BIIB vs GILD vs GRFS Stock Comparison

Biogen, Gilead Sciences and Grifols Prices as of Nov 4, 2026 Peers: Industry group
1 more company in this comparison (MRNA) Create a free account to keep reading and compare up to 10 companies.
BIIB Biogen Inc.
$254.46 +13.8% 1M +70.4% 1Y
Market cap
$36.95B
P/E
106.3x
Revenue (TTM)
$10.30B
Div. yield
–
Biotechnology Healthcare
4 wins
GILD Gilead Sciences, Inc.
$174.48 +20.6% 1M +41.9% 1Y
Market cap
$213.39B
P/E
–
Revenue (TTM)
$30.99B
Div. yield
–
Biotechnology Healthcare
5 wins
GRFS Grifols SA
$8.60 +16.1% 1M -6.7% 1Y
Market cap
$5.74B
P/E
12.9x
Revenue (TTM)
—
Div. yield
–
Biotechnology Healthcare
2 wins

Head to Head

11 decided of 12

Gilead Sciences leads on 5 of the 12 questions below (Gilead Sciences 5, Biogen 4, Grifols 2). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionBIIBGILDGRFSLeader
Larger companyMarket capitalisation $36.95B $213.39B $5.74B GILD
Cheaper on earningsLower P/E, profitable companies only 106.3x -55.2x 12.9x GRFS
Cheaper on forward earningsLower price / next fiscal year consensus EPS 19.9x — 9.1x GRFS
Faster revenue growthRevenue growth, trailing twelve months +2.3% +6.5% — GILD
More profitableNet margin, trailing twelve months 3.4% -12.5% — BIIB
Better return on capitalReturn on invested capital 1.3% -6.1% — BIIB
Less leveragedLower net debt / EBITDA 4.5x 43.8x — BIIB
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months +70.4% +41.9% -6.7% BIIB
Better 5-year returnAnnualised price return, 5 years -1.8%/yr +21.4%/yr -6.8%/yr GILD
Less volatileAnnualised volatility, 1 year 34.2% 27.6% 32.6% GILD
Higher overall scoreMean of the five percentile scores vs peers 59/100 61/100 56/100 GILD

Percentile Scorecard

BIIBGILDGRFS

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisBIIBGILDGRFS
Valuation 91 #56 of 634 90 #65 of 634 99 #9 of 634
Growth 25 #456 of 607 34 #402 of 607 –
Profitability 87 #75 of 557 84 #89 of 557 –
Financial Health 33 #437 of 654 23 #503 of 654 14 #566 of 654
Shareholder Returns – 74 #106 of 400 57 #173 of 400
Overall 59 61 56
  • BIIB ranked among 671 companies in Pharmaceuticals and Biotechnology
  • GILD ranked among 671 companies in Pharmaceuticals and Biotechnology
  • GRFS ranked among 671 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodBIIBGILDGRFSSPY
1 month +13.8%+20.6%+16.1% -1.0%
3 months +23.1%+32.4%+8.4% -0.4%
6 months +33.4%+28.0%+2.3% +4.5%
Year to date +44.6%+42.2%-8.0% +12.4%
1 year +70.4%+41.9%-6.7% +13.6%
3 years +2.0%+113.8%-7.6% +76.4%
3 years, per year +0.7%+28.9%-2.6% +20.8%
5 years -8.7%+163.1%-29.6% +63.7%
5 years, per year -1.8%+21.4%-6.8% +10.4%
10 years -8.1%+140.9%-41.1% +267.7%
10 years, per year -0.8%+9.2%-5.2% +13.9%

Risk

MeasureBIIBGILDGRFSSPY
Volatility, 1Y 34.2%27.6%32.6% 12.8%
Downside volatility, 1Y 32.7%23.9%34.1% 12.7%
Beta vs S&P 500, 1Y 0.250.290.88 1.00
Return / volatility, 1Y 2.061.52-0.21 1.06
Max drawdown, 5Y -64.4%-29.4%-58.8% -25.4%
From 52-week high 0.0%0.0%-11.5% -1.6%
52-week high $254.46$174.48$9.72 $779.14
52-week low $149.33$118.15$7.02 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleBIIBGILDGRFS
P/E now vs peer median 108.2xmedian 18.0x -56.1xmedian 18.0x 12.9xmedian 18.0x
P/S now vs peer median 3.7xmedian 9.1x 7.0xmedian 9.1x 0.7xmedian 9.1x
EV/EBITDA now vs peer median 32.9xmedian 16.2x 522.8xmedian 16.2x —median 16.2x
P/FCF now vs peer median 18.2xmedian 21.7x 15.7xmedian 21.7x 8.3xmedian 21.7x
P/B now vs peer median 2.0xmedian 2.2x 16.6xmedian 2.2x 0.7xmedian 2.2x
PEG now vs peer median -2.81median 0.38 1.45median 0.38 —median 0.38

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsBIIBGILDGRFS
Revenue $10.30B $30.99B –
Gross profit $7.62B $24.77B –
Operating income $445.10M -$2.36B –
Net income $347.50M -$3.86B –
Free cash flow $2.07B $13.78B –
R&D $2.15B $6.33B –
EPS (diluted) $2.35 $-3.09 –
Cash & equivalents $1.30B $6.44B $969.15M
Total debt $7.29B $26.23B $11.33B
Shares (diluted) 147.80M 1.25B 681.57M
Enterprise value $26.26B $188.50B $2.08B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricBIIBGILDGRFS
P/E 108.2x -56.1x 12.9x
P/FCF 18.2x 15.7x 8.3x
P/Operating cash flow 16.7x 15.0x –
P/S 3.7x 7.0x 0.7x
P/B 2.0x 16.6x 0.7x
P/Tangible book 6.8x -563.9x 1.0x
EV/EBITDA 32.9x 522.8x –
EV/EBIT 98.0x -100.1x –
EV/Revenue 4.2x 7.6x –
EV/FCF 21.1x 17.1x –
EV/Operating cash flow 19.4x 16.3x –
PEG (3Y EPS CAGR) -2.81 1.45 –

Growth

14 metrics
MetricBIIBGILDGRFS
Revenue growth (1Y) 2.3% 6.5% –
Revenue CAGR (3Y) 1.0% 4.2% –
Gross profit growth (1Y) 0.6% 8.2% –
Gross profit CAGR (3Y) 0.5% 4.7% –
Operating income growth (1Y) -76.6% -122.5% –
Operating income CAGR (3Y) -34.8% -31.7% –
Net income growth (1Y) -78.4% -147.6% –
Net income CAGR (3Y) -38.1% -38.5% –
EPS growth (1Y) -78.5% -147.7% –
EPS CAGR (3Y) -38.5% -38.6% –
Operating cash flow growth (1Y) -8.4% 49.8% –
Operating cash flow CAGR (3Y) 18.2% 19.9% –
Free cash flow growth (1Y) -10.1% 50.4% –
Free cash flow CAGR (3Y) 24.9% 20.6% –

Profitability

14 metrics
MetricBIIBGILDGRFS
Gross margin 74.0% 79.9% –
EBITDA margin 12.9% 1.5% –
Operating margin 4.3% -7.6% –
Pretax margin 4.3% -8.2% –
Net margin 3.4% -12.5% –
FCF margin 20.1% 44.5% –
Operating cash flow margin 21.8% 46.7% –
Return on equity 1.8% -31.2% –
Return on assets 1.1% -7.7% –
Return on invested capital 1.3% -6.1% –
Return on capital employed 1.6% -6.2% –
Asset turnover 0.3x 0.6x –
Cash conversion (OCF / net income) 6.5x -3.7x –
Stock comp / revenue 2.9% 2.9% –

Financial Health

11 metrics
MetricBIIBGILDGRFS
Debt / assets 22.7% 51.0% 48.9%
Debt / equity 0.4x 2.0x 1.3x
Net debt / EBITDA 4.5x 43.8x –
Debt / FCF 3.5x 1.9x –
Liabilities / assets 41.0% 74.6% 61.4%
Equity / assets 59.0% 25.4% 38.6%
Interest coverage – -2.3x –
Current ratio 1.9x 1.4x 2.5x
Quick ratio 0.9x 1.0x 0.8x
Cash ratio 0.3x 0.5x 0.4x
Altman Z-score 3.14 4.03 –

Shareholder Returns

7 metrics
MetricBIIBGILDGRFS
Dividend yield – 1.9% 1.3%
Net buyback yield – 0.5% –
Shareholder yield – 2.4% 1.3%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusBIIBGILDGRFS
Forward P/E 19.9xFY2026 – 9.1xFY2026
EPS, next fiscal year $12.81FY2026 $-0.39FY2026 $0.94FY2026
EPS growth, next FY -16.2%FY2026 -104.8%FY2026 +10.6%FY2026
EPS growth, the year after +36.5% – +26.6%
Revenue, next fiscal year $9.96BFY2026 $28.65BFY2026 $8.88BFY2026
Revenue growth, next FY +0.7%FY2026 -2.7%FY2026 +0.0%FY2026
Revenue growth, the year after +11.9% +18.1% +10.3%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersBIIBGILDGRFS
Held by institutions 96.4% 89.6% 21.0%
Institutions holding 1,038 2,293 168
Change in shares held, QoQ +6.0% +5.1% -0.5%
Institutions buying 550 1,113 75
Institutions selling 294 853 65
Buyers to sellers 1.87 1.30 1.15

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

BIIBGILDGRFS
BIIB 1.00 0.41 0.11
GILD 0.41 1.00 0.28
GRFS 0.11 0.28 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, BIIB, GILD and GRFS?

Gilead Sciences (GILD) is the largest by market capitalisation: Biogen (BIIB) $36.95B, Gilead Sciences (GILD) $213.39B, Grifols (GRFS) $5.74B.

Which stock is cheaper, BIIB, GILD and GRFS?

Grifols (GRFS) trades on the lowest price-to-earnings ratio (Biogen (BIIB) 106.3x, Gilead Sciences (GILD) -55.2x, Grifols (GRFS) 12.9x). On next year's consensus earnings, Grifols (GRFS) is cheapest (Biogen (BIIB) 19.9x, Grifols (GRFS) 9.1x). A lower multiple can reflect slower expected growth, so read it next to the growth figures.

Which company is growing faster?

Gilead Sciences (GILD) grew revenue fastest over the trailing twelve months: Biogen (BIIB) +2.3%, Gilead Sciences (GILD) +6.5%.

Which company is more profitable?

Biogen (BIIB) has the highest net margin (Biogen (BIIB) 3.4%, Gilead Sciences (GILD) -12.5%). On return on invested capital, Biogen (BIIB) leads (Biogen (BIIB) 1.3%, Gilead Sciences (GILD) -6.1%).

Which stock has performed better?

Over the past year Biogen (BIIB) returned the most: Biogen (BIIB) +70.4%, Gilead Sciences (GILD) +41.9%, Grifols (GRFS) -6.7%. Over five years, Gilead Sciences (GILD) compounded fastest (Biogen (BIIB) -1.8%/yr, Gilead Sciences (GILD) +21.4%/yr, Grifols (GRFS) -6.8%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Gilead Sciences (GILD) has been the steadiest (Biogen (BIIB) 34.2%, Gilead Sciences (GILD) 27.6%, Grifols (GRFS) 32.6%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, BIIB, GILD and GRFS?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Gilead Sciences (GILD) leads on 5. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.