BIIB vs REGN vs BNTX Stock Comparison

Biogen, Regeneron Pharmaceuticals and BioNTech SE Prices as of Oct 29, 2026 Peers: Industry group
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BIIB Biogen Inc.
$249.65 +9.9% 1M +68.8% 1Y
Market cap
$37.50B
P/E
107.9x
Revenue (TTM)
$10.30B
Div. yield
–
Biotechnology Healthcare
1 win
BNTX BioNTech SE
$89.13 -9.6% 1M -13.8% 1Y
Market cap
$21.24B
P/E
–
Revenue (TTM)
$3.09B
Div. yield
–
Biotechnology Healthcare

Head to Head

11 decided of 12

Regeneron Pharmaceuticals leads on 10 of the 12 questions below (Regeneron Pharmaceuticals 10, Biogen 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionBIIBREGNBNTXLeader
Larger companyMarket capitalisation $37.50B $95.37B $21.24B REGN
Cheaper on earningsLower P/E, profitable companies only 107.9x 22.0x -10.8x REGN
Cheaper on forward earningsLower price / next fiscal year consensus EPS 19.5x 14.3x — REGN
Faster revenue growthRevenue growth, trailing twelve months +2.3% +9.3% -1.1% REGN
More profitableNet margin, trailing twelve months 3.4% 27.9% -63.5% REGN
Better return on capitalReturn on invested capital 1.3% 9.6% -10.7% REGN
Less leveragedLower net debt / EBITDA 4.5x -1.4x 8.7x REGN
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months +68.8% +25.4% -13.8% BIIB
Better 5-year returnAnnualised price return, 5 years -1.3%/yr +5.1%/yr -20.4%/yr REGN
Less volatileAnnualised volatility, 1 year 34.3% 30.9% 46.6% REGN
Higher overall scoreMean of the five percentile scores vs peers 60/100 72/100 65/100 REGN

Percentile Scorecard

BIIBREGNBNTX

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisBIIBREGNBNTX
Valuation 92 #53 of 624 89 #69 of 624 90 #61 of 624
Growth 26 #444 of 601 42 #350 of 601 15 #512 of 601
Profitability 87 #72 of 541 90 #54 of 541 77 #123 of 541
Financial Health 33 #432 of 647 73 #174 of 647 89 #72 of 647
Shareholder Returns – 65 #127 of 359 52 #174 of 359
Overall 60 72 65
  • BIIB ranked among 671 companies in Pharmaceuticals and Biotechnology
  • REGN ranked among 671 companies in Pharmaceuticals and Biotechnology
  • BNTX ranked among 671 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodBIIBREGNBNTXSPY
1 month +9.9%+9.1%-9.6% +0.7%
3 months +20.1%+10.9%-4.0% +3.7%
6 months +31.9%+15.8%-13.8% +7.1%
Year to date +41.9%+6.1%-6.4% +12.8%
1 year +68.8%+25.4%-13.8% +11.9%
3 years +5.2%+5.3%-4.4% +85.2%
3 years, per year +1.7%+1.7%-1.5% +22.8%
5 years -6.4%+27.9%-68.0% +67.6%
5 years, per year -1.3%+5.1%-20.4% +10.9%
10 years -12.0%+130.1%— +262.0%
10 years, per year -1.3%+8.7%— +13.7%

Risk

MeasureBIIBREGNBNTXSPY
Volatility, 1Y 34.3%30.9%46.6% 12.7%
Downside volatility, 1Y 32.8%30.0%46.8% 12.6%
Beta vs S&P 500, 1Y 0.250.450.95 1.00
Return / volatility, 1Y 2.010.82-0.29 0.94
Max drawdown, 5Y -64.4%-59.8%-78.4% -25.4%
From 52-week high -1.7%-3.9%-25.3% -1.2%
52-week high $253.84$852.03$119.34 $779.14
52-week low $147.86$600.66$83.89 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleBIIBREGNBNTX
P/E now vs peer median 106.2xmedian 17.8x 19.4xmedian 17.8x -11.0xmedian 17.8x
P/S now vs peer median 3.6xmedian 9.1x 5.4xmedian 9.1x 7.3xmedian 9.1x
EV/EBITDA now vs peer median 32.3xmedian 15.0x 17.9xmedian 15.0x -6.0xmedian 15.0x
P/FCF now vs peer median 17.8xmedian 21.7x 22.4xmedian 21.7x 21.7xmedian 21.7x
P/B now vs peer median 2.0xmedian 2.2x 2.7xmedian 2.2x 1.1xmedian 2.2x
PEG now vs peer median -2.76median 0.35 7.31median 0.35 0.31median 0.35

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsBIIBREGNBNTX
Revenue $10.30B $15.53B $3.09B
Gross profit $7.62B $13.18B $2.34B
Operating income $445.10M $3.84B -$2.33B
Net income $347.50M $4.33B -$1.97B
Free cash flow $2.07B $3.76B $1.04B
R&D $2.15B $6.28B $2.54B
EPS (diluted) $2.35 $40.84 $-8.13
Cash & equivalents $1.30B $2.46B $11.13B
Total debt $7.29B $1.99B $102.80M
Shares (diluted) 147.80M 106.00M 241.70M
Enterprise value $26.81B $61.57B -$25.24B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricBIIBREGNBNTX
P/E 106.2x 19.4x -11.0x
P/FCF 17.8x 22.4x 21.7x
P/Operating cash flow 16.4x 18.0x 28.4x
P/S 3.6x 5.4x 7.3x
P/B 2.0x 2.7x 1.1x
P/Tangible book 6.7x 2.8x 1.1x
EV/EBITDA 32.3x 17.9x -6.0x
EV/EBIT 96.4x 20.3x -4.0x
EV/Revenue 4.2x 5.0x 3.0x
EV/FCF 20.7x 20.8x 8.9x
EV/Operating cash flow 19.1x 16.7x 11.6x
PEG (3Y EPS CAGR) -2.76 7.31 0.31

Growth

14 metrics
MetricBIIBREGNBNTX
Revenue growth (1Y) 2.3% 9.3% -1.1%
Revenue CAGR (3Y) 1.0% 7.0% -31.0%
Gross profit growth (1Y) 0.6% 8.4% -6.4%
Gross profit CAGR (3Y) 0.5% 6.4% -34.2%
Operating income growth (1Y) -76.6% 0.1% -142.6%
Operating income CAGR (3Y) -34.8% -3.9% -33.8%
Net income growth (1Y) -78.4% -2.9% -417.0%
Net income CAGR (3Y) -38.1% 0.2% -34.6%
EPS growth (1Y) -78.5% -0.5% -393.7%
EPS CAGR (3Y) -38.5% 2.7% -34.9%
Operating cash flow growth (1Y) -8.4% -1.3% 142.8%
Operating cash flow CAGR (3Y) 18.2% -0.4% -56.6%
Free cash flow growth (1Y) -10.1% -2.4% 164.1%
Free cash flow CAGR (3Y) 24.9% -3.3% -53.1%

Profitability

14 metrics
MetricBIIBREGNBNTX
Gross margin 74.0% 84.9% 75.5%
EBITDA margin 12.9% 28.1% -49.7%
Operating margin 4.3% 24.7% -75.2%
Pretax margin 4.3% 33.3% -61.4%
Net margin 3.4% 27.9% -63.5%
FCF margin 20.1% 24.2% 33.6%
Operating cash flow margin 21.8% 30.1% 25.6%
Return on equity 1.8% 13.7% -10.3%
Return on assets 1.1% 10.5% -9.0%
Return on invested capital 1.3% 9.6% -10.7%
Return on capital employed 1.6% 10.7% -9.9%
Asset turnover 0.3x 0.4x 0.1x
Cash conversion (OCF / net income) 6.5x 1.1x -0.4x
Stock comp / revenue 2.9% 6.4% 3.6%

Financial Health

11 metrics
MetricBIIBREGNBNTX
Debt / assets 22.7% 4.8% 0.4%
Debt / equity 0.4x 0.1x 0.0x
Net debt / EBITDA 4.5x -1.4x 8.7x
Debt / FCF 3.5x 0.5x 0.1x
Liabilities / assets 41.0% 24.0% 12.7%
Equity / assets 59.0% 76.0% 87.3%
Interest coverage – 69.4x -41.1x
Current ratio 1.9x 3.3x 65.1x
Quick ratio 0.9x 2.6x 50.7x
Cash ratio 0.3x 1.4x 50.0x
Altman Z-score 3.11 7.35 6.41

Shareholder Returns

7 metrics
MetricBIIBREGNBNTX
Dividend yield – 0.5% –
Net buyback yield – 3.0% -2.9%
Shareholder yield – 3.5% -2.9%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusBIIBREGNBNTX
Forward P/E 19.5xFY2026 14.3xFY2026 –
EPS, next fiscal year $12.81FY2026 $57.08FY2026 $-6.21FY2026
EPS growth, next FY -16.2%FY2026 +28.8%FY2026 –
EPS growth, the year after +36.5% +15.5% –
Revenue, next fiscal year $9.96BFY2026 $17.05BFY2026 $1.90BFY2026
Revenue growth, next FY +0.7%FY2026 +18.9%FY2026 -43.7%FY2026
Revenue growth, the year after +11.9% +13.0% +11.9%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersBIIBREGNBNTX
Held by institutions 96.4% 66.2% 19.4%
Institutions holding 1,037 1,326 282
Change in shares held, QoQ +6.0% +3.8% -1.2%
Institutions buying 549 605 136
Institutions selling 294 534 73
Buyers to sellers 1.87 1.13 1.86

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

BIIBREGNBNTX
BIIB 1.00 0.36 0.21
REGN 0.36 1.00 0.26
BNTX 0.21 0.26 1.00

Add a Peer

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Frequently Asked Questions

Which is bigger, BIIB, REGN and BNTX?

Regeneron Pharmaceuticals (REGN) is the largest by market capitalisation: Biogen (BIIB) $37.50B, Regeneron Pharmaceuticals (REGN) $95.37B, BioNTech SE (BNTX) $21.24B.

Which stock is cheaper, BIIB, REGN and BNTX?

Regeneron Pharmaceuticals (REGN) trades on the lowest price-to-earnings ratio (Biogen (BIIB) 107.9x, Regeneron Pharmaceuticals (REGN) 22.0x, BioNTech SE (BNTX) -10.8x). On next year's consensus earnings, Regeneron Pharmaceuticals (REGN) is cheapest (Biogen (BIIB) 19.5x, Regeneron Pharmaceuticals (REGN) 14.3x). A lower multiple can reflect slower expected growth, so read it next to the growth figures.

Which company is growing faster?

Regeneron Pharmaceuticals (REGN) grew revenue fastest over the trailing twelve months: Biogen (BIIB) +2.3%, Regeneron Pharmaceuticals (REGN) +9.3%, BioNTech SE (BNTX) -1.1%.

Which company is more profitable?

Regeneron Pharmaceuticals (REGN) has the highest net margin (Biogen (BIIB) 3.4%, Regeneron Pharmaceuticals (REGN) 27.9%, BioNTech SE (BNTX) -63.5%). On return on invested capital, Regeneron Pharmaceuticals (REGN) leads (Biogen (BIIB) 1.3%, Regeneron Pharmaceuticals (REGN) 9.6%, BioNTech SE (BNTX) -10.7%).

Which stock has performed better?

Over the past year Biogen (BIIB) returned the most: Biogen (BIIB) +68.8%, Regeneron Pharmaceuticals (REGN) +25.4%, BioNTech SE (BNTX) -13.8%. Over five years, Regeneron Pharmaceuticals (REGN) compounded fastest (Biogen (BIIB) -1.3%/yr, Regeneron Pharmaceuticals (REGN) +5.1%/yr, BioNTech SE (BNTX) -20.4%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Regeneron Pharmaceuticals (REGN) has been the steadiest (Biogen (BIIB) 34.3%, Regeneron Pharmaceuticals (REGN) 30.9%, BioNTech SE (BNTX) 46.6%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, BIIB, REGN and BNTX?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Regeneron Pharmaceuticals (REGN) leads on 10. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.