BEAM vs PGEN vs CRSP Stock Comparison

Beam Therapeutics, Precigen and CRISPR Therapeutics AG Prices as of Nov 5, 2026 Peers: Industry group
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BEAM Beam Therapeutics Inc.
$25.87 +2.5% 1M +12.1% 1Y
Market cap
$2.76B
P/E
–
Revenue (TTM)
$146.64M
Div. yield
–
Gene and Cell Therapy Healthcare
1 win
PGEN Precigen, Inc.
$4.22 -44.1% 1M +5.8% 1Y
Market cap
$1.49B
P/E
61.1x
Revenue (TTM)
$156.94M
Div. yield
–
Gene and Cell Therapy Healthcare
6 wins
CRSP CRISPR Therapeutics AG
$48.56 -10.1% 1M -14.8% 1Y
Market cap
$4.79B
P/E
–
Revenue (TTM)
$25.17M
Div. yield
–
Gene and Cell Therapy Healthcare
2 wins

Head to Head

9 decided of 12

Precigen leads on 6 of the 12 questions below (Precigen 6, CRISPR Therapeutics AG 2, Beam Therapeutics 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionBEAMPGENCRSPLeader
Larger companyMarket capitalisation $2.76B $1.49B $4.79B CRSP
Cheaper on earningsLower P/E, profitable companies only -25.5x 61.1x -10.5x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — 24.8x — –
Faster revenue growthRevenue growth, trailing twelve months +163.3% +2,387.6% -34.3% PGEN
More profitableNet margin, trailing twelve months -73.9% 15.6% -1,812.1% PGEN
Better return on capitalReturn on invested capital — 21.1% -23.3% PGEN
Less leveragedLower net debt / EBITDA 2.5x 1.2x 3.3x PGEN
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months +12.1% +5.8% -14.8% BEAM
Better 5-year returnAnnualised price return, 5 years -22.0%/yr -3.8%/yr -11.7%/yr PGEN
Less volatileAnnualised volatility, 1 year 70.8% 85.7% 57.1% CRSP
Higher overall scoreMean of the five percentile scores vs peers 67/100 72/100 47/100 PGEN

Percentile Scorecard

BEAMPGENCRSP

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisBEAMPGENCRSP
Valuation 53 #299 of 634 68 #206 of 634 51 #310 of 634
Growth 73 #165 of 608 90 #59 of 608 27 #445 of 608
Profitability 62 #211 of 557 86 #81 of 557 37 #354 of 557
Financial Health 79 #136 of 654 38 #409 of 654 69 #202 of 654
Shareholder Returns 65 #140 of 403 77 #92 of 403 51 #198 of 403
Overall 67 72 47
  • BEAM ranked among 671 companies in Pharmaceuticals and Biotechnology
  • PGEN ranked among 671 companies in Pharmaceuticals and Biotechnology
  • CRSP ranked among 671 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodBEAMPGENCRSPSPY
1 month +2.5%-44.1%-10.1% -5.9%
3 months -5.1%-38.9%-6.0% -4.6%
6 months -17.8%+1.7%-7.4% +0.2%
Year to date -6.7%+1.0%-7.4% +7.5%
1 year +12.1%+5.8%-14.8% +8.2%
3 years +11.0%+263.8%-5.9% +68.3%
3 years, per year +3.6%+53.8%-2.0% +19.0%
5 years -71.1%-17.4%-46.2% +56.5%
5 years, per year -22.0%-3.8%-11.7% +9.4%
10 years —-83.2%+219.5% +251.5%
10 years, per year —-16.4%+12.3% +13.4%

Risk

MeasureBEAMPGENCRSPSPY
Volatility, 1Y 70.8%85.7%57.1% 13.6%
Downside volatility, 1Y 64.3%84.2%53.6% 14.2%
Beta vs S&P 500, 1Y 2.041.631.78 1.00
Return / volatility, 1Y 0.170.07-0.26 0.60
Max drawdown, 5Y -85.3%-86.5%-66.8% -25.4%
From 52-week high -31.8%-50.7%-21.5% -5.9%
52-week high $37.92$8.56$61.89 $779.14
52-week low $20.60$3.10$44.34 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleBEAMPGENCRSP
P/E now vs peer median -25.0xmedian 17.8x 61.9xmedian 17.8x -10.3xmedian 17.8x
P/S now vs peer median 18.3xmedian 8.1x 9.6xmedian 8.1x 187.1xmedian 8.1x
EV/EBITDA now vs peer median -4.7xmedian 15.7x 39.6xmedian 15.7x -5.9xmedian 15.7x
P/FCF now vs peer median -6.7xmedian 21.0x -20.4xmedian 21.0x -12.5xmedian 21.0x
P/B now vs peer median 2.8xmedian 2.0x 18.1xmedian 2.0x 2.9xmedian 2.0x
PEG now vs peer median -0.69median 0.36 2.10median 0.36 5.33median 0.36

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsBEAMPGENCRSP
Revenue $146.64M $156.94M $25.17M
Gross profit – $143.48M –
Operating income -$392.54M $33.63M -$532.33M
Net income -$108.35M $24.41M -$456.14M
Free cash flow -$398.24M -$74.32M -$376.72M
R&D $409.01M $26.54M $291.14M
EPS (diluted) $-1.03 $0.06 $-4.72
Cash & equivalents $213.27M $14.96M $192.03M
Total debt $100.36M $94.26M $586.93M
Shares (diluted) 104.70M 421.16M 96.74M
Enterprise value -$1.89B $1.25B -$4.26B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricBEAMPGENCRSP
P/E -25.0x 61.9x -10.3x
P/FCF -6.7x -20.4x -12.5x
P/Operating cash flow -6.9x -20.7x -12.6x
P/S 18.3x 9.6x 187.1x
P/B 2.8x 18.1x 2.9x
P/Tangible book 2.8x 18.5x 2.9x
EV/EBITDA -4.7x 39.6x -5.9x
EV/EBIT -4.4x 46.4x -5.7x
EV/Revenue 11.8x 9.9x 120.2x
EV/FCF -4.4x -21.0x -8.0x
EV/Operating cash flow -4.5x -21.3x -8.1x
PEG (3Y EPS CAGR) -0.69 2.10 5.33

Growth

14 metrics
MetricBEAMPGENCRSP
Revenue growth (1Y) 163.3% 2,388% -34.3%
Revenue CAGR (3Y) 21.6% 185.3% -47.1%
Gross profit growth (1Y) – 7,400% –
Gross profit CAGR (3Y) – 478.3% –
Operating income growth (1Y) 15.8% 128.7% 7.3%
Operating income CAGR (3Y) 0.5% 33.6% -7.9%
Net income growth (1Y) 73.8% 109.9% 6.6%
Net income CAGR (3Y) 29.8% 31.8% -8.9%
EPS growth (1Y) 74.3% 104.2% 11.8%
EPS CAGR (3Y) 36.1% 29.5% -1.9%
Operating cash flow growth (1Y) -14.9% -0.8% -23.8%
Operating cash flow CAGR (3Y) -3.2% -3.2% -10.5%
Free cash flow growth (1Y) -13.0% 1.7% -24.3%
Free cash flow CAGR (3Y) -0.5% -3.5% -8.8%

Profitability

14 metrics
MetricBEAMPGENCRSP
Gross margin – 91.4% –
EBITDA margin -252.4% 25.1% -2,038%
Operating margin -267.7% 21.4% -2,115%
Pretax margin -73.2% 15.7% -1,802%
Net margin -73.9% 15.6% -1,812%
FCF margin -271.6% -47.4% -1,497%
Operating cash flow margin -265.0% -46.6% -1,488%
Return on equity -10.6% 38.3% -26.9%
Return on assets -8.1% 12.8% -17.5%
Return on invested capital – 21.1% -23.3%
Return on capital employed -31.5% 21.0% -21.6%
Asset turnover 0.1x 0.8x 0.0x
Cash conversion (OCF / net income) 3.6x -3.0x 0.8x
Stock comp / revenue 52.7% 8.0% 276.8%

Financial Health

11 metrics
MetricBEAMPGENCRSP
Debt / assets 7.9% 44.4% 23.0%
Debt / equity 0.1x 1.1x 0.4x
Net debt / EBITDA 2.5x 1.2x 3.3x
Debt / FCF -0.3x -1.3x -1.6x
Liabilities / assets 24.9% 60.5% 35.5%
Equity / assets 75.1% 39.5% 64.5%
Interest coverage – 2.8x –
Current ratio 13.0x 5.6x 16.2x
Quick ratio 12.7x 4.6x 16.1x
Cash ratio 12.7x 1.5x 16.1x
Altman Z-score 2.90 -6.00 2.20

Shareholder Returns

7 metrics
MetricBEAMPGENCRSP
Dividend yield – – –
Net buyback yield -0.6% -0.2% -2.9%
Shareholder yield -0.6% -0.2% -2.9%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusBEAMPGENCRSP
Forward P/E – 24.8xFY2026 –
EPS, next fiscal year $-4.31FY2026 $0.17FY2026 $-4.27FY2026
EPS growth, the year after – +288.2% –
Revenue, next fiscal year $42.67MFY2026 $249.16MFY2026 $33.04MFY2026
Revenue growth, next FY -69.5%FY2026 +2,474.0%FY2026 +841.2%FY2026
Revenue growth, the year after +10.3% +82.3% +271.8%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersBEAMPGENCRSP
Held by institutions 100.0% 39.2% 78.9%
Institutions holding 277 211 520
Change in shares held, QoQ +1.0% +4.9% -1.0%
Institutions buying 154 123 238
Institutions selling 75 46 139
Buyers to sellers 2.05 2.67 1.71

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

BEAMPGENCRSP
BEAM 1.00 0.26 0.76
PGEN 0.26 1.00 0.34
CRSP 0.76 0.34 1.00

Add a Peer

Largest companies in the same industry

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Frequently Asked Questions

Which is bigger, BEAM, PGEN and CRSP?

CRISPR Therapeutics AG (CRSP) is the largest by market capitalisation: Beam Therapeutics (BEAM) $2.76B, Precigen (PGEN) $1.49B, CRISPR Therapeutics AG (CRSP) $4.79B.

Which company is growing faster?

Precigen (PGEN) grew revenue fastest over the trailing twelve months: Beam Therapeutics (BEAM) +163.3%, Precigen (PGEN) +2,387.6%, CRISPR Therapeutics AG (CRSP) -34.3%.

Which company is more profitable?

Precigen (PGEN) has the highest net margin (Beam Therapeutics (BEAM) -73.9%, Precigen (PGEN) 15.6%, CRISPR Therapeutics AG (CRSP) -1,812.1%). On return on invested capital, Precigen (PGEN) leads (Precigen (PGEN) 21.1%, CRISPR Therapeutics AG (CRSP) -23.3%).

Which stock has performed better?

Over the past year Beam Therapeutics (BEAM) returned the most: Beam Therapeutics (BEAM) +12.1%, Precigen (PGEN) +5.8%, CRISPR Therapeutics AG (CRSP) -14.8%. Over five years, Precigen (PGEN) compounded fastest (Beam Therapeutics (BEAM) -22.0%/yr, Precigen (PGEN) -3.8%/yr, CRISPR Therapeutics AG (CRSP) -11.7%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, CRISPR Therapeutics AG (CRSP) has been the steadiest (Beam Therapeutics (BEAM) 70.8%, Precigen (PGEN) 85.7%, CRISPR Therapeutics AG (CRSP) 57.1%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, BEAM, PGEN and CRSP?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Precigen (PGEN) leads on 6. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.