.9x -90.8x 21.2x
EV/EBITDA 55.0x -49.7x 16.5x
EV/EBIT 65.4x -45.7x 25.7x
EV/Revenue 8.7x 18.1x 3.3x
EV/FCF 316.5x -89.2x 27.5x
EV/Operating cash flow 109.1x -115.9x 20.9x
PEG (3Y EPS CAGR) – -4.97 2.70

Growth

14 metrics
MetricCAIGHIQV
Revenue growth (1Y) 61.5% 42.7% 8.8%
Revenue CAGR (3Y) – 32.4% 5.2%
Gross profit growth (1Y) 86.2% 47.7% 6.6%
Gross profit CAGR (3Y) – – 3.4%
Operating income growth (1Y) 274.2% -2.1% 1.7%
Operating income CAGR (3Y) – 4.8% 6.2%
Net income growth (1Y) 151.4% -9.6% 9.0%
Net income CAGR (3Y) – 3.7% 7.8%
EPS growth (1Y) 114.2% -2.4% 11.7%
EPS CAGR (3Y) – 9.9% 11.5%
Operating cash flow growth (1Y) 15,464% 22.4% -2.4%
Operating cash flow CAGR (3Y) – 18.1% 11.7%
Free cash flow growth (1Y) 306.4% 11.4% -6.0%
Free cash flow CAGR (3Y) – 14.4% 16.3%

Profitability

14 metrics
MetricCAIGHIQV
Gross margin 69.1% 65.0% 33.1%
EBITDA margin 15.9% -36.5% 20.0%
Operating margin 13.4% -39.7% 12.8%
Pretax margin 9.3% -38.4% 9.0%
Net margin 9.2% -38.3% 8.1%
FCF margin 2.8% -20.3% 12.0%
Operating cash flow margin 8.0% -15.7% 15.8%
Return on equity 15.6% – 21.4%
Return on assets 7.7% -23.7% 4.6%
Return on invested capital 13.7% – 8.2%
Return on capital employed 12.9% -29.9% 9.9%
Asset turnover 0.8x 0.6x 0.6x
Cash conversion (OCF / net income) 0.9x 0.4x 2.0x
Stock comp / revenue 6.7% 16.2% 1.8%

Financial Health

11 metrics
MetricCAIGHIQV
Debt / assets 31.3% – 52.7%
Debt / equity 0.6x – 2.4x
Net debt / EBITDA -2.3x – 3.9x
Debt / FCF 13.6x – 7.7x
Liabilities / assets 49.1% 111.7% 77.7%
Equity / assets 50.9% -11.7% 22.3%
Interest coverage 3.3x -97.6x 2.8x
Current ratio 6.7x 4.0x 0.8x
Quick ratio 5.7x 3.5x 1.0x
Cash ratio 4.8x 3.1x 0.3x
Altman Z-score 8.52 4.42 2.24

Shareholder Returns

7 metrics
MetricCAIGHIQV
Dividend yield – – –
Net buyback yield 0.0% -1.8% 2.7%
Shareholder yield 0.0% -1.8% 2.7%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusCAIGHIQV
Forward P/E 302.0xFY2026 – 21.7xFY2026
EPS, next fiscal year $0.11FY2026 $-3.33FY2026 $12.14FY2026
EPS growth, next FY – – +1.8%FY2026
EPS growth, the year after +236.4% – +13.3%
Revenue, next fiscal year $1.06BFY2026 $1.42BFY2026 $18.58BFY2026
Revenue growth, next FY +30.1%FY2026 +44.5%FY2026 +13.9%FY2026
Revenue growth, the year after +21.6% +27.0% -3.5%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersCAIGHIQV
Held by institutions 52.0% 100.0% 94.1%
Institutions holding 246 597 1,085
Change in shares held, QoQ -6.3% -2.5% +0.3%
Institutions buying 175 356 532
Institutions selling 47 180 424
Buyers to sellers 3.72 1.98 1.25

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

CAIGHIQV
CAI 1.00 0.44 0.35
GH 0.44 1.00 0.31
IQV 0.35 0.31 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, CAI, GH and IQV?

Iqvia Holdings (IQV) is the largest by market capitalisation: Caris Life Sciences (CAI) $9.52B, Guardant Health (GH) $22.52B, Iqvia Holdings (IQV) $43.46B.

Which stock is cheaper, CAI, GH and IQV?

Iqvia Holdings (IQV) trades on the lowest price-to-earnings ratio (Caris Life Sciences (CAI) 98.2x, Guardant Health (GH) -49.4x, Iqvia Holdings (IQV) 31.2x). On next year's consensus earnings, Iqvia Holdings (IQV) is cheapest (Caris Life Sciences (CAI) 302.0x, Iqvia Holdings (IQV) 21.7x). A lower multiple can reflect slower expected growth, so read it next to the growth figures.

Which company is growing faster?

Caris Life Sciences (CAI) grew revenue fastest over the trailing twelve months: Caris Life Sciences (CAI) +61.5%, Guardant Health (GH) +42.7%, Iqvia Holdings (IQV) +8.8%.

Which company is more profitable?

Caris Life Sciences (CAI) has the highest net margin (Caris Life Sciences (CAI) 9.2%, Guardant Health (GH) -38.3%, Iqvia Holdings (IQV) 8.1%). On return on invested capital, Caris Life Sciences (CAI) leads (Caris Life Sciences (CAI) 13.7%, Iqvia Holdings (IQV) 8.2%).

Which stock has performed better?

Over the past year Guardant Health (GH) returned the most: Caris Life Sciences (CAI) +6.5%, Guardant Health (GH) +71.8%, Iqvia Holdings (IQV) +25.0%. Over five years, Guardant Health (GH) compounded fastest (Guardant Health (GH) +8.9%/yr, Iqvia Holdings (IQV) +1.3%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Iqvia Holdings (IQV) has been the steadiest (Caris Life Sciences (CAI) 69.8%, Guardant Health (GH) 52.0%, Iqvia Holdings (IQV) 40.7%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, CAI, GH and IQV?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Iqvia Holdings (IQV) leads on 5. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.