AMGN vs PTCT vs GILD Stock Comparison

Amgen, Ptc Therapeutics and Gilead Sciences Prices as of Oct 27, 2026 Peers: Industry group
AMGN Amgen Inc
$447.95 +8.0% 1M +53.9% 1Y
Market cap
$242.16B
P/E
27.7x
Revenue (TTM)
$38.10B
Div. yield
2.22%
Biotechnology Healthcare
8 wins
GILD Gilead Sciences, Inc.
$159.08 +5.4% 1M +32.0% 1Y
Market cap
$197.42B
P/E
–
Revenue (TTM)
$30.46B
Div. yield
2.04%
Biotechnology Healthcare
2 wins

Head to Head

11 decided of 12

Amgen leads on 8 of the 12 questions below (Amgen 8, Gilead Sciences 2, Ptc Therapeutics 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionAMGNPTCTGILDLeader
Larger companyMarket capitalisation $242.16B $5.17B $197.42B AMGN
Cheaper on earningsLower P/E, profitable companies only 27.7x -134.3x -61.0x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS 20.5x 56.4x — AMGN
Faster revenue growthRevenue growth, trailing twelve months +9.1% -42.8% +5.5% AMGN
More profitableNet margin, trailing twelve months 23.0% -3.8% -10.6% AMGN
Better return on capitalReturn on invested capital 14.3% 12.5% -6.0% AMGN
Less leveragedLower net debt / EBITDA 2.7x -7.3x 87.7x PTCT
Higher dividend yieldTrailing dividend yield 2.22% — 2.04% AMGN
Better 1-year returnPrice return, last 12 months +53.9% -7.4% +32.0% AMGN
Better 5-year returnAnnualised price return, 5 years +16.7%/yr +11.3%/yr +18.8%/yr GILD
Less volatileAnnualised volatility, 1 year 29.6% 40.8% 26.9% GILD
Higher overall scoreMean of the five percentile scores vs peers 66/100 64/100 61/100 AMGN

Percentile Scorecard

AMGNPTCTGILD

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisAMGNPTCTGILD
Valuation 86 #90 of 625 95 #34 of 625 90 #61 of 625
Growth 62 #231 of 602 42 #347 of 602 31 #416 of 602
Profitability 95 #31 of 551 86 #76 of 551 85 #83 of 551
Financial Health 22 #510 of 656 42 #381 of 656 21 #516 of 656
Shareholder Returns 68 #117 of 365 55 #165 of 365 77 #86 of 365
Overall 66 64 61
  • AMGN ranked among 672 companies in Pharmaceuticals and Biotechnology
  • PTCT ranked among 672 companies in Pharmaceuticals and Biotechnology
  • GILD ranked among 672 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodAMGNPTCTGILDSPY
1 month +8.0%-0.9%+5.4% -0.2%
3 months +14.0%-17.6%+18.4% +3.9%
6 months +31.9%-11.6%+23.1% +8.2%
Year to date +36.9%-18.3%+29.6% +12.9%
1 year +53.9%-7.4%+32.0% +12.3%
3 years +71.3%+235.4%+107.6% +87.4%
3 years, per year +19.7%+49.7%+27.6% +23.3%
5 years +116.2%+70.4%+136.2% +67.9%
5 years, per year +16.7%+11.3%+18.8% +10.9%
10 years +179.0%+868.6%+109.8% +261.1%
10 years, per year +10.8%+25.5%+7.7% +13.7%

Risk

MeasureAMGNPTCTGILDSPY
Volatility, 1Y 29.6%40.8%26.9% 12.7%
Downside volatility, 1Y 27.9%40.9%24.0% 12.7%
Beta vs S&P 500, 1Y 0.460.720.30 1.00
Return / volatility, 1Y 1.82-0.181.19 0.97
Max drawdown, 5Y -26.7%-69.4%-29.4% -25.4%
From 52-week high 0.0%-30.7%0.0% -1.2%
52-week high $447.95$89.55$159.08 $779.14
52-week low $291.16$59.24$117.88 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleAMGNPTCTGILD
P/E now vs peer median 27.7xmedian 17.2x -134.3xmedian 17.2x -61.0xmedian 17.2x
P/S now vs peer median 6.4xmedian 9.0x 5.1xmedian 9.0x 6.5xmedian 9.0x
EV/EBITDA now vs peer median 17.7xmedian 16.3x 21.1xmedian 16.3x 838.3xmedian 16.3x
P/FCF now vs peer median 23.8xmedian 18.7x -130.1xmedian 18.7x 15.3xmedian 18.7x
P/B now vs peer median 20.7xmedian 2.2x -31.3xmedian 2.2x 16.7xmedian 2.2x
PEG now vs peer median 10.44median 0.33 -2.13median 0.33 1.63median 0.33

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsAMGNPTCTGILD
Revenue $38.10B $1.01B $30.46B
Gross profit $26.48B $938.07M $24.24B
Operating income $11.43B $125.60M -$2.50B
Net income $8.74B -$38.38M -$3.24B
Free cash flow $10.18B -$39.78M $12.94B
R&D $7.63B $433.31M $6.07B
EPS (diluted) $16.07 $-0.42 $-2.61
Cash & equivalents $13.99B $1.05B $3.18B
Total debt $57.30B $905.19M $26.25B
Shares (diluted) 544.00M 92.02M 1.24B
Enterprise value $197.56B -$2.58B $171.53B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricAMGNPTCTGILD
P/E 27.7x -134.3x -61.0x
P/FCF 23.8x -130.1x 15.3x
P/Operating cash flow 19.4x -169.6x 14.6x
P/S 6.4x 5.1x 6.5x
P/B 20.7x -31.3x 16.7x
P/Tangible book -27.5x -9.1x -89.6x
EV/EBITDA 17.7x 21.1x 838.3x
EV/EBIT 25.0x 30.7x -88.3x
EV/Revenue 7.5x 3.8x 7.2x
EV/FCF 28.1x -96.8x 17.0x
EV/Operating cash flow 22.9x -126.2x 16.3x
PEG (3Y EPS CAGR) 10.44 -2.13 1.63

Growth

14 metrics
MetricAMGNPTCTGILD
Revenue growth (1Y) 9.1% -42.8% 5.5%
Revenue CAGR (3Y) 12.7% 7.2% 3.6%
Gross profit growth (1Y) 17.6% -45.3% 6.9%
Gross profit CAGR (3Y) 10.3% 6.9% 3.7%
Operating income growth (1Y) 39.5% -82.5% -131.0%
Operating income CAGR (3Y) 6.4% 30.3% -31.9%
Net income growth (1Y) 32.1% -106.1% -151.3%
Net income CAGR (3Y) 3.1% 60.4% -37.3%
EPS growth (1Y) 31.4% -105.2% -151.8%
EPS CAGR (3Y) 2.7% 63.1% -37.5%
Operating cash flow growth (1Y) 3.9% -104.3% 37.3%
Operating cash flow CAGR (3Y) 4.9% 50.2% 12.5%
Free cash flow growth (1Y) -4.1% -105.7% 38.1%
Free cash flow CAGR (3Y) 1.7% 47.7% 13.2%

Profitability

14 metrics
MetricAMGNPTCTGILD
Gross margin 69.5% 93.0% 79.6%
EBITDA margin 42.2% 18.1% 0.9%
Operating margin 30.0% 12.5% -8.2%
Pretax margin 27.0% -6.6% -6.4%
Net margin 23.0% -3.8% -10.6%
FCF margin 26.7% -3.9% 42.5%
Operating cash flow margin 32.8% -3.0% 44.5%
Return on equity 83.8% – -18.4%
Return on assets 9.3% -1.3% -6.1%
Return on invested capital 14.3% 12.5% -6.0%
Return on capital employed 16.7% 5.5% -6.0%
Asset turnover 0.4x 0.3x 0.6x
Cash conversion (OCF / net income) 1.4x 0.8x -4.2x
Stock comp / revenue 1.3% 8.4% 3.0%

Financial Health

11 metrics
MetricAMGNPTCTGILD
Debt / assets 59.9% 27.8% 53.2%
Debt / equity 4.9x -5.5x 2.2x
Net debt / EBITDA 2.7x -7.3x 87.7x
Debt / FCF 5.6x -22.8x 2.0x
Liabilities / assets 87.8% 105.1% 76.0%
Equity / assets 12.2% -5.1% 24.0%
Interest coverage 4.3x – -2.5x
Current ratio 1.4x 3.4x 1.3x
Quick ratio 0.9x 3.2x 0.7x
Cash ratio 0.5x 2.9x 0.3x
Altman Z-score 2.32 0.79 3.74

Shareholder Returns

7 metrics
MetricAMGNPTCTGILD
Dividend yield 2.2% – 2.0%
Net buyback yield – -2.0% 0.6%
Shareholder yield 2.2% -2.0% 2.6%
Payout ratio (earnings) 60.4% – –
Payout ratio (FCF) 51.9% – –
Dividend growth (1Y) 6.3% – –
Dividend CAGR (3Y) 6.7% – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusAMGNPTCTGILD
Forward P/E 20.5xFY2026 56.4xFY2026 –
EPS, next fiscal year $21.81FY2026 $1.10FY2026 $-0.39FY2026
EPS growth, next FY -0.1%FY2026 -85.9%FY2026 -104.8%FY2026
EPS growth, the year after +7.2% +125.5% –
Revenue, next fiscal year $41.51BFY2026 $1.33BFY2026 $28.65BFY2026
Revenue growth, next FY +12.9%FY2026 -23.2%FY2026 -2.7%FY2026
Revenue growth, the year after +2.3% -1.0% +18.1%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersAMGNPTCTGILD
Held by institutions 82.7% 100.0% 89.6%
Institutions holding 3,159 381 2,290
Change in shares held, QoQ +4.5% +5.0% +5.1%
Institutions buying 1,451 218 1,113
Institutions selling 1,217 111 850
Buyers to sellers 1.19 1.96 1.31

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

AMGNPTCTGILD
AMGN 1.00 0.26 0.52
PTCT 0.26 1.00 0.24
GILD 0.52 0.24 1.00

Add a Peer

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Frequently Asked Questions

Which is bigger, AMGN, PTCT and GILD?

Amgen (AMGN) is the largest by market capitalisation: Amgen (AMGN) $242.16B, Ptc Therapeutics (PTCT) $5.17B, Gilead Sciences (GILD) $197.42B.

Which company is growing faster?

Amgen (AMGN) grew revenue fastest over the trailing twelve months: Amgen (AMGN) +9.1%, Ptc Therapeutics (PTCT) -42.8%, Gilead Sciences (GILD) +5.5%.

Which company is more profitable?

Amgen (AMGN) has the highest net margin (Amgen (AMGN) 23.0%, Ptc Therapeutics (PTCT) -3.8%, Gilead Sciences (GILD) -10.6%). On return on invested capital, Amgen (AMGN) leads (Amgen (AMGN) 14.3%, Ptc Therapeutics (PTCT) 12.5%, Gilead Sciences (GILD) -6.0%).

Which stock has performed better?

Over the past year Amgen (AMGN) returned the most: Amgen (AMGN) +53.9%, Ptc Therapeutics (PTCT) -7.4%, Gilead Sciences (GILD) +32.0%. Over five years, Gilead Sciences (GILD) compounded fastest (Amgen (AMGN) +16.7%/yr, Ptc Therapeutics (PTCT) +11.3%/yr, Gilead Sciences (GILD) +18.8%/yr). Returns are price only, before dividends.

Which pays a higher dividend?

Amgen (AMGN) has the highest dividend yield: Amgen (AMGN) 2.22%, Gilead Sciences (GILD) 2.04%. Ptc Therapeutics (PTCT) pays no regular dividend.

Which stock is riskier?

By one-year price volatility, Gilead Sciences (GILD) has been the steadiest (Amgen (AMGN) 29.6%, Ptc Therapeutics (PTCT) 40.8%, Gilead Sciences (GILD) 26.9%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, AMGN, PTCT and GILD?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Amgen (AMGN) leads on 8. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.